Category: 27489-62-9

Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 27489-62-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 27489-62-9

Example 140; 5 -((R)-2-(5-fluoro-2-methoxypyridin-3 -yDpyrrolidin- 1-y l)-N-((trans)-4- hvdroxycvclohexyDpyrazolor 1 ,5-a1pyrimidine-3-carboxamide; To a solution of (R)-5-(2-(5-fluoro-2-methoxypyridin-3-yl)pyrrolidin-l- yl)pyrazolo[l,5-a]pyrimidine-3-carboxylic acid (Preparation K, 30 mg, 0.084 mmol) in anhydrous CH2Cl2 (2 mL) was added HOBt (34 mg, 0.25 mmol) followed by EDCI (48 mg, 0.25 mmol). The solution was stirred for 30 minutes, then treated with (trans)-4- aminocyclohexanol (29 mg, 0.25 mmol) followed by triethylamine (35 muL, 0.25 mmol). After stirring at ambient temperature for 5 hours, the reaction mixture was diluted with EtOAc, washed with saturated NH4Cl (20 mL), saturated NaHCO3, and brine, then dried (Na2SO4), filtered and concentrated. The crude material was purified by silica chromatography (4% MeOH/CH2Cl2) to yield the final product as white solid (23 mg, 60%). LCMS (apci) m/z = 455.1 (M+H).

The synthetic route of 27489-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARRAY BIOPHARMA INC.; ALLEN, Shelley; ANDREWS, Steven S.; CONDROSKI, Kevin Ronald; HAAS, Julia; HUANG, Lily; JIANG, Yutong; KERCHER, Timothy; SEO, Jeongbeob; WO2011/6074; (2011); A1;,
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Reference of 27489-62-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, molecular weight is 115.1735, as common compound, the synthetic route is as follows.

A solution of trans-4-aminocyclohexanol (5 g,33 mmol) in 1,4-dioxane (100 mL) was cooled to 0 C. After 15 min, sodium hydroxide (1.6 g,40 mmol) dissolved in water (40 mL) was added and allowed to cool for an additional 15 min. Asolution of di-tert-butyl dicarbonate (7.9 g, 36 mmol) dissolved in 1,4-dioxane (65 mL) was thenadded to the solution of aminoalcohol and allowed to stir at rt for 14 h. The reaction wasquenched by the addition of 1 M HCl (100 mL) followed by EtOAc (150 mL). The layers wereseparated and the aqueous layer was extracted further with EtOAc (2 × 150 mL). The combinedorganic layers were washed sequentially with water (100 mL), brine (100 mL), and dried(Na2SO4) before being concentrated in vacuo to give a white solid (5.3 g, 75%). Note: Theproduct can be carried forward to the mesylation step without further purification

The chemical industry reduces the impact on the environment during synthesis 27489-62-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Harty, Matthew; Nagar, Mitesh; Atkinson, Logan; Legay, Christina M.; Derksen, Darren J.; Bearne, Stephen L.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 1; (2014); p. 390 – 393;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 27489-62-9

Preparation of trans-4-(3-bromoimidazo[1,2-b]pyridazin-6-ylamino)cyclohexanol To 6-chloro-3-bromoimidazo[1,2-b]pyridazine (1.00 g, 4.30 mmol, 1.0 equiv) and p-TSA (818 mg, 4.30 mmol, 1.0 equiv) in DMSO (7.00 mL) was added trans-4-aminocyclohexanol (1.49 g, 12.9 mmol, 3.0 equiv). The mixture was heated at 100 C. for 24 h. Purification by column chromatography using 5% methanol in dichloromethane elution gave 1.1 g of the yellow solid, 83%.

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Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of trans-4-Aminocyclohexanol

In a round bottom flask fitted with a condenser, a mixture of 4- aminocyclohexan-1-ol (1.219 g, 10.58 mmol), 2,4-dichlorofuro[3,2-d]pyrimidine (2.000 g, 10.58 mmol), Hunig’s base (2.735 g, 3.686 mL, 21.16 mmol), and iPrOH (26.38 mL) was heated to 100 C for 16 h. The solvent was removed, and the crude residue was partitioned between EtOAc and saturated aqueous NH4Cl. The layers were separated, and the aqueous further extracted with EtOAc (2x). The combined organics were dried (Na2SO4), filtered and concentrated to furnish an orange solid. 1H NMR (CDCl3) shows clean desired 4-[(2-chlorofuro[3,2-d]pyrimidin-4- yl)amino]cyclohexanol (2.659 g, 9.932 mmol, 93.89%) along with residual EtOAc. Dried under vacuum overnight and carried forward as is. 1H NMR (400 MHz, CDCl3) delta 7.73 (d, J = 1.7 Hz, 1H), 6.78 (d, J = 2.1 Hz, 1H), 5.09 (s, 1H), 4.20 – 4.08 (m, 1H), 3.78 – 3.61 (m, 1H), 2.19 (d, J = 11.5 Hz, 2H), 2.05 (d, J = 10.8 Hz, 2H), 1.66 – 1.45 (m, 4H), 1.45 – 1.30 (m, 2H). ESI-MS m/z calc.267.07745, found 268.15 (M+1)+; Retention time: 0.56 minutes.

With the rapid development of chemical substances, we look forward to future research findings about 27489-62-9.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; MAXWELL, John, Patrick; JACKSON, Katrina, Lee; TANG, Qing; MORRIS, Mark, A.; RONKIN, Steven, M.; XU, Jinwang; COTTRELL, Kevin, M.; CHARIFSON, Paul, S.; (280 pag.)WO2019/143678; (2019); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 27489-62-9

General procedure: N,N-Diisopropylethylamine (3.0-4.0 eq) was added to 8-methoxyquinoline-3-carboxylic acid (1.0 eq) in solvent (dichloromethane, tetrahydrofuran,or N,N-dimethylformamide, 0.05 to 0.2 M) at room temperature. Then, 1-((dimethylamino)(dimethyliminio)methyl)-1H-[1,2,3]triazolo[4,5-b]pyridine 3-oxide hexafluorophosphate(V)(1.0-1.5 eq) was added and the reaction mixture was stirred for five minutes. Then, amine (1.0 – 2.0 eq) was added and the reaction mixture was stirred for one to sixteen hours. 10% Aqueous citric acid was added and the reaction mixture was extracted with dichloromethane, washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered,and concentrated. The resulting residue was purified by RP HPLC or silica gel chromatography to give the quinoline-3-carboxamide (1%-95% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Article; Deaton, David N.; Do, Young; Holt, Jason; Jeune, Michael R.; Kramer, H. Fritz; Larkin, Andrew L.; Orband-Miller, Lisa A.; Peckham, Gregory E.; Poole, Chuck; Price, Daniel J.; Schaller, Lee T.; Shen, Ying; Shewchuk, Lisa M.; Stewart, Eugene L.; Stuart, J. Darren; Thomson, Stephen A.; Ward, Paris; Wilson, Joseph W.; Xu, Tianshun; Guss, Jeffrey H.; Musetti, Caterina; Rendina, Alan R.; Affleck, Karen; Anders, David; Hancock, Ashley P.; Hobbs, Heather; Hodgson, Simon T.; Hutchinson, Jonathan; Leveridge, Melanie V.; Nicholls, Harry; Smith, Ian E.D.; Somers, Don O.; Sneddon, Helen F.; Uddin, Sorif; Cleasby, Anne; Mortenson, Paul N.; Richardson, Caroline; Saxty, Gordon; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1456 – 1478;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO

To a round bottom flask with stir bar was added (S)-4-(1-(tert- butoxycarbonylamino)ethyl)-2-chlorobenzoic acid (450 mg, 1.20 mmol), (lr,4r)-4- aminocyclohexanol (415 mg, 3.60 mmol), EDO HCI (460 mg, 2.40 mmol), 1-hydroxy-7-aza- benzotriazole (229 mg, 1.68 mmol) and DMF (6 mL). To this mixture was then added DIEA (629 pL, 3.60 mmol). Reaction mixture was allowed to stir at room temperature for 18 hours. The reaction mixture was diluted with water and extracted with EtOAc. The organic phaseswere combined, washed with twice with water, brine, dried (Na2SO4), filtered and concentrated to a brown crystalline tert-butyl (S)- 1 -(3-chloro-4-((1 r,4S)-4- hydroxycyclohexylcarbamoyl)phenyl)ethylcarbamate (330 mg, 0.83 mmol, 69 % yield). LCMS m/z391.1 (M + H), RtO.71 mm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; NOVARTIS AG; CHO, Young Shin; LEVELL, Julian Roy; SHAFER, Cynthia; SHULTZ, Michael David; WO2014/147586; (2014); A1;,
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Electric Literature of 27489-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The amino alcohol was dissolved in CH2Cl2(1 M) followed by addition of Et3N (2.5 equiv) and the resultingmixture stirred at room temperature for 30 min. Then, a solution of o-nitrobenzenesulfonyl chloride (0.85 equiv)in CH2CL2 (0.85 M) was added slowly and the reaction mixture stirred for 3 h.The reaction was followed by TLC (3% MeOH/ CH2Cl2) andquenched with a 1M HCl solution. Following aqueous phase extraction with CH2Cl2(3 ),the combined organic layers were washed with brine and dried over MgSO4.The solvent was removed under reduced pressure and the crude product purified byflash chromatography on silica gel with 100% Et2O (2a) or 3% MeOH/ CH2Cl2(2b-g) to afford the desiredcompound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Article; Vezina-Dawod, Simon; Derson, Antoine; Biron, Eric; Tetrahedron Letters; vol. 56; 2; (2015); p. 382 – 385;,
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Reference of 27489-62-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of trans-4-aminohexanol (10 g, 87 mmol) and triethylamine (18 mL, 0.13 mol) in dichloromethane (44 mL), di (tert-butyl) dicarbonate (21 g, 96 mmol) was added under cooling on ice. After stirring the obtained solution at room temperature for 6.5 hours, water and 1 N hydrochloric acid were added to the reaction solution, and the obtained solution was extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate and then concentrated under vacuum. The obtained crude product was purified by recrystallization with a mixed solvent of hexane/ethyl acetate, and the precipitated solid was recovered by filtration to obtain the title compound (13 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 1.12 – 1.21 (2H, m), 1.33 – 1.44 (11H, m), 1.97 – 2.01 (4H, m), 3.40 – 3.43 (1H, m), 3.60 – 3.61 (1H, m), 4.33 – 4.35 (1H, m).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; Toray Industries, Inc.; NISHIO, Yukihiro; KUBOTA, Yuko; YAMAMOTO, Masashi; NISHIMURA, Yutaka; MASUDA, Tomohide; TSUTSUI, Hideyuki; OKIMURA, Keiichi; UDAGAWA, Syuji; KAINO, Mie; MEGURO, Hiroyuki; SEKIYA, Yumiko; (105 pag.)EP3345893; (2018); A1;,
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Reference of 27489-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 2-(4,6-dichloropyrimidin-5-yl)acetaldehyde (5.0 g, 26.3 mmol) and (1 R.4R)- 4-aminocyclohexanol (3.0 g, 26.3 mmol) in EtOH (66 mL) was added DIEA (5.5 mL, 31.6 mmol). The reaction was heated at 80C overnight. The reaction mixture was cooled to room temperature, concentrated in vacuo, and purified by silica gel flash column chromatography (MeOH/ DCM: 0-10 %) to afford the title compound. MS m/z 252.0 (M + H+) (Method M).

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; IRM LLC; CHEN, Bei; FAIRHURST, Robin, Alec; FLOERSHEIMER, Andreas; FURET, Pascal; GUAGNANO, Vito; JIANG, Songchun; LU, Wenshuo; MARSILJE, Thomas, H.; MCCARTHY, Clive; MICHELLYS, Pierre-Yves; STAUFFER, Frederic; STUTZ, Stefan; VAUPEL, Andrea; WO2011/29915; (2011); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below., Computed Properties of C6H13NO

a. 4-[3-((2S,6R)-2,6-Dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-cyclohexylamine (Intermediate 17a) Sodium hydride (60% in mineral oil, 0.24 g, 6.00 mmol) was added to a stirred solution of trans-4-amino cyclohexanol (0.24 g, 2.08 mmol) in anhydrous DMF (8 mL) at RT under an argon atmosphere. The reaction mixture was stirred at RT for 30 min, then Intermediate 3c (0.50 g, 2.01 mmol) in anhydrous DMF (7 mL) was added and stirred at 60 C. for 4 h. After cooling, the reaction mixture was quenched by careful addition of a saturated aqueous solution of NH4Cl and water (1:1) and extracted with DCM (3*50 mL). The combined organic layers were washed with water followed by brine, dried and concentrated in vacuo. The resultant residue was purified by FCC using 0-10% [2M NH3 in MeOH] in DCM to afford the title compound (0.61 g, 88%) as a brown oil. LCMS (Method 3): Rt 2.19 min, m/z 344 [MH+].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Patent; CHIESI FARMACEUTICI S.p.A.; WOO, Chi-Kit; ALCARAZ, Lilian; CAPALDI, Carmelida; US2014/364411; (2014); A1;,
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