Category: 26153-38-8

《Protonation-Triggered Supramolecular Gel from Macrocyclic Diacetylene: Gelation Behavior, Topochemical Polymerization, and Colorimetric Response》 was written by Shin, Geon; Khazi, Mohammed Iqbal; Kim, Jong-Man. Name: 3,5-Dihydroxybenzaldehyde And the article was included in Langmuir in 2020. The article conveys some information:

Herein, a novel supramol. gel was fabricated through the protonation-triggered unidirectional self-assembly of pyridine-attached macrocyclic diacetylene (PyMCDA). Basic nitrogen of a pyridine ring with a strong affinity toward proton transforms the neutral PyMCDA into gelator in its protonated pyridinium salt form (PyMCDA-H+), which further evolves to nano-fibrillar networks to yield a supramol. gel. Under the irradiation of UV light, the white color gel turned to a robust covalently cross-linked blue-phase PDA gel. Interestingly, polymeric PyMCPDA-H+ gel exhibits a naked-eye detectable reversible blue-red colorimetric response for alternating acid/base (H2SO4/NH4OH) and colorimetric sensitivity toward selected anions: CH3COO-, CN-, HCOO-, and CH3CH2COO-. It is with the hope that this work point toward the utility and versatility of macrocyclic PDAs for constructing chromogenic supramol. gels for their possible use in sensing systems. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Name: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Name: 3,5-Dihydroxybenzaldehyde

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Product Details of 26153-38-8In 2021 ,《Design and synthesis of π-extended resveratrol analogues and in vitro antioxidant and anti-inflammatory activity evaluation》 appeared in Molecules. The author of the article were Nam, Ki Yoon; Damodar, Kongara; Lee, Yeontaek; Park, Lee Seul; Gim, Ji Geun; Park, Jae Phil; Jeon, Seong Ho; Lee, Jeong Tae. The article conveys some information:

The research on resveratrol (1) has been conducted intensively over a long time due to its proven antioxidant activity and disease-fighting capabilities. Many efforts have also been made to increase these biol. effects. In the present study, six new extended aromatic resveratrol analogs containing naphthalene (2) and its bioisosteres quinoline (3 and 4), isoquinoline (5) quinoxaline (6) and quinazoline (7) scaffolds were designed and synthesized using an annulation strategy. The antioxidant and anti-inflammatory activities of these compounds were investigated. All compounds showed better antioxidant activity than resveratrol in ABTS assay. As for the anti-inflammatory test, 5 and 7 exhibited better activity than resveratrol. It is worth noting that nitrogen substitution on the extended aromatic resveratrol analogs has a significant impact on cell viability. Taking the antioxidant activities and NO inhibition activities into consideration, we conclude that isoquinoline analog 5 may qualify for the further investigation of antioxidant and anti-inflammatory therapy. Furthermore, our study results suggest that in order to improve the biol. activity of polyphenolic compounds, extended aromaticity and nitrogen substitution strategy could be a viable method for the design of future drug candidates. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Product Details of 26153-38-8

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Kim, Yoon Jee; Duraisamy, Kalaiselvi; Jeong, Min-Hye; Park, Sook-Young; Kim, Soonok; Lee, Yookyung; Nguyen, Van Thi; Yu, Nan Hee; Park, Ae Ran; Kim, Jin-Cheol published an article in 2021. The article was titled 《Nematicidal activity of grammicin biosynthesis pathway intermediates in Xylaria grammica KCTC 13121BP against Meloidogyne incognita》, and you may find the article in Molecules.Recommanded Product: 3,5-Dihydroxybenzaldehyde The information in the text is summarized as follows:

Grammicin, a polyketide metabolite produced by the endolichenic fungus Xylaria grammica KCTC 13121BP, shows strong nematicidal activity against Meloidogyne incognita. This study was performed to elucidate the grammicin biosynthesis pathway of X. grammica KCTC 13121BP and to examine the nematicidal activity of the biosynthesis intermediates and derivatives against M. incognita. Two grammicin biosynthesis intermediates were isolated from a T-DNA insertion transformant (strain TR-74) of X. grammica KCTC 13121BP and identified as 2-(hydroxymethyl)cyclohexa-2,5-diene-1,4-dione (compound 1) and 2,5-dihydroxybenzaldehyde (compound 2), which were also reported to be intermediates in the biosynthesis pathway of patulin, an isomer of grammicin. This indicates that the grammicin biosynthesis pathway overlaps almost with that of patulin, except for the last few steps. Among 13 grammicin biosynthesis intermediates and their derivatives (except grammicin), toluquinol caused the highest M. incognita J2 mortality, with an LC50/72 h value of 11.13μg/mL, which is similar to grammicin with an LC50/72 h value of 15.95μg/mL. In tomato pot experiments, the wettable powder type formulations (WP) of toluquinol (17.78μg/mL) and grammicin (17.78μg/mL) also effectively reduced gall formation on the roots of tomato plants with control values of 72.22% and 77.76%, resp., which are much higher than abamectin (16.67%), but lower than fosthiazate (100%). The results suggest that toluquinol can be used directly as a biochem. nematicide or as a lead mol. for the development of new synthetic nematicides for the control of root-knot nematode diseases. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 3,5-Dihydroxybenzaldehyde) was used in this study.

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Recommanded Product: 3,5-Dihydroxybenzaldehyde

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Product Details of 26153-38-8In 2018 ,《Substituents modification of meso-aryl BODIPYs for tuning photophysical properties》 appeared in Tetrahedron. The author of the article were Ko, Sangwon; Kim, Cheul Yong; Damodar, Kongara; Lim, Hyun Min; Kim, Jin Ho; Lee, Chang-Hee; Lee, Jeong Tae. The article conveys some information:

The authors successfully synthesized eight meso-aryl BODIPYs with 2,6-diethyl- or 1,2,6,7-tetra-Et substituents and characterized their photophys. properties. The steric hindrance resulting from the phenolic group in the meso-aryl moiety and the Et groups on the BODIPY core affected the synthesis of dipyrromethanes as an intermediate as well as the UV-visible absorption and fluorescence emission of the BODIPYs due to the constrained rotation of the aryl ring. The potential use of the meso-hydroxyphenyl BODIPY as a pH sensor was also shown by the pH-dependent fluorescence emissions. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Product Details of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Product Details of 26153-38-8

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In 2019,Molecules included an article by Nakamae, Ikuko; Morimoto, Tsumoru; Shima, Hiroki; Shionyu, Masafumi; Fujiki, Hisayo; Yoneda-Kato, Noriko; Yokoyama, Takashi; Kanaya, Shigehiko; Kakiuchi, Kiyomi; Shirai, Tsuyoshi; Meiyanto, Edy; Kato, Jun-ya. Synthetic Route of C7H6O3. The article was titled 《Curcumin derivatives verify the essentiality of ROS upregulation in tumor suppression》. The information in the text is summarized as follows:

Curcumin has been shown to exert pleiotropic biol. effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties. Thirty-nine derivatives exhibited anti-proliferative activity toward human cancer cell lines, including CML-derived K562 leukemic cells, in a manner sensitive to an antioxidant, N-acetyl-cysteine (NAC). Some compounds exhibited lower GI50 values than curcumin, some efficiently induced cell senescence, and others markedly increased ROS levels, efficiently induced cell death and suppressed tumor formation in a xenograft mouse model, without any detectable side effects. A clustering anal. of the selected compounds and their measurement variables revealed that anti-tumorigenic activity was most well-correlated with an increase in ROS levels. Pulldown assays and a mol. docking anal. showed that curcumin derivatives competed with co-enzymes to bind to the resp. ROS metabolic enzymes and inhibited their enzymic activities. The anal. of novel curcumin derivatives established the importance of ROS upregulation in suppression of tumorigenesis, and these compounds are potentially useful for the development of an anti-cancer drug with few side effects. In the experiment, the researchers used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Synthetic Route of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Synthetic Route of C7H6O3

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《Synthesis and Biological Screening of New Lawson Derivatives as Selective Substrate-Based Inhibitors of Cytochrome bo3 Ubiquinol Oxidase from Escherichia coli》 was published in ChemMedChem in 2020. These research results belong to Elamri, Isam; Radloff, Melanie; Hohmann, Katharina F.; Nimbarte, Vijaykumar D.; Nasiri, Hamid R.; Bolte, Michael; Safarian, Schara; Michel, Hartmut; Schwalbe, Harald. Electric Literature of C7H6O3 The article mentions the following:

The respiratory chain of Escherichia coli contains two different types of terminal oxidase that are differentially regulated as a response to changing environmental conditions. These oxidoreductases catalyze the reduction of mol. oxygen to water and contribute to the proton motive force. The cytochrome bo3 oxidase (cyt bo3) acts as the primary terminal oxidase under atm. oxygen levels, whereas the bd-type oxidase is most abundant under microaerobic conditions. In E. coli, both types of respiratory terminal oxidase (HCO and bd-type) use ubiquinol-8 as electron donor. Here, we assess the inhibitory potential of newly designed and synthesized 3-alkylated Lawson derivatives through L-proline-catalyzed three-component reductive alkylation (TCRA). The inhibitory effects of these Lawson derivatives on the terminal oxidases of E. coli (cyt bo3 and cyt bd-I) were tested potentiometrically. Four compounds were able to reduce the oxidoreductase activity of cyt bo3 by more than 50 % without affecting the cyt bd-I activity. Moreover, two inhibitors for both cyt bo3 and cyt bd-I oxidase could be identified. Based on mol.-docking simulations, we propose binding modes of the new Lawson inhibitors. The mol. fragment benzyl enhances the inhibitory potential and selectivity for cyt bo3, whereas heterocycles reduce this effect. This work extends the library of 3-alkylated Lawson derivatives as selective inhibitors for respiratory oxidases and provides mol. probes for detailed investigations of the mechanisms of respiratory-chain enzymes of E. coli. The results came from multiple reactions, including the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

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Li, Zi; Ren, Xiangzhu; Sun, Peng; Ding, Hao; Li, Shumu; Zhao, Yilin; Zhang, Ke published an article in 2021. The article was titled 《Protecting-Group-Free Iterative Exponential Growth Method for Synthesizing Sequence-Defined Polymers》, and you may find the article in ACS Macro Letters.Electric Literature of C7H6O3 The information in the text is summarized as follows:

As a main synthetic strategy for monodisperse sequence-defined polymers, the known iterative exponential growth (IEG) methods were all developed on protecting-group chem., where the addnl. deprotection reactions increased their synthetic steps and decreased their atom economy. In this study, we developed a protecting-group-free IEG method for the formation of sequence-defined polymers by combining three orthogonal click reactions of copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), sulfur-fluoride exchange reaction (SuFEx), and Ugi four-component reaction (Ugi-4CR). In this approach, oligomer synthesis began with three parallel CuAAC, SuFEx, and Ugi-4CR couplings among three monomers each with two orthogonal clickable end groups. By iteratively applying parallel CuAAC, SuFEx, and Ugi-4CR to couple three resultant oligomers, each having two orthogonal clickable terminals, this approach could exponentially grow three different sequence-defined polymers simultaneously with high efficiency, requiring no protecting-group chem. Addnl., each Ugi-4CR coupling reaction could introduce two external side groups to provide the mol. variation and side-chain functionalization for the resultant sequence-defined polymers. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Electric Literature of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Electric Literature of C7H6O3

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In 2022,Ksila, Mohamed; Vejux, Anne; Prost-Camus, Emmanuelle; Durand, Philippe; Ghzaiel, Imen; Nury, Thomas; Duprey, Dorian; Meziane, Smail; Masmoudi-Kouki, Olfa; Latruffe, Norbert; Ghrairi, Taoufik; Prost, Michel; Lizard, Gerard; Vervandier-Fasseur, Dominique published an article in Molecules. The title of the article was 《Cytotoxic and Antioxidant Activities of Imine Analogs of Trans-Resveratrol towards Murine Neuronal N2a Cells》.Related Products of 26153-38-8 The author mentioned the following in the article:

Trans-resveratrol is a natural polyphenol showing numerous biol. properties, especially anti-tumoral and antioxidant activity. Among numerous resveratrol derivatives, aza-stilbenes, which bear an imine bound, show interesting biol. activities. In the present study, we synthesized a series of imine analogs of trans-resveratrol (seven aza-stilbenes) following an easy and low-cost procedure of green chem. The toxicity of synthesized aza-stilbenes, which is currently unknown, was evaluated on murine neuronal N2a cells, comparatively to trans-resveratrol, by considering: cell d. evaluated by staining with sulforhodamine 101; esterase activity, which is a criteria of cell viability, by staining with fluorescein diacetate; and transmembrane mitochondrial potential, which is known to decrease during cell death, by staining with DiOC6(3) using flow cytometry. In addition, the antioxidant activity was quantified with the KRL (Kit Radicaux Libres) assay, the DPPH (2,2- diphenyl-1-picrylhydrazyl radical) assay and the FRAP (ferric reducing antioxidant power) assay. The PAOT (Pouvoir Antioxidant Total) score was also used. The aza-stilbenes provide different cytotoxic and antioxidant activities, which are either higher or lower than those of trans-resveratrol. Based on their cytotoxic and antioxidant characteristics, all synthesized aza-stilbenes are distinguished from trans-resveratrol. After reading the article, we found that the author used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Related Products of 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Related Products of 26153-38-8

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《Bright and fast-response perovskite light-emitting diodes with an ICBA:modified-C60 nanocomposite electrical confinement layer》 was published in Nanoscale in 2020. These research results belong to Tsai, Chia-Lung; Lu, Yi-Chen; Chiang, Shou-En; Yu, Chih-Min; Cheng, Hsin-Ming; Hsu, Ching-Ling; Chiu, Kuo Yuan; Chang, Sheng Hsiung. Recommanded Product: 26153-38-8 The article mentions the following:

Bright and fast-response CH3NH3PbBr3 perovskite light-emitting diodes (PeLEDs) are realized by using ICBA:modified C60 (MC60) nanocomposites as the hole blocking layer (HBL) and electron transport layer (ETL). The photoluminescence spectrum shows that the use of hydrophilic MC60 in the ETL helps the surface passivation of the perovskite layer. In addition, the photoelectron spectra and water-droplet contact angle images show that the use of the ICBA:MC60 nanocomposite ETL can simultaneously confine the electrons and holes in the perovskite layer, which boosts the injected electron-hole radiative recombination efficiency and thereby increases the electroluminescence from 1 cd m-2 to 2080 cd m-2 at 6 V when the ICBA:3,5OEC60 nanocomposite ETL is used. In addition, the operational frequency of the optimal PeLED is up to 1.5 MHz. In the experimental materials used by the author, we found 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Recommanded Product: 26153-38-8)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is used as a building block in the synthesis of more complex structures. It is also used in the synthesis of terbutaline, which is an important bronchodilator.Recommanded Product: 26153-38-8

Referemce:
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Alcohols – Chemistry LibreTexts

In 2018,ChemMedChem included an article by Bian, Linglin; Cao, Shining; Cheng, Lihong; Nakazaki, Atsuo; Nishikawa, Toshio; Qi, Jianhua. Computed Properties of C7H6O3. The article was titled 《Semi-synthesis and Structure-Activity Relationship of Neuritogenic Oleanene Derivatives》. The information in the text is summarized as follows:

(3S,4R)-23,28-Dihydroxyolean-12-en-3-yl (2E)-3-(3,4-dihydroxyphenyl)acrylate (1a), which possesses significant neuritogenic activity, was isolated from the traditional Chinese medicine (TCM) plant, Desmodium sambuense. To confirm the structure and to assess biol. activity, the authors semi-synthesized 1a from com. available oleanolic acid. A series of novel 1a derivatives was then designed and synthesized for a structure-activity relationship (SAR) study. All synthetic derivatives were characterized by anal. of spectral data, and their neuritogenic activities were evaluated in assays with PC12 cells. The SAR results indicate that the number and position of the hydroxy groups on the Ph ring and the triterpene moiety, as well as the length of the (saturated or unsaturated) alkyl chain that links the Ph ring with the triterpene critically influence neuritogenic activity. Among all the tested compounds, 1e [(3S,4R)-23,28-dihydroxyolean-12-en-3-yl (2E)-3-(3,4,5-trihydroxyphenyl)acrylate] was found to be the most potent, inducing significant neurite outgrowth at 1 μM. The experimental process involved the reaction of 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Computed Properties of C7H6O3)

3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Computed Properties of C7H6O3

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