Category: 311-86-4

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, the common compound, a new synthetic route is introduced below. Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol

54 g of 2-bromo-3,3,3-trifluoropropanol, 79 g of methanol, 9.7 g of activated RaneyNi catalyst and 19.3 g of potassium carbonate were charged into a 300 mL autoclave, stirred, evacuated and replaced with hydrogen After three times, pressure 5Mpa, heated to 80 ° C, the reaction 3.0h, stop the reaction, cooling, discharge, distillation to 3,3,3 – trifluoropropanol; Yield 95.0percent.

The synthetic route of 311-86-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; Gu, Yujie; Lu, Jian; Ma, Hui; Wang, Zhixuan; Kang, Jianping; Du, Yongmei; Tu, Donghuai; Wan, Hong; Li, Yang; (5 pag.)CN105399607; (2016); A;,
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Synthetic Route of 311-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, molecular formula is C3H4BrF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 113 2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-methoxy-6-methylphenyl}azetidin-1-yl)-3,3,3-trifluoropropan-1-ol To a mixture of 1-[1-(3-azetidin-3-yl-5-chloro-2-methoxy-4-methylphenyl)ethyl]-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride (20 mg, 0.04 mmol, chrial intermediate from peak 1 of Example 1, step 7) and triethylamine (19 muL, 0.13 mmol) in acetonitrile (0.6 mL) was added 2-bromo-3,3,3-trifluoropropan-1-ol (from Synquest Labs, 9.2 mg, 0.048 mmol). N,N-dimethylformamide (0.3 mL) was added, which created a clear solution that was stirred at 70 C. overnight. The mixture was diluted water and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.6 mg (30%) of the desired product. The product was isolated as a mixture of diastereomers. LCMS calculated for C22H27ClF3N6O2 (M+H)+: m/z=499.2. Found: 499.1.

According to the analysis of related databases, 311-86-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Incyte Corporation; Li, Yun-Long; Yao, Wenqing; Combs, Andrew P.; Yue, Eddy W.; Mei, Song; Zhu, Wenyu; Glenn, Joseph; Maduskuie, JR., Thomas P.; Sparks, Richard B.; Douty, Brent; He, Chunhong; US2014/249132; (2014); A1;,
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Application of 311-86-4 ,Some common heterocyclic compound, 311-86-4, molecular formula is C3H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 1-[1-(3-azetidin-3-yl-5-chloro-2-methoxy-4-methylphenyl)ethyl]-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine dihydrochloride (20 mg, 0.04 mmol, chiral intermediate from peak 1 of Example 1, step 7) and triethylamine (19 muL, 0.13 mmol) in acetonitrile (0.6 mL) was added 2-bromo-3,3,3-trifluoropropan-1-ol (from Synquest Labs, 9.2 mg, 0.048 mmol). N,N-dimethylformamide (0.3 mL) was added, which created a clear solution that was stirred at 70 C. overnight. The mixture was diluted water and purified using RP-HPLC (XBridge C18 column, eluting with a gradient of acetonitrile/water containing 0.1% ammonium hydroxide, at flow rate of 30 mL/min) to give 6.6 mg (30%) of the desired product. The product was isolated as a mixture of diastereomers. LCMS calculated for C22H27ClF3N6O2 (M+H)+: m/z=499.2; Found: 499.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INCYTE CORPORATION; Li, Yun-Long; Yao, Wenqing; Combs, Andrew P.; Yue, Eddy W.; Mei, Song; Zhu, Wenyu; Glenn, Joseph; Maduskuie, JR., Thomas P.; Sparks, Richard B.; Douty, Brent; US2013/59835; (2013); A1;,
Alcohol – Wikipedia,
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Related Products of 311-86-4 ,Some common heterocyclic compound, 311-86-4, molecular formula is C3H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

733.2 mg of calcium hydroxide and 3343.3 mg of water were added to the reaction flask with the rectification apparatus.The mixture was heated to 90 C with stirring, and 1345 mg of 2-bromo-3,3,3-trifluoro-1-propanol was slowly added dropwise thereto for 1 h to obtain 1,1,1-trifluoro-2,3-epoxypropane. After chromatographic analysis, the yield was 74% and the selectivity was 100%, as shown in Figure 4.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanxi Prolong Petroleum Group Fugui Chemical Co., Ltd.; Dalian Institute of Chemical Physics; Liu Jianguo; Deng Weiqiao; Yang Fengbin; Yin Shuangliang; Sun Tongrui; Meng Qingyu; Zhang Ling; Wu Haitao; (15 pag.)CN109369602; (2019); A;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, molecular formula is C3H4BrF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Bromo-3,3,3-trifluoropropan-1-ol

2-bromo-1 ,1 , 1-trifluoropropan-3-ol (10 g, 0.0524mol) was placed in a 2-necked round bottom flask fitted with a distillation set up and then heated to 95 C. Sodium hydroxide (3 g, 0.0754 mol) was dissolved in water (12 g) at 0 C with stirring. Once the solution was homogenous it was then added dropwise to the 2-bromo-1 ,1 , 1-trifluoropropan-3-ol with rapid stirring via dropping funnel. As the head temperature reached 60 C clear liquid was collected in a receiver flask (4.2 g). GC area%: 1 , 1 , 1-trifluoro-1 ,2- epoxypropane (52%), 2-bromo-3,3,3-trifluoropropene + ethyl ether (26%), 3-acetoxy-2- bromo-1 , 1 , 1-trifluoropropane (7%), acetone (2%), unknown (13%).

With the rapid development of chemical substances, we look forward to future research findings about 311-86-4.

Reference:
Patent; MEXICHEM FLUOR S.A. DE C.V.; MURRAY, James Henry; SHARRATT, Andrew Paul; (32 pag.)WO2018/197897; (2018); A1;,
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Synthetic Route of 311-86-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol. A new synthetic method of this compound is introduced below.

Adding a moisture content of 4000 ppm in a 50 mL stainless steel autoclave equipped with agitation3,3,3-trifluoropropylene oxide (33.6 g, 0.3 mol), 3-bromo-1,1,1-trifluoro-2-propanol (2.3 g, 12 mol),2,3-dibromo-1,1,1,2,3,3-hexafluoropropane (5.6 g, 18 mol), imidazole (1.6 g, 24 mmol),After sealing, the reactor was replaced twice with CO2, and the stirring was set to a reaction temperature of 120 C.Continuously pass CO2 to maintain the reaction pressure at 2MPa, react for 4h, cool to normal temperature, and slowly releaseTo the excess CO2 gas, 50% water of a molar amount of 3,3,3-trifluoroepoxypropane was added to the reaction solution, and the reaction was stirred at 50 C for about 24 hours to obtain 3,3,3-trifluoro. Crude product of propylene carbonate and 3,3,3-trifluoro-1,2-propanediol, analysis of reaction product distribution by gas chromatography, separation,Refined process to get the target product3,3,3-trifluoropropene carbonate and42.3 g of 3,3,3-trifluoro-1,2-propanediol was used to calculate the yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Modern Chemical Institute; Lv Jian; Ma Hui; Zhang Wei; Wang Bo; Zeng Jijun; Zhao Bo; Yang Zhiqiang; Qin Yue; Bai Yanbo; Li Fengxian; (10 pag.)CN108178752; (2018); A;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol, blongs to alcohols-buliding-blocks compound. Quality Control of 2-Bromo-3,3,3-trifluoropropan-1-ol

54 g of 2-bromo-3,3,3-trifluoropropanol, 79 g of methanol, 9.7 g of activated RaneyNi catalyst and 19.3 g of potassium carbonate were charged into a 300 mL autoclave, stirred, evacuated and replaced with hydrogen After three times, pressure 5Mpa, heated to 80 C, the reaction 3.0h, stop the reaction, cooling, discharge, distillation to 3,3,3 – trifluoropropanol; Yield 95.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; Gu, Yujie; Lu, Jian; Ma, Hui; Wang, Zhixuan; Kang, Jianping; Du, Yongmei; Tu, Donghuai; Wan, Hong; Li, Yang; (5 pag.)CN105399607; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

311-86-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Calcium hydroxide: 72.8 gAnd 332 g of water were added to a reaction flask equipped with a rectification apparatus,Heated to 90 C with stirring,163.8 g of 3,3,3-trifluoro-2-bromopropanol was added dropwise,Control the distillation head temperature of 38-40 ,After the addition of the reaction for 1.0 h,The yield of trifluoropropylene oxide was 80.3%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol.

Reference:
Patent; Xi’an Modern Chemistry Research Institute; GU, YUJIE; LYU, JIAN; DU, YONGMEI; LYU, JING; LI, CHUNYING; WAN, HONG; MA, HUI; WANG, ZHIXUAN; WANG, BO; (5 pag.)CN103664833; (2016); B;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

311-86-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 311-86-4, name is 2-Bromo-3,3,3-trifluoropropan-1-ol, molecular formula is C3H4BrF3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a cold mixture of triphosgene (0.9 equiv.) and 2-bromo-3,3,3-trifluoropropan-1-ol (2equiv.) in THF was added pyridine (2 equiv.). The mixture was stirred at 0 C for 30 mm. In a separate flask, a suspension of Intermediate 2 (1 equiv.) in pyridine (2 equiv.) was cooled to 0C. To this suspension was added the mixture of triphosgene and bromopropanol via syringe, and the resulting mixture was heated to 60 C for 24 h. Contents were concentrated in vacuo, and the residue was diluted with ethyl acetate and washed with iN HC1 solution. The organic layer was dried over Mg504, filtered, and concentrated in vacuo to give a crude oil. The oil was purified via silica gel chromatography utilizing a 0-100% ethyl acetate/hexanes gradient todeliver the desired carbamate intermediate, 2-bromo-3,3,3-trifluoropropyl(2-( 1 -(2-fluorobenzyl)-5 -(isoxazol-3 -yl)- 1 H-pyrazol-3 -yl)pyrimidin-4-yl) carbamate (77 mg, 4% yield) as a light brown oil.1H NMR (500 MHz, CDC13) oe ppm 8.46 – 8.48 (m, 1 H), 8.07 (br. s., 1 H), 7.86 (d, 1 H), 7.44 -7.47 (m, 1 H), 7.17 – 7.24 (m, 1 H), 7.00 – 7.07 (m, 1 H), 6.93 – 7.00 (m, 1 H), 6.78 – 6.85 (m, 1 H), 6.57 – 6.62 (m, 1 H), 6.02 (s, 2 H), 4.28 (quind, 1 H), 3.93 – 4.15 (m, 2 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 311-86-4, 2-Bromo-3,3,3-trifluoropropan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NAKAI, Takashi; MOORE, Joel; PERL, Nicholas Robert; IYENGAR, Rajesh R.; MERMERIAN, Ara; IM, G-Yoon Jamie; LEE, Thomas Wai-Ho; HUDSON, Colleen; RENNIE, Glen Robert; JIA, James; RENHOWE, Paul Allen; BARDEN, Timothy Claude; YU, Xiang Y; SHEPPECK, James Edward; IYER, Karthik; JUNG, Joon; WO2014/144100; (2014); A2;,
Alcohol – Wikipedia,
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