Category: 27208-80-6

Combination of UPLC-Q-TOF/MS and Network Pharmacology to Reveal the Mechanism of Qizhen Decoction in the Treatment of Colon Cancer was written by Kong, Xianbin;Liu, Chuanxin;Lu, Peng;Guo, Yuzhu;Zhao, Chenchen;Yang, Yuying;Bo, Zhichao;Wang, Fangyuan;Peng, Yingying;Meng, Jingyan. And the article was included in ACS Omega in 2021.Reference of 27208-80-6 The following contents are mentioned in the article:

Traditional Chinese medicine (TCM) has been utilized for the treatment of colon cancer. Qizhen decoction (QZD), a potential compound prescription of TCM, possesses multiple biol. activities. It has been proven clin. effective in the treatment of colon cancer. However, the mol. mechanism of anticolon cancer activity is still not clear. This study aimed to identify the chem. composition of QZD. Furthermore, a collaborative anal. strategy of network pharmacol. and cell biol. was used to further explore the critical signaling pathway of QZD anticancer activity. First, ultraperformance liquid chromatog.-quadrupole time-of-flight/mass spectrometry (UPLC-Q-TOF/MS) was performed to identify the chem. composition of QZD. Then, the chem. composition database of QZD was constructed based on a systematic literature search and review of chem. constituents. Moreover, the common and indirect targets of chem. components of QZD and colon cancer were searched by multiple databases. A protein-protein interaction (PPI) network was constructed using the String database (https://www.string-db.org/). All of the targets were analyzed by Gene Oncol. (GO) bioanal. and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway anal., and the visual network topol. diagram of “Prescription-TCM-Chem. composition-Direct target-Indirect target-Pathway” was constructed by Cytoscape software (v3.7.1). The top mol. pathway ranked by statistical significance was further verified by mol. biol. methods. The results of UPLC-Q-TOF/MS showed that QZD had 111 kinds of chem. components, of which 103 were unique components and 8 were common components. Ten pivotal targets of QZD in the treatment of colon cancer were screened by the PPI network. Targets of QZD involve many biol. processes, such as the signaling pathway, immune system, gene expression, and so on. QZD may interfere with biol. pathways such as cell replication, oxygen-containing compounds, or organic matter by protein binding, regulation of signal receptors or enzyme binding, and affect cytoplasm and membrane-bound organelles. The main antitumor core pathways were the apoptosis metabolic pathway, the PI3K-Akt signal pathway, and so on. Expression of the PI3K-Akt signal pathway was significantly downregulated after the intervention of QZD, which was closely related to the inhibition of proliferation and migration of colon cancer cells by cell biol. methods. The present work may facilitate a better understanding of the effective components, therapeutic targets, biol. processes, and signaling pathways of QZD in the treatment of colon cancer and provide useful information about the utilization of QZD. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Reference of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 27208-80-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Impact of light irradiance on the biosynthesis of ABA-elicited phenolic compounds in suspension-cultured Vitis vinifera L. cells was written by Andi, Seyed Ali;Gholami, Mansour;Ford, Christopher M.;Maskani, Fereshteh. And the article was included in Plant Cell, Tissue and Organ Culture in 2021.Related Products of 27208-80-6 The following contents are mentioned in the article:

Phenolic compounds found in the berries of the grapevine Vitis vinifera L. are reported to reduce the incidence of some non-transmissible chronic pathologies such as cardiovascular diseases, cancer, obesity and diabetes. Elicitation of plant cell suspension cultures offers a way to exptl. determine how manipulating metabolic pathways can result in biosynthesis of higher levels of desired secondary metabolites. The goal of this work was, using cell suspension cultures of callus tissues obtained from berry slices of V. vinifera cv. Shahani grown on an optimized medium, to investigate the effects of elicitation on the synthesis of stilbene compounds including trans-resveratrol and its glucoside trans-piceid, and anthocyanin pigments. The effects of different concentrations of the phytohormone abscisic acid (ABA; 0, 50, 100 and 200μM) applied to cell suspension cultures grown under either high-level light irradiation (135.1μmol. s-1 m-2) or zero light conditions, were tested. The results showed that compared with dark conditions, cells treated with continuous light irradiation were capable of accumulating significantly higher levels of anthocyanin in all of the ABA concentrations Cell cultures subjected to high-level light irradiation did not show statistically higher piceid amounts than cells grown in dark condition except for 200μM ABA. A similar trend was found for resveratrol content of the cells exposed to the darkness. When cultures were grown in the presence of 200μM ABA under dark conditions, the accumulation of trans-resveratrol was seen at 4.12 and 3.02-fold higher levels than in dark and light-grown control cultures resp. Surprisingly, following light irradiation of 135.1μmol. s-1 m-2 with 200μM ABA, the cells accumulated the highest level of trans-piceid. This represented a remarkable increase of 19.97 and 12.71-fold in comparison with dark and light-grown control cultures resp. In addition, the combined elicitation of light irradiation and 50μM abscisic acid was found to be the most effective treatment for the production of anthocyanin. This value was 64.00 and 5.55-fold higher than those of the controls, resp. These data suggest that the transduction pathway of abscisic acid is part of a complex signaling network that includes the visible light signaling pathway. Similarly, the results of the current study suggest that combinations of dark/light together with abscisic acid can be used as an efficient method for the future scale-up of V. vinifera cell cultures for the production of high value phenolic compounds in a bioreactor system. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Related Products of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 27208-80-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Advances in understanding Norway spruce natural resistance to needle bladder rust infection: transcriptional and secondary metabolites profiling was written by Trujillo-Moya, Carlos;Ganthaler, Andrea;Stoeggl, Wolfgang;Arc, Erwann;Kranner, Ilse;Schueler, Silvio;Ertl, Reinhard;Espinosa-Ruiz, Ana;Martinez-Godoy, Maria Angeles;George, Jan-Peter;Mayr, Stefan. And the article was included in BMC Genomics in 2022.Reference of 27208-80-6 The following contents are mentioned in the article:

Needle rust caused by the fungus Chrysomyxa rhododendri causes significant growth decline and increased mortality of young Norway spruce trees in subalpine forests. Extremely rare trees with enhanced resistance represent promising candidates for practice-oriented reproduction approaches. They also enable the investigation of tree mol. defense and resistance mechanisms against this fungal disease. Here, we combined RNA-Seq, RT-qPCR and secondary metabolite analyses during a period of 38 days following natural infection to investigate differences in constitutive and infection-induced defense between the resistant genotype PRA-R and three susceptible genotypes. Gene expression and secondary metabolites significantly differed among genotypes from day 7 on and revealed already known, but also novel candidate genes involved in spruce mol. defense against this pathogen. Several key genes related to (here and previously identified) spruce defense pathways to needle rust were differentially expressed in PRA-R compared to susceptible genotypes, both constitutively (in non-symptomatic needles) and infection-induced (in symptomatic needles). These genes encoded both new and well-known antifungal proteins such as endochitinases and chitinases. Specific genetic characteristics concurred with varying phenolic, terpene, and hormone needle contents in the resistant genotype, among them higher accumulation of several flavonoids (mainly kaempferol and taxifolin), stilbenes, geranyl acetone, α-ionone, abscisic acid and salicylic acid. Combined transcriptional and metabolic profiling of the Norway spruce defense response to infection by C. rhododendri in adult trees under subalpine conditions confirmed the results previously gained on artificially infected young clones in the greenhouse, both regarding timing and development of infection, and providing new insights into genes and metabolic pathways involved. The comparison of genotypes with different degrees of susceptibility proved that several of the identified key genes are differently regulated in PRA-R, and that the resistant genotype combines a strong constitutive defense with an induced response in infected symptomatic needles following fungal invasion. Genetic and metabolic differences between the resistant and susceptible genotypes indicated a more effective hypersensitive response (HR) in needles of PRA-R that prevents penetration and spread of the rust fungus and leads to a lower proportion of symptomatic needles as well as reduced symptom development on the few affected needles. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Reference of 27208-80-6).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 27208-80-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antioxidant and anti-aging effects of Warburgia salutaris bark aqueous extract: Evidences from in silico, in vitro and in vivo studies was written by Abdelfattah, Mohamed A. O.;Dmirieh, Malak;Ben Bakrim, Widad;Mouhtady, Omar;Ghareeb, Mosad A.;Wink, Michael;Sobeh, Mansour. And the article was included in Journal of Ethnopharmacology in 2022.Recommanded Product: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

The genus Warburgia (family Canellaceae) is widely distributed over Afrotropical and Neotropical realms. Traditionally, W. salutaris (G. Bertol.) Chiov., and other Warburgia species are used as anti-inflammatory, antimalarial, antimicrobial, and for wound healing, and treating several skin complaints as well. Specifically, different extracts from W. salutaris were reported to possess diuretic, anti-inflammatory, and cytotoxic effects. This work aimed to investigate the phytochem. composition of an aqueous extract from W. salutaris bark, and evaluate its antioxidant and anti-aging activities in silico, in vitro, and in vivo. HPLC-PDA-MS/MS was used to investigate the phytochem. components of the extract The antioxidant potential of the extract was evaluated in vitro using DPPH and FRAP assays. The Caenorhabditis elegans nematodes model was adopted to investigate the antioxidant and the anti-aging effects in vivo by determining the worms′ survival rate, level of ROS, HSP16 expression, and nuclear translocation of the transcription factor DAF16. Mol. operating environment (MOE) software was utilized for in silico mol. docking of the extract′s components into different enzymes involved in the aging process. Anti-collagenase, anti-elastase, anti-tyrosinase, and anti-hyaluronidase assays were used to evaluate the anti-aging effects in vitro. HPLC-MS anal. furnished 30 compounds, among them catechin, 11α-hydroxy muzigadiolide, mukaadial, pereniporin B, and 11α-hydroxycinnamosmolide. The major components of the extract showed appropriate fitting in the binding site of the target enzymes adopted in the study with considerable min. free binding energy relative to the standard inhibitors. The extract showed substantial in vitro antioxidant activity in DPPH and FRAP assays and in vitro anti-aging assays against collagenase, elastase, tyrosinase, and hyaluronidase with comparable IC50 values to the reference standards Moreover, it attenuated oxidative stress in vivo as it significantly increased the survival rate of ROS stressed C. elegans worms, decreased intracellular ROS, decreased the juglone-induced HSP16 expression and enhanced the nuclear localization of DAF16 in a dose-dependent manner. Our results support the traditional use of W. salutaris to counteract inflammation and oxidative stress associated with several pathol. conditions. In addition, W. salutaris bark extract can be considered as a substantial source for bioactive metabolites with strong potential as anti-aging and antioxidant agents. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6Recommanded Product: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A potential species for cosmetic and pharmaceutical industries: Insight to chemical and biological investigation of naturally grown and cultivated Salvia multicaulis Vahl was written by Akdeniz, Mehmet;Yener, Ismail;Yilmaz, Mustafa Abdullah;Irtegun Kandemir, Sevgi;Tekin, Fethullah;Ertas, Abdulselam. And the article was included in Industrial Crops and Products in 2021.COA of Formula: C20H22O8 The following contents are mentioned in the article:

The importance of Salvia L. species, being used as traditional medicine, in the scientific world is increasing day by day. The relationship between health and traditional-modern life, promotes the creation of new value added food products. Within this context, in this study, it was aimed to biol. and chem. investigate the essential oil and ethanol extracts of the Salvia multicaulis Vahl. Chem. and biol. study results of naturally grown and cultivated (uninvestigated in the literature) samples of S. multicaulis were compared. The essential oil, aroma and terpenoid-steroid contents of the species were determined by gas chromatog.-mass spectrometry (GC-MS) and phenolic content by liquid chromatog.-mass spectrometry/mass spectrometry (LC-MS/MS). In addition, the bioactivities of the extracts were screened for antioxidant, cytotoxic, antialzheimer, antiurease, antityrosinase, antielastase and anticollagenase activities. It was found that the enzyme activities of the essential oil and the antioxidant activities of all ethanol extracts of the species were quite high. It was determined that especially essential oil and the ethanol extracts of the leaf parts exhibited high cytotoxic effect in cancer cell lines (PDF (Healthy primary dermal fibroblast cell line), HT-29 (colon cancer cell line), MCF-7 (breast cancer cell line), Caco-2 (colon cancer cell line) and Skov-3 (ovary cancer cell line)). According to the GC-MS results, in the natural specimen 1,8-cineole (33.05 %) and D-limonene (21.18 %), in the cultivated sample 1,8-cineole (42.35 %) and α-pinene (15.74 %) were detected to be as the major components of the essential oil and aroma, resp. It was observed that both natural and cultivated samples were rich in β-Sitosterol. Moreover, the root extract of natural samples was found to be richer than the other extracts in terms of abieatane diterpene (ferruginol, cryptanol, sugiol, and inuroyleanone) compounds According to the LC-MS/MS results, it is seen that both natural and cultivated samples are very rich in rosmarinic acid. Especially, the flower part of the natural sample (98.10 mg analyte/g extract) was found to contain more rosmarinic acid than the other parts. Due to the high total phenolic and rosmarinic acid content, cytotoxic, anti-aging, and antioxidant potential of the ethanol extract of the leaf parts of the species, it has the potential to be used as a food supplement, food preservative and in the pharmaceutical industry. This study involved multiple reactions and reactants, such as (2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6COA of Formula: C20H22O8).

(2S,3R,4S,5S,6R)-2-(3-Hydroxy-5-((E)-4-hydroxystyryl)phenoxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol (cas: 27208-80-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C20H22O8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts