Category: 27292-49-5

Ma, Yao published the artcileNonpeptidic quinazolinone derivatives as dual nucleotide-binding oligomerization domain-like receptor 1/2 antagonists for adjuvant cancer chemotherapy, Name: 3-Morpholinophenol, the publication is European Journal of Medicinal Chemistry (2020), 112723, database is CAplus and MEDLINE.

Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD1/2) receptors are potential immune checkpoints. In this article, a quinazolinone derivative, I, as a NOD1/2 dual antagonist was identified that significantly sensitizes B16 tumor-bearing mice to paclitaxel treatment by inhibiting both nuclear factor κB (NF-κB) and mitogen-activated protein kinase inflammatory signaling that mediated by NOD1/2.

European Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Name: 3-Morpholinophenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Elslager, Edward F. published the artcileSynthetic schistosomicides. XVI. 5-(Mono- and dialkylamino)-2-nitrosophenols, 2-amino-5-(dialkylamino)phenols, and related compounds, Formula: C10H13NO2, the publication is Journal of Medicinal Chemistry (1970), 13(3), 370-6, database is CAplus and MEDLINE.

Various 5-(mono- and dialkylamino)-2-nitrosophenols were prepared by nitrosation of the corresponding m-(mono- and dialkylamino)phenols, obtained by heating resorcinol with an excess of the appropriate amine at 200°, or by alkylation of m-aminophenol with an alkyl halide. 5-(Dimethylamino)-2-nitrosophenol, 5-(diethylamino)-2-nitrosophenol (I), 2-nitroso-5-(1-pyrrolidinyl)phenol, and 2-amino-5-(diethylamino)phenol, a potential metabolite of I, displayed strong schistosomicidal activity and effected a 70-100% reduction of adult Schistosoma mansoni in mice at daily doses of 177-568 mg/kg for 14 days. Structure-activity relationship are summarized, and information concerning potential metabolites and the possible mode of action of the nitrosophenols is discussed.

Journal of Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pein, Wesley L. published the artcileNickel-Catalyzed Ipso-Borylation of Silyloxyarenes via C-O Bond Activation, Application In Synthesis of 27292-49-5, the publication is Organic Letters (2021), 23(12), 4588-4592, database is CAplus and MEDLINE.

The conversion of silyloxyarenes to boronic acid pinacol esters via Ni catalysis is described. In contrast to other borylation protocols of inert C-O bonds, the method is competent in activating the C-O bond of silyloxyarenes in isolated aromatic systems lacking a directing group. The catalytic functionalization of benzyl silyl ethers was also achieved under these conditions. Sequential cross-coupling reactions were achieved by leveraging the orthogonal reactivity of silyloxyarenes, which could then be functionalized subsequently.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Application In Synthesis of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Lei published the artcileRapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2003), 5(19), 3515-3517, database is CAplus and MEDLINE.

A rapid and direct amination of aryl halides has been developed, in good to high yields, under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines, e.g., I, from ortho- or para-substituted Ph halides. The proposed mechanism proceeds through a benzyne intermediate.

Organic Letters published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C15H18BF3O4, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Ling published the artcileThe pH-influenced PET processes between pyronine and different heterocycles, Related Products of alcohols-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2017), 15(39), 8402-8409, database is CAplus and MEDLINE.

The OFF-ON and ON-OFF type pH probes based on rosamine were designed by using the relative electron densities between pyronine and various linked heterocycles. Probe 1a with an indole-pyronine skeleton gave an OFF-ON pH response (pK_a = 1.41) with decreasing pH, and the relative fluorescence intensity increased 15-fold, while probe 1b with an imidazole-pyronine skeleton did not give an ON-OFF response to different pH values. When pyronine was connected with a quinolinyl group, i.e., probes 1c-d, the red emission (around 575-800 nm) gave a monotonous ON-OFF pH response (pK_a = 3.26 and 2.62, resp.) with decreasing pH. The relative fluorescence intensities decreased 263- and 46-fold, resp. Changes in the electron donating abilities of the nitrogen containing heterocycles were used to explain variations in PET processes within the probes, and their pH-dependent PET mechanisms were verified using time-dependent d. functional theory calculations Confocal fluorescence imaging was also used to evaluate the potential biomedical application of probes 1a-d. Ultimately, probe 1d (I) with an appropriate pK_a value and good biocompatibility showed lysosome targeting ability.

Organic & Biomolecular Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C11H21BF4N2O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shen, Xiao published the artcileAlkyl Aryl Ether Bond Formation with PhenoFluor, COA of Formula: C10H13NO2, the publication is Angewandte Chemie, International Edition (2015), 54(19), 5662-5665, database is CAplus and MEDLINE.

An alkyl aryl ether bond formation reaction between phenols and primary and secondary alcs. with PhenoFluor has been developed. The reaction features a broad substrate scope and tolerates many functional groups, and substrates that are challenging for more conventional ether bond forming processes may be coupled. A preliminary mechanistic study indicates reactivity distinct from conventional ether bond formation.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C8H10S, COA of Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Hwalkee published the artcileA novel morpholine-based rhodamine fluorescent chemosensor for the rapid detection of Hg²⁺ ions, Quality Control of 27292-49-5, the publication is Journal of Nanoscience and Nanotechnology (2019), 19(11), 6893-6898, database is CAplus and MEDLINE.

A novel rhodamine-based receptor bearing a morpholine (RDM) was developed as a fluorescent chemosensor with high selectivity toward Hg²⁺. After the addition of Hg²⁺ to RDM, the color of the solution changed from colorless to pink, and the new absorption band appears at 580 nm. The fluorescent of RDM appears to orange color in the presence of Hg²⁺. Upon the addition of Hg²⁺, ring-opening of the corresponding spirolactam gives rise to fluorescence, and a 1:1 metal-ligand complex formed.

Journal of Nanoscience and Nanotechnology published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Quality Control of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wiensch, Eric M. published the artcileNickel-Catalyzed Amination of Silyloxyarenes through C-O Bond Activation, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2018), 57(34), 11045-11049, database is CAplus and MEDLINE.

Silyloxyarenes were utilized as electrophilic coupling partners with amines in the synthesis of aniline derivatives A diverse range of amine substrates were used, including cyclic or acyclic secondary amines, secondary anilines, and sterically hindered primary anilines. Addnl., a range of sterically hindered and unhindered primary aliphatic amines were employed, which have previously been challenging with other classes of aryl ether electrophiles. Orthogonal couplings of silyloxyarenes with aryl Me ethers are illustrated, where selectivity between the two C-O electrophiles is determined by ligand control, thereby allowing complementary and selective late-stage diversification of either electrophile. Finally, a sequential coupling displays the utility of this amination method along with the reversal in intrinsic reactivity between aryl Me ethers and silyloxyarenes.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C9H8BNO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beyzavi, Hudson published the artcile¹⁸F-Deoxyfluorination of Phenols via Ru π-Complexes, Formula: C10H13NO2, the publication is ACS Central Science (2017), 3(9), 944-948, database is CAplus and MEDLINE.

The deficiency of robust and practical methods for ¹⁸F-radiofluorination is a bottleneck for positron emission tomog. (PET) tracer development. Here, we report the first transition-metal-assisted ¹⁸F-deoxyfluorination of phenols. The transformation benefits from readily available phenols as starting materials, tolerance of moisture and ambient atm., large substrate scope, and translatability to generate doses appropriate for PET imaging.

ACS Central Science published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Formula: C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lamani, Manjunath published the artcilePiperidine and piperazine inhibitors of fatty acid amide hydrolase targeting excitotoxic pathology, Product Details of C10H13NO2, the publication is Bioorganic & Medicinal Chemistry (2019), 27(23), 115096, database is CAplus and MEDLINE.

FAAH inhibitors offer safety advantages by augmenting the anandamide levels “on demand” to promote neuroprotective mechanisms without the adverse psychotropic effects usually seen with direct and chronic activation of the CB1 receptor. FAAH is an enzyme implicated in the hydrolysis of the endocannabinoid N-arachidonoylethanolamine (AEA), which is a partial agonist of the CB1 receptor. Herein, we report the discovery of a new series of highly potent and selective carbamate FAAH inhibitors and their evaluation for neuroprotection. The new inhibitors showed potent nanomolar inhibitory activity against human recombinant and purified rat FAAH, were selective (>1000-fold) against serine hydrolases MGL and ABHD6 and lacked any affinity for the cannabinoid receptors CB1 and CB2. Evaluation of FAAH inhibitors 9(I) and 31(II) using the in vitro competitive activity-based protein profiling (ABPP) assay confirmed that both inhibitors were highly selective for FAAH in the brain, since none of the other FP-reactive serine hydrolases in this tissue were inhibited by these agents. Our design strategy followed a traditional SAR approach and was supported by mol. modeling studies based on known FAAH cocrystal structures. To rationally design new mols. that are irreversibly bound to FAAH, we have constructed “precovalent” FAAH-ligand complexes to identify good binding geometries of the ligands within the binding pocket of FAAH and then calculated covalent docking poses to select compounds for synthesis. FAAH inhibitors I and II were evaluated for neuroprotection in rat hippocampal slice cultures. In the brain tissue, both inhibitors displayed protection against synaptic deterioration produced by kainic acid-induced excitotoxicity. Thus, the resultant compounds produced through rational design are providing early leads for developing therapeutics against seizure-related damage associated with a variety of disorders.

Bioorganic & Medicinal Chemistry published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Product Details of C10H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts