Category: 31775-67-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31775-67-4, name is trans-2-Aminocyclopentanol hydrochloride, the common compound, a new synthetic route is introduced below. COA of Formula: C5H12ClNO

To a solution of 1-(4-bromobenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (0.83 g) known from a document (Journal of Medicinal Chemistry, 2007, 50, 5471) in DMF (20 mL) were added (1,2-trans)-2-aminocyclopentanol hydrochloride (0.38 g), O-(7-azabenzotriazol-1-yl)-N,N,N’,N’-tetramethyluronium hexafluorophosphate (1.1 g) and triethylamine (0.80 mL), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the precipitate was collected by filtration and dried to give the title compound (1.0 g) as a pale-yellow solid. 1H NMR (300MHz, DMSO-d6) delta 1.37-1.94 (5H, m), 2.00-2.17 (1H, m), 3.88-4.10 (2H, m), 5.77 (2H, s), 5.86 (1H, s), 7.13-7.30 (2H, m), 7.44-7.97 (5H, m), 8.29-8.44 (1H, m), 9.08 (1H, s), 10.03 (1H, d, J = 7.4 Hz).

The synthetic route of 31775-67-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Takeda Pharmaceutical Company Limited; SAKAMOTO, Hiroki; SUGIMOTO, Takahiro; EP2821401; (2015); A1;,
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Related Products of 31775-67-4 ,Some common heterocyclic compound, 31775-67-4, molecular formula is C5H12ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 1-(4-fluorobenzyl)-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid (Intermediate 20), (110 mg) in DMF (2.1 mL) stirred at rt under nitrogen was added HATU (248 mg) and TEA (0.11 mL). This mixture was left to stir for 15 minutes and then trans-2-aminocyclopentanol hydrochloride (56.0 mg) was introduced. The reaction was left to stir overnight at room temperature, at which point LC-MS indicated completion. The reaction mixture was transferred to a separating flask and EtOAc and water were added. The phases were separated and the aqueous phase was extracted twice more with ethyl acetate. The organic phases were combined, washed with brine and the solvent was removed in vacuo. The residue was purified by column chromatography (normal phase, 25 g, Biotage SNAP cartridge KP-Sil, 25 mL per min, gradient 0% to 100% EtOAc in hexane, followed by 0-15% MeOH/EtOAc) to give the desired product as a racemic mixture of trans isomers (65 mg). LCMS: m/z 354.57 [M+H]+. 1H NMR (400 MHz, CDCl3) ppm 1.64-1.91 (m, 4H) 1.97-2.15 (m, 1H) 2.17-2.35 (m, 1H) 4.05-4.22 (m, 2H) 5.29 (s, 2H) 6.93-7.22 (m, 5H) 7.59 (d, J=8.3 Hz, 1H) 8.09 (s, 1H) 8.48 (d, J=4.7 Hz, 1H) 9.11 (d, J=3.1 Hz, 1H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,31775-67-4, its application will become more common.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; PAYNE, Andrew; CASTRO PINEIRO, Jose Luis; BIRCH, Louise Michelle; KHAN, Afzal; BRAUNTON, Alan James; KITULAGODA, James Edward; SOEJIMA, Motohiro; WO2015/49574; (2015); A1;,
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Application of 31775-67-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31775-67-4, name is trans-2-Aminocyclopentanol hydrochloride. A new synthetic method of this compound is introduced below.

A mixture of methyl 5-bromo-3-chloro-2-hydroxy-4- methylbenzoate (2.90 g) , trans-2-aminocyclopentanolhydrochloride (2.84 g) and triethylamine (4.20 g) inmethanol/dichloromethane was stirred with heating under reflux for 3 days. The reaction mixture was concentrated, andpurified by silica gel column chromatography (ethylacetate/petroleum ether) to give the title compound (1.70 g) .1H NMR (400 MHz, CDC13) delta 1.65-1.95 (4H, m) , 2.02-2.10 (1H, m) , 2.25-2.35 (1H, m) , 2.55 (3H, s) , 3.55 (1H, brs), 4.02-4.12 (2H, m) , 6.45 (1H, brs), 7.51 (1H, s) . 1H was not observed.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,31775-67-4, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; SUGIMOTO, Takahiro; SUZUKI, Shinkichi; SAKAMOTO, Hiroki; YAMADA, Masami; NAKAMURA, Minoru; KAMATA, Makoto; SHIMOKAWA, Kenichiro; OGINO, Masaki; KIMURA, Eiji; MURAKAMI, Masataka; YONEMORI, Jinichi; KOJIMA, Takuto; (281 pag.)WO2016/208775; (2016); A1;,
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