Category: 2807-30-9

2807-30-9, Name is 2-Propoxyethanol, molecular formula is C5H12O2, belongs to alcohols-buliding-blocks compound, is a common compound. In a patnet, author is Capriolo, G., once mentioned the new application about 2807-30-9, SDS of cas: 2807-30-9.

High-temperature oxidation of propanol isomers in the mixtures with N2O at high Ar dilution conditions

This work provides, for the first time, new information regarding the kinetics interaction between N2O and propyl alcohol isomers. To this end, the formation and consumption of atomic oxygen were measured behind the reflected shock waves using Atomic Resonance Absorption Spectroscopy (ARAS) technique for 1-10 ppm n- i- propanol + 10 ppm N2O + Ar mixtures, at 2-3 bar and over a wide temperature range of 1700-3200 K. The Konnov and POLIMI detailed combustion mechanisms were assessed against experimental data and also employed to study the main reactions influencing the oxidation dynamics of fuel mixtures under the investigated conditions. The study highlighted a certain difficulty by the models tested in predicting the formation of atomic oxygen at T < 2000 K. The rate of production and the sensitivity analysis was performed with the attempt to identify the most important reactions involved in the process oxidation for future kinetic model refinements. If you¡¯re interested in learning more about 2807-30-9. The above is the message from the blog manager. SDS of cas: 2807-30-9.

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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2807-30-9, name is 2-Propoxyethanol. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Propoxyethanol

10 g of the remaining bottoms of the distillation and 100 g of 2-n-propoxyethanol, 0.05 g of 4-pyrrolidinopyridine was charged into a reaction vessel equipped with a reflux condenser, Example 3 was carried out Distillation yielded 10 g of the preceding distillation and 123.8 g of thionyl chloride (Content 98.8%, sulfuryl chloride content 0.4%) were mixed,The stirring was started, and the mixture was slowly added dropwise to the reaction vessel. The procedure was as in Example 2. After completion of the dropping, heating was started, and the temperature was gradually raised to 98 C according to the reaction gas evolution rate.Until no gas release, continue to heat 4h get crude; The crude product was directly purified by distillation to obtain 116.41g of chloroethyl n-propyl ether. The product chromatogram was 99.2% and the water content was 0.15%. The yield was 98.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; Shandong Kaisheng New Materials Co.,Ltd.; Zhang, Taiming; Wang, Ronghai; Zhang, Qingxin; Zhang, Shanmin; Sun, Fengchun; Bi, Yixia; (6 pag.)CN105384612; (2016); A;,
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Adding a certain compound to certain chemical reactions, such as: 2807-30-9, 2-Propoxyethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-Propoxyethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-Propoxyethanol

example: of pretilachlor, wherein the steps of specific reaction of producing pretilachlor is: Reacting the ethylene glycol monopropyl The present invention comprises a process for the production ether with thionyl chloride to form a chloroether, carried out condensation reaction of chloroether with aniline to obtain a condensation product. The condensed product is distillated to obtain distilled amine ether, and the distilled amine ether is subjected to an acylation reaction to obtain pretilachlor. In the step of producing the chloroether, the thionyl chloride is mixed with the ethylene glycol monopropyl ether by dropwise addition.The step of producing the chlorinated ether is: The ethylene glycol monopropyl ether placed into the reactor, stirring, thionyl chloride was added drop wise. after the completion of drop wise addition the insulation reaction was carried out for 2 hours to produce hydrogen chloride and sulfur dioxide tail gas and chloroether. the mentioned produced chloroether further comprises the step of treating the hydrogen chloride and the sulfur dioxide tail gas, wherein the step of treating the hydrogen chloride and the sulfur dioxide tail gas is: Hydrogen chloride and sulfur dioxide tail gas are absorbed by both water and alkali, hydrogen chloride prepared hydrochloric acid and sulfur dioxide made of sodium sulfite.The step of carrying out the condensation reaction of the chloroether with aniline is: Aniline and chloroether placed into the reactor, raise the reaction temperature using thermal conductive oil , the end of the reaction layers were separated by adding liquid caustic, oil layer into the next distillation step, water layer was drained. The step of distillating the condensed product to obtain a rectified amine ether is: The condensation product is added to the aniline distillation kettle and carried out distillation, an excess of aniline is separated and applied, then amine ether was placed into distillation kettle to carried distillation of amine ether until the acceptance of qualified amine ether and a small amount of high boiling point residue was directly slag discharged.the steps of acylation reaction of distilled amine ether is as follow: after the qualified amine ether was metered it was put into the acylation kettle, and then placed into the solvent of toluene and liquid caustic soda, slowly dropwise added the measured Chloroacetyl chloride and after the completion of the dropwise addition the reaction was incubation for one hour. then it was placed into the water kettle and wash with water. The upper layer into the desolvation process and the water layer to the sewage treatment. the steps of mentioned desolvation process is: the washed pretilachlor and toluene liquid put into the lifting film for desolvation and the solvent into the application appliquer and finally obtained pretilachlor crude oil .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2807-30-9, 2-Propoxyethanol, and friends who are interested can also refer to it.

Reference:
Patent; Jiangsu Huifeng Technology Co Ltd; Sun, Lei; He, erjin; Mao, Jian; Zhu, Jianmin; Xu, Xujin; Zhao, Jianlong; Zhang, DaLiang; Tian, tongmei; (4 pag.)CN105272869; (2016); A;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 2807-30-9, 2-Propoxyethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2807-30-9, blongs to alcohols-buliding-blocks compound. Formula: C5H12O2

Dimethyl 4-nitro-1H-pyrazole-3, 5-dicarboxylate (WO00/24745, page 48, preparation 2) (15g, 60mmol), 2-propoxyethanol (8.2mL,70mmol) and triphenylphosphine(18. 9g,70mmol) were dissolved in tetrahydrofuran(150mL) and the solution cooled to0 C. The solution was treated withdiisopropyl azodicarboxylate (14.2mL,70mmol) and the reaction mixture stirred at0 C for 3 hours before being allowed to warm to room temperature. The reaction mixture was concentrated in vacuo and the residue purified by column chromatography on silica gel eluting with ethyl acetate: pentane 15: 85 and then againeluting withdichloromethane to yield the title product. ‘H NMR (CD30D, 400MHz) a : 0.82 (t, 3H), 1.47 (q, 2H), 3.34 (t, 2H), 3.78 (t, 2H), 3.91 (s, 6H), 4.76 (t, 2H). MS APCI+ m/z 316 [MH] +

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/49616; (2005); A1;,
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Synthetic Route of 2807-30-9 ,Some common heterocyclic compound, 2807-30-9, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Examples 3 to 14 – synthesis of 2-amino-4-substituted-6-(4-fluorophenyl)-pyrido(3,2-d) pyrimidinesTo a solution of the 2-amino-4-thiomethyl-6-(4-fluorophenyl)-pyrido(3,2- d)pyrimidine of example 2 (56 mg) in a suitable alcohol (5 ml) was added a 2 M solution of lithium diisopropylamide (LDA) in tetrahydrofuran (1 ml). The reaction mixture was stirred at room temperature for 3 days. The excess alcohol was evaporated in vacuo and the crude residue was purified by preparative thin layer chromatography on silica using a mixture of toluene and acetonitrile as the mobile phase (in a volume ratio of 1 :1 ). If necessary a second purification was performed by HPLC on a C18-RP column (100 x30mm Gemini 5 mum) with a gradient of H2O, 0.05% TEA-acetonitrile. The resulting compounds were isolated in yields varying from 30 to 50%, depending on the alcohol used, and were characterized by their mass spectra MS as indicated below.2-amino-4-(2-propoxyethoxy)-6-(4-fluorophenyl)pyrido(3,2-d)pyrimidine (example 3) was obtained from 2-propoxyethanol; MS (m/z) : 343 ([M+H]+, 100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.

Reference:
Patent; GILEAD SCIENCES, INC.; WO2008/77650; (2008); A1;,
Alcohol – Wikipedia,
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2807-30-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2807-30-9, name is 2-Propoxyethanol. This compound has unique chemical properties. The synthetic route is as follows.

Compound 170: 2-((S)-1-[1,4]Dioxan-2-ylmethoxy)-9-(2-propoxy-ethoxy)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one Intermediate 6 (0.15 g, 0.45 mmol, 1 eq.), 2-Propoxy-ethanol (63 muL, 0.55 mmol, 1.2 eq.) and PPh3 (144 mg, 0.55 mmol, 1.2 eq.) were suspended in 1,4-dioxane (5 mL) and the mixture was degassed with N2. DIAD (0.108 mL, 0.55 mmol, 1.2 eq.) was added and the reaction was stirred at RT overnight. 0.5 eq. of DIAD and PPh3 were added, and the reaction mixture was stirred at room temperature for an extra 2 h. Reaction mixture was diluted with brine, extracted with EtOAc, dried over MgSO4 and concentrated. Crude product was purified on silicagel column to give compound 170.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; GALAPAGOS NV; LABEGUERE, Frederic Gilbert; NEWSOME, Gregory John Robert; ALVEY, Luke Jonathan; SANIERE, Laurent Raymond Maurice; FLETCHER, Stephen Robert; US2013/165437; (2013); A1;,
Alcohol – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2807-30-9, name is 2-Propoxyethanol. This compound has unique chemical properties. The synthetic route is as follows. 2807-30-9

100 g of 2-n-propoxyethanol,0.1 g of dodecyltrimethylammonium chloride was addedIn a reaction vessel equipped with a reflux condenser,120 g of thionyl chloride (content 99.0%Sulfuryl chloride content of 0.1%) by adding constant pressure dropping funnel,Stirring, slow to the reaction container dropwise addition of thionyl chloride, the reaction process release sulfur dioxide and hydrogen chloride gas,The temperature of the reaction solution was maintained at 30 ¡À 5 C by controlling the dropwise addition of thionyl chloride.Dropping of sulfoxide is completed, turn on heating,The temperature was gradually raised to 90 C according to the reaction gas evolution rate,Until no gas release, continue to heat 2h get crude; Crude direct distillation purification,105.9 g of chloroethyl n-propyl ether was obtained,After testing, product chromatographic content of 99.51%The water content was 0.17% and the yield was 89.97%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; Shandong Kaisheng New Materials Co., Ltd.; Zhang, Taiming; Bi, Yixia; Wang, Ronghai; Zhang, Shanmin; Li, Wenjuan; Jia, Yuanchao; (6 pag.)CN105348051; (2016); A;,
Alcohol – Wikipedia,
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In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2807-30-9 as follows., 2807-30-9

General procedure: Method A To a solution of compound 3 (150 mg, o.27 mmol), alcohol (0.81 mmol), and EDCI (576 mg, 3.0 mmol) in CH2Cl2 (30 mL) was added DMAP (122 mg, 1.0 mmol), and the mixture was stirred at room temperature for 12 h. Ethyl acetate (60 mL) was added, and the organic phase was washed three times with water, once with brine, dried, and finally concentrated. There is no need to further purify the residue.

The chemical industry reduces the impact on the environment during synthesis 2807-30-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Liu, Shan Xiang; Jin, Hui Zi; Shan, Lei; Zeng, Hua Wu; Chen, Bing Yang; Sun, Qing Yan; Zhang, Wei Dong; Bioorganic and Medicinal Chemistry Letters; vol. 23; 7; (2013); p. 2207 – 2211;,
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