Category: 26153-38-8

Category: alcohols-buliding-blocksIn 2021 ,《Design and synthesis of novel terpyridine-based ligands with one and two terminal aurophilic moieties and their Rh(III) and Ru(II) complexes for the adsorption on metal surfacesã€?was published in Polyhedron. The article was written by Salimova, Irina O.; Berezina, Anna V.; Shikholina, Ilona A.; Zyk, Nikolai V.; Beloglazkina, Elena K.. The article contains the following contents:

Novel terpyridine ligands with one and two terminal aurophilic sulfur containing fragments, (S)-11-(4-([2,2′:6′,2”-terpyridin]-4′-yl)phenoxy)undecyl 5-(1,2-dithiolan-3-yl)pentanoate (7), (S)-((4-([2,2′:6′,2”-terpyridin]-4′-yl)-1,3-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11a), (S)-((4-([2,2′:6′,2”-terpyridin]-4′-yl)-1,2-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11b), (S)-((5-([2,2′:6′,2”-terpyridin]-4′-yl)-1,3-phenylene)bis(oxy))bis(undecane-11,1-diyl) bis(5-((S)-1,2-dithiolan-3-yl)pentanoate) (11c) were synthesized and employed to synthesis of mononuclear ruthenium(II) and rhodium(III) complexes. Electrochem. studies of the obtained ligands and coordination compounds and their ability to chemisorb on gold electrodes surfaces have been carried out. Among the obtained metal complexes, compounds with the min. time of chemisorption with the formation of Au-S bonds were revealed, which are complexes of 3,4- and 3,5-substituted phenylterpyridines. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Category: alcohols-buliding-blocks

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Schwartz, Zachary T.; Theisen, Peter D.; Bjornstal, Olaf T.; Rodebaugh, Mary; Jemal, Mauricio A.; Lee, Dallas; Shelton, Spencer D.; Zhao, Zhenze; Du, Liqin; Kerwin, Sean M. published an article in 2022. The article was titled 《Scalable Synthesis and Cancer Cell Cytotoxicity of Rooperol and Analogues》, and you may find the article in Molecules.Formula: C7H6O3 The information in the text is summarized as follows:

Plant polyphenols, such as the African potato (Hypoxis hemerocallidea)-derived bis-catechol rooperol, can display promising anticancer activity yet suffer from rapid metabolism Embarking upon a program to systematically examine potentially more metabolically stable replacements for the catechol rings in rooperol, we report here a general, scalable synthesis of rooperol and analogs that builds on our previous synthetic approach incorporating a key Pd-catalyzed decarboxylative coupling strategy. Using this approach, we have prepared and evaluated the cancer cell cytotoxicity of rooperol and a series of analogs. While none of the analogs examined here were superior to rooperol in preventing the growth of cancer cells, analogs containing phenol or methylenedioxyphenyl replacements for one or both catechol rings were nearly as effective as rooperol. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Formula: C7H6O3

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《Synthesis and Antimicrobial Activity of δ-Viniferin Analogues and Isosteres》 was written by Mattio, Luce Micaela; Pinna, Cecilia; Catinella, Giorgia; Musso, Loana; Pedersen, Kasandra Juliet; Krogfelt, Karen Angeliki; Dallavalle, Sabrina; Pinto, Andrea. HPLC of Formula: 26153-38-8This research focused onviniferin analog preparation antibacterial; antimicrobials; benzofuran nucleus; stilbenoids; viniferin derivatives. The article conveys some information:

The construction of stilbenoid-derived 2,3-diaryl-5-substituted benzofurans, which allowed to prepare a focused collection of dehydro-δ-viniferin analogs. was reported. The antimicrobial activity of the synthesized compounds was evaluated against S. aureus ATCC29213. The simplified analog 5,5′-(2-(4-hydroxyphenyl)benzofuran-3,5-diyl)bis(benzene-1,3-diol), obtained in three steps from 4-bromo-2-iodophenol (63% overall yield), emerged as a promising candidate for further investigation (MIC = 4μg/mL). In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.HPLC of Formula: 26153-38-8

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In 2022,Li, Hu; Wu, Zheng-Rong; Chu, Qing-Ru; Liang, Hong-Jie; Liu, Ying-Qian; Wu, Tian-Lin; Ma, Yue published an article in New Journal of Chemistry. The title of the article was 《Potential application value of hydroxychalcones based on isoliquiritigenin in agricultural plant diseases》.Formula: C7H6O3 The author mentioned the following in the article:

To improve the fungicidal activity of the lead compound isoliquiritigenin, 33 hydroxychalcones were designed and prepared Their in vitro antifungal activities against four pathogenic fungi (Rhizoctonia solani, Botrytis cinerea, Fusarium graminearum, and Sclerotinia sclerotiorum) were evaluated systematically. We found the most potent agricultural fungicides to be compounds LH-4, LH-5, LH-14 and LH-15 with EC50 values in the range of 5.96 – 10.06 μg mL-1, which are superior to the lead compound isoliquiritigenin and pos. control azoxystrobin, with compound LH-4 displaying the best in vitro antifungal activity against R. solani with an EC50 value of 5.96 μg mL-1, approx. 6 times more potent than isoliquiritigenin (EC50 = 36.91 μg mL-1). Moreover, the preliminary antifungal mechanism of compound LH-4 illustrated that it could affect the hyphal morphol. and ultrastructure feature of R. solani; its antifungal activity can be associated with the hyphal distortion that results from the disruption of the cell membrane integrity. Besides, SAR studies revealed that the chalcones with few hydroxyls on the A- and B-rings exhibited noticeable antifungal activity. However, chalcones with multi-hydroxyl groups showed unsatisfactory activity. Herein, we report and discuss hydroxychalcones based on isoliquiritigenin as bioactive compounds useful in treating agricultural plant diseases.3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Formula: C7H6O3) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Formula: C7H6O3

Referemce:
Alcohol – Wikipedia,
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In 2019,Bioorganic Chemistry included an article by Choi, Wonbeen; Villegas, Valente; Istre, Hannah; Heppler, Ben; Gonzalez, Niki; Brusman, Nicole; Snider, Lindsey; Hogle, Emily; Tucker, Janelle; Onate, Alma; Onate, Sandra; Ma, Lili; Paula, Stefan. HPLC of Formula: 26153-38-8. The article was titled 《Synthesis and characterization of CAPE derivatives as xanthine oxidase inhibitors with radical scavenging properties》. The information in the text is summarized as follows:

Inhibitors of the enzyme xanthine oxidase (XO) with radical scavenging properties hold promise as novel agents against reperfusion injuries after ischemic events. By suppressing the formation of damaging reactive oxygen species (ROS) by XO or scavenging ROS from other sources, these compounds may prevent a buildup of ROS in the aftermath of a heart attack or stroke. To combine these two properties in a single mol., we synthesized and characterized the non-purine XO inhibitor caffeic acid phenethylester (CAPE) and 19 derivatives using a convenient microwave-assisted Knoevenagel condensation protocol. Varying systematically the number and positions of the hydroxyl groups at the two Ph rings, we derived structure-activity relationships based on exptl. determined XO inhibition data. Mol. docking suggested that critical enzyme/inhibitor interactions involved π-π interactions between the phenolic inhibitor ring and Tyr914, hydrogen bonds between inhibitor hydroxyl groups and Glu802, and hydrophobic interactions between the CAPE Ph ring and non-polar residues located at the entrance of the binding site. To effectively scavenge the stable radical DPPH, two hydroxyl groups in 1,2- or 1,4-position at the Ph ring were required. Among all compounds tested, E-Ph 3-(3,4-dihydroxyphenyl)acrylate, a CAPE analog without the Et tether, showed the most promising properties. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8HPLC of Formula: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.HPLC of Formula: 26153-38-8

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The author of 《Fluorous hydrophobic fluorescent (E)-Stilbene derivatives for application on security paper》 were Granados, Albert; Vallribera, Adelina. And the article was published in Dyes and Pigments in 2019. Name: 3,5-Dihydroxybenzaldehyde The author mentioned the following in the article:

(E)-Stilbene hydrophobic fluorophores (e.g., I) possessing long perfluorinated or hydrocarbonated chains have been prepared through a stereoselective Wittig-Schlosser reaction. When covalently grafted upon paper, they give rise to a fluorescent-labeled paper upon irradiation with UV light. The hydrophobicity and oleophobicity of the fluorous (E)-stilbene derivative furnish self-cleaning properties. Application in the detection of money counterfeiting is envisioned. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Name: 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
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Kuranaga, Takefumi; Tamura, Miho; Ikeda, Hiroaki; Terada, Sakahiro; Nakagawa, Yusuke; Kakeya, Hideaki published an article in 2021. The article was titled 《Identification and Total Synthesis of an Unstable Anticancer Macrolide Presaccharothriolide Z Produced by Saccharothrix sp. A1506》, and you may find the article in Organic Letters.Quality Control of 3,5-Dihydroxybenzaldehyde The information in the text is summarized as follows:

Saccharothriolides A-F are 10-membered microbial macrolides proposed to be generated from their precursors presaccharothriolides X-Z. Previously, we isolated presaccharothriolide X, and its unique natural prodrug-like properties have intrigued us. However, the other congeners were not detected. Herein, we detected presaccharothriolide Z using our highly sensitive labeling reagent. Moreover, chem. synthesis of presaccharothriolide Z, the first total synthesis of saccharothriolide-class macrolides, was achieved, and the structure and biol. activity of presaccharothriolide Z were determined In the part of experimental materials, we found many familiar compounds, such as 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
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Safety of 3,5-DihydroxybenzaldehydeIn 2021 ,《Design and microwave synthesis of new (5Z) 5-arylidene-2-thioxo-1,3-thiazolinidin-4-one and (5Z) 2-amino-5-arylidene-1,3-thiazol-4(5H)-one as new inhibitors of protein kinase DYRK1A》 appeared in Pharmaceuticals. The author of the article were Bourahla, Khadidja; Guiheneuf, Solene; Limanton, Emmanuelle; Paquin, Ludovic; Le Guevel, Remy; Charlier, Thierry; Rahmouni, Mustapha; Durieu, Emilie; Lozach, Olivier; Carreaux, Francois; Meijer, Laurent; Bazureau, Jean-Pierre. The article conveys some information:

Here, we report on the synthesis of libraries of new 5-arylidene-2-thioxo-1,3-thiazolidin-4-ones 3 (twenty-two compounds) and new 2-amino-5-arylidene-1,3-thiazol-4(5H)-ones 5 (twenty-four compounds) with stereo controlled Z-geometry under microwave irradiation The 46 designed final compounds were tested in order to determine their activity against four representative protein kinases (DYR1A, CK1, CDK5/p25, and GSK3α/β). Among these 1,3-thiazolidin-4-ones, the mols. (5Z) 5-(4-hydroxybenzylidene)-2-thioxo-1,3-thiazolidin-4-one 3e (IC50 0.028 μM) and (5Z)-5-benzo[1,3]dioxol-5-ylmethylene-2-(pyridin-2-yl)amino-1,3-thiazol-4(5H)-one 5s (IC50 0.033 μM) were identified as lead compounds and as new nanomolar DYRK1A inhibitors. Some of these compounds in the two libraries have been also evaluated for their in vitro inhibition of cell proliferation (Huh7 D12, Caco2, MDA-MB 231, HCT 116, PC3, and NCI-H2 tumor cell lines). These results will enable us to use the 1,3-thiazolidin-4-one core as pharmacophores to develop potent treatment for neurol. or oncol. disorders in which DYRK1A is fully involved. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Safety of 3,5-Dihydroxybenzaldehyde)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Safety of 3,5-Dihydroxybenzaldehyde

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Quality Control of 3,5-DihydroxybenzaldehydeIn 2022 ,《Preparation of a resveratrol-ascorbic acid mem conjugate》 appeared in Heterocyclic Letters. The author of the article were Amin, Rasidul; Hunt, David A.. The article conveys some information:

The preparation of a resveratrol-ascorbic acid conjugate in support of pharmacodynamic and pharmacokinetic studies has been achieved through a seven-step convergent synthesis. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Quality Control of 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Quality Control of 3,5-Dihydroxybenzaldehyde

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Zinc oxide catalyzed, environmentally benign protocol for the synthesis of substituted carboxylic acid》 was written by Shaikh, Majid; Shaikh, Mujahed; Wagare, Devendra; Kasim, Sayyad Sultan. Application of 26153-38-8This research focused onzinc oxide substituted carboxylic acid benign protocol synthesis. The article conveys some information:

Carboxylic acid act as a versatile precursor to synthesized biol. valuable mol. like amide, acid chloride and many more. Hence, we have developed convenient method to synthesized substituted carboxylic acid. The previous synthetic method found limitations regarding the use of hazardous solvent, tedious work-up, slow and moderate product yields. To over come, these lacunas herein we have developed a facial and highly efficient synthetic protocol for the synthesis of carboxylic acids from the reaction of substituted aldehydes and hydrogen peroxide (70%) with zinc oxide (10% mol) as a catalyst and in onion extract Reported method is better substitute for the existing previous methods because it has many advantages such as easy work-up, reduces the reaction time in just 1-2 h with excellent yield and most important the Zinc oxide easily removed with filtration. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Application of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Application of 26153-38-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts