Category: 261723-32-4

Reference of 261723-32-4, Adding some certain compound to certain chemical reactions, such as: 261723-32-4, name is (3-Bromo-2-fluorophenyl)methanol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 261723-32-4.

To a solution of (3-bromo-2-fluorophenyl)methanol (29; 4.00 g,19.5 mmol) in THF (40 mL) were added tert-butyl(chloro)dimethylsilane (3.50 g, 23.0 mmol) and 1H-imidazole (2.0 g,29.4 mmol). After being stirred at room temperature for 1 h, themixture was diluted with H2O, and extracted with EtOAc. Theorganic layer was dried over MgSO4, and concentrated in vacuo.The residue was purified by column chromatography on silica gel(hexane/EtOAc = 1:0 to 9:1) to give the product (5.90 g, 95%) as acolorless oil. 1H NMR (DMSO-d6): d 0.09 (6H, s), 0.90 (9H, s), 4.78(2H, s), 7.16-7.20 (1H, m), 7.43-7.47 (1H, m), 7.59-7.64 (1H, m);MS (CI) m/z [M+H]+ 321.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 261723-32-4, (3-Bromo-2-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yamaki, Susumu; Yamada, Hiroyoshi; Nagashima, Akira; Kondo, Mitsuhiro; Shimada, Yoshiaki; Kadono, Keitaro; Yoshihara, Kosei; Bioorganic and Medicinal Chemistry; vol. 25; 21; (2017); p. 6024 – 6038;,
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Electric Literature of 261723-32-4, Adding some certain compound to certain chemical reactions, such as: 261723-32-4, name is (3-Bromo-2-fluorophenyl)methanol,molecular formula is C7H6BrFO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 261723-32-4.

6.4 {2-Fluoro-3-[2-(3-methoxyphenyl)imidazo[1,2-a]pyridin-6-yl]phenyl}methanol 300 mg of (3-bromo-2-fluorophenyl)methanol are dissolved in 15 ml of toluene and 5 ml of ethanol and degassed under a stream of argon for 10 min. 101 mg of tetrakis(triphenylphosphine)palladium, 580 mg of 2-(3-methoxyphenyl)imidazo[1,2-a]pyridine-6-boronic acid and 5 ml of a 2M sodium carbonate solution are subsequently added thereto. The mixture is heated at 80 C. for 16 hours and then, after cooling to ambient temperature, concentrated under reduced pressure. The residue is taken up between water and ethyl acetate and then the organic phase is separated, dried and concentrated under reduced pressure. The residue is purified by chromatography on silica gel, elution being carried out with a dichloromethane/ethyl acetate mixture. 254 mg of compound are obtained. M.p.=143-144 C. 1H NMR spectrum (d6-DMSO, delta in ppm): 3.85 (s, 3H); 4.65 (d, 2H); 5.35 (t, 1H); 6.95 (d, 1H); from 7.3 to 7.4 (m, 2H); 7.45 (d, 1H); from 7.5 to 7.65 (m, 4H); 7.7 (d, 1H); 8.5 (s, 1H); 8.75 (s, 1H). M+H=349.

According to the analysis of related databases, 261723-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; sanofi-aventis; US2011/65699; (2011); A1;,
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Synthetic Route of 261723-32-4 ,Some common heterocyclic compound, 261723-32-4, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of (3-bromo-2-fluoro-phenyl)methanol (2.750 g, 13.413 mmol) in dichloromethane (50 mL) was added manganese dioxide (9.32 g, 107.31 mmol) and the resulting mixture was stirred at 45C overnight. Once complete, the reaction was filtered through diatomaceous earth and washed with dichloromethane to obtain 3-bromo-2-fluoro-benzaldehyde as a white solid (2.24 g, 83%). lU NMR (400 MHz, DMSO-i ) delta 10.19 (dt, = 1.3, 0.7 Hz, 1H), 8.05 (tdd, = 6.8, 3.1, 1.5 Hz, 1H), 7.85 (ddt, = 7.9, 6.4, 1.5 Hz, 1H), 7.37 (tdt, = 7.8, 1.6, 0.8 Hz, 1H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 261723-32-4, (3-Bromo-2-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; YU, Jiang; WU, Guosheng; YUEN, Po-Wai; VILLEMURE, Elisia; SCHWARZ, Jacob; LY, Cuong; SELLERS, Benjamin; VOLGRAF, Matthew; WO2015/52226; (2015); A1;,
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Related Products of 261723-32-4 ,Some common heterocyclic compound, 261723-32-4, molecular formula is C7H6BrFO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To an ice-cold solution of Compound II (500 mg) in THF (5.0 mL) were added sodium hydride (160 mg, 55% contents) and methyl iodide (608 muL), and the resulting mixture was stirred at room temperature overnight. To the reaction mixture was added water, and the mixture was concentrated under reduced pressure. The residue was diluted with water, and extracted with ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=4/1) to give Compound III (426 mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 261723-32-4, (3-Bromo-2-fluorophenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; DAINIPPON SUMITOMO PHARMA CO., LTD.; US2012/225876; (2012); A1;,
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Application of 261723-32-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 261723-32-4, name is (3-Bromo-2-fluorophenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Pyridinium chlorochromate (22.3 g, 103 mmol, 1.91 eq) was dissolved in DCM (140 mL) and 4 Molecular Sieves (22.3 g) were added to the solution. The reaction mixture was stirred for 30 minutes. A solution of benzyl alcohol 40 (11 g, 54 mmol, 1 eq) in DCM (140 mL) was added dropwise over the course of 5 min. The orange reaction mixture immediately turned dark brown upon addition of alcohol. After stirring for 30 min, the reaction mixture was diluted with 70% Hexane/EtOAc solution (250 mL) and filtered through a plug of silica gel (150 g). The silica gel was washed with Hexane/EtOAc (500 mL), and concentrated in vacuo to afford 9.8 g of aldehyde 41 as a white solid. Yield 70% over 2 steps.

According to the analysis of related databases, 261723-32-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Infinity Discovery, Inc.; US2008/114167; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts