Category: 30379-58-9

Adding a certain compound to certain chemical reactions, such as: 30379-58-9, Benzyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 30379-58-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 30379-58-9

Into a 100-mL round-bottom flask, was placed (2S)-2-[[(tert- butoxy)carbonyl](methyl)amino]-3-cyclopropylpropanoic acid (1.5 g, 6.17 mmol, 1.00 equiv), benzyl 2-hydroxyacetate (1.02 g, 6.14 mmol, 1.00 equiv) in dichloromethane (30 mL). This was followed by the addition of DCC (1.52 g, 7.37 mmol, 1.20 equiv), 4-dimethylaminopyridine (900 mg, 7.37 mmol, 1.20 equiv) and HOBt (1.0 g, 7.40 mmol, 1.20 equiv) respectively in portions with stirring at 0oC. The resulting solution was stirred for 12 h at room temperature. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (3:1). This resulted in 2 g (83%) of 2-(benzyloxy)-2- oxoethyl (2S)-2-[[(tert-butoxy)carbonyl](methyl)amino]-3-cyclopropylpropanoate as yellow oil. MS (ES, m/z): 392 (M+H); 1HNMR (300 MHz,CDCl3, ppm): delta 7.42-7.32 (m, 5H), 5.19 (s, 2H), 4.96-4.91 (m, 0.5H), 4.71-4.65 (m, 2H), 4.65-4.63 (m, 0.5H), 2.87 (d, J=14.1 Hz, 3H), 1.90-1.62 (m, 2H), 1.47 (d, J=6.0 Hz, 9H), 0.78-0.67 (m, 1H), 0.49-0.42 (m, 2H), 0.13-0.09 (m, 2H).

The synthetic route of 30379-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERIAL, INC.; de FALLOIS, Loic, Le Hir; PACOFSKY, Gregory; LONG, Alan; MENG, Charles; LEE, Hyoung, Ik; (461 pag.)WO2017/116702; (2017); A1;,
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Related Products of 30379-58-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 30379-58-9, name is Benzyl 2-hydroxyacetate. A new synthetic method of this compound is introduced below.

To a tetrahydrofuran (40.0 mL) solution of the compound (3.68 g, 10.0 mmol)obtained in above Process 1 and benzyl glycolate (4.99 g, 30.0 mmol), potassium tertbutoxide (2.24 g, 20.0 mmol) was added at OC and stirred at room temperature for 15 minutes. The reaction solution was charged with ethyl acetate and water at OC and extracted with ethyl acetate and chloroform. The obtained organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure. The obtained residues were dissolved in dioxane (40.0 mL) and water (10.0 mL), charged with sodium hydrogen carbonate (1.01 g, 12.0 mmol) and 9-fluorenylmethyl chloroformate (2.59 g, 10.0 mmol), and stirred at room temperature for 2 hours. The reaction solution was charged with water and extracted with ethyl acetate. The obtained organic layer was dried over sodium sulfate and filtered. The solvent was removed under reduced pressure and the obtained residues were purified by silica gel column chromatography [hexane: ethyl acetate = 100 : 0 (v/v) – 0: 1001 to yield the titled compound in colorless oily substance (1.88 g, 40%).1HNMR (400 MHz, CDC13) delta: 3.84 (2H, d, J = 5.5 Hz), 4.24 (3H, t, J = 6.5 Hz),4.49 (2H, d, J = 6.7 Hz), 4.88 (2H, d, J = 6.7 Hz), 5.15-5.27 (1H, m), 5.19 (2H, s), 6.74(1H, brs), 7.3 1-7.39 (7H, m), 7.43 (2H, t, J = 7.4 Hz), 7.61 (2H, d, J = 7.4 Hz), 7.79(2H, d, J = 7.4 Hz).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Patent; DAIICHI SANKYO COMPANY, LIMITED; HETTMANN, Thore; ABRAHAM, Reimar; BLUM, Sabine; UENO, Suguru; WO2015/155998; (2015); A1;,
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Application of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.

10129] l3enzyl glycolate (30 g, 0.25 mol) and Hoc anhydride (39.1 g, 0.19 mol) were dissolved in 30 ml of dichloromethane. 5 ml of DMAP (4.62 g, 0.038 mol) in dichloromethane solution was added dropwise into the resultant reaction liquid at 80 C. Afier that, the reaction liquid was reacted at 15 C. for 0.5 h. Afier completion of the reaction, the reaction liquid was poured into ice water, extracted with ethyl acetate, the combined resultant organic phase was washed with water and saturated salt water successively. The organic phase was concentrated and recrystallized with petroleum ether/ethyl acetate in a ratio of 10:1 to give a white solid (32.5 g, 66%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Patent; JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD.; Zhou, Wei; Jing, Yunrong; Wang, Yongfeng; Wang, Guocheng; (81 pag.)US2016/340365; (2016); A1;,
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Electric Literature of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.

General procedure: The compounds 12 (A-G) were synthesized using a similar procedure. Monomethyl ester 7 (2.73 g, 10 mmol) was dissolved in 40 ml of CHCl3, and diluted thionyl chloride was added (1.1 ml, 15 mmol). The mixture was stirred at rt for 8 h. The volatile components were evaporated under reduced pressure, and the residue was dissolved in 20 ml of benzene and evaporated again. The residue was re-dissolved in 40 ml of CHCl3, and the resulting solution was added dropwise to the mixture of D-benzyl 2-hydroxy acetate 11(A-G) (10 mmol) and triethylamine (3.5 ml, 25 mmol) in 20 ml of CHCl3 at C. The solution was stirred at rt for 3 days (monitored with TLC: Petroleum ether/ethyl acetate, 2:1) and then washed successively with 1M NaOH, water, 5% HCl, water, 10% NaHCO3, and brine (25 ml of each). The organic phase was dried over anhydrous sodium sulfate, filtered and evaporated under reduced pressure to offer crude products, which were was purified by flash column chromatography eluted with petroleum ether/ethyl acetate solution to afford the compounds 12 (A-G) as colorless or light yellow viscous liquid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Article; Jia, Chao; Yang, Ke-Wu; Liu, Cheng-Cheng; Feng, Lei; Xiao, Jian-Min; Zhou, Li-Sheng; Zhang, Yi-Lin; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 482 – 484;,
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Related Products of 30379-58-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The benzyl glycolate or thiobenzyl glycolate (1.5 equivalent) was added to the stirred suspension of peracetobromo-alpha-D-glucose, mannose, galactose (1 equivalent) and indium tribromide (10-15 mol%) in anhydrous dichloromethane (2 mL) at room temperature for an hour. The progress of reaction was monitored with thin layer chromatography. After the completion of the reaction, the reaction mixture was diluted with water and quenched with 10% aqueous acidic acid solution (1 mL). The organic layer washed with water and brine, the solvent was evaporated under reduced pressure and the crude product was purified by flash column chromatography on silica gel (90% ethyl acetate/hexanes). The corresponding beta-carboxymethyl glucosides (beta-CMGL) were afforded in good yield with high anomeric selectivity.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Article; Chandra, Sunena; Yadav, Ram N.; Paniagua, Armando; Banik, Bimal K.; Tetrahedron Letters; vol. 57; 13; (2016); p. 1425 – 1429;,
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Synthetic Route of 30379-58-9 ,Some common heterocyclic compound, 30379-58-9, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

step 4-; A mixture of 43 (400 mg, 1.74 mmol), hydroxy-acetic acid benzyl ester (0.394 mL, 2.78 mmol) and Cs2CO3 (1.19 g, 3.65 mmol) and DMF (95 mL) was heated to 70 C. overnight. The same amount of hydroxy-acetic acid benzyl ester and Cs2CO3 was then added and heating at 73 C. was continued for 62 hours. The reaction was cooled at RT and water was added. The mixture was acidified by addition of HCl (1M) and extracted with EtOAc. The combined organic layers were dried (MgSO4), filtered and concentrated. The residue was purified via SiO2 chromatography eluting with DCM/MeOH/NH4OH (60/10/1) to afford 0.213 g of 44.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30379-58-9, Benzyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lemoine, Remy; Melville, Chris Richard; Rotstein, David Mark; Wanner, Jutta; US2007/191335; (2007); A1;,
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Reference of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

General procedure: 7-Alkyl-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-diones 1;General ProcedureTo a two-necked round-bottom flask (100 mL) equipped with a condenserwas added a mixture, consisting of an alcohol (0.012 mol),TsTh (3.3 g, 0.01 mol), and DBU (3.0 g, 0.02 mol) in MeCN (50mL). The mixture was heated at reflux and heating was continueduntil TLC indicated no further improvement in the conversion (Table3). The solvent was evaporated under vacuum and the remainingfoam was dissolved in CHCl3 (100 mL) and subsequently washedwith H2O (2 ¡Á 100 mL). The organic layer was dried (Na2SO4) andevaporated. The crude product was purified by recrystallizationand/or column chromatography (silica gel).

Statistics shows that 30379-58-9 is playing an increasingly important role. we look forward to future research findings about Benzyl 2-hydroxyacetate.

Reference:
Article; Soltani Rad, Mohammad Navid; Behrouz, Somayeh; Najafi, Hosnieh; Synthesis; vol. 46; 10; (2014); p. 1380 – 1388;,
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Adding a certain compound to certain chemical reactions, such as: 30379-58-9, Benzyl 2-hydroxyacetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 30379-58-9, blongs to alcohols-buliding-blocks compound. Computed Properties of C9H10O3

To a mixture of 78 (0.14 g, 2.51 mmol) and CS2C03 (0.16 g, 5.0 mmol) in DMF (2 mL) was added benzyl glycolate (0.05g, 3 mmol), and resulting mixture was stirred at 70 C for 8 h. DMF was removed in vacuo and residue was purified by flash chromatography on silica gel eluting with 10%MeOH/DCM to afford O.lg (62%) 79: MS (ES+) m/z 640 (M + H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/121145; (2005); A2;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C9H10O3

Example 166; 2-[5-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-2-oxo-1,3,4-oxadiazol-3(2H)-yl]acetic acid [Show Image] 5-{2-[(4R,6S)-8-Chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]ethyl}-1,3,4-oxadiazol-2(3H)-one (73 mg) was dissolved in tetrahydrofuran (2 mL). To the resulting solution were added triphenylphosphine (103 mg) and benzyl glycolate (33 mul). A toluene solution (40% solution, 178 mul) of diethyl diazodicarboxylate was added. The resulting mixture was stirred at room temperature for 4 hours. After concentration of the reaction mixture under reduced pressure, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=7:1) and dissolved in ethyl acetate (2 mL). To the resulting solution was added 10% palladium-carbon (water content: 50%) (85 mg). Under a hydrogen gas stream, the resulting mixture was vigorously stirred at room temperature under a constant pressure for 7 hours. The reaction mixture was filtered through a Kiriyama funnel. The filtrate was concentrated under reduced pressure. The residue was purified by thin layer silica gel chromatography (chloroform:methanol=10:1) to give the title compound (35 mg). MS(FAB)m/z:526(M++H). 1H-NMR(CDCl3)delta:2.20-2.42(2H,m),2.57-2.77(1H,m),2.79-2.94(1H,m),3.36(3H,s),3.79(3H,s),4.10-4.42(3H,m),5.65(1H,s),6.26(2H,br s),6.67(1H,s),6.81-6.91(1H,m),7.10(1H,m),7.15(1H,s),7.20-7.39(3H,m).

With the rapid development of chemical substances, we look forward to future research findings about 30379-58-9.

Reference:
Patent; Daiichi Sankyo Company, Limited; EP1939205; (2008); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Benzyl 2-hydroxyacetate

PREPARATION 42 N-{2-t-Butyl-5-[3-(benzyloxycarbonylmethoxycarbonyloxy)-4-cyclohexylbutyl]phenyl}-2-(9H-xanthen-9-yl)acetamide A solution of 55 mul (0.46 mmol) of trichloromethyl chloroformate in 1 ml of tetrahydrofuran was added dropwise to a solution of 74 mul (0.91 mmol) of pyridine in 1 ml of tetrahydrofuran, whilst ice-cooling, and then the temperature of the resulting mixture was allowed to rise gradually to room temperature. The mixture was stirred for 1 hour at room temperature, after which it was again cooled, and a solution of 400 mg (0.76 mmol) of N-[2-t-butyl-5-(4-cyclohexyl-3-hydroxybutyl)phenyl]-2-(9H-xanthen-9-yl)acetamide (prepared as described in Example 12) in 3 ml of tetrahydrofuran was added dropwise. The mixture was stirred for 1 hour at the same temperature, and then the solvent was removed by distillation under reduced pressure, to give a colorless foam-like material as a residue. This residue was dissolved in 1 ml of methylene chloride, and a solution of 151 mg (0.91 mmol) of benzyl alpha-hydroxyacetate in 1.5 ml of methylene chloride and then 110 mg (0.91 mmol) of 4-(N,N-dimethylamino)pyridine were added dropwise, whilst ice-cooling. The mixture was stirred at room temperature for 1 hour, and then the reaction mixture was diluted with methylene chloride, after which it was washed with water and with a saturated aqueous solution of sodium chloride, in that order. The organic phase was dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting residue was purified by column chromatography through 75 g of silica gel, using a 1:9 by volume mixture of methylene chloride and ethyl acetate as the eluent, to give 522 mg (yield 96%) of the title compound as a colorless foam-like material. Infrared Absorption Spectrum (KBr) numax cm-1: 3274, 2924, 2853, 1750, 1655, 1480, 1458, 1422, 1256, 1194, 758.

With the rapid development of chemical substances, we look forward to future research findings about 30379-58-9.

Reference:
Patent; Sankyo Company, Limited; US5534529; (1996); A;,
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