Category: 26153-38-8

Recommanded Product: 3,5-DihydroxybenzaldehydeIn 2018 ,《Synthetic resveratrol-curcumin hybrid derivative inhibits mitosis progression in estrogen positive MCF-7 breast cancer cells》 appeared in Toxicology In Vitro. The author of the article were Silva, Matheus de Freitas; Coelho, Leticia Ferreira; Guirelli, Isadora Mitestainer; Pereira, Rodrigo Machado; Ferreira-Silva, Guilherme Alvaro; Graravelli, Graciana Y.; Horvath, Renato de Oliveira; Caixeta, Ester Siqueira; Ionta, Marisa; Viegas, Claudio. The article conveys some information:

Curcumin (1) and resveratrol (2) are bioactive natural compounds that display wide pharmacol. properties, including antitumor activity. However, their clin. application has been limited due to their low solubility and bioavailability. Nevertheless, independent studies have considered these compounds as interesting prototypes for developing new chem. structures useful for anticancer therapy. Herein, we report the synthesis of novel curcumin-like hydrazide analogs (3a and 3b), and a series of curcumin-resveratrol hybrid compounds (4a-f), and the evaluation of their cytotoxic potential on three tumor cell lines MCF-7 (breast), A549 (lung), and HepG2 (liver). Cell viability was significantly reduced in all tested cell lines when compounds 4c-4e were used. The IC50 values for these compounds on MCF-7 cells were lower than those for curcumin, resveratrol, or curcumin combined with resveratrol. We evidenced that 4c promoted a drastic increase of G2/M population. The accumulation of cells in mitosis onset in treated cultures was due to, at least in part, the ability of 4c to modulate nuclear kinase proteins, which orchestrate important events in mitosis progression. We have also observed significant reduction of the relative RNAm abundance of CCNB1, PLK1, AURKA, AURKB in samples treated with 4c, with concomitant increase of CDKN1A (p21). Thus, compound 4c is a promising multi-target antitumor agent that should be considered for further in vivo studies. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 3,5-Dihydroxybenzaldehyde

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《Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives》 was published in Journal of Inorganic Biochemistry in 2020. These research results belong to Wei, Xiaonan; Yang, Yaxing; Ge, Jiangfeng; Lin, Xue; Liu, Dandan; Wang, Shuxiang; Zhang, Jinchao; Zhou, Guoqiang; Li, Shenghui. Related Products of 26153-38-8 The article mentions the following:

Thirteen novel palladium(II) complexes of the general formula [Pd(bipy)(O,O’-dkt)](PF6), (where bipy is 2,2′-bipyridine and O,O’-dkt is β-diketonate ligand hispolon or its derivative) have been prepared through a metal-ligand coordination method that involves spontaneous formation of the corresponding diketonate scaffold. The obtained palladium(II) complexes have been characterized by NMR spectroscopy, ESI-mass spectrometry as well as elemental anal. The cytotoxicity anal. indicates that most of the obtained palladium(II) complexes show promising growth inhibition in three human cancer cell lines. Flow cytometry anal. shows complex 3e could promote intracellular reactive oxygen species (ROS) accumulation and lead cancer cell death. And the suppression of ROS accumulation and the rescue of cell viability in HeLa cells by N-acetyl-L-cysteine (NAC) suggest the possible link between the increase in ROS generation and cytotoxicity of complex 3e. Flow cytometry anal. also reveal that complex 3e cause cell cycle arrest in the G2/M phase and collapse of the mitochondrial membrane potential, promote the generation of ROS and lead to tumor cell apoptosis. The interactions of complex 3e with calf thymus DNA (CT-DNA) have been evaluated by UV-Vis spectroscopy, fluorescence quenching experiments and viscosity measurements, which reveal that the complex interact with CT-DNA through minor groove binding and/or electrostatic interactions. Further, the results of fluorescence titration and site marker competitive experiment on bovine serum albumin (BSA) suggest that complex 3e can quench the fluorescence of BSA via a static quenching process and bind to BSA in Sudlow’s site II. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8) was used in this study.

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HPLC of Formula: 26153-38-8In 2021 ,《Solution-processable and functionalizable ultra-high molecular weight polymers via topochemical synthesis》 appeared in Nature Communications. The author of the article were Anderson, Christopher L.; Li, He; Jones, Christopher G.; Teat, Simon J.; Settineri, Nicholas S.; Dailing, Eric A.; Liang, Jiatao; Mao, Haiyan; Yang, Chongqing; Klivansky, Liana M.; Li, Xinle; Reimer, Jeffrey A.; Nelson, Hosea M.; Liu, Yi. The article conveys some information:

Topochem. polymerization reactions hold the promise of producing ultra-high mol. weight crystalline polymers. However, the totality of topochem. polymerization reactions has failed to produce ultra-high mol. weight polymers that are both soluble and display variable functionality, which are restrained by the crystal-packing and reactivity requirements on their resp. monomers in the solid state. Herein, we demonstrate the topochem. polymerization reaction of a family of para-azaquinodimethane compounds that undergo facile visible light and thermally initiated polymerization in the solid state, allowing for the first determination of a topochem. polymer crystal structure resolved via the cryoelectron microscopy technique of microcrystal electron diffraction. The topochem. polymerization reaction also displays excellent functional group tolerance, accommodating both solubilizing side chains and reactive groups that allow for post-polymerization functionalization. The thus-produced soluble ultra-high mol. weight polymers display superior capacitive energy storage properties. This study overcomes several synthetic and characterization challenges amongst topochem. polymerization reactions, representing a critical step toward their broader application. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.HPLC of Formula: 26153-38-8

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《Design, synthesis and evaluation of benzothiazole derivatives as multifunctional agents》 was published in Bioorganic Chemistry in 2020. These research results belong to Djuidje, Ernestine Nicaise; Sciabica, Sabrina; Buzzi, Raissa; Dissette, Valeria; Balzarini, Jan; Liekens, Sandra; Serra, Elena; Andreotti, Elisa; Manfredini, Stefano; Vertuani, Silvia; Baldisserotto, Anna. Recommanded Product: 3,5-Dihydroxybenzaldehyde The article mentions the following:

Oxidative stress is the product or etiol. of various multifactorial diseases; on the other hand, the development of multifunctional compounds is a recognized strategy for the control of complex diseases. A series of benzothiazole derivatives I (R = H, COOH, SO2NH2; R1 = Ph, 2-hydroxyphenyl, 3,4-dihydroxyphenyl, etc.) was synthesized and evaluated for their multifunctional effectiveness as antioxidant, sunscreen (filter), antifungal and antiproliferative agents. Compounds were easily synthesized via condensation reaction between 2-aminothiophenol and different benzaldehydes R1CHO. SAR study, particularly in position 2 and 6 of benzothiazoles, led to the identification of I (R = H, R1 = 2,5-dihydroxyphenyl (A); R = H, R1 = 2,4,5-trihydroxyphenyl) as very interesting potential compounds for the design of multifunctional drugs. In particular, compound (A) is the best blocker of hERG potassium channels expressed in HEK 293 cells exhibiting 60.32% inhibition with IC50 = 4.79μM. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 3,5-Dihydroxybenzaldehyde

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SDS of cas: 26153-38-8In 2020 ,《Monoaryl derivatives as transthyretin fibril formation inhibitors: Design, synthesis, biological evaluation and structural analysis》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Lidia, Ciccone; Nencetti, Susanna; Nicolo, Tonali; Carole, Fruchart-Gaillard; William, Shepard; Elisa, Nuti; Caterina, Camodeca; Armando, Rossello; Orlandini, Elisabetta. The article conveys some information:

Transthyretin (TTR) is a ss-sheet-rich homotetrameric protein that transports thyroxine (T4) and retinol both in plasma and in cerebrospinal fluid. TTR also interacts with amyloid-β, playing a protective role in Alzheimer′s disease. Dissociation of the native transthyretin (TTR) tetramer is widely accepted as the critical step in TTR amyloids fibrillogenesis, and is responsible for extracellular deposition of amyloid fibrils. Small mols., able to bind in T4 binding sites and stabilize the TTR tetramer, are interesting tools to treat and prevent systemic ATTR amyloidosis. We report here the synthesis, in vitro evaluation and three-dimensional crystallog. analyses of new monoaryl-derivatives in complex with TTR. Of the derivatives reported here, the best inhibitor of TTR fibrillogenesis, 1d, exhibits an activity similar to diflunisal. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8SDS of cas: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.SDS of cas: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 26153-38-8In 2019 ,《Synthesis, anticancer activity and molecular docking studies of some novel quinoline hydrazide derivatives of substituted benzaldehydes》 appeared in Rasayan Journal of Chemistry. The author of the article were Gayam, Venkatareddy; Ravi, Subban; Ravikumar, G. M. V. N. A. R.; Thangamani, Arumugam. The article conveys some information:

A novel series of quinoline hydrazide bridged derivatives were synthesized by a multistep reaction from vanillic acid. The reactions involved esterification, O-alkylation, nitration, reduction, cyclization, to get 7-(3-hloropropoxy)-4-hydroxy-6-methoxyquinoline-3-carbonitrile 5 which further reacted with Et bromoacetate to yield the corresponding ester 6. Compound 6 react with hydrazine hydrate to afford the hydrazide 7, which then reacted with substituted benzaldehydes to afford the corresponding quinoline-hydrazides 8 – 19. The synthesized compounds were characterized by IR, NMR and MS data. Compounds 7-19 were tested for their cytotoxic activity by Trypan blue, MTT and LDH assays. All the tested compounds showed cytotoxic activity and the results are comparable with the standard compound bosutinib. Compound 12 showed an IC50 value of 26.93 ± 2.8 and 28.92 ± 1.6μg/mL by MTT and trypan blue assay resp. Structure activity relationship was discussed among the compounds 7-19. Mol. docking studies were carried out for all the compounds 7-19 against BCR-ABL T315I protein. Compound 12 showed very good interactions with the protein like any other tyrosine kinase inhibitors. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Li, Xue-Lian; Wu, Dong-En; Qiao, Qiwei; Guo, Qing-Hui; Cai, Yu-Jie published an article in Journal of the Iranian Chemical Society. The title of the article was 《The isomeric effect on structure and photophysical property of organic fluorescent material: synthesis, structures, and photophysical properties of two novel D-π-π-A prototype fluorescent material》.Recommanded Product: 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

Two novel D-π-π-A prototype organic fluorescent compounds, namely (E)-2-(3-([1,1′-biphenyl]-4-yl)-1-(naphthalen-2-yl)allylidene)malononitrile (3-BNM) and (E)-2-(1-([1,1′-biphenyl]-4-yl)-3-(naphthalen-2-yl)allylidene)malononitrile (1-BNM) were synthesized to examine the isomeric effect on their structures and photophys. properties. The results indicated that 3-BNM and 1-BNM display different crystal packing and optical properties, because of the differences in substitution position. 3-BNM mols. packed into a 2D layer structure, while a 2D layer structure was formed in 1-BNM. Compared to that of 1-BNM, red-shifted emissions were observed in the crystal and dilute solution of 3-BNM. The structure-property relationship of the two isomers showed that it is the differences in electronic structures that lead to their different emission behaviors. The obvious isomeric effect indicated that subtle manipulation of substitution position is indeed a feasible and efficient way for tuning the structures and photophys. properties of D-π-π-A prototype organic fluorescent materials. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 3,5-Dihydroxybenzaldehyde

Referemce:
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Alcohols – Chemistry LibreTexts

Related Products of 26153-38-8In 2022 ,《Alkyne Metathesis with d2 Re(V) Alkylidyne Complexes Supported by Phosphino-Phenolates: Ligand Effect on Catalytic Activity and Applications in Ring-Closing Alkyne Metathesis》 appeared in Journal of the American Chemical Society. The author of the article were Cui, Mingxu; Sung, Herman H. Y.; Williams, Ian D.; Jia, Guochen. The article conveys some information:

A family of d2 Re(V) alkylidyne complexes bearing two decorated phosphino-phenolates (POs) and a labile pyridine ligand were prepared that can efficiently promote alkyne metathesis reactions in toluene. The relative activity of these complexes varies with the PO ligands. Complexes with an electron-rich metal center have a higher activity. Ligand exchange experiments suggest that the pyridine ligands of the Re(V) alkylidynes with more electron-donating PO ligands are more labile and are more easily released to generate catalytically active species. However, complexes with electron-withdrawing PO ligands are more air-stable than those with electron-donating PO ligands. These Re(V) alkylidyne catalysts can promote the homometathesis of functionalized internal alkyl- and aryl-alkynes, as well as ring-closing alkyne metathesis (RCAM) of Me-capped diynes, forming macrocycles with a ring size ≥12 efficiently for concentrations ≤5 mM. These reactions represent the 1st examples of RCAM mediated by nond0 alkylidyne complexes. The Re(V) alkylidyne catalysts tolerate a wide range of functional groups including ethers, esters, ketones, aldehydes, alcs., phenols, amines, amides, and heterocycles. Also, the catalytic RCAM reactions promoted by robust Re(V) alkylidyne catalysts could also proceed normally in wet toluene. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,European Journal of Medicinal Chemistry included an article by Selka, Ayyoub; Doiron, Jeremie A.; Lyons, Pierre; Dastous, Sonia; Chiasson, Alison; Cormier, Marc; Turcotte, Sandra; Surette, Marc E.; Touaibia, Mohamed. Related Products of 26153-38-8. The article was titled 《Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells》. The information in the text is summarized as follows:

The inhibition of 5-lipoxygenase (5-LO), the key enzyme for the biosynthesis of leukotrienes (LTs), has generated increasing enthusiasm as anti-inflammatory and antitumor strategies in recent years. Based on our previous studies, we synthesized a series of dihydroxycinnamic acid-based analogs that might be 5-LO inhibitors. LTs biosynthesis inhibition in HEK293 cells and polymorphonuclear leukocytes (PMNL) was measured and antitumor activities were investigated in Renal Cell Carcinoma (RCC). Results showed that the 2,5-dihydroxycinnamic acid phenethyl ester (10b) was the best 5-LO inhibitor and was 7-fold more potent than Zileuton (1), the only clin. approved 5-LO inhibitor. 2,5-Dihydroxy substitution was more favorable to 5-LO inhibition since compound 10b is twice as active as CAPE (2) which is a 3,4-dihydroxylcinnamic acid ester. Meanwhile, 10b reduced the cell viability of renal cancer cells and was more selective toward RCC4 and 786.0 cells which are deficient for the Von Hippel-Lindau (VHL) tumor suppressor gene. As to the underlying cell-death mechanisms, 10b induced apoptosis in VHL-deficient RCC4 cells. Also, increases in LC3B and p62 expression suggest a blockage of the autophagic flux in RCC in response to 10b. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Related Products of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Muniyasamy, Harikrishnan; Chinnadurai, Chithiraikumar; Nelson, Malini; Kubendran, Aravind Manikka; Sukumaran, Karthika; Balasubramaniem, Ashokkumar; Sepperumal, Murugesan; Ayyanar, Siva; Govindasamy, Mani; Ghfar, Ayman; Alsubaied, Fehaid Mohammed published an article in 2021. The article was titled 《Highly selective flurogenic chemosensor for cyanide ion in aqueous medium and its applications of logic gate and Hela cells》, and you may find the article in Journal of Molecular Liquids.Computed Properties of C7H6O3 The information in the text is summarized as follows:

We have successfully synthesized triphenylamine-based fluorophores (MK and HK) with cyanoacrylic acid as a receptor for CN- ion sensing in a 99% aqueous medium. From the emission titration spectra, the detection limit of cyanide ion calculated toward MK and HK, resp., are 234 nM and 11 nM. The observed binding constants for MK and HK, resp., are 27 x 10-3 M and 10 X 10-2 M. The plausible sensing mechanism is confirmed by various methods such as Job′plot experiment, proton NMR titration, and d. functional theory. Furthermore, the prominent application is the naked-eye detection of cyanide from non-fluorescent to greenish-yellow fluorescent under 365 nm UV light. Based on the observed data from fluorescence spectroscopic studies, a new logic circuit is designed. Moreover, the potential application of HK and MK in the Hela cell line exhibited turn on fluorescence image for cyanide ion through the inhibition of the ICT process. In addition to that, the probe MK and HK is successfully applied in the anal. of the real sample for the rapid detection of cyanide ions. In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Computed Properties of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Computed Properties of C7H6O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts