Category: 29194-04-5

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 29194-04-5, name is 2-(Benzyl(methyl)amino)-1-phenylethanol, the common compound, a new synthetic route is introduced below. name: 2-(Benzyl(methyl)amino)-1-phenylethanol

EXAMPLE 5 Asymmetric reduction by use of (+)-2-N-benzyl-N-methylamino-1-phenylethanol: To a solution of 1.08 g (0.0284 mole) of LiAlH4 in 85 cc of ethyl ether, while being cooled in ice, was added dropwise 22 cc of an ether solution containing 6.86 g (0.0284 mole) of (+)-2-N-benzyl-N-methylamino-1-phenylethanol followed by 40 cc of an ether solution containing 6.90 g (0.0564 mole) of N-ethylaniline. After having been stirred at room temperature for 3 hours, the mixture was cooled to -78 C. To the mixture was added dropwise 55 cc of an ether solution containing 2.75 g (0.0095 mole) of (E)-1-(4-chlorphenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one. The mixture was stirred at said temperature for 3 hours and left standing overnight at room temperature. To the mixture was then added 105 cc of 2 N hydrochloric acid to effect decomposition. The organic layer was separated, washed successively with 100 cc of a saturated aqueous sodium hydrogencarbonate solution and 100 cc of ice-cooled water, then dried over anhydrous sodium sulfate, and concentrated under reduced pressure to obtain 2.83 g of a crude product: [alpha]D24 -6.44 (c=1.05, CHCl3). A 2.8 g portion of the crude product was recrystallized three times from a cyclohexane-methanol mixture to obtain 0.82 g of (-)-(E)-1-(4-chlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-ol: [alpha]D24 -14.9 (c=1.0, CHCl3).

The synthetic route of 29194-04-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Company, Limited; US4435203; (1984); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 29194-04-5, Adding some certain compound to certain chemical reactions, such as: 29194-04-5, name is 2-(Benzyl(methyl)amino)-1-phenylethanol,molecular formula is C16H19NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29194-04-5.

General procedure: A mixture of the substituted benzaldehyde (1.0mmol),finelyground sarcosine (0.13 g, 1.5 mmol),and paraformaldehyde (0.09g, 3.0 mmol)was refluxedin dry benzene (3.3 mL),with magnetic stirring and removal of formed water by means of a Dean-Starktrap, for 6-8h. The resulting solution was evaporated in vacuo to give the oily 5-aryl-3-methyloxazolidine 6. This was dissolved in toluene (1 mL)and quickly added to asolution of ArMgBr prepared from ArBr (1.5 mmol)and Mg (0.04g, 1.5 mmol)in THF (2mL)at 0 C with vigorous stirring. The mixture was left overnight at room temperature. Concentrated HCl (0.25 mL, 3.0 mmol)and toluene (3mL)were added with stirring to the cooled solution ( 5 C). The organic layer was decanted and the precipitate additionally washed with toluene and Et 2O. After basification with an excess of aq NH 3, extraction with CH 2Cl2 (2 2 mL),drying over Na 2SO4, and evaporation, the corresponding N-benzyl-b-hydroxyphenethylamine 7 was obtained. This was dissolved in CH 2Cl2 (2 mL)and treated dropwise with concd H2SO4 (2 mL)(96%-for 7a,b, 75%-for 7d,e) over 5min. After stirring for 2h, ice chips were added and the aq solution made basic with aq NaOH solution. The mixture was extracted with CH 2Cl2 (2 2 mL)and the combined organic extracts dried over anhydrous Na 2SO4, filteredthrough athin layer of silica gel and concentrated in vacuo. Amino alcohols 7c and 7f were cyclized using AlCl 3 in CH 2Cl2 (4.0 equiv, reflux,1.5 h)and polyphosphoric acid (1.1gof PPA- 1 mmol of 7f, 80-90 C, 1.5 h),respectively. The free bases were converted into hydrochloride salts with anhydrous ethereal HCl solution generated in situ from i-PrOH (1.3 equiv)and AcCl (1.1equiv).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29194-04-5, 2-(Benzyl(methyl)amino)-1-phenylethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Moshkin, Vladimir S.; Sosnovskikh, Vyacheslav Ya.; Tetrahedron Letters; vol. 54; 21; (2013); p. 2699 – 2702;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts