Category: 32462-30-9

On August 30, 2013, Tang, Kewen; Wu, Guohui; Zhang, Panliang; Zhou, Congshan; Liu, Jiajia published an article.SDS of cas: 32462-30-9 The title of the article was Experimental and model study on enantioselective reactive extraction of p-hydroxyphenylglycine enantiomers with metal phosphine complexes. And the article contained the following:

Equilibrium study on enantioselective reactive extraction of p-hydroxyphenylglycine (HPG) enantiomers employing (S)-BINAP-metal complexes as host (selector) was performed in a batch system at 5°C. A reactive extraction model with an interfacial reaction of HPG enantiomers with (S)-BINAP-metal complexes was established to describe the exptl. data. The equilibrium formation constants at the interface and other important parameters were determined exptl. The extraction system shows good selectivity towards HPG enantiomers. Complex with palladium (PdCl2-(S)-BINAP) exhibits the highest selectivity among the metal complexes studied, which is solubilized in the organic phase and preferentially extracts L-HPG from aqueous phase. Efficiency of extraction depends, often strongly, on a number of process variables, including types of organic solvents and metal precursors, concentration of ligand, pH, and temperature The model quant. predicts extraction performance as a function of key operating parameters, providing a simple computational approach to process optimization. The model was verified exptl. with excellent results. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).SDS of cas: 32462-30-9

The Article related to hydroxyphenylglycine enantioselective reactive extraction metal phosphine complex exptl modeling, Organic Analytical Chemistry: Separations and other aspects.SDS of cas: 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On May 31, 2015, Zhao, Yanfang; Xu, Lubin published an article.Recommanded Product: H-Phg(4-OH)-OH The title of the article was Chiral Separation of D,L-p-Hydroxyphenylglycine by Ligand Exchange Micellar Electrokinetic Capillary Chromatography. And the article contained the following:

D-P-Hydroxyphenylglycine (D-p-HPG) is an important intermediate for the synthesis of semi-synthetic antibiotics. Owing to the importance of optical purity of D-p-HPG, it is necessary to be able to chirally sep. D,L-p-HPG and monitor the enantiomeric purity of D-p-HPG in the pharmaceutical industry. A Cu(II) complex with L-valine (L-Val) was used as a chiral selector for ligand exchange chiral separation of D,L-p-HPG by micelle electrokinetic capillary chromatog. Optical resolution of D,L-p-HPG was obtained with a running buffer of 20 mM NH4OAc, 40 mM sodium dodecylsulfate (SDS), 10 mM Cu(II) and 20 mM L-Val at pH 8.5 in <10 min. The enantiomer migration order was L-p-HPG before D-p-HPG, which was most suitable for the determination of minor L-p-HPG in the presence of a large excess of D-p-HPG. Separation parameters such as pH, SDS concentration, the molar ratio of Cu(II) to L-Val, the concentration of the chiral metal complex, and capillary temperature were studied. The present method can also be used for assaying the enantiomeric excess of D-p-HPG. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to hydroxyphenylglycine enantioseparation ligand exchange micellar electrokinetic capillary chromatog, Organic Analytical Chemistry: Separations and other aspects.Recommanded Product: H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 31, 2015, Wu, Enqi; Kim, Kyung Tae; Adidi, Sreenivas Kalyan; Lee, Young Keun; Cho, Jong Woon; Lee, Wonjae; Kang, Jong Seong published an article.Product Details of 32462-30-9 The title of the article was Enantioseparation and chiral recognition of α-amino acids and their derivatives on (-)-18-crown-6-tetracarboxylic acid bonded silica by capillary electrochromatography. And the article contained the following:

Capillary electrochromatog. was employed for enantioseparation of α-amino acids and their derivatives (-)-18-Crown-6-2,3,11,12-tetracarboxylic acid bonded on the silica was used as the chiral stationary phase and methanol/Tris-citric acid (20 mM, pH 3.0-4.5) (20:80, volume/volume) was used as mobile phase. The enantioseparation performance is discussed and structure-chiral separation relation were tried to be explained. The enantiomeric resolution was increased when the pH of the mobile phase decreased or hydrogen of amino acid was substituted with halogen. The resolution of 4-bromophenylalanine was 2.37 at pH 4.5, however, this value was increased to 3.35 at pH 3.0. Bromo- or chloro-substituted phenylalanine tended to show higher resolution than fluoro-substituted one. For fluoro-substituted phenylalanine the resolution was increased in order of 4-, 3- and 2-substituted one. α-Methyltryptamine did not show reasonable separation As the thermodn. study is a useful tool to understand the chiral recognition, the temperature effect on the enantioseparation was studied and the thermodn. parameters were calculated The most important mechanism of chiral recognition for the analytes tested could be barrier effects based on the thermodn. calculations The coefficient of determination between hydrophobicity and separation factor is 0.87, indicating favorable separation with higher hydrophobicity of amino acids. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Product Details of 32462-30-9

The Article related to amino acid derivative enantioseparation chiral recognition capillary electrochromatog, chiral crowntetracarboxylic acid bonded silica column capillary electrochromatog, Organic Analytical Chemistry: Separations and other aspects.Product Details of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On September 16, 2022, Moore, Keith P.; Schwaid, Adam G.; Tudor, Matthew; Park, Sangho; Beshore, Douglas C.; Converso, Antonella; Shipe, William D.; Anand, Rajan; Lan, Ping; Moningka, Remond; Rothman, Deborah M.; Sun, Wanying; Chi, An; Cornella-Taracido, Ivan; Adam, Gregory C.; Bahnck-Teets, Carolyn; Carroll, Steven S.; Fay, John F.; Goh, Shih Lin; Lusen, Jeffrey; Quan, Shuo; Rodriguez, Silveria; Xu, Min; Andrews, Christine L.; Song, Cheng; Filzen, Tracey; Li, Jing; Hollenstein, Kaspar; Klein, Daniel J.; Lammens, Alfred; Lim, U-Ming; Fang, Zhiyu; McHale, Carolyn; Li, Yuan; Lu, Meiqing; Diamond, Tracy L.; Howell, Bonnie J.; Zuck, Paul; Balibar, Carl J. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells. And the article contained the following:

Although current antiretroviral therapy can control HIV-1 replication and prevent disease progression, it is not curative. Identifying mechanisms that can lead to eradication of persistent viral reservoirs in people living with HIV-1 (PLWH) remains an outstanding challenge to achieving cure. Utilizing a phenotypic screen, we identified a novel chem. class capable of killing HIV-1 infected peripheral blood mononuclear cells. Tool compounds ICeD-1 and ICeD-2 (“inducer of cell death-1 and 2”), optimized for potency and selectivity from screening hits, were used to deconvolute the mechanism of action using a combination of chemoproteomic, biochem., pharmacol., and genetic approaches. We determined that these compounds function by modulating dipeptidyl peptidase 9 (DPP9) and activating the caspase recruitment domain family member 8 (CARD8) inflammasome. Efficacy of ICeD-1 and ICeD-2 was dependent on HIV-1 protease activity and synergistic with efavirenz, which promotes premature activation of HIV-1 protease at high concentrations in infected cells. This in vitro synergy lowers the efficacious cell kill concentration of efavirenz to a clin. relevant dose at concentrations of ICeD-1 or ICeD-2 that do not result in complete DPP9 inhibition. These results suggest engagement of the pyroptotic pathway as a potential approach to eliminate HIV-1 infected cells. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to screening preparation dpp9 inhibitor hiv1 infected leukocyte, Placeholder for records without volume info and other aspects.Quality Control of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Moon, Jihyeon; Ok, Kang Min published an article in 2022, the title of the article was (R)- and (S)-[C8H10NO3]2[NbOF5]: noncentrosymmetric niobium oxyfluorides with large optical anisotropy.Formula: C8H9NO3 And the article contains the following content:

Huge crystals of noncentrosym. (NCS) organic-inorganic hybrid niobium oxyfluorides, (R)-[C8H10NO3]2[NbOF5] [(R)-Nb] and (S)-[C8H10NO3]2[NbOF5] [(S)-Nb], have been easily grown via a slow evaporation method in high yields through the systematic driving of chiral structure-directing agents, 4-hydroxy-D-(-)-2-phenylglycine [(R)-HPG] and 4-hydroxy-L-(+)-2-phenylglycine [(S)-HPG], resp. Both (R)-Nb and (S)-Nb crystallizing in the NCS nonpolar space group, P21212, exhibit pseudo-three-dimensional structures assembled via multiple hydrogen bonding interactions between distorted [Nb(O/F)2F4]2- octahedra and the resp. protonated HPG cations. Interestingly, crystals of (R)-Nb and (S)-Nb exhibit large birefringence (ηnexp) of [email protected] nm attributable to the strong p-p interactions arising from the stacked benzene rings in HPG cations. The reported materials exhibit strong stability in most solvents in a wide range of polarities. Detailed characterization studies, including thermal properties, various spectroscopic analyses, second-harmonic generation measurements, and electronic structure calculations on the reported materials, are also described. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Formula: C8H9NO3

The Article related to carboxybenzyloxy ammonium niobium pentoxide noncentrosym optical anisotropy, Placeholder for records without volume info and other aspects.Formula: C8H9NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 30, 2018, Li, Yong-Xin; Yang, Jia-Ying; Alcantara, Miguel; Abelian, Grigor; Kulkarni, Ashutosh; Staubli, Ursula; Foster, Aalan C. published an article.HPLC of Formula: 32462-30-9 The title of the article was Inhibitors of the neutral amino acid transporters ASCT1 and ASCT2 are effective in in vivo models of schizophrenia and visual dysfunction. And the article contained the following:

The N-methyl-D-aspartate receptor coagonist D-serine is a substrate for the neutral amino acid transporters ASCT1 and ASCT2, which may regulate its extracellular levels in the central nervous system (CNS). We tested inhibitors of ASCT1 and ASCT2 for their effects in rodent models of schizophrenia and visual dysfunction, which had previously been shown to be responsive to D-serine. L-4-fluorophenylglycine (L-4FPG), L-4-hydroxyPG (L-4OHPG), and L-4-chloroPG (L-4ClPG) all showed high plasma bioavailability when administered systemically to rats and mice. L-4FPG showed good brain penetration with brain/plasma ratios of 0.7-1.4; however, values for L-4OHPG and L-4ClPG were lower. Systemically administered L-4FPG potently reduced amphetamine-induced hyperlocomotion in mice, whereas L-4OHPG was 100-fold less effective and L-4ClPG inactive at the doses tested. L-4FPG and L-4OHPG did not impair visual acuity in naive rats, and acute systemic administration of L-4FPG significantly improved the deficit in contrast sensitivity in blue light-treated rats caused by retinal degeneration. The ability of L-4FPG to penetrate the brain makes this compound a useful tool to further evaluate the function of ASCT1 and ASCT2 transporters in the CNS. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).HPLC of Formula: 32462-30-9

The Article related to neutral amino acid transporter asct1 asct2 schizophrenia visual dysfunction, Placeholder for records without volume info and other aspects.HPLC of Formula: 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Man-yu; Shi, Ya-jing; Wang, Lan-zhi; Song, Hui-hua published an article in 2019, the title of the article was Syntheses, crystal structures and electrochemical properties of two chiral Cu complexes based on D(-)/L(+)-4-hydroxyphenylglycine.Safety of H-Phg(4-OH)-OH And the article contains the following content:

Two chiral coordination compounds based on D(-)/L(+)-4-hydroxyphenylglycine (D/L-Hhpg), {[Cu(D-hpg)(phen)(NO3)]·1.5H2O}n (1) and {[Cu(L-hpg)(phen)(NO3)]·2H2O}n (2) (phen=1,10-phenanthroline) have been synthesized and characterized by elemental anal., IR spectroscopy, powder X-ray diffraction, single-crystal X-ray diffraction, solid-state CD spectra and TG-DSC anal. Compounds 1 and 2 are orthorhombic, P212121 chiral space groups. They are 1D chain structure, which is extended into a 3D supramol. structure by the hydrogen bond. Interestingly, the compounds 1 and 2 exist left-handed or right-handed supramol. helix chains along the b axis direction by the hydrogen bond resp., which is extended by the hydrogen bond between coordinated nitrate anion and lattice water. Furthermore, based on the central metal ions of Cu(Π), further explored the compounds 1 and 2 of electrochem. properties, Anal. of cyclic voltammetry at varying scan rates (0.03 to 0.13 V·s-1) demonstrates a linear relationship between the anode peak current and the scan rate, indicating a surface-controlled electrochem. process. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to crystal structure electrochem chiral copper complex hydroxyphenylglycine synthesis, Placeholder for records without volume info and other aspects.Safety of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On April 13, 2021, Pandey, Renu; Collins, Meghan; Lu, Xiyuan; Sweeney, Shannon R.; Chiou, Jennifer; Lodi, Alessia; Tiziani, Stefano published an article.Electric Literature of 32462-30-9 The title of the article was Novel Strategy for Untargeted Chiral Metabolomics using Liquid Chromatography-High Resolution Tandem Mass Spectrometry. And the article contained the following:

Stereospecific recognition of metabolites plays a significant role in the detection of potential disease biomarkers thereby providing new insights in diagnosis and prognosis. D-Hdroxy/amino acids are recognized as potential biomarkers in several metabolic disorders. Despite continuous advances in metabolomics technologies, the simultaneous measurement of different classes of enantiomeric metabolites in a single anal. run remains challenging. Here, we develop a novel strategy for untargeted chiral metabolomics of hydroxy/amine groups (-OH/-NH2) containing metabolites, including all hydroxy acids (HAs) and amino acids (AAs), by chiral derivatization coupled with liquid chromatog.-high resolution tandem mass spectrometry (LC-HR-MS/MS). Diacetyl-tartaric anhydride (DATAN) was used for the simultaneous derivatization of-OH/-NH2 containing metabolites as well as the resulting diastereomers, and all the derivatized metabolites were resolved in a single anal. run. Data independent MS/MS acquisition (DIA) was applied to pos. identify DATAN-labeled metabolites based on reagent specific diagnostic fragment ions. We discriminated chiral from achiral metabolites based on the reversal of elution order of D and L isomers derivatized with the enantiomeric pair (±) of DATAN in an untargeted manner. Using the developed strategy, a library of 301 standards that consisted of 214 chiral and 87 achiral metabolites were separated and detected in a single anal. run. This approach was then applied to investigate the enantioselective metabolic profile of the bone marrow (BM) and peripheral blood (PB) plasma samples from patients with acute myeloid leukemia (AML) at diagnosis and following completion of the induction phase of chemotherapeutic treatment. The sensitivity and selectivity of the developed method enabled the detection of trace levels of the D-enantiomer of HAs and AAs in primary plasma patient samples. Several of these metabolites were significantly altered in response to chemotherapy. The developed LC-HR-MS method entails a valuable step forward in chiral metabolomics. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to untargeted chiral metabolomics liquid chromatog high resolution mass spectrometry, tandem, Placeholder for records without volume info and other aspects.Electric Literature of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 21, 2020, Forneris, Clarissa C.; Nguy, Andy K. L.; Seyedsayamdost, Mohammad R. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Mapping and Exploiting the Promiscuity of OxyB toward the Biocatalytic Production of Vancomycin Aglycone Variants. And the article contained the following:

Vancomycin is one of the most important clin. antibiotics in the fight against infectious disease. Its biol. activity relies on three aromatic cross-links, which create a cup-shaped topol. and allow tight binding to nascent peptidoglycan chains. The cytochrome P 450 enzymes OxyB, OxyA, and OxyC have been shown to introduce these synthetically challenging aromatic linkages. The ability to utilize the P 450 enzymes in a chemo-enzymic scheme to generate vancomycin derivatives is appealing but requires a thorough understanding of their reactivities and mechanisms. Herein, we systematically explore the scope of OxyB biocatalysis and report installation of diverse diaryl ether and biaryl cross-links with varying macrocycle sizes and compositions, when the enzyme is presented with modified vancomycin precursor peptides. The structures of the resulting products were determined using one-dimensional/two-dimensional NMR spectroscopy, high-resolution mass spectrometry (HR-MS), tandem HR-MS, and isotopic labeling, as well as UV-visible light absorption and fluorescence emission spectroscopies. An exploration of the biol. activities of these alternative OxyB products surprisingly revealed antifungal properties. Taking advantage of the promiscuity of OxyB, we chemo-enzymically generated a vancomycin aglycon variant containing an expanded macrocycle. Mechanistic implications for OxyB and future directions for creating vancomycin analog libraries are discussed. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to oxyb monooxygenase vancomycin aglycon variant, biosynthesis, chemo-enzymatic synthesis, macrocycles, vancomycin, Placeholder for records without volume info and other aspects.Quality Control of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Man-yu; Shi, Ya-jing; Wang, Lan-zhi; Song, Hui-hua published an article in 2019, the title of the article was Syntheses, crystal structures and electrochemical properties of two chiral Cu complexes based on D(-)/L(+)-4-hydroxyphenylglycine.Safety of H-Phg(4-OH)-OH And the article contains the following content:

Two chiral coordination compounds based on D(-)/L(+)-4-hydroxyphenylglycine (D/L-Hhpg), {[Cu(D-hpg)(phen)(NO3)]·1.5H2O}n (1) and {[Cu(L-hpg)(phen)(NO3)]·2H2O}n (2) (phen=1,10-phenanthroline) have been synthesized and characterized by elemental anal., IR spectroscopy, powder X-ray diffraction, single-crystal X-ray diffraction, solid-state CD spectra and TG-DSC anal. Compounds 1 and 2 are orthorhombic, P212121 chiral space groups. They are 1D chain structure, which is extended into a 3D supramol. structure by the hydrogen bond. Interestingly, the compounds 1 and 2 exist left-handed or right-handed supramol. helix chains along the b axis direction by the hydrogen bond resp., which is extended by the hydrogen bond between coordinated nitrate anion and lattice water. Furthermore, based on the central metal ions of Cu(Π), further explored the compounds 1 and 2 of electrochem. properties, Anal. of cyclic voltammetry at varying scan rates (0.03 to 0.13 V·s-1) demonstrates a linear relationship between the anode peak current and the scan rate, indicating a surface-controlled electrochem. process. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to crystal structure electrochem chiral copper complex hydroxyphenylglycine synthesis, Placeholder for records without volume info and other aspects.Safety of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts