Category: 26153-38-8

《Utiziling a copper-free Sonogashira reaction in the synthesis of the leukotriene a4 hydrolase modulator batatasin IV》 was published in Tetrahedron Letters in 2020. These research results belong to Petruncio, Greg; Girgis, Michael; Moummi, Sanae; Jayatilake, Meth; Lee, Kyung Hyeon; Paige, Mikell. Electric Literature of C7H6O3 The article mentions the following:

Batatasin IV is a dihydrostilbenoid isolated from Chinese yams which was shown to have inhibitory activities against plant growth. Later studies showed that this compound may exhibit anti-inflammatory properties by inhibiting the epoxide hydrolase activity of the leukotriene A4 hydrolase enzyme. To access the dihydrostilbenoid skeleton, a copper-free SPhos-mediated Sonogashira reaction was conceived and the substrate scope was explored. Our results indicate that the reaction can tolerate the presence of free alcs., aldehydes, nitro groups, and anilinyl groups. However, a substituent with an acidic phenol or carboxylic acid group gave significantly lower yields. Next, a total synthesis of batatasin IV was accomplished in 16% overall yield incorporating the reported copper-free Sonogashira reaction. Finally, we show that batatasin IV inhibits the hydrolysis of alanine p-nitroanilide by leukotriene A4 hydrolase with an IC50 of 91.4μM.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

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《Synthesis, α-glycosidase inhibitory potential and molecular docking study of benzimidazole derivatives》 was published in Bioorganic Chemistry in 2020. These research results belong to Taha, Muhammad; Rahim, Fazal; Zaman, Khalid; Selvaraj, Manikandan; Uddin, Nizam; Farooq, Rai Khalid; Nawaz, Muhammad; Sajid, Muhammad; Nawaz, Faisal; Ibrahim, Mohamad; Khan, Khalid Mohammed. Reference of 3,5-Dihydroxybenzaldehyde The article mentions the following:

A series of twenty-six analogs of benzimidazole based oxadiazole I [R = 4-HOC6H4, 2-thienyl, 3-pyridyl, etc.] was synthesized and evaluated against alpha-glycosidase enzyme. Compounds I [R = 2,3-(OH)2C6H3, 2,5-(OH)2C6H3, 3,4-(OH)2C6H3, 4-FC6H4] with IC50 values 4.6 ± 0.1, 9.50 ± 0.3, 2.6 ± 0.1 and 9.30 ± 0.4μM resp. showed excellent inhibitory potential than reference drug acarbose (IC50 = 38.45 ± 0.80μM). Some of the analogs like I [R = 3-MeC6H4, 4-MeOC6H4, 3-MeOC6H4, 3,4-(OMe)2C6H4] with Me and methoxy substituent on Ph ring showed hydrophobic interaction and were found with no inhibitory potential. The binding interactions between synthesized analogs I and ligands protein were confirmed through mol. docking study. These derivatives were synthesized by simple mode of synthesis like heterocyclic ring formation. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Reference of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Reference of 3,5-Dihydroxybenzaldehyde

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Electric Literature of C7H6O3In 2020 ,《Synthesis of symmetrical bis-Schiff base-disulfide hybrids as highly effective anti-leishmanial agents》 was published in Bioorganic Chemistry. The article was written by Taha, Muhammad; Sain, Amyra Amat; Ali, Muhammad; Anouar, El Hassane; Rahim, Fazal; Ismail, Nor Hadiani; Adenan, Mohd Ilham; Imran, Syahrul; Al-Harrasi, Ahmed; Nawaz, Fasial; Iqbal, Naveed; Khan, Khalid Mohammed. The article contains the following contents:

Leishmaniasis has affected a wider part of population around the globe. Most often, the existing regiments to battle against leishmaniasis are inadequate and limited. In our ongoing efforts to develop new leishmanicidal agents, we have synthesized a series of novel and sym. bis-Schiff base-disulfide hybrids 1-27. Intermediate disulfide was synthesized from corresponding 2-aminothiol followed by reacting the coupled adduct with various aromatic aldehydes. All these compounds showed outstanding inhibition when compared with standard (Table 1). Out of twenty seven analogs, twenty two analogs i.e. 1-5, 7-13, 17-21, 23-27 analogs showed excellent inhibitory potential with EC50 values ranging from 0.010 ± 0.00 to 0.096 ± 0.01μM while five compounds i.e. 6, 14-16, and 22 showed good inhibitory potential with EC50 values ranging from 0.10 ± 0.00 to 0.137 ± 0.01μM when compared with the standard Amphotericin B. Structure-activity relationship has been established while mol. docking studies were performed to pin the binding interaction of active mols. This study will help to develop new antileishmanial lead compounds In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Electric Literature of C7H6O3

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In 2018,Gu, Xuesong; Xie, Shubo; Chen, Qiang; Chen, Shufeng; Zhao, Haiying; Bian, Zhanxi published 《Anti-migration and burning rate catalytic performances of novel ferrocene-based porphyrins and their transition-metal complexes》.New Journal of Chemistry published the findings.Product Details of 26153-38-8 The information in the text is summarized as follows:

Two series of novel ferrocene-based porphyrins and their transition metal (Zn, Co, Ni, and Cu) complexes were synthesized and characterized. One has ferrocene on the skirt of meso-tetraphenylporphyrin (TPP) via long chain alkoxy groups (HP1 and HP2); the other has a close connection of TPP and ferrocene containing long chain alkyl groups by ester linkage (HP3). Their UV-visible absorption spectra, fluorescence spectra, thermal stability and electrochem. properties were studied. They were applied for the 1st time as burning rate catalysts (BRCs) in a simulative solid propellant to overcome the migration problem. Their catalytic effects on the thermal degradation of ammonium perchlorate (AP) were evaluated by thermogravimetric and DSC techniques, and the catalytic effects of free porphyrin, Zn(II) porphyrin and Ni(II) porphyrin were similar to that of catocene. While Cu(II) and Co(II) porphyrins exhibited higher catalytic effects than catocene, the Co(II) complexes lowered the thermal decomposition temperature of AP more dramatically compared with Cu(II) complexes. What’s more, these compounds displayed nonmigratory ability in the migration test. Therefore, the novel ferrocene-based porphyrin derivatives are nonmigratory BRCs with high catalytic efficiency for composite solid propellants and have potential applications in aerospace. The experimental part of the paper was very detailed, including the reaction process of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Product Details of 26153-38-8

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In 2018,Mogharabi-Manzari, Mehdi; Amini, Mohsen; Abdollahi, Mohammad; Khoobi, Mehdi; Bagherzadeh, Ghodsieh; Faramarzi, Mohammad Ali published 《Co-immobilization of Laccase and TEMPO in the Compartments of Mesoporous Silica for a Green and One-Pot Cascade Synthesis of Coumarins by Knoevenagel Condensation》.ChemCatChem published the findings.HPLC of Formula: 26153-38-8 The information in the text is summarized as follows:

Co-immobilization of bio- and chemocatalysts produces sustainable, recyclable hybrid systems that open new horizons for green cascade approaches in organic synthesis. Here, the co-immobilization of laccase and 2,2,6,6-tetramethylpiperidin-1-oxyl (TEMPO) in mesoporous silica was used for the one-pot aqueous synthesis of 30 coumarin-3-carboxylate derivatives under mild conditions through the condensation of in situ oxidized 2-hydroxybenzyl alcs. and malonate derivatives A maximum yield was obtained after incubating at pH 6.0 and 45°C for 24 h. An efficient organic synthesis was catalyzed by the hybrid catalyst in 10% organic solvent. More than 95% of the initial activity of the enzyme was preserved after 10 cycles, and no significant catalyst deactivation occurred after 10 runs. This new system efficiently catalyzed the in situ aerobic oxidation of salicyl alcs., followed by Knoevenagel condensation, which confirmed the possibility of producing efficient hybrid catalysts by co-immobilization of catalytic species in mesoporous materials. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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SDS of cas: 26153-38-8In 2020 ,《In vitro study and structure-activity relationship analysis of stilbenoid derivatives as powerful vasorelaxants: Discovery of new lead compound》 was published in Bioorganic Chemistry. The article was written by Chan, Sock Ying; Loh, Yean Chun; Oo, Chuan Wei; Yam, Mun Fei. The article contains the following contents:

The development of vasorelaxant as the antihypertensive drug is important as it produces a rapid and direct relaxation effect on the blood vessel muscles. Resveratrol (RV), as the most widely studied stilbenoid and the lead compound, inducing the excellent vasorelaxation effect through the multiple signalling pathways. In this study, the in vitro vascular response of the synthesized trans-stilbenoid derivatives were primarily evaluated by employing the phenylephrine (PE)-precontracted endothelium-intact isolated aortic rings. Herein we report trans-3,4,4′-trihydroxystilbene (SB 8b) exhibited surprisingly more than 2-fold improvement to the maximal relaxation (Rmax) of RV. This article also highlights the characterization of the aromatic protons in terms of their unique splitting patterns in 1H NMR. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8SDS of cas: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.SDS of cas: 26153-38-8

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《Design, synthesis and biological evaluation of novel triazole N-acylhydrazone hybrids for alzheimer’s disease》 was written by de Freitas Silva, Mathesus; Lima, Ellen Tardelli; Pruccoli, Letizia; Castro, Newton G.; Guimaraes, Marcos Jorge R.; da Silva, Fernanda M. R.; Nadur, Nathalia Fonseca; Luiz de Azevedo, Luciana; Kummerle, Arthur Eugen; Guedes, Isabella Alvim; Dardenne, Laurent Emmanuel; Gontijo, Vanessa Silva; Tarozzi, Andrea; Viegas, Claudio Jr.. COA of Formula: C7H6O3This research focused ontriazole acylhydrazone hybrid preparation diastereoselective antialzheimer cholinesterase inhibitor docking; pharmacokinetic antioxidant neurotoxicity triazole acylhydrazone hybrid; Alzheimer’s disease; curcumin; molecular hybridization; resveratrol. The article conveys some information:

The goal of this study was the design and synthesis of novel triazole N-acylhydrazone hybrids I [R1 = H, OH, OMe; R2 = H, F, 1-piperidyl, etc.; R3 = H, OH, OMe, F, Cl; R4 = H, F, Cl] with multifunctional pharmacol. activity by mol. hybridization of structural fragments of curcumin and resveratrol connected by an N-acyl-hydrazone function linked to a 1,4-disubstituted triazole system. Among these hybrid compounds, compound I [R1 = OMe, R2 = OH, R3 = R4 = H (II)] showed the ability to inhibit acetylcholinesterase activity, the intracellular formation of reactive oxygen species as well as the neurotoxicity elicited by Aβ42 oligomers in neuronal SH-SY5Y cells. In parallel, compound II showed a good profile of safety and ADME parameters. Taken together, these results suggested that compound II could be considered a lead compound for the further development of AD therapeutics. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8COA of Formula: C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.COA of Formula: C7H6O3

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《Unusual Reactivity and Metal Affinity of Water-Soluble Dipyrrins》 was written by El Khatib, Mirna; Cheprakov, Andrei V.; Vinogradov, Sergei A.. Recommanded Product: 26153-38-8This research focused onwater soluble dipyrrin preparation metal affinity. The article conveys some information:

The primary goal of the study was to evaluate dipyrrins functionalized with ester and amide groups in 2,2′-positions in sensing applications. While developing the synthesis, it was found that 3,3′,4,4′-tetraalkyldipyrrins 2,2′-diesters as well as 2,2′-diamides can undergo facile addition of water at the meso-bridge, transforming into colorless meso-hydroxydipyrromethanes. Spectroscopic and computational investigation revealed that this transformation proceeds via dipyrrin cations, which exist in equilibrium with the hydroxydipyrromethanes. While trace amounts of acid favor conversion of dipyrrins to hydroxydipyrromethanes, excess acid shifts the equilibrium toward the cations. Similarly, the presence of Zn2+ facilitates elimination of water from hydroxydipyrromethanes with chromogenic regeneration of the dipyrrin system. In organic solutions in the presence of Zn2+, dipyrrin-2,2′-diesters exist as mixtures of mono-(LZnX) and bis-(L2Zn) complexes. In L2Zn, the dipyrrin ligands are oriented in a nonorthogonal fashion, causing strong exciton coupling. In aqueous solutions, dipyrrins bind Zn2+ in a 1:1 stoichiometry, forming mono-dipyrrinates (LZnX). Unexpectedly, dipyrrins with more electron-rich 2,2′-carboxamide groups revealed ~20-fold lower affinity for Zn2+ than the corresponding 2,2′-diesters. D. Functional Theory (DFT) calculations with explicit inclusion of water reproduced the observed trends and allowed to trace the low affinity of the dipyrrin-diamides to the stabilization of the corresponding free bases via hydrogen bonding with water mols. Overall, the results reveal unusual trends in the reactivity of dipyrrins and provide clues for the design of dipyrrin-based sensors for biol. applications.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 26153-38-8

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The author of 《In vitro and in vivo evidence of tyrosinase inhibitory activity of a synthesized (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT)》 were Bang, EunJin; Lee, Eun Kyeong; Noh, Sang-Gyun; Jung, Hee Jin; Moon, Kyoung Mi; Park, Mi Hwa; Park, Yeo Jin; Hyun, Min Kyung; Lee, A. Kyoung; Kim, Su Jeong; Yang, Jungho; Park, Yujin; Chun, Pusoon; Moon, Hyung Ryong; Chung, Hae Young. And the article was published in Experimental Dermatology in 2019. Related Products of 26153-38-8 The author mentioned the following in the article:

Tyrosinase is a key enzyme that catalyzes the initial rate-limiting steps of melanin synthesis. Due to its critical role in melanogenesis, various attempts were made to find potent tyrosinase inhibitors although many were not safe and effective in vivo. We evaluated tyrosinase inhibitory activity of six compounds Among them, (Z)-5-(3-hydroxy-4-methoxybenzylidene)-2-thioxothiazolidin-4-one (5-HMT) had the greatest inhibitory effect and potency as the IC50 value of 5-HMT was lower than that of kojic acid, widely-known tyrosinase inhibitor. Based on in silico docking simulation, 5-HMT had a greater binding affinity than kojic acid with a different binding conformation in the tyrosinase catalytic site. Furthermore, its skin depigmentation effect was confirmed in vivo as 5-HMT topical treatment significantly reduced UVB-induced melanogenesis in HRM2 hairless mice. In conclusion, our study demonstrated that 5-HMT has a greater binding affinity and inhibitory effect on tyrosinase and may be a potential candidate for a therapeutic agent for preventing melanogenesis. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Related Products of 26153-38-8

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The author of 《A smart pH-sensitive delivery system for enhanced anticancer efficacy via paclitaxel endosomal escape》 were Yang, Yihua; Wang, Zhe; Peng, Ying; Ding, Jinsong; Zhou, Wenhu. And the article was published in Frontiers in Pharmacology in 2019. Quality Control of 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

Micelles are highly attractive nano-drug delivery systems for targeted cancer therapy. While they have been demonstrated to significantly alleviate the side-effects of their cargo drugs, the therapy outcomes are usually suboptimal partially due to ineffective drug release and endosome entrapment. Stimulus-responsive nanoparticles have allowed controlled drug release in a smart fashion, and we want to use this concept to design novel micelles. Herein, we reported pH-sensitive paclitaxel (PTX)-loaded poly (ethylene glycol)-phenylhydrazone-dilaurate (PEG-BHyd-dC12) micelles (PEG-BHyddC12/ PTX). The micelles were spherical, with an average particle size of ∼135 nm and a uniform size distribution. The pH-responsive properties of the micelles were certified by both colloidal stability and drug release profile, where the particle size was strikingly increased accompanied by faster drug release as pH decreased from 7.4 to 5.5. As a result, the micelles exhibited much stronger cytotoxicity than the pH-insensitive counterpart micelles against various types of cancer cells due to the hydrolysis of the building block polymers and subsequent rapid PTX release. Overall, these results demonstrate that the PEG-BHyd-dC12 micelle is a promising drug delivery system for cancer therapy. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

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