Category: 32328-03-3

Adding a certain compound to certain chemical reactions, such as: 32328-03-3, Diethyl 3-hydroxyglutarate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Diethyl 3-hydroxyglutarate, blongs to alcohols-buliding-blocks compound. Application In Synthesis of Diethyl 3-hydroxyglutarate

General Preparation of 3-hvdroxy protected glutaric acid. A four-neck round bottom flask fitted with a mechanical stirrer, condenser and charging tube, was charged with methylene dichloride (675 ml) followed by charging of imidazole (187.2 g), t-butyldimethylsilyl chloride (248.3 g) under nitrogen atmosphere. Reaction mass was maintained for 1-2 hours at 20-300C followed by addition of a solution of 3-hydroxy diethyl glutarate in methylene chloride (225 g). The mass was maintained for 4-6 hours followed by water and brine washing of the reaction mass. Methylene dichloride under vacuum at 30- 350C was distilled out and residue was charged into a solution of 30-40% aq. methyl alcohol (1850 ml), sodium hydroxide (96.8 g) at 25-350C and mixed for 20-30 hours. Solvent is distilled out under vacuum at 40-450C, mass was further diluted with water and 1-12N hydrochloric acid was added to bring pH to 2.5-4 and the product was extracted with t-butyl methyl ether and concentrated to give 71 % of 3-hydroxy protected glutaric acid.

The synthetic route of 32328-03-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2008/130638; (2008); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32328-03-3, name is Diethyl 3-hydroxyglutarate. This compound has unique chemical properties. The synthetic route is as follows. Formula: C9H16O5

Diethyl 3-hydroxy glutarate (6, 25g, 122.4 mmol) in TetaF (100 mL) was added dropwise to a IM solution OfLiAlH4 in THF (400 mL) at 0 0C under argon atmosphere with vigorous stirring. After addition, reaction mixture was allowed to reach r. t. (~4 h) and stirred for overnight. The reaction mixture was cooled to -78 0C (acetone/dry ice bath) and quenched by dropwise addition of saturated NH4Cl solution (50 rnL) giving white precipitate. The reaction mixture was diluted with another 500 mL of THF and white precipitate was filtered through Celite. The precipitate was treated with boiling THF (250 mL) and filtered. The combined organic solution was dried over anhydrous MgSO4 and solvent removed by rotoevaporation. The residue was purified on a silica gel flash column chromatography using DCM/EtOAc/methanol (6:3:1) affording triol 7 (11.4 g, 95.5 mmol, 78%) as a colorless oil. %). 1H-NMR (DMSO-d6, 400 MHz): deltal.39-1.54 (m, 4H, -CH2CH(OH)CH2-), 3.47 (t, J= 6.6, 4eta, 1 & 5 -CH2-), 3.61-3.68 (m, 1eta, -CH(HO)-) and 4.23 (bs, 3H, 1,3 & 5-OH).

With the rapid development of chemical substances, we look forward to future research findings about 32328-03-3.

Reference:
Patent; IDERA PHARMACEUTICALS, INC.; WO2008/73959; (2008); A2;,
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Related Products of 32328-03-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 32328-03-3, name is Diethyl 3-hydroxyglutarate. This compound has unique chemical properties. The synthetic route is as follows.

A 3-Methoxypentane-1,5-diol 25 ml of methyl trifluoromethylsulfonate are added to a solution of 30 g of diethyl 3-hydroxyglutarate and 33 ml of 2,6-di-tert-butylpyridine in 500 ml of DCM and the mixture is refluxed for 5 hours. After cooling, 500 ml of a 0.5N solution of HCl are added, the organic phase is decanted and dried over magnesium sulfate and the solvent is evaporated off under vacuum. The solid obtained is taken up with 200 ml of anhydrous THF, the mixture is filtered and the filtrate is then cooled to -5 C. 160 ml of a 1M solution of lithium aluminum hydride in THF are then added slowly and the mixture is stirred for 16 hours, the temperature being allowed to rise to RT. The reaction mixture is cooled to 0 C. and 5.5 ml of water, 18 ml of a 15% solution of NaOH and 5.5 ml of water are added successively. The mineral salts are filtered off and the filtrate is evaporated under vacuum to give the expected product after distillation under reduced pressure. B.p.=104 C. under 1.5 Pa.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 32328-03-3, Diethyl 3-hydroxyglutarate.

Reference:
Patent; Sanofi; US5618833; (1997); A;,
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Adding a certain compound to certain chemical reactions, such as: 32328-03-3, Diethyl 3-hydroxyglutarate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 32328-03-3, blongs to alcohols-buliding-blocks compound. Safety of Diethyl 3-hydroxyglutarate

Sodium hydroxide (0.80 g, 20 mmol) was dissolved in water (10 mL), diethyl 3-hydroxyglutarate (0.95 g, 5.0 mmol) was added thereto, and the mixture was stirred at room temperature for 1 hour. Next, after cooling the reaction solution on ice,65% nitric acid was added in an equimolar amount to sodium hydroxide and stirred for 1 hour under ice cooling. to this, An aqueous solution (0.70 mL) containing silver nitrate (1.70 g, 10 mmol) was added dropwise and the mixture was further stirred for 1 hour. Thereafter, the precipitated white precipitate was collected by filtration.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32328-03-3, its application will become more common.

Reference:
Patent; NOF CORPORATION; TAGAMI, YASUNOBU; MORISHITA, TAKEHIRO; MICHINISHI, JUNYA; (16 pag.)JP2015/107938; (2015); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32328-03-3, name is Diethyl 3-hydroxyglutarate. A new synthetic method of this compound is introduced below., Recommanded Product: 32328-03-3

1. Synthesis of 1,3,5-Pentanetriol (II)Diethyl 3-hydroxyglutarate (I, 1.0 g, 4.9 mmol) in anhydrous THF (10 mL) was added dropwise to a suspension of LiAlH4 in anhydrous THF (110 mL) under nitrogen with a cold water bath. Upon addition, the bath was removed and the suspension was stirred at room temperature for 2 days. The resulting mixture was quenched by adding 13 mL of brine very slowly with an ice-water bath. A white suspension was resulted, and the mixture was stirred at room temperature overnight. The solid was filtered, and washed with THF. The filtrate and wash were combined, and solvent evaporated to give 0.70 g of pale oil. Column chromatography of the crude product (230-400 mesh SiO2, 100 mL, 0-12% methanol gradient in chloroform) afforded 0.54 g of II as colourless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 32328-03-3, Diethyl 3-hydroxyglutarate.

Reference:
Patent; Tekmira Pharmaceuticals Corporation; Manoharan, Muthiah; Jayaraman, Muthusamy; Rajeev, Kallanthottathil G.; Eltepu, Laxman; Ansell, Steven; Chen, Jianxin; US9186325; (2015); B2;,
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