Category: 32462-30-9

On June 4, 2019, Godlewski, Grzegorz; Cinar, Resat; Coffey, Nathan J.; Liu, Jie; Jourdan, Tony; Mukhopadhyay, Bani; Chedester, Lee; Liu, Ziyi; Osei-Hyiaman, Douglas; Iyer, Malliga R.; Park, Joshua K.; Smith, Roy G.; Iwakura, Hiroshi; Kunos, George published an article.Safety of H-Phg(4-OH)-OH The title of the article was Targeting Peripheral CB1 Receptors Reduces Ethanol Intake via a Gut-Brain Axis. And the article contained the following:

Endocannabinoids acting on the cannabinoid-1 receptor (CB1R) or ghrelin acting on its receptor (GHS-R1A) both promote alc.-seeking behavior, but an interaction between the two signaling systems has not been explored. Here, we report that the peripheral CB1R inverse agonist JD5037 reduces ethanol drinking in wild-type mice but not in mice lacking CB1R, ghrelin peptide or GHS-R1A. JD5037 treatment of alc.-drinking mice inhibits the formation of biol. active octanoyl-ghrelin without affecting its inactive precursor desacyl-ghrelin. In ghrelin-producing stomach cells, JD5037 reduced the level of the substrate octanoyl-carnitine generated from palmitoyl-carnitine by increasing fatty acid 尾-oxidation Blocking gastric vagal afferents abrogated the ability of either CB1R or GHS-R1A blockade to reduce ethanol drinking. We conclude that blocking CB1R in ghrelin-producing cells reduces alc. drinking by inhibiting the formation of active ghrelin and its signaling via gastric vagal afferents. Thus, peripheral CB1R blockade may have therapeutic potential in the treatment of alcoholism. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Safety of H-Phg(4-OH)-OH

The Article related to behavior role: bsu (biological study, unclassified), biol (biological study), body weight role: bsu (biological study, unclassified), biol (biological study), signal transduction role: bsu (biological study, unclassified), biol (biological study), 尾-oxidation role: bsu (biological study, unclassified), biol (biological study), and other aspects.Safety of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On March 31, 2013, Schrauwen, Patrick; Timmers, Silvie; Hesselink, Matthijs K. C. published an article.Quality Control of H-Phg(4-OH)-OH The title of the article was Blocking the entrance to open the gate. And the article contained the following:

A review. The research of Keung et al. (2013) entitled ‘Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice’ is reviewed with commentary and references The article by these authors revisits the Randle hypothesis of a reciprocal relationship between fat and glucose oxidation Inhibition of mitochondrial entry of fatty acids by oxfenicine resulted in improved glucose tolerance and insulin sensitivity in high-fat diet-fed mice, while body mass was maintained. The authors confirmed that oxfenicine was indeed able to reduce fat oxidation with a concomitant increase in glucose oxidation facilitated by increased pyruvate dehydrogenase activity. GLUT4 translocation was improved. The results of Keung et al. may provide insight into new targets for diabetes treatment. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Quality Control of H-Phg(4-OH)-OH

The Article related to review etomoxir cpt1 inhibitor antidiabetic agent type 2 diabetes, Pharmacology: Reviews and other aspects.Quality Control of H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On July 31, 2022, Wu, Di; Hu, Luni; Han, Mengwei; Deng, Yichen; Zhang, Yime; Ren, Guanqun; Zhao, Xingyu; Li, Zongxian; Li, Peng; Zhang, Yinlian; Chen, Shanwen; Li, Jun; Shi, Yanyan; Xue, Jianxin; Wang, Pengyuan; Zhong, Chao published an article.Application of 32462-30-9 The title of the article was PD-1 signaling facilitates activation of lymphoid tissue inducer cells by restraining fatty acid oxidation. And the article contained the following:

Anti-programmed death-1 (PD-1) immunotherapy that aims to restore T cell activity in cancer patients frequently leads to immune-related adverse events such as colitis. However, the underlying mechanism is still elusive. Here, we find that Pdcd1-deficient mice exhibit disrupted gut microbiota and aggravated dextran sulfate sodium (DSS)-induced colitis. In addition to T cells, PD-1 is also substantially expressed in colonic lymphoid tissue inducer (LTi) cells. During DSS-induced colitis, LTi cell activation is accompanied by increased PD-1 expression, whereas PD-1 deficiency results in reduced interleukin-22 (IL-22) production by LTi cells and exacerbated inflammation. Mechanistically, activated LTi cells reprogram their metabolism toward carbohydrate metabolism and fatty acid synthesis, while fatty acid oxidation (FAO) is unchanged. However, PD-1 deficiency leads to significantly elevated FAO in LTi cells, which in turn attenuates their activation and IL-22 production Consistently, FAO suppression efficiently restores IL-22 production in Pdcd1-/- LTi cells. Thus, our study provides unforeseen mechanistic insight into colitis occurrence during anti-PD-1 immunotherapy through LTi cell metabolic reconfiguration. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Application of 32462-30-9

The Article related to antiprogrammeddeath1 signalling lymphoid tissue inducer cell fatty acid oxidation, Immunochemistry: Immunogenetics and other aspects.Application of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On December 31, 2019, Amano, Kohei; Matsumoto, Tsubasa; Tanaka, Kenichi; Funatsu, Kimito; Kotera, Masaaki published an article.Electric Literature of 32462-30-9 The title of the article was Metabolic disassembler for understanding and predicting the biosynthetic units of natural products. And the article contained the following:

Natural products are the source of various functional materials such as medicines, and understanding their biosynthetic pathways can provide information that is helpful for their effective production through the synthetic biol. approach. A number of studies have aimed to predict biosynthetic pathways from their chem. structures in a retrosynthesis manner; however, sometimes the calculation finishes without reaching the starting material from the target mol. In order to address this problem, the method to find suitable starting materials is required. In this study, we developed a predictive workflow named the Metabolic Disassembler that automatically disassembles the target mol. structure into relevant biosynthetic units (BUs), which are the substructures that correspond to the starting materials in the biosynthesis pathway. This workflow uses a biosynthetic unit library (BUL), which contains starting materials, key intermediates, and their derivatives We obtained the starting materials from the KEGG PATHWAY database, and 765 BUs were registered in the BUL. We then examined the proposed workflow to optimize the combination of the BUs. To evaluate the performance of the proposed Metabolic Disassembler workflow, we used 943 mols. that are included in the secondary metabolism maps of KEGG PATHWAY. About 95.8% of them (903 mols.) were correctly disassembled by our proposed workflow. For comparison, we also implemented a genetic algorithm-based workflow, and found that the accuracy was only about 52.0%. In addition, for 90.7% of mols., our workflow finished the calculation within one minute. The Metabolic Disassembler enabled the effective disassembly of natural products in terms of both correctness and computational time. It also outputs automatically highlighted color-coded substructures corresponding to the BUs to help users understand the calculation results. The users do not have to specify starting mols. in advance, and can input any target mol., even if it is not in databases. Our workflow will be very useful for understanding and predicting the biosynthesis of natural products. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to metabolic glucose mannose tropane galactose monobactam vinblastine scopoletin coumarin, biosynthetic pathway, natural products, starting material, Biochemical Methods: Biological and other aspects.Electric Literature of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dongala, Venkatesham; Tigulla, Parthasarathy published an article in 2013, the title of the article was The novel antioxidant activity method for phenolic compounds.Recommanded Product: H-Phg(4-OH)-OH And the article contains the following content:

A simple sensitive spectrophotometric method was developed using Phenolic compounds The method is based on the reaction of the secondary amine as n-electron donor with the π-acceptor 2,3,5,6-tetra chloro 1,4-benzo quinone. The colored charge-transfer complex was measured at 412nm. The Free radical generation was confirmed with the polymerization of acrylonitrile with charge transfer complex as initiator. The procedure was applied successfully to the determination of the Free radical Scavenging activity of the title compounds Among the Sixteen analogs, V16 exhibited highest antioxidant activity and very low IC50 value, V6 exhibited least antioxidant activity with highest IC50 value. In the present study, Quant. Structure-activity relationship modeling was performed on a series of Phenolic derivatives IP, EN, Soft and EI are found to be the explainable variables for the semi empirical methods. The statistical parameters from the models indicate that the data well fitted and have high predictive ability. The external predictive capability of the established model was evaluated by test set of 16 compounds It is recommended that the bulky electron-donation groups at the R1 and R3 position can increase the biol. activities of the inhibitors. It is expected that the developed model could provide some useful information for the future synthesis of highly potent Transferase inhibitor. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Recommanded Product: H-Phg(4-OH)-OH

The Article related to antioxidant spectrophotometry phenolic compound, Pharmacology: Structure-Activity and other aspects.Recommanded Product: H-Phg(4-OH)-OH

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On January 1, 2010, Wang, Haofan; Byun, Youngjoo; Barinka, Cyril; Pullambhatla, Mrudula; Bhang, Hyo-eun C.; Fox, James J.; Lubkowski, Jacek; Mease, Ronnie C.; Pomper, Martin G. published an article.Synthetic Route of 32462-30-9 The title of the article was Bioisosterism of urea-based GCPII inhibitors: Synthesis and structure-activity relationship studies. And the article contained the following:

We report a strategy based on bioisosterism to improve the physicochem. properties of existing hydrophilic, urea-based GCPII inhibitors. Comprehensive structure-activity relation studies of the P1′ site of ZJ-43- and DCIBzL-based compounds identified several glutamate-free inhibitors with Ki values below 20 nM. Among them, compound 32d (Ki = 11 nM) exhibited selective uptake in GCPII-expressing tumors by SPECT-CT imaging in mice. A novel conformational change of amino acids in the S1′ pharmacophore pocket was observed in the x-ray crystal structure of GCPII complexed with 32d. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Synthetic Route of 32462-30-9

The Article related to gcpii inhibitor urea derivative bioisosterism preparation structure activity, Pharmacology: Structure-Activity and other aspects.Synthetic Route of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On February 29, 2012, Koide, Haruki; Narasaki, Ritsuko; Hasegawa, Keiko; Nishimura, Naoko; Hasumi, Keiji published an article.Related Products of 32462-30-9 The title of the article was A new series of the SMTP plasminogen modulator with a phenylglycine-based side chain. And the article contained the following:

Our previous studies established fermentation conditions that enable efficient production of an SMTP (Stachybotrys microspora tripenyl phenols) congener through feeding of a precursor amine to S. microspora. In this study, we isolated five new SMTP congeners with a phenylglycine-based side chain to investigate structure-activity relationships further. This paper deals with the isolation and characterization of these congeners. A culture fed with an optically active precursor afforded single major product (SMTP-43, -43D, -44, or -44D), whereas a culture fed with racemic 3-hydroxy-D,L-phenylglycine gave two major products, which were separable each other on reversed-phase HPLC. SMTP-43, which had an L-2-phenylglycine moiety as the N-linked side chain, was potent in enhancing plasminogen activation. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Related Products of 32462-30-9

The Article related to stachybotrys microspora tripenyl phenol fermentation plasminogen modulator sar, Pharmacology: Structure-Activity and other aspects.Related Products of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On October 12, 2020, Wang, Yue; Zhao, Xueqi; Yu, Zhi; Xu, Zhangrun; Zhao, Bing; Ozaki, Yukihiro published an article.COA of Formula: C8H9NO3 The title of the article was A chiral-label-free SERS strategy for the synchronous chiral discrimination and identification of small aromatic molecules. And the article contained the following:

A versatile and robust chiral discrimination strategy for small aromatic compounds is of significant importance in multidisciplinary fields. However, most current methods lack either the sufficient sensitivity for recognizing the chirality of the target mols. or their mol. specificity information. We have developed a versatile and chiral-label-free surface-enhanced Raman scattering (SERS)-based chiral discrimination sensing system for small aromatic mols., where the mol. structural specificity and enantioselectivity can be given synchronously in a single SERS spectrum. More than 10 types of chiral aromatic mols. were successfully identified by using this system. This work has enormous potential for recognizing chiral products effectively in sophisticated systems, especially in the fields of chiral synthesis and chiral catalysis. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).COA of Formula: C8H9NO3

The Article related to sers synchronous chiral discrimination aromatic compound, sers, charge transfer, chiral discrimination, small aromatic molecules, Organic Analytical Chemistry: Detections and other aspects.COA of Formula: C8H9NO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On August 31, 2022, Qian, Heying; Guo, Huimin; Zhang, Xiao; Liu, Mingzhu; Zhao, Guodong; Xu, Anying; Li, Gang published an article.Electric Literature of 32462-30-9 The title of the article was Metabolic characterization of hemolymph in Bombyx mori varieties after Bombyx mori nucleopolyhedrovirus infection by GC-MS-based metabolite profiling. And the article contained the following:

The “Huakang 2” silkworm variety, bred by the Sericulture Research Institute of the Chinese Academy of Agricultural Sciences, is highly resistant to Bombyx mori nucleopolyhedrovirus (BmNPV) and effectively solves the issue of frequent Bombyx mori nuclear polyhedrosis in sericultural production The mol. mechanism of its resistance to BmNPV, however, is still unknown. The purpose of the present study was therefore to identify these anti-BmNPV mechanisms by using metabolomics in combination with transcriptomics after s.c. injection of budded virus (BV) with high concentrations of BmNPV from specimens of the Baiyu N variety (which is highly resistant to BmNPV) and the Baiyu variety (which is sensitive to BmNPV). A total of 375 differential metabolites were identified, which mainly included sugars, acids, amines, alcs., glycosides, and other small mols. KEGG enrichment anal. and functional clustering of differential metabolites identified possible metabolic pathways, including tyrosine metabolism, oxidative phosphorylation, and alanine, aspartate, and glutamate metabolism The differentially expressed genes (DEGs) identified by transcriptome anal. were annotated in KEGG. Association anal. showed that the metabolic pathways of different silkworm varieties are affected differently by BmNPV infection, triggering a series of complex physiol. and biochem. changes in the organism. In particular, oxidative phosphorylation might be an essential pathway involved in regulation of disease resistance. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Electric Literature of 32462-30-9

The Article related to bmnpv infection hemolymph oxidative phosphorylation gc ms, Nonmammalian Biochemistry: Metabolism and other aspects.Electric Literature of 32462-30-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On November 30, 2018, Guo, Heying; Sun, Yu; Niu, Xiaoying; Wei, Nannan; Pan, Congjie; Wang, Guoxiu; Zhang, Huige; Chen, Hongli; Yi, Tao; Chen, Xingguo published an article.Category: alcohols-buliding-blocks The title of the article was The preparation of poly-levodopa coated capillary column for capillary electrochromatography enantioseparation. And the article contained the following:

Levodopa (L-DOPA) is promising as chiral stationary phase for open tubular capillary electrochromatog. (OT-CEC) enantioseparation owing to its self-polymerization adhesive property and chiral recognition potential. In this work, CuSO4/H2O2 was used as a trigger agent to accelerate the polymerization process of L-DOPA and the poly-levodopa (poly-(L-DOPA)) coated column was successfully prepared for the first time by depositing it on the inner wall of fused silica capillary via the rapid and in-situ approach at room temperature The performance of the poly-(L-DOPA) coated capillary was validated by the separation of different chiral analytes, including chiral amine drugs, neurotransmitters and amino acids, and the good enantioseparation efficiencies were achieved. For five consecutive runs, the relative standard deviations (RSDs) for the migration time of the analytes for intra-day, inter-day and column-to-column were in the range of 0.19-1.33%, 0.96-4.47%, and 2.21-7.79%, resp. Addnl., the poly-(L-DOPA) coated capillary column could be successively used over 250 runs without observable change in the separation efficiency. The experimental process involved the reaction of H-Phg(4-OH)-OH(cas: 32462-30-9).Category: alcohols-buliding-blocks

The Article related to electrochromatog enantioseparation polylevodopa capillary column, enantioseparation, open tubular capillary electrochromatography, poly-levodopa, Biochemical Methods: Chromatographic and other aspects.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts