Category: 26153-38-8

《Newly synthesized imino-derivatives analogues of resveratrol exert inhibitory effects in breast tumor cells》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Iacopetta, Domenico; Lappano, Rosamaria; Mariconda, Annaluisa; Ceramella, Jessica; Sinicropi, Maria Stefania; Saturnino, Carmela; Talia, Marianna; Cirillo, Francesca; Martinelli, Fabio; Puoci, Francesco; Rosano, Camillo; Longo, Pasquale; Maggiolini, Marcello. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Breast cancer represents the most frequently diagnosed malignancy in women worldwide. Various therapeutics are currently used in order to halt the progression of breast tumor, even though certain side effects may limit the beneficial effects. In recent years, many efforts have been addressed to the usefulness of natural compounds as anticancer agents due to their low toxicity. Resveratrol, a stilbene found in grapes, berries, peanuts and soybeans, has raised a notable interest for its antioxidant, anti-inflammatory, and antitumor properties. Here, we report the design, the synthesis and the characterization of the anticancer activity of a small series of imino N-aryl-substituted compounds that are analogs of resveratrol. In particular, the most active compound, named 3, exhibited anti-tumor activity in diverse types of breast cancer cells through the inhibition of the human topoisomerase II and the induction of apoptotic cell death. Therefore, the abovementioned compound maybe considered as a promising agent in more comprehensive treatments of breast cancer.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

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In 2022,Li, Xipeng; Zeng, Qin; Zhang, Ruijing; Li, Jiajun; Xing, Da; Zhang, Tao published an article in Chemical Engineering Journal (Amsterdam, Netherlands). The title of the article was 《Mitochondria-specific gadolinium (III) porphyrinate as efficient ROS generator for MRI visualization and sonodynamic-immunotherapy of deep localized tumors》.Related Products of 26153-38-8 The author mentioned the following in the article:

Conventional sonodynamic therapy (SDT) is still limited in conquering localized tumors owing to its low reactive oxygen species (ROS)-based therapeutic effect and undesirably inhibiting effect of immunosuppressive tumor microenvironment (ITM). In this study, we reasonably designed a new sonosensitizer, gadolinium (III) porphyrinate (GdPorP), which could efficiently produce ROS upon ultrasound irradiation and specifically accumulate in mitochondria. The GdPorP-based mitochondria-specific sonodamage could induce high-efficiency cell apoptosis and cascade to producing large-scale immunogenic cell death. After GdPorP systematically delivered together with the indoleamine 2,3-dioxygenase (IDO) inhibitor by a pH-sensitive nanomedicine, the localized liver tumor was specifically mapped by the “”switching-on”” MRI. And the nanomedicine could not only efficiently suppress the progression of primary liver tumors but also simultaneously boost the systematic antitumor immune effect via the inhibition of ITM. The GdPorP-approved sonodynamic-immunotherapy (SDIT) has thereby been established as a new paradigm for upgrading the efficacy of cancer SDT. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Related Products of 26153-38-8

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In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Bete, Sarah C.; Wuertele, Christian; Otte, Matthias. Synthetic Route of C7H6O3. The article was titled 《A bio-inspired imidazole-functionalized copper cage complex》. The information in the text is summarized as follows:

An imidazole-functionalized cage (I) was synthesized that can coordinate to Cu(I). X-ray anal. reveals a T-shaped coordination of Cu by the imidazole ligands reminiscent of the coordination geometry found in enzymic active sites. This cage complex can catalyze the oxidation of benzylic alcs. to benzaldehydes using O as the terminal oxidant. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3

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《Photosensitizing and antioxidant activities of humic substances: A case study of β2-adrenoceptor agonist terbutaline》 was published in Journal of Photochemistry and Photobiology, A: Chemistry in 2020. These research results belong to Zhou, Lei; Sleiman, Mohamad; Halladja, Sabrina; Ferronato, Corinne; Chovelon, Jean-Marc; Richard, Claire. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Humic substances (HS) play an important role in the phototransformation of micro-pollutants in surface waters and a significant part of this reactivity is often attributed to oxidant triplet excited states (3HS*). The present study aims to understand why 3HS* were found to be negligibly involved in the HS-mediated phototransformation of β2-adrenoceptor agonist terbutaline (TBL) while this chem. shows a high reactivity towards triplet 3-carboxybenzophenone (3CBP*), a typical HS model sensitizer. To clarify this apparent discrepancy, several experiments were conducted. We first confirmed that TBL can be easily oxidized by triplet riboflavin (3RF*), another sensitizer (k = (1.7 ± 0.4)x109 M-1 s-1). Afterwards, we studied the effect of TBL on the HS-mediated phototransformation of 2,4,6-trimethylphenol (TMP), chosen for its high reactivity with 3HS*. TBL was found to enhance the rate of TMP loss. This result is rationalized by postulating that (i) TMP and TBL are both oxidized by 3HS* to yield the phenoxyl radicals TMP•-H and TBL•-H, resp., and (ii) TBL•-H is further reduced by TMP which generates addnl. TMP•-H. Fitting the exptl. data gives k = (1.8 ± 0.5)x109 M-1 s-1 for the reaction between 3HS* and TBL and DFT calculations further support the conclusion that TBL•-H can be reduced by a lot of phenols. Hence, in the case of TBL, the oxidant effect of 3HS* is counterbalanced by the antioxidant properties of HS. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products, can be used to produce pesticide epoxiconazole, etc.Name: 3,5-Dihydroxybenzaldehyde

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Marinho, Juliane Aparecida; Martins Guimaraes, Daniel Silqueira; Glanzmann, Nicolas; de Almeida Pimentel, Giovana; Karine da Costa Nunes, Izabelle; Gualberto Pereira, Henrique Marcelo; Navarro, Maribel; de Pilla Varotti, Fernando; David da Silva, Adilson; Abramo, Clarice published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization》.HPLC of Formula: 26153-38-8 The article contains the following contents:

Chloroquine (CQ) has been the main treatment for malaria in regions where there are no resistant strains. Mol. hybridization techniques have been used as a tool in the search for new drugs and was implemented in the present study in an attempt to produce compound candidates to treat malarial infections by CQ-resistant strains. Two groups of mols. were produced from the 4-aminoquinoline ring in conjugation to hydrazones (HQ) and imines (IQ). Physicochem. and pharmacokinetic properties were found to be favorable when analyzed in silico and cytotoxicity and antiplasmodial activity were assayed in vitro and in vivo showing low cytotoxicity and selectiveness to the parasites. Candidates IQ5 and IQ6 showed important values of parasite growth inhibition in vivo on the 5th day after infection (IQ5 15 mg/kg = 72.64% and IQ6 15 mg/kg = 71.15% and 25 mg/kg = 93.7%). IQ6 also showed interaction with ferriprotoporphyrin IX similarly to CQ. The process of applying condensation reactions to yield imines is promising and capable of producing mols. with antiplasmodial activity. In the experiment, the researchers used many compounds, for example, 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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Esmaeili, Sajjad; Ghobadi, Nazanin; Nazari, Donya; Pourhossein, Alireza; Rasouli, Hassan; Adibi, Hadi; Khodarahmi, Reza published their research in Medicinal Chemistry (Sharjah, United Arab Emirates) in 2021. The article was titled 《Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes》.Category: alcohols-buliding-blocks The article contains the following contents:

Curcumin, as the substantial constituent of the turmeric plant (Curcuma longa), plays a significant role in the prevention of various diseases, including diabetes. It possesses ideal structure features as an enzyme inhibitor, including a flexible backbone, hydrophobic nature, and several available hydrogen bond (H-bond) donors and acceptors. The present study aimed at synthesizing several novel curcumin derivatives and further evaluation of these compounds for possible antioxidant and anti-diabetic properties along with inhibitory effect against two carbohydrate-hydrolyzing enzymes, α-amylase and α-glucosidase, as these enzymes are therapeutic targets for attenuation of postprandial hyperglycemia. Therefore, curcumin-based pyrido[2,3-d]pyrimidine derivatives were synthesized and identified using an instrumental technique like NMR spectroscopy and then screened for antioxidant and enzyme inhibitory potential. Total antioxidant activity, reducing power assay and 1,1-diphenyl-2- picrylhydrazyl (DPPH•) radical scavenging activity were done to appraise the antioxidant potential of these compounds in vitro. Compounds L6-L9 showed higher antioxidant activity while L4, L9, L12 and especially L8 exhibited the best selectivity index (lowest α-amylase/α-glucosidase inhibition ratio). These antioxidant inhibitors may be potential anti-diabetic drugs, not only to reduce glycemic index but also to limit the activity of the major reactive oxygen species (ROS) producing pathways.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Category: alcohols-buliding-blocks

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Safety of 3,5-DihydroxybenzaldehydeIn 2019 ,《Small molecule inhibitors of the BfrB-Bfd interaction decrease Pseudomonas aeruginosa fitness and potentiate fluoroquinolone activity》 appeared in Journal of the American Chemical Society. The author of the article were Punchi Hewage, Achala N. D.; Yao, Huili; Nammalwar, Baskar; Gnanasekaran, Krishna Kumar; Lovell, Scott; Bunce, Richard A.; Eshelman, Kate; Phaniraj, Sahishna M.; Lee, Molly M.; Peterson, Blake R.; Battaile, Kevin P.; Reitz, Allen B.; Rivera, Mario. The article conveys some information:

The iron storage protein bacterioferritin (BfrB) is central to bacterial iron homeostasis. The mobilization of iron from BfrB, which requires binding by a cognate ferredoxin (Bfd), is essential to the regulation of cytosolic iron levels in P. aeruginosa. This paper describes the structure-guided development of small mol. inhibitors of the BfrB-Bfd protein-protein interaction. The process was initiated by screening a fragment library and followed by obtaining the structure of a fragment hit bound to BfrB. The structural insights were used to develop a series of 4-(benzylamino)- and 4-((3-phenylpropyl)amino)-isoindoline-1,3-dione analogs that selectively bind BfrB at the Bfd binding site. Challenging P. aeruginosa cells with the 4-substituted isoindoline analogs revealed a dose-dependent growth phenotype. Further investigation determined that the analogs elicit a pyoverdin hyperprodn. phenotype that is consistent with blockade of the BfrB-Bfd interaction and ensuing irreversible accumulation of iron in BfrB, with concomitant depletion of iron in the cytosol. The irreversible accumulation of iron in BfrB prompted by the 4-substituted isoindoline analogs was confirmed by visualization of BfrB-iron in P. aeruginosa cell lysates separated on native PAGE gels and stained for iron with Ferene S. Challenging P. aeruginosa cultures with a combination of com. fluoroquinolone and our isoindoline analogs results in significantly lower cell survival relative to treatment with either antibiotic or analog alone. Collectively, these findings furnish proof of concept for the usefulness of small mol. probes designed to dysregulate bacterial iron homeostasis by targeting a protein-protein interaction pivotal for iron storage in the bacterial cell. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

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Alcohol – Wikipedia,
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In 2022,Hassan, Ahmed H. E.; Kim, Hyeon Jeong; Gee, Min Sung; Park, Jong-Hyun; Jeon, Hye Rim; Lee, Cheol Jung; Choi, Yeonwoo; Moon, Suyeon; Lee, Danbi; Lee, Jong Kil; Park, Ki Duk; Lee, Yong Sup published an article in Journal of Enzyme Inhibition and Medicinal Chemistry. The title of the article was 《Positional scanning of natural product hispidol′s ring-b: discovery of human monoamine oxidase-b inhibitor downregulating neuroinflammation for neurodegenerative diseases》.HPLC of Formula: 26153-38-8 The author mentioned the following in the article:

Multifunctional mols. might offer better treatment of complex multifactorial neurol. diseases. Monoaminergic pathways dysregulation and neuroinflammation are common convergence points in diverse neurodegenerative and neuropsychiatric disorders. Aiming to target these diseases, polypharmacol. agents modulating both monoaminergic pathways and neuroinflammatory were addressed. A library of analogs of the natural product hispidol was prepared and evaluated for inhibition of monoamine oxidases (MAOs) isoforms. Several mols. emerged as selective potential MAO B inhibitors. The most promising compounds were further evaluated in vitro for their impact on microglia viability, induced production of proinflammatory mediators and MAO-B inhibition mechanism. Amongst tested compounds, was a safe potent competitive reversible MAO-B inhibitor and inhibitor of microglial production of neuroinflammatory mediators; NO and PGE2. In-silico study provided insights into mol. basis of the observed selective MAO B inhibition. This study presents compound as a promising lead compound for management of neurodegenerative disease. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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Alcohol – Wikipedia,
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《Synthesis and application of a novel 5-hydroxymethyl resorcinol diglycidyl ether-terminated polyurethane》 was published in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. These research results belong to Li, Shuan; Sun, Mingming; Liu, Caizhao; Zhang, Xugang; Li, Jianhui; Wang, Weiping; Zhang, Bin. Name: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Epoxy resin containing active hydroxymethyl group, 5-hydroxymethyl resorcinol diglycidyl ether, was synthesized to produce 5-hydroxymethyl resorcinol diglycidyl ether-terminated polyurethane (ETPU1000). The synthesized epoxy resin is a small monomer mol., and no polymer is produced during the synthesis process. A monomer contains one hydroxyl group, and more flexible polyurethane segments can be introduced into the main chain when synthesizing the epoxy-terminated polyurethane. The synthesis process of ETPU1000 was investigated by FT-IR spectroscopy. The disappearance of NCO peak in the FT-IR spectrum showed that diisocyanate has completely reacted to form ETPU1000. Then, a series of epoxy cured systems were prepared by changing the mass ratio of ETPU1000 and the diglycidyl ether of bisphenol A (DGEBA), and cured with 4,4′-diaminodiphenyl methane (DDM). The effect of the content of ETPU1000 on the thermal properties, mech. properties and fracture morphol. of epoxy cured systems were investigated. The results showed that when the DGEBA/ETPU1000 blends with 75 wt% ETPU1000, impact strength of the cured systems reached 29.6 kJ·m-2, which significantly increased by 176.6% compared to that of neat epoxy. SEM was used to observe the fracture surfaces of cured DGEBA/ETPU1000 blends, which showed obvious ductile fracture characteristics. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Computed Properties of C7H6O3In 2021 ,《A simple strategy for simultaneously enhancing photostability and mitochondrial-targeting stability of near-infrared fluorophores for multimodal imaging-guided photothermal therapy》 appeared in Journal of Materials Chemistry B: Materials for Biology and Medicine. The author of the article were Zhang, Shuping; Chen, Hua; Wang, Liping; Liu, Chunli; Liu, Li; Sun, Yu; Shen, Xing-can. The article conveys some information:

Near-IR fluorophores are emerging as promising mol. tools for cancer theranostics because of their inherent biodegradability, low toxicity, and synthetic flexibility. However, they still suffer from several limitations, such as poor photostability and insufficient organelle-targeting stability during photothermal therapy. In this work, we introduce an “”aldehyde functionalization”” strategy for simultaneously enhancing photostability and mitochondria-immobilization of near-IR fluorophores for the first time. Based on the proposed strategy, representative near-IR organic mols., namely AF-Cy, were rationally designed and synthesized. Upon aldehyde modification, the AF-Cy dyes displayed both remarkable photostability and mitochondrial-targeting stability. The strong absorption in the near-IR region confers the AF-Cy dyes with outstanding fluorescent/photoacoustic imaging and photothermal therapy capabilities. Finally, in vitro and in vivo studies revealed the enhanced performance in inhibiting the growth of breast tumors under NIR laser radiation, and these results suggested the strong potential of AF-Cy dyes as efficient multimodal imaging-guided photothermal therapy agents, further highlighting the value of this simple strategy in the design high performance near-IR fluorophores for tumor theranostics. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Computed Properties of C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Computed Properties of C7H6O3

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Alcohol – Wikipedia,
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