Category: 27292-49-5

Zhang, Liang published the artcileMetal- and solvent-free conditions for the acylation reaction catalyzed by carbon tetrabromide (CBr₄), Computed Properties of 27292-49-5, the publication is Green Chemistry (2007), 9(9), 1022-1025, database is CAplus.

An efficient and useful catalyst, carbon tetrabromide (CBr₄), was discovered to be highly effective for the acylation of phenols, alcs., and thiols under metal- and solvent-free conditions.

Green Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H6F3NO, Computed Properties of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Velu, Sadanandan E. published the artcileTethered Dimer Inhibitors of NAD Synthetase: Parallel Synthesis of an Aryl-Substituted SAR Library, Recommanded Product: 3-Morpholinophenol, the publication is Journal of Combinatorial Chemistry (2005), 7(6), 898-904, database is CAplus and MEDLINE.

The authors previously reported that tethered dimers containing indoles on one end and a permanent pos. charge on the other, using a 6-9 carbon polymethylene tether, provided NAD synthetase inhibitors with impressive antibacterial activities against Gram-positives. Here, the authors report that the Ph ring is a good substitute for indole, and the authors utilize solution-phase parallel synthesis to explore structure-activity relationships for substituents on that ring. General conclusions are that nonpolar substituents are more effective than polar ones and that different positional isomers often have very different enzyme inhibition activities. This latter observation reveals that enzyme activity is sensitive to minor structural changes and suggests that nonspecific detergent actions are not important for the observed effects.

Journal of Combinatorial Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C7H6Cl2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Dong-Xing published the artcileStereodivergent Synthesis of Enantioenriched 2,3-Disubstituted Dihydrobenzofurans via a One-Pot C-H Functionalization/Oxa-Michael Addition Cascade, Recommanded Product: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2021), 143(23), 8583-8589, database is CAplus and MEDLINE.

A one-pot rhodium-catalyzed C-H functionalization/organocatalyzed oxa-Michael addition cascade reaction has been developed. This methodol. enables the stereodivergent synthesis of diverse 2,3-disubstituted dihydrobenzofurans with broad functional group compatibility in good yields with high levels of stereoselectivity under exceptionally mild conditions. The full complement of stereoisomers of chiral 2,3-disubstituted dihydrobenzofurans and 3,4-disubstituted isochromans could be accessed at will by appropriate permutations of the two chiral catalysts. The current work provides a rare example of two chiral catalysts independently controlling two contiguous stereogenic centers subsequently via a two-step reaction in a single operation.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C17H14O5, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lu, Hai-hua published the artcileCatalytic asymmetric intramolecular hydroarylations of ω-aryloxy- and arylamino-tethered α,β-unsaturated aldehydes, Recommanded Product: 3-Morpholinophenol, the publication is Chemistry – A European Journal (2009), 15(12), 2742-2746, database is CAplus and MEDLINE.

The first organocatalytic asym. intramol. hydroarylation of phenol- and aniline-derived enals I (X = O, NMe, NCH₂Ph, NBoc, etc.; R¹ = H, Me, NMe₂, 1-pyrrolidinyl, 4-morpholinyl, etc.; R² = H, Me, OMe, OEt) offers one of the most straightforward and atom-economic approaches to enantioenriched chromans and tetrahydroquinolines II with up to 96% ee.

Chemistry – A European Journal published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bender, Christoph published the artcileStereoselective 1-arylation of isoquinolines via chiral N-acylisoquinolinium salts, Quality Control of 27292-49-5, the publication is ARKIVOC (Gainesville, FL, United States) (2008), 111-136, database is CAplus.

Reaction of isoquinolines with (R)-menthyl chlorocarbonate or (S)-α-Cbz-aminoacyl fluorides and arenes or heteroarenes gave access to the corresponding 2-R¹-1-R²-1,2-dihydroisoquinolines I [R¹ = H, Br, Ph, 4-ClC₆H₄; R² = menthyloxycarbonyl, N-benzyloxycarbonyl-2-amino-3-phenylpropionyl, N-benzyloxycarbonyl-2-amino-propionyl; R³ = 4-(1-dimethylaminonaphthyl), 4-Et₂NC₆H₄, 3-indolyl, etc.] in a Mannich-type reaction via intermediate N-acylisoquinolinium salts. As an alternative, aryl metal compounds could be used. Modest stereoselectivities were achieved. Further reduction and hydrolysis of the products gave access to 1,2,3,4-tetrahydroisoquinolines II (R² = H, Me; R³ = Ph, 4-Et₂NC₆H₄, 3-MeOC₆H₄, 4-MeOC₆H₄, 3-indolyl).

ARKIVOC (Gainesville, FL, United States) published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bacher, Emily P. published the artcileA Phosphine-Mediated Dearomative Skeletal Rearrangement of Dianiline Squaraine Dyes, Synthetic Route of 27292-49-5, the publication is Organic Letters (2021), 23(8), 2853-2857, database is CAplus and MEDLINE.

A phosphorus(III)-mediated dearomatization of ortho-substituted dianiline squaraine dyes results in an unusual skeletal rearrangement to provide exotic, highly conjugated benzofuranone and oxindole scaffolds bearing a C3 side chain comprised of a linear conflagration of an enol, a phosphorus ylide, and 2,4-disubstituted aniline. Employing exptl. and computational anal., a mechanistic evaluation revealed a striking dependence on the acidity of the aniline ortho substituent. Notably, the rearrangement adducts underwent rapid and complete reversion to the parent squaraine in the presence of a Bronsted acid.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Synthetic Route of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kemnitzer, William published the artcileDiscovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 2. Structure-activity relationships of the 7- and 5-, 6-, 8-positions, Recommanded Product: 3-Morpholinophenol, the publication is Bioorganic & Medicinal Chemistry Letters (2005), 15(21), 4745-4751, database is CAplus and MEDLINE.

As a continuation of our efforts to discover and develop the apoptosis inducing 4-aryl-4H-chromenes as novel anticancer agents, the authors explored the SAR of 4-aryl-4H-chromenes with modifications at the 7- and 5-, 6-, 8-positions. It was found that a small hydrophobic group, such as NMe₂, NH₂, NHEt, and OMe, is preferred at the 7-position. Di-substitution at either the 5,7-positions or the 6,7-positions generally led to a large decrease in potency. Di-substitution at the 7,8-positions, in general, was found to result in potent compounds 7-NMe₂, 7-NHEt, 7-OMe, and 7,8-di-NH₂ analogs were found to have similar SAR for the 4-aryl group, and several 7-substituted and 7,8-di-substituted analogs were found to have similar potencies as the lead compound MX58151 (I) both as caspase activators and inhibitors of cell proliferation.

Bioorganic & Medicinal Chemistry Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Recommanded Product: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Kai published the artcileCatalytic Amination of Phenols with Amines, Name: 3-Morpholinophenol, the publication is Journal of the American Chemical Society (2022), 144(3), 1144-1151, database is CAplus and MEDLINE.

Herein, a rhodium-catalyzed amination of phenols, which provided concise access to diverse anilines, with water as the sole byproduct was described. The arenophilic rhodium catalyst facilitated the inherently difficult keto-enol tautomerization of phenols by means of π-coordination, allowing for the subsequent dehydrative condensation with amines. The generality of this redox-neutral catalysis by carrying out reactions of a large array of phenols with various electronic properties and a wide variety of primary and secondary amines was demonstrated. Several examples of late-stage functionalization of structurally complex bioactive mols., including pharmaceuticals, further illustrated the potential broad utility of the method.

Journal of the American Chemical Society published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Name: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tanioka, Masaru published the artcileStepwise structural and fluorescent colour conversion in rhodamine analogues based on light and acid stimulations, Category: alcohols-buliding-blocks, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2020), 8(2), 543-549, database is CAplus.

The research and development of multi-stimuli, multi-responsive mols. have attracted considerable attention in chem., biol., and material science. Herein, the authors propose a multi-stimuli-responsive multi-fluorescence system in a single mol. This system is based on the isomerization that involves ring-opening/closing reactions of spirolactones of rhodamine analogs (ABPXs), developed by the authors’ group, which can be independently controlled by light and chem. stimuli. UV light irradiation opens one of the spirolactones to give thermally stable colored isomer (Z) in solution Detailed synthetic and theor. studies reveal that the ring-opening reaction of ABPXs proceeds via the formation of a photo-induced charge separated state, followed by the recombination of the biradicals. Furthermore, the authors explore the structure-kinetic relations and demonstrate that the introduction of electron-donating substituents into the xanthene ring can tune the lifetime of the photo-generated isomer. Chem. stimulation by an acid further promotes the ring-opening reaction to give a red shifted isomer (D). These light and chem. input signals can be converted into output signals of distinct color and fluorescence. The multi-stimuli-responsive multi-color fluorescence could be distinctively expressed through the combinatorial logic gate.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C30H24BrCuN2P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jingwu published the artcileReaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and H₂ without oxidants and hydrogen acceptors, Computed Properties of 27292-49-5, the publication is Chemical Science (2015), 6(8), 4674-4680, database is CAplus and MEDLINE.

It was widely believed that the dehydrogenation of organic compounds was a thermodynamically unfavorable process, and thus required stoichiometric oxidants such as dioxygen and metal oxides or sacrificial hydrogen acceptors to remove the hydrogen from the reaction mixture to drive the equilibrium towards the products. A previously unappreciated combination of common com. Pd/C and H₂ which dehydrogenated a wide range of substituted cyclohexanones and 2-cyclohexenones to their corresponding phenols with high isolated yields, with H₂ as the only byproduct was reported. The reaction requires no oxidants or hydrogen acceptors because instead of removing the generated hydrogen with oxidants or hydrogen acceptors, it was used as a cocatalyst to help power the reaction. The method for phenol synthesis manifested a high atom economy, and was inherently devoid of the complications normally associated with oxidative dehydrogenations.

Chemical Science published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C38H24F4O4P2, Computed Properties of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts