Category: 29055-08-1

Reference of 29055-08-1, Adding some certain compound to certain chemical reactions, such as: 29055-08-1, name is (2-(Methylamino)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29055-08-1.

To a solution (50 [ML)] of [2- (methylamino) phenyl] methanol (1.37 g: synthesized according to the method described in WO 01/32652) in tetrahydrofuran were added pyridine (1.05 [ML),] acetic anhydride (1.23 [ML)] and 4-dimethylaminopyridine (0.18 g), and the mixture was stirred at room temperature for 8 hrs. Water (100 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (100 mL). The organic layer was washed successively with a 5percent aqueous copper (II) sulfate solution (50 mL), a saturated aqueous sodium hydrogen carbonate solution (50 mL) and saturated brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by flash silica gel column chromatography (eluted with ethyl acetate: hexane=1 : 5, then 1: 3) to give the title compound (0.38 g) as a white solid. [H-NMR] [(CDCL3)] [: 2.] 08 (3H, s), 2.87 (3H, s), 4.40 [(LH,] br), 5.08 (2H, s), 6.64-6. 74 (2H, m), 7.17-7. 32 (2H, m).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29055-08-1, (2-(Methylamino)phenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/105845; (2003); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29055-08-1, name is (2-(Methylamino)phenyl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 29055-08-1

General procedure: To a solution of 13 (500 mg, 1.86 mmol) in DMF (5.0 mL) were added N-methylaniline (241 muL, 2.23 mmol), 1-hydroxybenzotriazole (251 mg, 1.86 mmol) and 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride (534 mg, 2.79 mmol) at room temperature. The reaction mixture was stirred at room temperature for 12 h. Water was then added, and the mixture was extracted with a mixture of toluene and EtOAc (1:1). The organic layer was washed with H2O and brine, and dried over anhydrous sodium sulfate. After filtration, the solvent was removed in vacuo, and the residue was purified by silica gel column chromatography using hexane/EtOAc (1:1, v/v) as eluent. The solvent was removed in vacuo, and the resulting solid was recrystallized from iPrOH to give 14 (547 mg, 82percent) as a white solid

With the rapid development of chemical substances, we look forward to future research findings about 29055-08-1.

Reference:
Article; Fukaya, Takayuki; Kodo, Toru; Ishiyama, Takeo; Kakuyama, Hiroyoshi; Nishikawa, Hiroyuki; Baba, Satoko; Masumoto, Shuji; Bioorganic and Medicinal Chemistry; vol. 20; 18; (2012); p. 5568 – 5582;,
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Related Products of 29055-08-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.29055-08-1, name is (2-(Methylamino)phenyl)methanol, molecular formula is C8H11NO, molecular weight is 137.179, as common compound, the synthetic route is as follows.

[00263] To a solution of 2-(N-methylamino)-benzylalcohol(b) (536 mg, 3.9 mmol) in dry dichloromethane (25 ml) and diisopropylethylamine (681 mul, 3.9 mmol) was added dropwise chloromethyl chloroformate (360 mul, 4.0 mmol) and the reaction mixture was stirred at 0° C. with occasional check of the reaction progress by t.l.c (n-hexane:ethyl acetate=2:1). After 2 h, the starting material disappeared on t.l.c and the solution was used directly for the following reaction. [00264] Step 2 [00265] To the reaction mixture were added diisopropylethylamine (900 mul, 5.0 mmol) and acetic anhydride (400 mg) and stirred for 3 h at ambient temperature. The reaction mixture was partitioned with dichloromethane (50 ml) and water (30 ml). The water layer was separated and extracted again with dichloromethane (50 ml). The combined organic layer was washed with brine (30 ml.x.2), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting yellowish oil was purified on a column of silica gel (wakogel C-200 10 g, eluent dichloromethane_methanol=200:1) to give the title compound(c) as colorless syrup (740 mg, 70percent). EI-MS: m/z 271(M+); 1H-NMR (270 MHz, CDCl3): delta 2.10 (3H, s), 3.30 (3H, s), 5.07-5.78 (2H, br.d), 5.60 (0.8H, d, J=5.9), 5.73 (0.8H, d, J=5.9), 5.85 (0.4H, br.s), 7.16-7.23 (1H, m), 7.37-7.49 (3H, m).

Statistics shows that 29055-08-1 is playing an increasingly important role. we look forward to future research findings about (2-(Methylamino)phenyl)methanol.

Reference:
Patent; Basilea Pharmaceutica AG; US6812238; (2004); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts