Category: 27292-49-5

Chung, Shu-Ting published the artcileSynthesis and anti-inflammatory activities of 4H-chromene and chromeno[2,3-b]pyridine derivatives, SDS of cas: 27292-49-5, the publication is Research on Chemical Intermediates (2016), 42(2), 1195-1215, database is CAplus.

Several derivatives of 4H-chromene and chromeno[2,3-b]pyridine were efficiently prepared under microwave irradiation in a one-pot reaction, and their anti-inflammatory activities were evaluated. Six synthetic products (1b, 1c, 1h, 2d, 2j, and 2l) exhibited more powerfully inhibited the production of tumor necrosis factor-α-induced nitric oxide (NO) than quercetin and exhibited comparable cell viability in both human and porcine chondrocytes. In particular, 2d at dosages of 10 and 20 mg/kg had a very potent anti-inflammatory effect by suppressing the formation of carrageenan-induced rat paw edema and prostaglandin E₂. The results herein suggest that these compounds may have potential as structural templates in the design and development of new anti-inflammatory drugs.

Research on Chemical Intermediates published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, SDS of cas: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kirpichenok, M. A. published the artcileSynthesis of 4-chloro-7-(dialkylamino)coumarins, Related Products of alcohols-buliding-blocks, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1990), 830-5, database is CAplus.

The title coumarins I (R = Et, R₂N = piperidino, morpholino, R¹ = H, Et, cyclohexyl, benzyl) and II were prepared in 15-42% yields by heating aminophenols III or benzoquinolizinol IV with R¹CH(CO₂H)₂ in excess POCl₃. Treating I (R = Et, R¹ = H) with NaOEt, Bu₂NH, and N₂H₄.H₂O gave 45, 63, and 17% coumarins V (R² = OEt, Bu₂N, NHNH₂).

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Esguerra, Kenneth Virgel N. published the artcileA biomimetic catalytic aerobic functionalization of phenols, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2014), 53(23), 5877-5881, database is CAplus and MEDLINE.

A biomimetic approach that converts phenolic C-H bonds into C-O, C-N, and C-S bonds at the sole expense of reducing O₂ to water (H₂O) was reported. This method hinges on a regio- and chemoselective Cu-catalyzed aerobic oxygenation to provide orthoquinones. Orthoquinones are versatile intermediates, whose direct catalytic aerobic synthesis from phenols enables a mild and efficient means of synthesizing polyfunctional aromatic rings.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Blaser, Hans-Ulrich published the artcileNo Stirring Necessary: Parallel Carbonylation of Aryl Halides with CO and Various Alcohols under Pressure, HPLC of Formula: 27292-49-5, the publication is Journal of Organic Chemistry (2003), 68(9), 3725-3728, database is CAplus and MEDLINE.

The parallel carbonylation of aryl and heteroaryl halides R¹X (R¹ = 4-MeCOC₆H₄, X = Br; R¹ = 2-pyridyl, X = Cl) with 6-25 bar of CO in 1-mL vials in a standard autoclave in the presence of an O-nucleophile R²OH (R² = Bu, PhCH₂, cyclopentyl, etc.) to give the corresponding esters R¹CO₂R² was investigated. With 2-chloropyridine as a model substrate, 102 different O-nucleophiles (primary and secondary alcs., phenols) were studied. No inertization during the loading was necessary. Fifty esters (43 new, yield up to 60%) were isolated and characterized. Ether, ester, ketone, and sometimes even olefin functionalities were usually tolerated. The new method is suitable for screening and small scale synthesis.

Journal of Organic Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, HPLC of Formula: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barut, Burak published the artcileNovel water soluble morpholine substituted Zn(II) phthalocyanine: Synthesis, characterization, DNA/BSA binding, DNA photocleavage and topoisomerase I inhibition, SDS of cas: 27292-49-5, the publication is International Journal of Biological Macromolecules (2017), 105(Part_1), 499-508, database is CAplus and MEDLINE.

In this study, novel peripherally tetra 3-morpholinophenol substituted zinc(II) phthalocyanine (4) and its water soluble form quaternized zinc(II) phthalocyanine (ZnQ) were synthesized for the first time. These novel compounds were characterized by a combination of different spectroscopic techniques such as FT-IR, ¹H NMR, ¹³C NMR, UV-vis and mass. The DNA binding of ZnQ was investigated using UV-vis absorption titration, competitive ethidium bromide, thermal denaturation and viscosity experiments that the ZnQ bound to CT-DNA via intercalation mode. ZnQ indicated photocleavage activity on supercoiled pBR322 plasmid DNA via formation of singlet oxygen under irradiation at 700 nm. Besides, the topoisomerase I inhibitory effect experiments showed that ZnQ inhibited topoisomerase I enzyme in a concentration-dependent manner. The bovine serum albumin (BSA) binding experiments indicated that ZnQ bound to proteins through a static quenching mechanism. All of these results claim that ZnQ has potential agent for photodynamic therapy owing to its nucleic acid interactions and photobiol. or photochem. properties.

International Journal of Biological Macromolecules published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, SDS of cas: 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barut, Burak published the artcileWater soluble axially morpholine disubstituted silicon phthalocyanines: Synthesis, characterisation, DNA/BSA binding, DNA photocleavage properties, Name: 3-Morpholinophenol, the publication is Synthetic Metals (2017), 22-32, database is CAplus.

In this study axially 1-morpholinopropan-2-ol disubstituted silicon phthalocyanine 4 and axially 3-morpholinophenol disubstituted silicon phthalocyanine 5 and their quaternised water soluble derivatives (4a and 5a) were synthesized for the first time. The structural characterisations of these novel compounds were performed by a combination of FT-IR, ¹H NMR, UV-vis and mass. The binding propensity of the compounds with CT-DNA was performed using UV-vis absorption titration, competitive ethidium bromide and thermal denaturation experiments These studies revealed that 4a and 5a intercalate to CT-DNA with 3.94 ± (0.11) × 10⁴ M^-1 and 1.71 ± (0.09) × 10⁴ M^-1. The DNA cleavage ability of 4a and 5a was investigated using supercoiled pBR322 plasmid DNA on agarose gel electrophoresis. 4a indicated excellent photocleavage activity under light irradiation at 650 nm in a concentration-dependent manner. However, 5a showed low cleavage activities under light irradiation at 12.5 μM and 25 μM but it had moderate cleavage activity at 50 μM. The BSA interaction experiment showed that quenching mechanisms of BSA with 4a and 5a were found as static quenching using UV-vis spectroscopy. All of these results suggest that 4a has a superior photosensitizer agent for photodynamic therapy to that of 5a due to DNA photocleavage properties.

Synthetic Metals published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Name: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Knight, Zachary A. published the artcileIsoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold, Recommanded Product: 3-Morpholinophenol, the publication is Bioorganic & Medicinal Chemistry (2004), 12(17), 4749-4759, database is CAplus and MEDLINE.

Phosphoinositide 3-kinases (PI3-Ks) are an ubiquitous class of signaling enzymes that regulate diverse cellular processes including growth, differentiation, and motility. Physiol. roles of PI3-Ks have traditionally been assigned using two pharmacol. inhibitors, LY294002 and wortmannin. Although these compounds are broadly specific for the PI3-K family, they show little selectivity among family members, and the development of isoform-specific inhibitors of these enzymes has been long anticipated. Herein, the preparation of two classes of arylmorpholine PI3-K inhibitors and the characterization of their specificity against a comprehensive panel of targets within the PI3-K family are reported. Multiplex inhibitors that potently inhibit distinct subsets of PI3-K isoforms, including the first selective inhibitor of p110β/p110δ (IC₅₀ p110β = 0.13 μM, p110δ = 0.63 μM), were identified. Trends that suggest certain PI3-K isoforms may be more sensitive to potent inhibition by arylmorpholines, thereby guiding future drug design based on this pharmacophore, were also identified.

Bioorganic & Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Tianzhang published the artcileIntermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis, Formula: C10H13NO2, the publication is Advanced Synthesis & Catalysis (2019), 361(16), 3886-3892, database is CAplus.

An intermol. multiple dehydrogenative coupling between ketones RC(O)CH₂CH₃ (R = Ph, thiophen-2-yl, (E)-2-phenylethenyl, etc.), cyclohexanone and nucleophilic amines NHR¹R² [R¹ = H; R² = Ph, pyridin-2-yl, morpholin-4-yl, etc.; R¹R² = (C₂)₂O(C₂)₂, (C₂)₅] or boronic acids ArB(OH)₂ (Ar = Ph, furan-2-yl, anthracen-9-yl, etc.) using inexpensive copper(I) oxide as a catalyst was reported. This method provides a facile access to highly desirable chem. products such as α,β-unsaturated ketones (E)-RC(O)CH=CHAr, enaminones (E)-RC(O)CH=CHNR¹R², and synthetically relevant meta-substituted phenols R³C₆H₄OH (R³ = phenylaminyl, morpholin-4-yl, Ph, etc.).

Advanced Synthesis & Catalysis published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H12BNO4S, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Poupart, Marc-Andre published the artcileSolid-Phase Synthesis of Peptidomimetic Inhibitors for the Hepatitis C Virus NS3 Protease, Quality Control of 27292-49-5, the publication is Journal of Organic Chemistry (2001), 66(14), 4743-4751, database is CAplus and MEDLINE.

The NS3 serine protease enzyme of the hepatitis C virus (HCV) is essential for viral replication. Short peptides mimicking the N-terminal substrate cleavage products of the NS3 protease are known to act as weak inhibitors of the enzyme and have been used as templates for the design of peptidomimetic inhibitors. Automated solid-phase synthesis of a small library of compounds based on such a peptidomimetic scaffold has led to the identification of potent and highly selective inhibitors of the NS3 protease enzyme.

Journal of Organic Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Huan-Ming published the artcileThree-Component, Interrupted Radical Heck/Allylic Substitution Cascade Involving Unactivated Alkyl Bromides, Recommanded Product: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2020), 142(22), 10173-10183, database is CAplus and MEDLINE.

Developing efficient and selective strategies to approach complex architectures containing (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and industry. Catalytic cascade reactions represent a powerful means of rapidly leveraging mol. complexity from simple feedstocks. Unfortunately, carrying-out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet challenge owing to unavoidable β-hydride elimination. Herein, we show that a modular, practical and general palladium catalyzed, radical three-component coupling can indeed overcome the aforementioned limitations through an interrupted Heck/allylic substitution sequence mediated by visible light. Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achieved by employing different com. available nitrogen-, oxygen-, sulfur- or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5 E/Z, >20:1 rr). Sequential C(sp3)-C(sp3) and C-X (N, O, S) bonds have been constructed efficiently with a broad scope and high functional group tolerance. The flexibility and versatility of the strategy has been illustrated in a gram-scale reaction and streamlined syntheses of complex ether, sulfone and tertiary amine products, some of which would be difficult to access via currently established methods.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts