Category: 30379-58-9

Related Products of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

To a solution of 4-(methylsulfonamidomethyl)benzoic acid (0.4 g, 1.745 mmol) and benzyl 2-hydroxyacetate (0.290 g, 1.745 mmol) in a mixture of DCM and THF 1/1 (50 ml), EDC (0.334 g, 1.745 mmol) and DMAP (0.256 g, 2.094 mmol) were added in one portion. The reaction was stirred at RT for 3h. The solvent was removed under vacuum and the resulting crude was portioned between EtOAc and HC1 2N. The organic phase was separated, washed with brine and dried over Na2S04. The solvent was removed under vacuum affording 2-(benzyloxy)-2- oxoethyl 4-(methylsulfonamidomethyl) benzoate (0.4 g, 1.060 mmol, 60.7% yield, MS/ESr 377.9 [MH] +). This product was employed in the following step without any further purification.

The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria; WO2013/45280; (2013); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: Benzyl 2-hydroxyacetate

General procedure: The suitable acid (1.1 equiv), DCC (1.1 equiv) and a catalytic amount of DMAP (0.1-0.2 equiv.) were added to a solution of the alcohol in anhydrous DCM, and stirred at room temperature for several hours. The solid was removed by filtration, and the filtrate was washed successively with a 1N aqueous acetic acid solution and water, dried over MgSO4, filtered, and concentrated under vacuum.The resulting residue was purified by silica gel chromatography to yield the expected compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Article; El Hilali, Mostafa; Reux, Bastien; Debiton, Eric; Leal, Fernand; Galmier, Marie-Josephe; Vivier, Magali; Chezal, Jean-Michel; Miot-Noirault, Elisabeth; Coudert, Pascal; Weber, Valerie; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5692 – 5708;,
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Synthetic Route of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

To a solution of anhydrous CH2Cl2 (3 mL), 4 A mol. sieves (0.1 g), protected glycolicacid 6 (150 g, 0.91 mmol) and compound 5 (500 g, 0.91 mmol) was added, at 20 C under argon atmosphere, TMSOTf (15 muL, 0,075 mmol). Afterwards the reaction mixture was stirred at this temperature for 3 h until TLC showed full conversion (PE:EtOAc 7:3, Rf 0.3). Than the mixture wasquenched by the addition of Et3N, filtered and the residue washed with CH2Cl2 (100 mL). The organic layer was concentrated. Pd-C catalyst was added to a solution of the oily mixture obtained from the previous reaction in 75 mL of (1:1) THF-MeOH. Afterwards, under stirring, the reaction mixture was placed under an H2 gas atmosphere (atmospheric pressure) and the deprotection of the benzyl ester was continued overnight. When full conversion had taken place (TLC examination), the H2 flow was replaced by Argon and the reaction mixture was filtered and washed (MeOH, 200 mL) through a pad of Celite. Upon concentration of the filtrate, a white solid material was obtained, and added CH2Cl2 was evaporated to remove traces of MeOH to afford 7 as a white solid (274 g, 0.6 mmol, 65% yield).

The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Ghidini, Alice; Steunenberg, Peter; Murtola, Merita; Stromberg, Roger; Molecules; vol. 19; 3; (2014); p. 3135 – 3148;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 30379-58-9, name is Benzyl 2-hydroxyacetate, the common compound, a new synthetic route is introduced below. Safety of Benzyl 2-hydroxyacetate

To a solution of lithium 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)methylsulfonamido)benzoate (theoric 0.869 mmol) and EDC (349 mg, 1.821 mmol) in dry DCM (3 ml), benzyl 2-hydroxyacetate (151 mg, 0.910 mmol) and DMAP (111 mg, 0.910 mmol) were added at RT. The final mixture was stirred for 2 days, then the solvent was evaporated, the residue was portioned between water and EtOAc, the organic layer was washed with NaHCO3 sat. sol. and brine, dried over Na2SO4 and evaporated. The crude was purified by flash chromatography on silica gel (eluent: DCM/MeOH/32% NH4OH 95/5/0.5) to give 2-(benzyloxy)-2-oxoethyl 3-(cyclopropylmethoxy)-4-(N-(2-(4-methylpiperazin-1-yl)ethyl)-methylsulfonamido)benzoate as a colorless oil (370 mg, 0.661 mmol, 76% yield over 2 steps, MS/ESI+ 560.1 [MH]+)

The synthetic route of 30379-58-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chiesi Farmaceutici S.p.A.; ARMANI, Elisabetta; Amari, Gabriele; Capaldi, Carmelida; Esposito, Oriana; Peretto, Ilaria; US2013/79313; (2013); A1;,
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Electric Literature of 30379-58-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

Reagent B : 150 mg (0.90 mmol) benzyl 2-hydroxyacetate and 142 mg (1. 81 mmol) pyridine are dissolved in 1 ml dichloromethane at 0C. 191 mg (0.95 mmol) 4-nitrophenyl chloroformiate is added, the reaction solution is warmed to room temperature, and stirring is continued for 1 hour. The reaction mixture is partitioned between dichloromethane and 2 N hydrochloric acid, the organic layer is washed sequentially with water and saturated aq. sodium chloride solution, dried over magnesium sulfate and evaporated to dryness in vacuo. The residue is used as Reagent B in the following reaction.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Patent; BAYER HEALTHCARE AG; WO2005/82863; (2005); A2;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.SDS of cas: 30379-58-9

(S)-l -benzyl 2-methyl aziridine-l,2-dicarboxylate (5.105 g, 21.70 mmol), and benzyl 2-hydroxyacetate (6.16 ml, 43.4 mmol) were dissolved in DCM (43.4 ml) and cooled to 0C followed by the addition of BF3.0Et2 (0.275 ml, 2.170 mmol). The reaction was stirred for 2 h. TLC showed the aziridine starting material to be consumed. The reaction was stirred for and additional 14 h. Saturated sodium bicarbonate solution was added to the reaction and the biphasic mixture was vigorously stirred for 20 min. The reaction was diluted with DCM and separated from the aquious phase. The organic layer was washed with brine, dried over sodium sulate and concentrated under vacuum. The crude material was purified by flash chromatography using 10-40% EtOAc/Hexanes. The product fractions were collected and the solvent removed under vacuum to give methyl 0-(2-(benzyloxy)-2-oxoethyl)-N-((benzyloxy)carbonyl)-L-serinate, 3.0 (34%). ESI-MS(+) m/z 402.1 (M+l). NMR (400MHz, CHLOROFORM-d) d 7.43 – 7.30 (m, 10H), 5.95 (d, J=8.0 Hz, IH), 5.18 (s, 2H), 5.15 (s, 2H), 4.50 (dt, J=8.4, 3.1 Hz, IH), 4.12 (d, J=2.8 Hz, 2H), 4.10 – 4.04 (m, IH), 3.81 (dd, J=9.4, 3.1 Hz, IH), 3.77 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30379-58-9, Benzyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; SUN, Li-Qiang; ZHAO, Qian; MULL, Eric; GILLIS, Eric P.; SCOLA, Paul Michael; (290 pag.)WO2016/57624; (2016); A1;,
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Synthetic Route of 30379-58-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of starting compound 68 (16 g, 41,1 mmol) and benzyl 2 -hydroxy-acetate 77a (13,6 g, 82,2 mmol) in 160 ml DCE was added Sc(OTf)3 (1,41 g, 2,88 mmol). The solution was stirred at 90C for 16 h to achieve complete conversion. The reaction mixture was poured into 200 ml sat. NaHC03 and extracted with 3 x 100 ml DCM. The combined organic phases were dried over anhydrous Na2S04, filtered and the filtrate was concentrated in vacuo. The residue was purified by column chromatography (PE:EtOAc 1:1) and then reverse flash chromatography (neutral), yielding 12,0 g (60 %) of the title compound 78a as yellow oil. MS [M+H]+ (m/z) = 496,0

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 30379-58-9, Benzyl 2-hydroxyacetate.

Reference:
Patent; SANOFI; HOFMEISTER, Armin; JAHN-HORMANN, Kerstin; (0 pag.)WO2019/170731; (2019); A1;,
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Reference of 30379-58-9 ,Some common heterocyclic compound, 30379-58-9, molecular formula is C9H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A previously dried round bottom flask fitted with a magnetic stirrer was charged with NaH (19 mg, 0.81 mmol) and then benzyl glycolate (230 muIota, 1 .62 mmol) in anhydrous THF (3 ml) were added in dropwise. Immediately after the addition was complete, a solution of 2-methanesulfonyl-3-(4-trifluoromethoxy-benzyl)-3H-imidazo[4,5-b]pyridine (90 mg, 0.24 mmol) in anhydrous THF (3 ml) was added. Reaction was left stirring under N2 at r.t. over the weekend. The reaction was quenched with water and a white solid crashed out of solution. This solid was filtered off and dried to afford the title compound (76 mg, 69%). [00355] LCMS Method: 1 , RT: 5.51 min, Ml: 458 [M+1] [00356] 1H NMR, Method 1 : (DMSO) 8.17 (dd 1 H), 7.84 (dd 1 H), 7.43 (d 2H), 7.40 – 7.36 (m 1 H), 7.32 (s 4H), 7.27 (d 2H), 7.22 (dd 1 H), 5.34 (s 2H), 5.29 (s 2H), 5.22 (s 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 30379-58-9, Benzyl 2-hydroxyacetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; STOCKLEY, Martin Lee; MACDONALD, Ellen Catherine; PRITOM, Shah; JORDAN, Allan; HITCHIN, James; HAMILTON, Niall; (217 pag.)WO2016/124939; (2016); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.Quality Control of Benzyl 2-hydroxyacetate

2-(Fluorenylmethoxycarbonyl)hydroxyacetic acid benzyl ester (657). To a solution of benzyl glycolate (6.0 g, 36.1 mmol) in CH2Cl2, cooled via ice-water bath, was added fluorenylmethoxy chloroformate (14 g, 1.5 equiv.) then diisopropylethylamine (9 mLs, 1.5 equiv.). After 1 hour, reaction mixture was poured into a saturated aqueaous solution of ammonium chloride and extracted with CH2Cl2, dried over Na2SO4 then concentrated in vacuo. The product was triturated from MeOH to obtain 2.2 g of 657 as a first crop of white solid. 2-(Fluorenylmethoxycarbonate) acetic acid (658). To a solution of 657 (2.2 g, 5.93 mmol) in tetrahydrofuran was added 5% Pd/C (220 mg). The resulting suspension was vigorously stirred under hydrogen atmosphere. After 90 min, the reaction mixture was filterred through Celite. The filtrate was poured into saturated aqueous NaHCO3 and washed twice with EtOAc. The aqueous layer was then acidified and the product extracted twice with CH2Cl2, dried over Na2SO4 and concentrated in vacuo to afford 1.46 g (88%) of 658 as a white solid. 2-(Fluorenylmethoxycarbonate) acetyl chloride (659), was prepared from 658 by the method used to prepare 643 to afford 659 as a crude product. (3S)-3-[(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-(2-fluorenylmethoxycarbonate)acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetylamino]4-oxo-butyric acid tert-butyl ester semicarbazone (660), was synthesised from 600b, using 659, by methods used to prepare 604d from 600b to afford 453 mg of 660. (3S)-3-[(3S)-2-Oxo-3-(3,5-dichloro-4-hydroxybenzoyl)amino-5-(2-hydroxy)acetyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetylamino]4-oxo-butyric acid tert-butyl ester semicarbazone (661). A solution of 660 (423 mg) in MeOH:Et2NH (1:1, v/v) was stirred at ambient temperature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30379-58-9, Benzyl 2-hydroxyacetate, and friends who are interested can also refer to it.

Reference:
Patent; Vertex Pharmaceuticals Incorporated; US6204261; (2001); B1;,
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Related Products of 30379-58-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 30379-58-9, name is Benzyl 2-hydroxyacetate. This compound has unique chemical properties. The synthetic route is as follows.

Benzyl 2-hydroxyacetate (3.2 ml, 22.2 mmol), sodium sulfate (0.63 g, 4.4 mmol), and MeCN (34 ml) were placed in a 100 ml two-necked RBF fitted with a magnetic stirrer, a dropping funnel and a refluxing condenser. 2,2-Difluoro-2-(fluorosulfonyl)acetic acid (9.18 ml, 89 mmol) was then added with stirring at 45 0C. After addition, the mixture was further stirred for 1 h at this temperature. The reaction mixture was poured into 10% aqueous sodium carbonate and was extracted with diethyl ether, the combined extracts were washed with 10% aqueous sodium carbonate, water, brine, dried over sodium sulfate, and concentrated. The crude material was purified by column chromatography (4:1 Hexanes/EtOAc) to afford the intermediate benzyl 2-(difluoromethoxy)acetate which was dissolved in EtOAc (34 mL). N-Ethyl-N-isopropylpropan-2 -amine (0.561 ml, 3.2 mmol) was added and after degassing with nitrogen, palladium on carbon (0.680 g, 0.64 mmol) was added. The reaction was purged with hydrogen and stirred under 50 PSI of hydrogen for 24 hours. The degassed reaction was filtered through a pad of Celite and concentrate to afford the titled product as the amine salt which was used directly for subsequent reaction steps without further purification.

According to the analysis of related databases, 30379-58-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMGEN INC.; WO2008/147547; (2008); A1;,
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