Category: 27489-62-9

《Efficient access to 3,5-disubstituted 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines involving SNAr and Suzuki cross-coupling reactions》 was written by Jismy, Badr; Tikad, Abdellatif; Akssira, Mohamed; Guillaumet, Gerald; Abarbri, Mohamed. SDS of cas: 27489-62-9 And the article was included in Molecules in 2020. The article conveys some information:

An efficient and original synthesis of various 3,5-disubstituted 7-(trifluoromethyl)pyrazolo [1,5-a]pyrimidines was reported. A library of compounds diversely substituted in C-3 and C-5 positions was easily prepared from a common starting material, 3-bromo-7-(trifluoromethyl)pyrazolo[1,5-a] pyrimidin-5-one. In C-5 position, a SNAr type reaction was achieved by first activating the C-O bond of the lactam function with PyBroP (Bromotripyrrolidinophosphonium hexafluorophosphate), followed by the addition of amine or thiol giving monosubstituted derivatives, whereas in C-3 position, arylation was performed via Suzuki-Miyaura cross-coupling using the com. available aromatic and heteroaromatic boronic acids. Moreover, trifluoromethylated analogs of potent Pim1 kinase inhibitors were designed following this concise synthetic methodol. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9SDS of cas: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.SDS of cas: 27489-62-9

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In 2019,Organic Letters included an article by Yi, Jun; Badir, Shorouk O.; Kammer, Lisa Marie; Ribagorda, Maria; Molander, Gary A.. Application In Synthesis of trans-4-Aminocyclohexanol. The article was titled 《Deaminative Reductive Arylation Enabled by Nickel/Photoredox Dual Catalysis》. The information in the text is summarized as follows:

Described is a cross-electrophilic, deaminative coupling strategy harnessing Katritzky salts as a new species of electrophile in Ni/photoredox dual catalytic reductive cross-coupling reactions. Distinguishing features of this arylation protocol include its mild reaction conditions, high chemoselectivity, and adaptability to a variety of complex substrates [i.e., pyridinium salts derived from amines and partners derived from (hetero)aryl bromides]. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9Application In Synthesis of trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application In Synthesis of trans-4-Aminocyclohexanol

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The author of 《Tailoring the degradation and mechanical properties of poly(e-caprolactone) incorporating functional e-caprolactone-based copolymers》 were Xu, Mi; Guo, Cuili; Dou, Haozhen; Zuo, Yi; Sun, Yawei; Zhang, Jinli; Li, Wei. And the article was published in Polymer Chemistry in 2019. Recommanded Product: 27489-62-9 The author mentioned the following in the article:

A series of functional block copolymers (COPs) was synthesized through the ring-opening polymerization of ε-caprolactone (CL) and γ-(carbamic acid benzyl ester)-ε-caprolactone (CABCL) monomers at different ratios, and then the effects of the COP additives on the hydrolytic and oxidative degradation and mech. properties of PCL/COP samples were studied. From characterization using DSC, POM, AFM, WAXD, SAXS, etc., it was demonstrated that the content and distribution of pendant side chains in the COPs can alter the nucleation of macromol. chains, and then modulate the lamellar thickness and crystallinity of the PCL/COP samples. Such variations of the macromol. structures result in distinct changes in the mech. properties during degradation These results provide useful guidance for the development of ideal materials for biodegradable polymer stents with tunable degradation rates and the desirable evolution of the mech. properties. In the part of experimental materials, we found many familiar compounds, such as trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 27489-62-9

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In 2017,Rapacz, Anna; Waszkielewicz, Anna M.; Panczyk, Katarzyna; Pytka, Karolina; Koczurkiewicz, Paulina; Piska, Kamil; Pekala, Elzbieta; Budziszewska, Boguslawa; Starek-Swiechowicz, Beata; Marona, Henryk published 《Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols》.MedChemComm published the findings.Name: trans-4-Aminocyclohexanol The information in the text is summarized as follows:

New derivatives of N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated via rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indexes were evaluated for analgesic activity using the formalin test for neurogenic pain. They were also evaluated for their influence on cytotoxic activity using in vitro cellular models (HepG2 and CRL-2534 cell lines). Experiments performed using MTT and neutral red cytotoxicity assays showed that all evaluated compounds were safe for normal, glial cells (astrocytes) and did not induce hepatotoxic effects. Based on the results from the in vitro studies, the safety of the evaluated compounds was inferred. The most promising compound in this research was 1-{2-[2-(2,3-dimethylphenoxy)ethoxy]ethyl}piperidin-3-ol hydrochloride. Addnl., in silico metabolism prediction for the compound has been performed. The results came from multiple reactions, including the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Name: trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Name: trans-4-Aminocyclohexanol

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The author of 《Synthesis of N-Fused Polycyclic Indoles via Ligand-Free Palladium-Catalyzed Annulation/Acyl Migration Reactionã€?were Dong, Zhan; Zhang, Xiao-Wen; Li, Weishuang; Li, Zi-Meng; Wang, Wen-Yan; Zhang, Yan; Liu, Wei; Liu, Wen-Bo. And the article was published in Organic Letters in 2019. COA of Formula: C6H13NO The author mentioned the following in the article:

An efficient synthesis of N-fused polycyclic indoles I (R1 = Me, Bn, etc.; R2 = 2-Me, 3-Me, 2-F, etc.) by a palladium-catalyzed annulation/acyl migration cascade reaction is described. The reaction is ligand-free, scalable, and provides access to a diverse range of useful indole scaffolds from readily available starting materials. Supporting mechanistic studies indicate that the reaction likely proceeds via an intramol. α-arylation mechanism. The synthetic utility of this protocol is demonstrated by a gram-scale reaction and syntheses toward indole alkaloids and a HSP90 inhibitor. In addition to this study using trans-4-Aminocyclohexanol, there are many other studies that have used trans-4-Aminocyclohexanol(cas: 27489-62-9COA of Formula: C6H13NO) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C6H13NO

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HPLC of Formula: 27489-62-9In 2017 ,《Selective Catalytic Hydrogenation of Arenols by a Well-Defined Complex of Ruthenium and Phosphorus-Nitrogen PN3-Pincer Ligand Containing a Phenanthroline Backboneã€?was published in ACS Catalysis. The article was written by Li, Huaifeng; Wang, Yuan; Lai, Zhiping; Huang, Kuo-Wei. The article contains the following contents:

Selective catalytic hydrogenation of aromatic compounds is extremely challenging using transition-metal catalysts. Hydrogenation of arenols to substituted tetrahydronaphthols or cyclohexanols has been reported only with heterogeneous catalysts. Herein, we demonstrate the selective hydrogenation of arenols to the corresponding tetrahydronaphthols or cyclohexanols catalyzed by a phenanthroline-based PN3-ruthenium pincer catalyst. In the experiment, the researchers used trans-4-Aminocyclohexanol(cas: 27489-62-9HPLC of Formula: 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 â†?R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.HPLC of Formula: 27489-62-9

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In 2019,Organic Letters included an article by Huang, Rong; Li, Zhihong; Yu, Jianghui; Chen, Hongli; Jiang, Biao. Synthetic Route of C6H13NO. The article was titled 《H2O-Regulated Chemoselectivity in Oxa- Versus Aza-Michael Reactionsã€? The information in the text is summarized as follows:

A H2O-regulated chemoselective addition in oxa- and aza-Michael reactions for aminoalcs. and mixtures of structurally similar alcs. and amines was reported. The oxa-Michael reactions might be kinetically controlled, and the reactions to produce O-selective products were slowed by the addition of water. The electrophilicity of Michael acceptors and the steric hindrance of Michael donors also affect the ratios of O/N products. This method offers novel ideas over conventional metal-catalyzed or ligand-induced strategies. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Synthetic Route of C6H13NO)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Synthetic Route of C6H13NO

Referemce:
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In 2018,Cooper, Anna G.; Oyagawa, Caitlin R. M.; Manning, Jamie J.; Singh, Sameek; Hook, Sarah; Grimsey, Natasha L.; Glass, Michelle; Tyndall, Joel D. A.; Vernall, Andrea J. published 《Development of selective, fluorescent cannabinoid type 2 receptor ligands based on a 1,8-naphthyridin-2-(1H)-one-3-carboxamide scaffoldã€?MedChemComm published the findings.Related Products of 27489-62-9 The information in the text is summarized as follows:

Cannabinoid type 2 (CB2) receptor has been implicated in several diseases and conditions, however no CB2 receptor selective drugs have made it to market. The aim of this study was to develop fluorescent ligands as CB2 receptor tools, to enable an increased understanding of CB2 receptor expression and signalling and thereby accelerate drug discovery. Fluorescent ligands have been successfully developed for other receptors, however none with adequate subtype selectivity or imaging properties have been reported for CB2 receptor. A series of 1,8-naphthyridin-2-(1H)-one-3-carboxamides with linkers and fluorophores appended in the N1 and C3-positions were developed. Mol. modeling indicated the C3 cis-cyclohexanol-linked compounds directed the linker out of the CB2 receptor between transmembrane helixes 1 and 7. Herein we report fluorescent ligand 32 (hCB2 pKi = 6.33 ± 0.02) as one of the highest affinity, selective CB2 receptor fluorescent ligands reported. Despite 32 displaying poor specific labeling of CB2 receptor, the naphthyridine scaffold with this linker remains highly promising for future development of CB2 receptor tools. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Related Products of 27489-62-9)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 27489-62-9

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Alcohol – Wikipedia,
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《One-pot Synthesis of 4-Aminocyclohexanol Isomers by Combining a Keto Reductase and an Amine Transaminaseã€?was written by Sviatenko, Olha; Rios-Lombardia, Nicolas; Moris, Francisco; Gonzalez-Sabin, Javier; Venkata Manideep, Kollipara; Merdivan, Simon; Guenther, Sebastian; Suess, Philipp; Hoehne, Matthias. Recommanded Product: trans-4-AminocyclohexanolThis research focused ontransaminase ketoreductase aminocyclohexanol cascade enantioselective synthesis. The article conveys some information:

The efficient multifunctionalization by one-pot or cascade catalytic systems has developed as an important research field, but is often challenging due to incompatibilities or cross-reactivities of the catalysts leading to side product formation. Herein we report the stereoselective preparation of cis- and trans-4-aminocyclohexanol from the potentially bio-based precursor 1,4-cyclohexanedione. We identified regio- and stereoselective enzymes catalyzing reduction and transamination of the diketone, which can be performed in a one-pot sequential or cascade mode. For this, we identified regioselective keto reductases for the selective mono reduction of the diketone to give 4-hydroxycyclohexanone. The system is modular and by choosing stereocomplementary amine transaminases, both cis- and trans-4-aminocyclohexanol were synthesized with good to excellent diastereomeric ratios. Furthermore, we identified an amine transaminase that produces cis-1,4-cyclohexanediamine with diastereomeric ratios >98 : 2. These examples highlight that the high selectivity of enzymes enable short and stereoselective cascade multifunctionalizations to generate high-value building blocks from renewable starting materials. Introduction. In the experiment, the researchers used many compounds, for example, trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: trans-4-Aminocyclohexanol)

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)â€? RS(O)2â€? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ€?; the products are amides of the corresponding acids.Recommanded Product: trans-4-Aminocyclohexanol

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In 2018,ACS Catalysis included an article by Ociepa, Michal; Turkowska, Joanna; Gryko, Dorota. Recommanded Product: 27489-62-9. The article was titled 《Redox-Activated Amines in C(sp3)-C(sp) and C(sp3)-C(sp2) Bond Formation Enabled by Metal-Free Photoredox Catalysisã€? The information in the text is summarized as follows:

The amino group represents one of the most prevalent structural motifs in organic chem. Therefore, application of amines as alkylating agents in synthesis is highly compelling. Herein, we present a metal-free photoredox strategy for the formation of C(sp3)-C(sp) and C(sp3)-C(sp2) bonds from redox-activated primary amine derivatives The developed reaction of 2,4,6-triphenylpyridinium salts with alkynyl p-tolylsulfones, leading to functionalized alkynes, is easily scalable and offers broad substrate scope, high chemoselectivity, and mild conditions. Its potential is also highlighted by diversification of complex mol. scaffolds. Addnl., the approach is also suitable for synthesis of (E)-alkenes from vinyl Ph sulfones. Mechanistic studies contribute to the elucidation of unexpected differences in reactivity of primary and secondary alkyl substituted pyridinium salts.trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9) was used in this study.

trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Recommanded Product: 27489-62-9

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts