Category: 29335-36-2

Karpina, V. R.; Kovalenko, S. S.; Kovalenko, S. M.; Zaremba, O. V.; Silin, O. V.; Langer, T. published the artcile< The synthesis and biological assessment of [[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides with an 1,2,4-oxadiazole cycle in positions 6, 7 and 8>, Computed Properties of 29335-36-2, the main research area is oxadiazolyl triazolopyridyl acetamide preparation antibacterial antifungal cytochrome HT2C inhibition.

A novel method was developed for the synthesis of 32 analogs of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides and biol. assessment was conducted. A convenient scheme for the synthesis of the title compounds started from com. available 2-chloropyridine-3-/4-/5-carboxylic acids with amidoximes to form the corresponding 2-chloro-[1,2,4-oxadiazol-5-yl]pyridines then followed by the hydrazinolysis with an excess of hydrazine hydrate. The process continued via the ester formation with the pyridine ring closure, followed by amide formation. A series of new 2-[6/7/8-(1,2,4-oxadiazol-5-yl)[1,2,4]triazolo[4,3-a]pyridine-3-yl]acetamides were obtained in good yields and their structures were proved by the method of 1H NMR spectroscopy. The prognosis and study of their pharmacol. activity were also conducted. The synthetic approach of obtaining the representatives of 2-[(1,2,4-oxadiazol-5-yl)-[1,2,4] triazolo[4,3-a]pyridine-3-yl]acetamides previously unknown can be used as an applicable method for the synthesis of diverse functionalized [1,2,4]triazolo[4,3-a]pyridine derivatives

Zhurnal Organichnoi ta Farmatsevtichnoi Khimii published new progress about 5-HT2C receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 29335-36-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C3H8N2O, Computed Properties of 29335-36-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Le, Thuy G.; Kundu, Abhijit; Ghoshal, Atanu; Nguyen, Nghi H.; Preston, Sarah; Jiao, Yaqing; Ruan, Banfeng; Xue, Lian; Huang, Fei; Keiser, Jennifer; Hofmann, Andreas; Chang, Bill C. H.; Garcia-Bustos, Jose; Wells, Timothy N. C.; Palmer, Michael J.; Jabbar, Abdul; Gasser, Robin B.; Baell, Jonathan B. published the artcile< Novel 1-Methyl-1H-pyrazole-5-carboxamide Derivatives with Potent Anthelmintic Activity>, Category: alcohols-buliding-blocks, the main research area is anthelmintic resistance phenotypic screen Haemonchus SAR hookworms whipworms.

A phenotypic screen of two different libraries of small mols. against the motility and development of the parasitic nematode Haemonchus contortus led to the identification of two 1-methyl-1H-pyrazole-5-carboxamide derivatives Medicinal chem. optimization targeted modifications of the left-hand side, middle section, and right-hand side of the hybrid structure of these two hits to elucidate the structure-activity relationship (SAR). Initial SAR around these hits allowed for the iterative and directed assembly of a focused set of 30 analogs of their hybrid structure. Compounds 10, 17, 20, and 22 were identified as the most potent compounds, inhibiting the development of the fourth larval (L4) stage of H. contortus at sub-nanomolar potencies while displaying strong selectivity toward the parasite when tested in vitro against the human MCF10A cell line. In addition, compounds 9 and 27 showed promising activity against a panel of other parasitic nematodes, including hookworms and whipworms.

Journal of Medicinal Chemistry published new progress about Anthelmintics. 29335-36-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C3H8N2O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Markov, Andrey V.; Sen’kova, Aleksandra V.; Popadyuk, Irina I.; Salomatina, Oksana V.; Logashenko, Evgeniya B.; Komarova, Nina I.; Ilyina, Anna A.; Salakhutdinov, Nariman F.; Zenkova, Marina A. published the artcile< Novel 3'-substituted-1',2',4'-oxadiazole derivatives of 18βH-glycyrrhetinic acid and their O-acylated amidoximes: synthesis and evaluation of antitumor and anti-inflammatory potential in vitro and in vivo>, Recommanded Product: N-Hydroxypropionimidamide, the main research area is oxadiazolyl oleanen preparation antitumor anti inflammatory agent SAR; acetoxy oxooleanen amidoxime preparation antitumor anti inflammatory agent SAR; 18βH-glycyrrhetinic acid; anti-inflammatory activity; antitumor activity; apoptosis; derivatives; heterocyclic moiety; metastasis; molecular docking; oxadiazole; target prediction.

A series of novel 18βH-glycyrrhetinic acid (GA) derivatives containing 3′-(alkyl/phenyl/pyridin(-2”, -3”, and -4”)-yl)-1′,2′,4′-oxadiazole moieties at the C-30 position were synthesized by condensation of triterpenoid’s carboxyl group with corresponding amidoximes and further cyclization. Screening of the cytotoxicity of novel GA derivatives on a panel of tumor cell lines showed that the 3-acetoxy triterpenoid intermediates-O-acylated amidoxime I [R = Me, Et, i-Pr, t-Bu, etc]display better solubility under bioassay conditions and more pronounced cytotoxicity compared to their 1′,2′,4′-oxadiazole analogs II [R = 2-pyridine, 3-pyridine, 4-pyridine] (median IC50 = 7.0 and 49.7μM, resp.). Subsequent replacement of the 3-acetoxy group by the hydroxyl group of pyridin(-2”, 3”, and -4”)-yl-1′,2′,4′-oxadiazole-bearing GA derivatives produced compounds III [R = 2-pyridine, 3-pyridine, 4-pyridine], showing the most pronounced selective toxicity toward tumor cells (median selectivity index (SI) > 12.1). Further detailed anal. of the antitumor activity of hit derivative III [R = 2-pyridine] revealed its marked proapoptotic activity and inhibitory effects on clonogenicity and motility of HeLa cervical carcinoma cells in vitro, and the metastatic growth of B16 melanoma in vivo. Addnl., the comprehensive in silico study revealed intermediate I [R = t-Bu], bearing the tert-Bu moiety in O-acylated amidoxime, as a potent anti-inflammatory candidate, which was able to effectively inhibit inflammatory response induced by IFNγ in macrophages in vitro and carrageenan in murine models in vivo, probably by primary interactions with active sites of MMP9, neutrophil elastase, and thrombin. Taken together, our findings provide a basis for a better understanding of the structure-activity relationship of 1′,2′,4′-oxadiazole-containing triterpenoids and reveal two hit mols. with pronounced antitumor III [R = 2-pyridine] and anti-inflammatory I [R = t-Bu] activities.

International Journal of Molecular Sciences published new progress about Amidoximes Role: PAC (Pharmacological Activity), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 29335-36-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C3H8N2O, Recommanded Product: N-Hydroxypropionimidamide.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Kawaljit; Kaur, Gurminder; Shanika, Petrus Siningu; Dziwornu, Godwin Akpeko; Okombo, John; Chibale, Kelly published the artcile< Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity>, SDS of cas: 29335-36-2, the main research area is fusidic acid fusidane triterpenoid synthesis SAR tuberculostatic tuberculosis; Anti-mycobacterial activity; Bioisosteres; Cytotoxicity; Fusidic acid.

Fusidic acid (FA) is a potent congener of the fusidane triterpenoid class of antibiotics. Structure-activity relationship (SAR) studies suggest the chem. structure of FA is optimal for its antibacterial activity. SAR studies from our group within the context of a drug repositioning approach in tuberculosis (TB) suggest that, as with its antibacterial activity, the C-21 carboxylic acid group is indispensable for its anti-mycobacterial activity. Further studies have led to the identification of 16-deacetoxy-16β-ethoxyfusidic acid (58), an analog which exhibited comparable activity to FA with an in vitro MIC99 value of 0.8μM. Preliminary SAR studies around the FA scaffold suggested that the hydrophobic side chain at C-20, like the C-11 OH group, was required for activity. The C-3 OH group, however, can be functionalized to obtain more potent compounds

Bioorganic & Medicinal Chemistry published new progress about Structure-activity relationship. 29335-36-2 belongs to class alcohols-buliding-blocks, and the molecular formula is C3H8N2O, SDS of cas: 29335-36-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts