Category: 27489-62-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: trans-4-Aminocyclohexanol

To a solution of di-tert-butyl dicarbonate (4.087 mL, 21.01 mmol) and diisopropylethylamine (2.87 mL, 17.4 mmol) in THF (60 mL) was added (1R,4R)-4-aminocyclohexanol (2.00 g, 17.4 mmol) and was stirred at rt for 4h. The reaction was concentrated to dryness and the residue was dried under reduced pressure to yield the title compound as a white solid (3.49 g, 87.0% yield), which was used without further purification.

With the rapid development of chemical substances, we look forward to future research findings about 27489-62-9.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CAI, Min; ARORA, Nidhi; BACANI, Genesis M.; BARBAY, Joseph Kent; BEMBENEK, Scott D.; CHEN, Wei; DECKHUT, Charlotte Pooley; EDWARDS, James P.; GHOSH, Brahmananda; KREUTTER, Kevin D.; LI, Gang; TICHENOR, Mark S.; VENABLE, Jennifer D.; WEI, Jianmei; WIENER, John J. M.; WU, Yao; XIAO, Kun; ZHANG, Feihuang; ZHU, Yaoping; (524 pag.)WO2018/103060; (2018); A1;,
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Application of 27489-62-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a flask was added 29 B008 (0.4g, 1.07mmol), 102 DMSO (10mL), 103 K2CO3 (0.3g, 2.14mmol), 104 3-chloro-4-fluoroaniline (0.31g, 2.14mmol). The mixture was heated and stirred at 90C for 8h, cooled to rt, poured into ice-water (50mL). The solid was collected by filtration and recrystallized from methanol 4 times to afford a white 105 solid (0.23g, yield 45%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 27489-62-9, trans-4-Aminocyclohexanol.

Reference:
Article; Feng, Yue; Xie, Xiao-Yang; Yang, Yi-Qiu; Sun, Yu-Tong; Ma, Wen-Hui; Zhou, Peng-Jun; Li, Zi-Yao; Liu, Hui-Qiang; Wang, Yi-Fei; Huang, Yun-Sheng; European Journal of Medicinal Chemistry; vol. 174; (2019); p. 181 – 197;,
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Synthetic Route of 27489-62-9 ,Some common heterocyclic compound, 27489-62-9, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4.2.31 8-(trans-4-Hydroxycyclohexylamino)-1-(3-morpholinopropyl)oxazolo[4,5-g]quinazolin-2(1H)-one (6e) Trans-4-aminocyclohexanol (148 mg, 1.28 mmol) and TEA (150 mg, 2.14 mmol) was added to a solution of compound 13 (300 mg, 1.07 mmol) in isopropanol (12 ml) and stirred at 60 C for 24 h. The mixture was cooled to room temperature and concentrated in vacuo, the residue was treated with aqueous NaHCO3 (10 ml) and extracted with EtOAc/MeOH (20:1, 30 ml). The organic layer was washed with brine, dried over MgSO4, and concentrated. Chromatography of the residue on silica gel with DCM-MeOH (90/1,v/v) gave 361 mg (yield, 79%) of the title compound as pale yellow solid: Mp: 312-315 C; HRMS, ESI+, m/z: Calcd for C22H30N5O4 (M + H)+, 428.2292; found, 428.2295; 1H NMR (500 MHz, DMSO-d6) delta:8.70 (1H, s), 7.80 (1H, s), 7.74 (1H, s), 4.14 (1H, s), 4.00 (2H, t, J = 6.4 Hz), 3.52 (4H, t, J = 4.2 Hz), 2.33 (2H, t, J = 6.3 Hz), 2.26 (4H, m), 2.00 (2H, p, J = 6.4 Hz); 13C NMR (75 MHz, DMSO-d6) delta:165.61, 159.43, 153.45, 153.26, 152.57, 152.00, 148.36, 148.27, 147.64, 147.03, 134.26, 132.23, 120.73, 112.49, 106.61, 106.06, 106.38, 101.58, 100.19, 66.00, 65.86, 55.01, 54.77, 54.15, 53.16, 53.12, 40.59, 40.33, 22.19, 22.91.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 27489-62-9, trans-4-Aminocyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Lin, Jinsheng; Shen, Wei; Xue, Jingwei; Sun, Juan; Zhang, Xue; Zhang, Can; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 39 – 48,10;,
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Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H13NO, blongs to alcohols-buliding-blocks compound. Computed Properties of C6H13NO

Preparation of N-Boc-£r°ws-4-aminocyclohexanolcrystallization IValphans-4-aminocyclohexanol hydrochloride (Aldrich, 96.5g, 0.636 mole) was added with mechanical stirring to 636 mL of 1.0N NaOH in a 3L 3N RBF, equipped with a 50OmL addition runnel. After a clear solution was obtained 30OmL of dioxane was added, and then the misture was cooled in an ice bath to about 50C. A solution of di-tert-butyldicarbonate (Aldrich, 138.9g, 0.636 mole) in dioxane (30OmL) was added to the addition runnel and added dropwise to the reaction mixture over 1 hour. The reaction was then allowed to slowly warm to room temperature with stirring in the bath overnight (milky white mixture). The whole was extracted with EtOAc (I x 80OmL, 2 x 50OmL), the organics were combined and washed with water and brine. At this point the product began to precipitate from the organic layer. 400 mL of ethanol was added to aid solubility of the product. The mixture was dried over magnesium sulfate then filtered and evaporated to 50OmL. Then hexanes (600 mL) was added slowly with stirring. The product, N-Boc-^ralphaMs-4-aminocycIohexanoI, was filtered, and washed thoroughly with hexanes to afford the product as white flakes. (98g, 72%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,27489-62-9, trans-4-Aminocyclohexanol, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2007/62334; (2007); A2;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C6H13NO

The aryl fluoride (2 g, 10.6 mmol) was placed in a 100 ml round-bottomed flask and stirred in 20 ml acetonitrile at room temperature. Potassium carbonate (3.3 g, 23.9 mmol, 2.2 eq) and 1,4-trans- amino-cyclohexanol (1.34 g, 11.6 mmol, 1.1 eq) were added and the mixture was then heated at 90 C overnight. The mixture was cooled to room temperature and then concentrated under vacuum. The crude material was purified by silica gel chromatography using 20 – 40 % ethyl acetate in petroleum ether to elute. The product-containing fractions were combined and concentrated under vacuum to provide 1 g (33 %) of the desired aniline as a yellow oil. (ES, m/z): [M+H]+ 285.0; NMR (300 MHz, DMSO): delta 8.04 (d, J = 9.3 Hz, 1H), 7.42 (d, J = 7.8 Hz, 1H), 7.06 (d, J = 1.8 Hz, 1H), 6.82 – 6.86 (m, 1H), 4.59 (d, J = 4.2 Hz, 1H), 3.39 – 3.49 (m, 2H), 1.78 – 1.94 (m, 4H), 1.18 – 1.32 (m, 4H).

With the rapid development of chemical substances, we look forward to future research findings about 27489-62-9.

Reference:
Patent; MERIAL INC.; LONG, Alan; WILKINSON, Douglas, Edward; (224 pag.)WO2016/118638; (2016); A1;,
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Alcohols – Chemistry LibreTexts

Reference of 27489-62-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 27489-62-9, name is trans-4-Aminocyclohexanol. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 3-(methylcarbamoyl)-1-(1-(1-tosyl-1H-indol-4-yl)ethyl)-1H-pyrazole-5-carboxylic acid (255 mg, 0.547 mmol) in DMF (4 mL) was added HATU (312 mg, 0.820 mmol) followed by (1r,4r)-4- aminocyclohexan-1-ol (126 mg, 1.093 mmol, commercially available from, for example, Fluorochem) and DIPEA (0.477 mL, 2.73 mmol). The resulting reaction mixture was stirred at rt in air for 5 h. The reaction mixture was concentrated in vacuo to remove DMF and partitioned between ethyl acetate and saturated aq. LiCl solution. The organic layer was separated, washed with brine, dried (hydrophobic frit) and concentrated to give a crude orange oil. This was purified by chromatography on silica gel column, eluting with 0-50% (25% ethanol in ethyl acetate)/ethyl acetate to give the desired product (330 mg, 0.439 mmol, 80 % yield) as a pale yellow oil. (0529) LCMS (2 min Formic): Rt = 1.07 min, [M+Na]+ = 586

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen John; DEMONT, Emmanuel Hubert; HARRISON, Lee Andrew; LIWICKI, Gemma Michele; LUCAS, Simon Christopher Cranko; PRESTON, Alexander G; SEAL, Jonathan, Thomas; WALL, Ian David; WATSON, Robert J; (0 pag.)WO2018/158212; (2018); A1;,
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Reference of 27489-62-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27489-62-9, name is trans-4-Aminocyclohexanol. A new synthetic method of this compound is introduced below.

To a solution of trans-A- aminocyclohexanol (3 g, 26 mmol) in DMF (130 mL) at 0 C was added 60% sodium hydride in oil. The reaction mixture was stirred at 0 C for lh and then 4-fluorobenzonitrile (3.9 g, 32.6 mmol) was added. It was heated to 60 C for 2h and stirred for 12 h at room temperature. The reaction mixture was diluted with EtOAc and washed with water and brine. The organic layer was dried, filtered, and concentrated under reduced pressure to provide the titled compound (2.5 g, 44% yield). NMR (300 MHz, DMSO-c¾): 67.72 (d, J = 9 Hz, 2H), 7.09 (d, J = 9 Hz, 2H), 4.48-4.34 (m, 1H), 2.68-2.55 (m, 1H), 2.07-1.94 (m, 2H), 1.85-1.71 (m, 2H), 1.46-1.11 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27489-62-9, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; HAMMOCK, Bruce, D.; HWANG, Sung, Hee; WECKSLER, Aaron, T.; MORISSEAU, Christophe; WO2012/112570; (2012); A1;,
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Related Products of 27489-62-9 , The common heterocyclic compound, 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In THF (20 mL) were dissolved 2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-((3-chloro-4 -methoxybenzyl)amino)pyrimidine-5-carboxylic acid (180 mg, 0.48 mmol), trans-4-hydroxycyclohexylamine (66 mg, 0.58 mmol) and HATU(220 mg, 0.58 mmol). The solution was cooled in an ice bath and DIEA (0.25 mL, 1.44 mmol) was added then. The reaction was conducted at ambient temperature for 8 h, followed by concentration, addition of water and extraction with ethyl acetate. The organic phase was dried, concentrated and purified by silica gel column chromatography (DCM / methanol = 20 / 1) to give 2-(3-azabicyclo[3.1.0]hexan-3-yl)-4-((3-chloro-4-methoxybenzyl)amino)-N-(trans-4-hydrox ycyclohexanyl)pyrimidine-5-formamide (141 mg, 62 % yield). Molecular formula: C24H30ClN5O3 Molecular weight: 472.0 MS (m/e): 472.0 (M+1) 1H-NMR (400 MHz, CDCl3): delta 8.99 (t, 1H), 8.08 (s, 1H), 7.38 (d, 1H), 7.18 (d, 1H), 6.86 (d, 1H), 5.66 (d, 1H), 4.53 (m, 2H), 3.88(s, 3H), 3.87 (m, 1H), 3.86 (d, 2H), 3.64(m, 1H), 3.50 (d, 2H), 1.29-1.85 (m, 11H), 0.74 (m, 1H), 0.20 (m, 1H).

The synthetic route of 27489-62-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; WU, Frank; WANG, Aichen; EP2886540; (2015); A1;,
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Synthetic Route of 27489-62-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 27489-62-9, name is trans-4-Aminocyclohexanol, molecular formula is C6H13NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-Fluoro-2-nitrobenzotrifluoride (400 mg, 1.91 mmol) and trans-4- aminocyclohexanol (220 mg, 1.91 mmol) are dissolved in dimethylsulfoxide (10 mL) and the reaction is then heated at 95C for 3.5 hours. After cooling to room temperature, the mixture is diluted with dichloromethane (15 mL) and washed with water (3 x 10 mL). The organic phase is collected and dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product is recrystallised from petrol ether. The desired product is finally isolated as a yellow solid (84% yield).

According to the analysis of related databases, 27489-62-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; CHASSAING, Christophe Pierre Alain; MEYER, Thorsten; WO2010/146083; (2010); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 27489-62-9 ,Some common heterocyclic compound, 27489-62-9, molecular formula is C6H13NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 6-chloro-3-(7-methoxythieno[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyridazine (20 mg, 0.0631 mmol, 1.0 equiv) in DMSO (2.0 mL) was added p-toluene sulfonic acid monohydrate (12 mg, 0.0631 mmol, 1.0 equiv) and amine (36 mg, 0.316 mmol, 5.0 equiv) and heated to 100 C. for 24 h. The reaction mixture was diluted with water and extracted with ethyl acetate. Purification by column chromatography using 5% methanol in dichloromethane elution gave 20 mg of the yellow solid, 80%. [0598] Compound 213, 217 was physically characterized by electrospray ionization mass spectrometry. Structures and molecular masses are given below in Table 59.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 27489-62-9, trans-4-Aminocyclohexanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Califia Bio, Inc.; GOODFELLOW, VAL S.; NGUYEN, THONG X.; RAVULA, SATHEESH B.; GELBARD, HARRIS A.; US2014/256733; (2014); A1;,
Alcohol – Wikipedia,
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