Category: 29908-11-0

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29908-11-0, name is (1,4-Dioxan-2-yl)methanol, the common compound, a new synthetic route is introduced below. Formula: C5H10O3

[0284] An oven dried multineck round bottom flask equipped with a condenser and an inlet septum under N2 is loaded with NaH (1.25 equiv., 60% in mineral oil) and dry THF (2.67 mL/mmol). An alcohol (1.2 equiv.) is added dropwise and the resulting mixture is stirred at room temperature for 20 min and subsequently heated at 50 C for 20 min. Then 4-chloro-6,7-dihydrobenzo[a]quinolizin-2-one derivative is added (1.0 equiv.) as a dry solid to the alkoxide mixture (any material that can not be transferred as such is dissolved in dry THF (1.3 mL/mmol) and added to the mixture). The mixture is briefly purged with N2 and heated at 70 C until all starting material is consumed. The mixture is cooled down to room temperature and quenched with saturated aq. NaHCO3. The mixture is then concentrated in vacuo and partitioned between DCM and brine. The aqueous layer is extracted once with DCM and combined organics are dried over Na2SO4 and concentrated to dryness. The crude product is dissolved in MeCN and refluxed for 15 min. The mixture is cooled down to room temperature and the precipitate is separated by filtration. The precipitate is discarded and the filtrate is washed with pentane. The MeCN phase is concentrated to dryness affording the desired product.

The synthetic route of 29908-11-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS NV; MENET, Christel, Jeanne, Marie; DOYON, Julien, Georges, Pierre-Olivier; CLAES, Pieter, Isabelle, Roger; ALLART, Brigitte; DE WACHTER, Maxim, Maria, Paul; TRICARICO, Giovanni, Alessandro; (168 pag.)WO2016/169911; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 29908-11-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 29908-11-0, name is (1,4-Dioxan-2-yl)methanol. A new synthetic method of this compound is introduced below.

To a solution of(l, 4-dioxan-2-yl) methanol (2.4 g) in dimethylsulfoxide (24 mL) was added 5-bromo-2-chloropyridine (3.91 g) and sodium hydride (0.81 g) at 20 C under nitrogen flow. Thereaction mixture was stirred at 60 C for 10 hours under nitrogen atmosphere. The reaction was diluted with water (40 mL) at 25 C and extracted with ethyl acetate (3 x 40 mL). The combined organic layers were washed with brine (5 x 20 mL) and dried over sodium sulfate. After filtration, the filtrate was concentrated to give a residue which was purified by colunm chromatography on silica gel (eluted with petroleum ether:ethyl acetate = 100:1 to 20:1) to give the title compound. ?H NMR (400 MHz, CDC13) 6ppm 8.15 (d, 1H), 7.63 (dd, 1H), 6.70 (d, 111) 4.38-4.49 (m, 2H), 3.78-3.85 (m, 2H), 3.59-3.71 (m, 6H),3.52 (dd, 2H), 3.35 (s, 311).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,29908-11-0, its application will become more common.

Reference:
Patent; ABBVIE INC.; ABBVIE DEUTSCHLAND GMBH & CO. KG; BRAJE, Wilfried; DOHERTY, George; JANTOS, Katja; JI, Cheng; JUDD, Andrew; KUNZER, Aaron; MASTRACCHIO, Anthony; SONG, Xiaohong; SOUERS, Andrew; SULLIVAN, Gerard; TAO, Zhi-Fu; TESKE, Jesse; WANG, Xilu; WENDT, Michael; PENNING, Thomas; LAI, Chunqui; KLING, Andreas; POHLKI, Frauke; (197 pag.)WO2019/35911; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts