Category: 2968-93-6

Jian, Yanlin et al. published their research in European Journal of Medicinal Chemistry in 2020 | CAS: 2968-93-6

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 2968-93-6

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents was written by Jian, Yanlin;Hulpia, Fabian;Risseeuw, Martijn D. P.;Forbes, He Eun;Munier-Lehmann, Helene;Caljon, Guy;Boshoff, Helena I. M.;Van Calenbergh, Serge. And the article was included in European Journal of Medicinal Chemistry in 2020.Related Products of 2968-93-6 This article mentions the following:

The synthesis of a series of aryl-shifted cyanopyridone analogs I [R = H, 2-Cl, OPh, etc.; R1 = H, 4-ClC6H4O, OBn, etc.; R2 = H, 4-Cl, 4-MeC6H4O, etc.] was reported. These compounds generally lacked significant MtbTMPK inhibitory potency, but some analogs did exhibit promising antitubercular activity. Analog I [R = H; R1 = H; R2 = 4-Ph] demonstrated a 10-fold increased antitubercular activity. Many analogs with whole-cell antimycobacterial activity were devoid of significant cytotoxicity. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Related Products of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lv, Haiping et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 2968-93-6

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 2968-93-6

Photocatalyzed cross-dehydrogenative coupling of silanes with alcohols and water was written by Lv, Haiping;Laishram, Ronibala Devi;Chen, Jingchao;Khan, Ruhima;Zhu, Yuanbin;Wu, Shiyuan;Zhang, Jianqiang;Liu, Xingyuan;Fan, Baomin. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2021.Related Products of 2968-93-6 This article mentions the following:

An efficient method for the dehydrogenative coupling of hydrosilanes with alcs. and phenols under photocatalysis with ruthenium bipyridine complex was developed, providing access for aryloxy, aralkyloxy and alkoxysilanes. The reaction proceeded in the presence of Ru(bpy)3Cl2 (0.5 mol%) under visible light irradiation in acetonitrile at room temperature The developed methodol. was also applicable for the synthesis of silanols using water as a coupling partner. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Related Products of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakafuku, Kohki M. et al. published their research in Nature Chemistry | CAS: 2968-93-6

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 2968-93-6

Enantioselective radical C-H amination for the synthesis of β-amino alcohols was written by Nakafuku, Kohki M.;Zhang, Zuxiao;Wappes, Ethan A.;Stateman, Leah M.;Chen, Andrew D.;Nagib, David A.. And the article was included in Nature Chemistry.Reference of 2968-93-6 This article mentions the following:

Asym., radical C-H functionalizations are rare but powerful tools for solving modern synthetic challenges. Specifically, the enantio- and regioselective C-H amination of alcs. to access medicinally valuable chiral β-amino alcs. remains elusive. To solve this challenge, a radical relay chaperone strategy was designed, wherein an alc. was transiently converted to an imidate radical that underwent intramol. H-atom transfer (HAT). This regioselective HAT was also rendered enantioselective by harnessing energy transfer catalysis to mediate selective radical generation and interception by a chiral copper catalyst. The successful development of this multi-catalytic, asym., radical C-H amination enabled broad access to chiral β-amino alcs. from a variety of alcs. containing alkyl, allyl, benzyl and propargyl C-H bonds. Mechanistic experiments revealed that triplet energy sensitization of a Cu-bound radical precursor facilitates catalyst-mediated HAT stereoselectivity, enabling the synthesis of several important classes of chiral β-amines by enantioselective, radical C-H amination. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Reference of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 2968-93-6

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Alcohol – Wikipedia,
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Matsuoka, Keitaro et al. published their research in Journal of the American Chemical Society in 2021 | CAS: 2968-93-6

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 2968-93-6

Chemoselective Cleavage of Si-C(sp3) Bonds in Unactivated Tetraalkylsilanes Using Iodine Tris(trifluoroacetate) was written by Matsuoka, Keitaro;Komami, Narumi;Kojima, Masahiro;Mita, Tsuyoshi;Suzuki, Kimichi;Maeda, Satoshi;Yoshino, Tatsuhiko;Matsunaga, Shigeki. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 2968-93-6 This article mentions the following:

Herein chemoselective cleavage of Si-C(sp3) bonds of unactivated tetraalkylsilanes was reported using iodine tris(trifluoroacetate). The reaction proceeded smoothly under mild conditions (-50°C to room temperature) and tolerated various polar functional groups, thus enabling subsequent Tamao-Fleming oxidation to provide the corresponding alcs. NMR experiments and d. functional theory calculations on the reaction indicated that the transfer of alkyl groups from Si to the I(III) center and the formation of the Si-O bond proceed concertedly to afford an alkyl-λ3-iodane and silyl trifluoroacetate. The developed method enabled the use of unactivated tetraalkylsilanes as highly stable synthetic precursors. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Related Products of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Andrew D. et al. published their research in Chemical Science | CAS: 2968-93-6

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 2968-93-6

Radical cascade synthesis of azoles via tandem hydrogen atom transfer was written by Chen, Andrew D.;Herbort, James H.;Wappes, Ethan A.;Nakafuku, Kohki M.;Mustafa, Darsheed N.;Nagib, David A.. And the article was included in Chemical Science.Application of 2968-93-6 This article mentions the following:

A radical cascade strategy for the modular synthesis of five-membered heteroarenes (e.g. oxazoles, imidazoles) I (R1 = Ph, 4-MeOC6H4, 4-F3C6H4, 2-naphthyl, biphenyl-4-yl, etc.; R2 = Ph, 2-pyridinyl, 4-IC6H4, 3-MeC6H4, etc.), II (R3 = 4-F3CC6H4, CCl3) from feedstock reagents (e.g. alcs., (R2CH2CH2OH), amines (such as., benzylamine, morpholine, pyrrolidine), nitriles R1CN) has been developed. This double C-H oxidation is enabled by in situ generated imidate R1C(=N)OCH2CH2R2 and acyloxy radicals, which afford regio- and chemo-selective β C-H bis-functionalization. The broad synthetic utility of this tandem hydrogen atom transfer (HAT) approach to access azoles is included, along with experiments and computations that provide insight into the selectivity and mechanism of both HAT events. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Application of 2968-93-6).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application of 2968-93-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some scientific research about 2968-93-6

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2968-93-6, its application will become more common.

Application of 2968-93-6 ,Some common heterocyclic compound, 2968-93-6, molecular formula is C9H9F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a mixture of caffeic acid fine powder (1.0 g, 5.56 mmol, 1.0 equiv.),alcohol (5.56 mmol, 1.0 equiv.) in nitromethane (125 mL) was addedytterbium triflate (34.4 mg, 0.056 mmol, 0.01 equiv.). After 5 min inan ultrasonic bath the mixture without protective gas was stirred ona 120 C oil bath for a given time. The reaction mixture was cooled toroom temperature, washed with deionised water (30 mL), 2% NaHCO3(30 mL) and brine, dried over anhydrous Na2SO4 and evaporated underreduced pressure to give the crude product, which was purified on asilica gel column to give the compounds 1-5 and 8-30.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2968-93-6, its application will become more common.

Reference:
Article; Xie, Dongsheng; Yang, Fengzhi; Xie, Jin; Zhang, Man; Liu, Wenlu; Fu, Lei; Journal of Chemical Research; vol. 38; 11; (2014); p. 695 – 700;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Extended knowledge of 2968-93-6

According to the analysis of related databases, 2968-93-6, the application of this compound in the production field has become more and more popular.

Reference of 2968-93-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2968-93-6, name is 2-(4-(Trifluoromethyl)phenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

0.5 g (1.71 mmol) of 2,4-dichloro-5- (2,2,2-trifluoroethylsulfinyl) phenol,0.38 g (1.74 mmol) of 2- (4-trifluoromethylphenyl) ethanol and 0.49 g (1.87 mmol) of triphenylphosphine in 30 ml of tetrahydrofuran at room temperature was added 0.38 g (1. 87 mmol) was added and the mixture was stirred for 16 hours. The solvent was distilled off under reduced pressure, and the residue was purified by silica gel chromatography (developing solvent, n-hexane: ethyl acetate = 5: 1) to obtain 0.41 g (yield 52%) of the objective compound.

According to the analysis of related databases, 2968-93-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kumai Chemical Industry CO Ltd; Ito, Seisuke; Matsuda, Takeshi; Mukawa, Shigeyuki; (47 pag.)JP2015/160813; (2015); A;,
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Introduction of a new synthetic route about 2-(4-(Trifluoromethyl)phenyl)ethanol

Statistics shows that 2968-93-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-(Trifluoromethyl)phenyl)ethanol.

Synthetic Route of 2968-93-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2968-93-6, name is 2-(4-(Trifluoromethyl)phenyl)ethanol, molecular formula is C9H9F3O, molecular weight is 190.16, as common compound, the synthetic route is as follows.

General procedure: To a stirred solution of alcohol 9 (8.00mmol) in toluene (40mL) under argon were added sequentially diethyl phosphonoacetic acid (1.35mL, 8.40mmol), DIPEA (3.62mL, 20.8mmol) and propyl phosphonic anhydride (6.62g, 10.4mmol, 50% w/w solution in ethyl acetate/THF). The solution was stirred at rt for 4h after which time it was diluted with water (50mL) and extracted with ethyl acetate (3¡Á100mL) followed by sequential washing of the combined organic extracts with 10% aqHCl (50mL), satd aqNaHCO3 (50mL) and brine (50mL). The organic extracts were dried over MgSO4 and concentrated in vacuo, affording the alpha-(diethoxyphosphoryl)acetate product 10, which was used without further purification.

Statistics shows that 2968-93-6 is playing an increasingly important role. we look forward to future research findings about 2-(4-(Trifluoromethyl)phenyl)ethanol.

Reference:
Article; Lloyd, Matthew G.; D’Acunto, Mariantonietta; Taylor, Richard J.K.; Unsworth, William P.; Tetrahedron; vol. 71; 39; (2015); p. 7107 – 7123;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts