Category: 2807-30-9

Reference of 2807-30-9 , The common heterocyclic compound, 2807-30-9, name is 2-Propoxyethanol, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 227; In 2 ml of tetrahydrofuran were dissolved 340 mg of the compound represented by the formula (IIa-1) and 170 mg of 2-propoxyethanol, 70 mg of sodium hydride (60% oily) and 0.5 ml of tetrahydrofuran were added under ice-cooling, and the mixture was stirred at room temperature for 2 hours . Thereafter, an aqueous saturated ammonium chloride solution was added to the reaction mixture, followed by extraction with t-butyl methyl ether. The organic layer was dried with sodium sulfate, and concentrated under reduced pressure. The residue was subjected to medium pressure preparative liquid chromatography to obtain 290 mg of a compound represented by the formula (227) :(hereinafter, referred to as present compound (227)) . 1H-NMR (CDCl3, TMS) delta (ppm) : 4.69-4.67 (2H, m) , 3.81-3.78 (2H, m) , 3.46 (2H, t) , 3.04 (6H, . br) , 1.66-1.57 (2H, m) , 0.92 (3H, t)

The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; WO2008/32858; (2008); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2807-30-9, name is 2-Propoxyethanol, the common compound, a new synthetic route is introduced below. Safety of 2-Propoxyethanol

General procedure: A mixture of the corresponding 4-((1H-benzo[d][1,2,3]triazol-1-yl)oxy)-6-aryl-3,4,5,6-tetrahydropyrido[2,3-d]pyrimidine-7(8H)-one (VI) (0.42 mmol), Cs2C03 (0.54 mmol) and the corresponding alcohol (9 ml) was heated a reflux overnight. The resulting solution was cooled down, water (100 mL) was added and the reaction crude was neutralized with 2M HCI. The solid was collected by filtration and washed with water, and EtOEt to afford the corresponding 4-alkoxy-substituted pyrido[2,3- d]pyrimidine (XXVII). 1H N M R (400 MHz, DMSO-d(6): delta 10.51 (s, 1H), 7.58 – 7.47 (m, 2H), 7.37 (t, J = 8.1 Hz, 1H), 6.42 (s, 2H), 4.63 (dd, J = 12.9, 9.2 Hz, 1H), 4.35 – 4.32 (m, 2H), 3.63 (t, J = 4.9 Hz, 2H), 3.35 (t, J = 6.6 Hz, 2H), 2.93 – 2.79 (m, 2H), 1.46 (hex, J = 7.3 Hz, 2H), 0.80 (t, J = 7.4 Hz, 3H).

The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUT QUIMIC DE SARRIA, CETS FUNDACIO PRIVADA; BORRELL BILBAO, Jose Ignacio; TEIXIDO CLOSA, Jordi; CAMARASA NAVARRO, Marta; PUIG DE LA BELLACASA CAZORLA, Raimon; MARTINEZ DE LA SIERRRA, Miguel Angel; FRANCO CIRERA, Sandra; BADIA CORCOLES, Roger; CLOTET SALA, Bonaventura; ESTE ARAQUE, Jose; WO2015/118110; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2807-30-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2807-30-9, name is 2-Propoxyethanol. A new synthetic method of this compound is introduced below.

A 500 ml, round-bottom flask equipped with a 10-tray Oldershaw column and decanting head, thermometer, and a connecting tube with stopcock was charged with 126 grams (1.0 mole) of 3-cyclohexene-1-carboxylic acid, 99 grams (0.95 mole) of 2-propoxyethanol, and 100 ml of toluene. The reaction mass was stirred and brought to reflux. Then 1.1 grams of titanium tetrabutoxide was added via the connecting tube. The temperature of the reaction mass was slowly increased to 200 C. and held at this temperature while removing water and solvent overhead. After a reaction time of 8 hours, the product was cooled and washed with 50 ml of dilute phosphoric acid (10 weight percent in water) and filtered to remove the titanium salts. The organic layer was separated from the water layer, and the organic layer was successively washed with 50 ml portions of a saturated sodium bicarbonate solution and with water. Distillation of the crude product under vacuum through a 12-cm Vigreux column gave 152 grams (75% yield) of 2-propoxyethyl 3-cyclohexenecarboxylate (b.p. 88-90 C. at 2.0 mm Hg) with a chromatographically analyzed purity exceeding 98%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2807-30-9, 2-Propoxyethanol, and friends who are interested can also refer to it.

Reference:
Patent; Union Carbide Chemicals & Plastics Technology Corporation; US5268489; (1993); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2807-30-9 ,Some common heterocyclic compound, 2807-30-9, molecular formula is C5H12O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 5 2-Fluoro-6-(2-propoxyethoxy)pyridine 2-Propoxyethanol (1.89 g, 18.1 mmol) was dissolved in 50 mL THF, treated with potassium tert-butoxide (3.05 g, 27.2 mmol), stirred to uniform solution, placed in an addition funnel, and added dropwise to a solution of 2,6-difluoropyridine in 50 mL THF. After stirring overnight at room temperature, the solution was diluted with brine and extracted with ether. The ether extracts were combined and dried over Na2SO4, then concentrated in vacuo to yield 2-fluoro-6-(2-propoxyethoxy)-pyridine (3.33 g, 93%) as a yellow oil.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.

Reference:
Patent; Dow AgroSciences LLC; US6369083; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 2807-30-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2807-30-9, name is 2-Propoxyethanol. A new synthetic method of this compound is introduced below.

General procedure: p-Toluensulfonyl chloride (2.6 g, 0.014 mol) was slowly added to the mixture of appropriate2-alkoxyethanol respectively (oxiran-2-yl)methanol (0.014 mol) and triethylamine (1.84 g, 0.018 mol) indichlormethane (20 mL) cooled at 0 C. The mixture was then stirred for 1 h at ambient temperature.The precipitate was filtered and the organic phase was washed with 2 M HCl, saturated solutionof Na2CO3 and water, dried over MgSO4, and then the solvent was evaporated. Product T2 wasrecrystallized from petroleum ether/diethyl ether in ratio 5:1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2807-30-9, its application will become more common.

Reference:
Article; Marvanova, Pavlina; Padrtova, Tereza; Odehnalova, Klara; Hosik, Ondrej; Oravec, Michal; Mokry, Petr; Molecules; vol. 21; 12; (2016);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2807-30-9, name is 2-Propoxyethanol, the common compound, a new synthetic route is introduced below. name: 2-Propoxyethanol

Compound 2 (100 mg,0.15 mmol) was treated with 30% HBr/acetic acid (5 ml), and theresulted solution was stirred at room temperature for 2 h. Severaltypes of alcohol (50 ml) were added to the solution, and themixture was stirred at 30e80 C for 4 h under N2 protection. Then50 mL of DCM was added and separated, the combined organiclayers were washed with water (3 50 mL). The solvent wasevaporated and the residue was dissolved in THF (5 mL). Theresulted solution was treated with 1M LiOH (0.75 mL, 0.75 mmol),and the resulting mixture was stirred at room temperature for1e2 h. 1 M HCl solution was added to the mixture until pH 3 wasattained. Then the suspensionwas extracted with DCM (3 50 mL).The combined organic layers were washed with water (3 50 mL)and dried over anhydrous Na2SO4. The organic solvent wasremoved under reduced pressure and the residue was purified bycolumn chromatography over silica gel to afford black solid 5e13.

The synthetic route of 2807-30-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chen, Dan-Ye; Chen, Zhi-Long; Gao, Ying-Hua; O’Shea, Donal F.; Wu, Dan; Wu, Xiao-Feng; Yan, Yi-Jia; Zhu, Wei; Zhu, Xue-Xue; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2807-30-9, Adding some certain compound to certain chemical reactions, such as: 2807-30-9, name is 2-Propoxyethanol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2807-30-9.

Using toluene with CEP-0 No.: toluene = 1: 2 (w / w) as a solvent, First in low temperature (-5 ~ 0 ) under the conditions of absorption of phosgene,Then the temperature of 0 ~ 5 dropping CEP-0 for photochemical reaction,The dropwise addition of phosgene continued to the end of the photochemical reaction,Slowly warmed to 30 , 30 under the conditions of nitrogen to catch the light, the light after the end of the transfer into the CEP-1No. drop tank spare.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2807-30-9, 2-Propoxyethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Lier Chemical Co., Ltd.; Li Shihong; Cheng Ke; Wang Fuxiong; Zuo Xiang; (9 pag.)CN107311863; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 2807-30-9, Adding some certain compound to certain chemical reactions, such as: 2807-30-9, name is 2-Propoxyethanol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2807-30-9.

Compound 172: 2-((R)-1-[1,4]Dioxan-2-ylmethoxy)-9-(2-propoxy-ethoxy)-6,7-dihydro-pyrimido[6,1-a]isoquinolin-4-one Intermediate 7 (0.25 g, 0.76 mmol, 1 eq.), 2-Propoxy-ethanol (105 muL, 0.91 mmol, 1.2 eq.) and PPh3 (238 mg, 0.91 mmol, 1.2 eq.) were suspended in 1,4-dioxane (10 mL) and the mixture was degassed with N2. DIAD (0.180 mL, 0.91 mmol, 1.2 eq.) was added and the reaction was stirred at RT overnight. 0.3 eq. of DIAD and PPh3 were added, and the reaction mixture was stirred at room temperature for an extra 24 h. Reaction mixture was diluted with brine, extracted with EtOAc, dried over MgSO4 and concentrated. Crude product was purified on silicagel column to give compound 172.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2807-30-9, 2-Propoxyethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GALAPAGOS NV; LABEGUERE, Frederic Gilbert; NEWSOME, Gregory John Robert; ALVEY, Luke Jonathan; SANIERE, Laurent Raymond Maurice; FLETCHER, Stephen Robert; US2013/165437; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 2807-30-9, Adding some certain compound to certain chemical reactions, such as: 2807-30-9, name is 2-Propoxyethanol,molecular formula is C5H12O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2807-30-9.

Diisopropyl azodicarboxylate (14.2mL, 70MMOL) was added to an ice-cooled solution OF 4-NITRO-1 H-PYRAZOLE-3, 5-DICARBOXYLIC acid dimethyl ester (EP 1241170, prep 10) (15g, 60MMOL), 2-propoxyethanol (8.2mL, 70MMOL) and TRIPHENYLPHOSPHINE (18. 9g, 70MMOL) in tetrahydrofuran (150ML), and the reaction stirred at 0C for 2.5 hours, then allowed to stir at room temperature for a further 18 hours. The reaction was concentrated in vacuo and the residue purified by column chromatography on silica gel using ethyl acetate: pentane as eluant, and then re-columned using DICHLOROMETHANE as eluant to afford the title compound as a solid, 14g. 1H NMR (CD30D, 400MHZ) 5 : 0.82 (t, 3H), 1.47 (m, 2H), 3.34 (t, 2H), 3.78 (t, 2H), 3.91 (s, 6H), 4.76 (t, 2H). LRMS: m/z APCI+ 316 [MH] +

According to the analysis of related databases, 2807-30-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/96810; (2004); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 2807-30-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2807-30-9, name is 2-Propoxyethanol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Synthesis of intermediate 3 a shown by formula (3 a); [Show Image] A four-necked reactor equipped with a condenser, a thermometer, and a dropping funnel was charged with 15 g (0.09 mol) of 5-formylsalicylic acid, 28.1 g (0.27 mol) of ethylene glycol monopropyl ether, 1.7 g (0.009 mol) of p-toluenesulfonic acid monohydrate, and 1000 ml of toluene under a nitrogen stream to prepare a homogenous solution. The solution was stirred for eight hours under reflux. Water produced during the reaction was removed together with toluene by azeotropic dehydration while adding toluene. After completion of the reaction, the reaction mixture was washed with water. After drying the toluene layer over anhydrous magnesium sulfate, magnesium sulfate was filtered off. Toluene was evaporated from the filtrate under reduced pressure to obtain a yellow oil. The yellow oil was purified by silica gel column chromatography (n-hexane:THF=3:1) to obtain 12.6 g of a light yellow solid intermediate 3a (yield: 55.5%). The structure of the intermediate 3a was identified by 1H-NMR. 1H-NMR (400 MHz, CDCl3, TMS, delta ppm): 11.34 (s, 1H), 9.89 (s, 1H), 8.42 (d, 1H, J=2.0 Hz), 8.01 (dd, 1H, J=2.0 Hz, J=8.6 Hz), 7.11 (d, 1H, J=8.6 Hz), 4.56 (t, 2H, J=4.6), 3.80 (t, 2H, J=4.6 Hz), 3.49 (t, 2H, J=6.6 Hz), 1.68-1.59 (m, 2H), 0.94 (t, 3H, J=7.6 Hz)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2807-30-9, 2-Propoxyethanol.

Reference:
Patent; Zeon Corporation; EP2143710; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts