Category: 261763-21-7

Adding a certain compound to certain chemical reactions, such as: 261763-21-7, (5-Chloro-2-(trifluoromethyl)phenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C8H6ClF3O, blongs to alcohols-buliding-blocks compound. COA of Formula: C8H6ClF3O

To a solution of(5-chloro-2- (trifluoromethyl)phenyl)methanol (400 mg, 1.90 mmol)and triethylamine (0.794 mL, 5.70mmol) in DCM (8 mL) was added methanesulfonyl chloride (0.148 mL, 1.90 mmol) at 0C. The reaction was stirred for 1 hour at 0 C, then quenched with water (10 mL) and extracted with DCM (10 mL x 3). The combined organic layers were washed with brine (saturated, 10 mL), dried over Mg504 and filtered. The filtrate was concentrated under reduced pressure to give the title compound, which was used in the next step without purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,261763-21-7, (5-Chloro-2-(trifluoromethyl)phenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; CHOBANIAN, Harry, R.; HE, Shuwen; HAO, Jinsong; PIO, Barbara; GUO, Yan; XIAO, Dong; (213 pag.)WO2018/118670; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 261763-21-7, name is (5-Chloro-2-(trifluoromethyl)phenyl)methanol. A new synthetic method of this compound is introduced below., Product Details of 261763-21-7

Dissolve (5-chloro-2-trifluoromethylphenyl)-methanol (347 mg, 1.66 mmol) in dichloromethane (10 mL). Add pyridinium chlorochromate (717 mg, 3.32 mmol) and stir for 2 h. Dilute with diethyl ether and stir for 1 h. Filter and concentrate. Chromatograph on silica gel eluting with 10% ethyl acetate in hexane to give the title compound as a clear EPO oil (285 mg, 82%). 1HNMR (400 MHz, MeOH-d4) delta 10.33 (s, IH), 7.90 (s, IH), 7.69 (d, IH5 J = 8.4 Hz), 7.54 (d, IH, J = 8.4 Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 261763-21-7, (5-Chloro-2-(trifluoromethyl)phenyl)methanol.

Reference:
Patent; ELI LILLY AND COMPANY; WO2006/44454; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts