New downstream synthetic route of 2854-16-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Electric Literature of 2854-16-2 ,Some common heterocyclic compound, 2854-16-2, molecular formula is C4H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 444-(cyclopropylmethoxy)-N-(2-{[(2-hydroxy-2-methylpropyl)amino]methyl}-4-methyl-1H-indol-5-yl)benzamide4-(Cyclopropylmethoxy)-N-(2-formyl-4-methyl-1H-indol-5-yl)benzamide (298 mg) obtained in Reference Example 41 and 1-amino-2-methylpropan-2-ol (153 mg) were suspended in NMP (3.0 mL), acetic acid (1.0 mL) was added at room temperature, and the mixture was stirred at the same temperature for 2 hr.Sodium triacetoxyborohydride (363 mg) was added, the mixture was stirred at room temperature for 16 hr, and diluted with ethyl acetate, and 2N aqueous sodium hydroxide solution (20 mL) was added at room temperature.The mixture was poured into water, and the organic layer was washed with water and then with saturated brine, dried over sodium sulfate, and concentrated under reduced pressure.The residue was suspended in ethyl acetate, and the precipitate was collected by filtration, washed with ethyl acetate, and dried under reduced pressure to give the title compound (307 mg, yield 85percent) as a brown solid.1H NMR (300 MHz, CDCl3) delta: 0. 34 – 0.43 (2 H, m), 0.63-0.72 (2 H, m), 1.22 (6 H, s), 1.25 – 1.36 (1 H, m), 2.45 (3 H, s), 2.61 (2 H, s), 3.88 (2 H, d, J=7.2 Hz), 4.02 (2 H, s), 6.38 (1 H, d, J=1.1 Hz), 6.98 (2 H, d, J=8.3 Hz), 7.19 (1 H, d, J=8.3 Hz), 7.34 (1 H, d, J=7.6 Hz), 7.58 (1 H, br. s.), 7.88 (2 H, d, J=8.0 Hz), 8.48 (1 H, br. s.).melting point: 186¡ãCelemental analysis (C25H31N3O3*0.2H2O)Calculated: C, 70.63; H, 7.44; N, 9.88.Found: C, 70.57; H, 7.38; N, 9.68.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2522657; (2012); A1;,
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Share a compound : 2854-16-2

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Application of 2854-16-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows.

[00274j THF (290 mL), 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)- pyridin-4-yl)-i,3,5-triazin-2-amine (29.0 g, 0.06893 mol), sodium bicarbonate (8.68 g, 0.1033 mol), and 1,1-dimethylaminoethanol (7.37 g, 0.0827 1 mol) are added to the reaction vessel at 20?35 ¡ãC. The resulting slurry is heated to reflux (75-80 ¡ãC) for 16-20 h. The reaction is cooled to 30-40 ¡ãC and THF evaporated at below 45 ¡ãC under reduced pressure. The reaction mixture is cooled to 20?35 ¡ãC and rinsed with ethyl acetate and water, and the ethyl acetate layer collected. The organic layer is concentrated under vacuum at below 45 ¡ãC then rinsed with dichloromethane and hexanes, filtered and washed with hexanes and dried for 8-iOh at 45-50 ¡ãC under vacuum to provide 2-methyl-i -(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)- pyridin-4-ylamino)- 1,3,5 -triazin-2-ylamino)propan-2-ol.

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; AGRESTA, Samuel, V.; (135 pag.)WO2016/53850; (2016); A1;,
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Sources of common compounds: 2854-16-2

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 1-Amino-2-methylpropan-2-ol

General procedure: A suspension of 26c (2.00 g, 5.47 mmol), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride (2.27 g, 8.21 mmol) and 1-amino-2-methylpropan-2-ol (0.585 g, 6.56 mmol) in THF (25 mL) and 2-propanol (25 mL) was stirred at room temperature for 19 h. The mixture was concentrated in vacuo, acidified with 1 N HCl, and extracted twice with EtOAc. The organic layers were combined, washed with saturated aqueous solution of NH4Cl and brine, dried over anhydrous Na2SO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane-EtOAc). The product was recrystallized from hexane-EtOAc to give 28h (2.06 g, 89percent) as a white solid.

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yamamoto, Satoshi; Tomita, Naoki; Suzuki, Yuri; Suzaki, Tomohiko; Kaku, Tomohiro; Hara, Takahito; Yamaoka, Masuo; Kanzaki, Naoyuki; Hasuoka, Atsushi; Baba, Atsuo; Ito, Mitsuhiro; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2338 – 2352;,
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Some scientific research about 2854-16-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.

Synthetic Route of 2854-16-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. A new synthetic method of this compound is introduced below.

To a solution of V-2 (10 mg, 0.020 mmol) in DMF (1 mL) were added l-amino-2- methylpropan-2-ol (9.13 mg, 0.102 mmol), DIEA (0.036 mL, 0.205 mmol) and HATU (14.01 mg, 0.037 mmol) at rt. The reaction was stirred under argon at rt for 1.5 h. Purification by reverse phase chromatography afforded Example V-3 as white solid (9.0 mg, 98percent). LC-MS (ESI) m/z: 446.1 [M+H]+; XH NMR (500MHz, DMSO-d6) 5 9.18 (br. s., 1H), 8.61 (d, J=4.7 Hz, 1H), 8.54 (s, 1H), 8.21 (br. s., 1H), 8.09 (d, J=8.0 Hz, 1H), 7.88 (d, J=5.0 Hz, 1H), 7.83 (s, 1H), 7.75 (d, J=7.4 Hz, 1H), 7.63 (d, J=8.0 Hz, 1H), 7.53 (s, 1H), 7.50 – 7.45 (m, 1H), 7.45 – 7.38 (m, 1H), 5.52 (q, J=6.2 Hz, 1H), 4.62 – 4.47 (m, 3H), 3.25 (d, J=5.8 Hz, 2H), 1.58 (d, J=6.3 Hz, 3H), 1.10 (s, 6H); Analytical HPLC RT E: 0.99 min, F: 1.27 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; QUAN, Mimi L.; HU, Zilun; WANG, Cailan; PATIL, Sharanabasappa; WO2015/2915; (2015); A1;,
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Brief introduction of 2854-16-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2854-16-2, blongs to alcohols-buliding-blocks compound. SDS of cas: 2854-16-2

General procedure: By the same conditions as the example 2 of an experiment, the compound 7 was synthesized except having replaced with isobutyl amine and having used 2-hydroxy-2-methylpropyl amine. Yield was 67percent. The compound 7 was obtained like the example 7-1 of an experiment except having changed reaction conditions, such as a catalyst, a solvent, reaction temperature, and time, like the following table 2 description. Yield is shown in Table 2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2854-16-2, its application will become more common.

Reference:
Patent; TSUMURA & CO; IGARASHI, YASUSHI; (20 pag.)JP5742190; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sources of common compounds: 2854-16-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.

Related Products of 2854-16-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. A new synthetic method of this compound is introduced below.

General procedure: The proper 1,4-pentanedione 48 (2.28 mmol) and the suitableamine (2.28 mmol) were dissolved in ethanol (2 ml) in a sealedglass tube equipped with a stirring bar in the presence of p-toluenesulfonicacid (30 mg, 0.17 mmol). The tube was heated in thecavity of the microwave reactor for 30 min (150W, internal temperature160 ¡ãC, and internal pressure 150 psi). At the end, thereaction mixture was cooled down and concentrated. The crudematerial was purified by chromatography on aluminum oxide(activity II-III, according to Brockmann) with cyclohexane to givethe expected pyrroles 49a-n? as solids in satisfactory yields.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2854-16-2, 1-Amino-2-methylpropan-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Poce, Giovanna; Cocozza, Martina; Alfonso, Salvatore; Consalvi, Sara; Venditti, Giulia; Fernandez-Menendez, Raquel; Bates, Robert H.; Barros Aguirre, David; Ballell, Lluis; De Logu, Alessandro; Vistoli, Giulio; Biava, Mariangela; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 539 – 550;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some scientific research about 2854-16-2

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2854-16-2, 1-Amino-2-methylpropan-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C4H11NO, blongs to alcohols-buliding-blocks compound. Formula: C4H11NO

THF (290 mL), 4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoro-methyl)-pyridin-4-yl)-1,3,5-triazin-2-amine (29.0 g, 0.06893 mol), sodium bicarbonate (8.68 g, 0.1033 mol), and 1,1-dimethylaminoethanol (7.37 g, 0.08271 mol) were added to the reaction vessel at 20-35¡ã C. The resulting slurry was heated to reflux (75-80¡ã C.) for 16-20 h. The reaction was cooled to 30-40¡ã C. and THF was evaporated at below 45¡ã C. under reduced pressure. The reaction mixture was cooled to 20-35¡ã C., rinsed with ethyl acetate and water, and the ethyl acetate layer was collected. The organic layer was concentrated under vacuum at below 45¡ã C. then rinsed with dichloromethane and hexanes, filtered and washed with hexanes and dried for 8-10 h at 45-50¡ã C. under vacuum to provide 2-methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)-pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol.

The synthetic route of 2854-16-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Celgene Corporation; Agios Pharmaceuticals, Inc.; Bhat, Sreenivas S.; Burnside, Scott; Parikh, Darshan; Gu, Chong-Hui; Altaf, Syed; (34 pag.)US2018/64715; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A new synthetic route of 1-Amino-2-methylpropan-2-ol

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Related Products of 2854-16-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2854-16-2, name is 1-Amino-2-methylpropan-2-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of [2-(7-methyl-5-{[6-(methylsulfonyl)pyridin-3-yl]oxy}-1H-indol-2-yl)-4,5-dihydro-1,3-thiazol-5-yl]acetic acid (300 mg) and 2-amino-2-methyl-2-propanol (90 mg) in N,N-dimethylformamide (20 mL) were added 1-hydroxybenzotriazole (137 mg) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (194 mg) under ice-cooling, and the mixture was stirred under ice-cooling and then at room temperature for 15 hr. Water was added to the reaction solution, and the mixture was extracted with ethyl acetate. The organic layer was washed with aqueous sodium hydrogen carbonate solution and saturated brine, dried over magnesium sulfate, filtered and concentrated under reduced pressure. The obtained residue was subjected to silica gel column chromatography (ethyl acetate:methanol = 100:0 to 90:10, volume ratio) to give colorless crystals. The obtained crystals were recrystallized from tetrahydrofuran-ethyl acetate to give the title compound (280 mg, yield 81percent) as colorless crystals. melting point 184-186¡ãC. MS 517 (MH+).

According to the analysis of related databases, 2854-16-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP2371826; (2011); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Some tips on 2854-16-2

Statistics shows that 2854-16-2 is playing an increasingly important role. we look forward to future research findings about 1-Amino-2-methylpropan-2-ol.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2854-16-2, name is 1-Amino-2-methylpropan-2-ol. This compound has unique chemical properties. The synthetic route is as follows. 2854-16-2

Example 15. 6-Bromo-8-cvclopentyl-2-(2-hvdroxy-2-methylpropylamino)-4-methylpyridof2.3-ty|pyrimidin- 7(betaH)-one; To a solution of 6-bromo-8-cyclopentyl-4-methyl-2-(methylsulfinyl)pyrido[2,3-cdpyrimidin-7(8/-/)- one (600 mg, 1.62 mmol) and 1-amino-2-methylpropan-2-ol (294 mg, 2.34 mmol) in dioxane (6 ml_) was added triethylamine (1.2 ml_, 8.6 mmol). The mixture was then heated at 110 0C in a sealed tube for 1 h. The solution was poured into brine and extracted with ethyl acetate. The organic was dried (anhydrous sodium sulfate), filtered and concentrated to dryness. The crude product was purified by silica gel flash chromatography to give the title compound as a solid (565 mg, 88percent).LRMS: 395, 397 (M+H)+.1H NMR (CDCI3, 400 MHz): 8.07 (1 H, s), 5.91-6.13 (1 H, m), 5.46-5.90 (1 H, m), 3.52 (2H, d, J = 6.32 Hz), 2.54 (3H, s), 2.17-2.43 (2H, m), 1.95-2.16 (2H, m), 1.76-1.95 (2H, m), 1.56-1.74 (3H, m), 1.30 (6H, s).

Statistics shows that 2854-16-2 is playing an increasingly important role. we look forward to future research findings about 1-Amino-2-methylpropan-2-ol.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/32162; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A new synthetic route of 2854-16-2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2854-16-2.

2854-16-2, Adding some certain compound to certain chemical reactions, such as: 2854-16-2, name is 1-Amino-2-methylpropan-2-ol,molecular formula is C4H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2854-16-2.

Preparation of compound 2-4 To a solution of 2-3 (10 g, 41 mmol) and TEA (5 g, 49 mmol) in DCM was added 2-a (3 g, 34 mmol) dropwise. The mixture was stirred for 12 hrs at 40¡ãC. The solution was cooled down to r.t., and washed with brine, dried over anhydrous Na2SO4 and filtered. The filtration was concentrated and crude product was obtained. Further purification by silica gel column chromatography (PE: EA=1: 1) afforded 6.0 g desiredproduct, yield 50percent.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 2854-16-2.

Reference:
Patent; ASCEND BIOPHARMACEUTICALS PTY LTD; PIETERSZ, Geoffrey, Alan; WO2013/67597; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts