Category: 2615-15-8

Related Products of 2615-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation of Compound 29a To a solution of hexaethylene glycol (25.0 g, 88.5 mmol) in DCM (100 mL) were added triethylamine (61.7 mL, 443 mmol) and ^-toluenesulfonyl chloride (50.6 g, 266 mmol) at 0 C under N2. After 5 hours at 0 C, the reaction mixture was poured into 1 N aq. HC1 (200 mL) and extracted with DCM (2 x 200 mL). The combined organic layers were washed with saturated aq. NaHCO3 (100 mL) and brine (100 mL), and dried over anhydrous Na2SO4. After filtration and concentration, the residue was purified by column chromatography, which produced the compound 29a (45.0 g, 87 %) as brown oil. 1H- MR (400 MHz, CDC13) delta 7.79 (d, J= 7.6 Hz, 4H), 7.34 (d, J= 7.6 Hz, 4H), 4.16-4.14 (m, 4H), 3.69-3.67 (m, 4H), 3.64-3.56 (m, 16H), 2.44 (s, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; LEGOCHEM BIOSCIENCES, INC.; KIM, Yong, Zu; OH, Yeong, Soo; CHAE, Jeiwook; SONG, Ho, Young; CHUNG, Chul-woong; PARK, Yun, Hee; CHOI, Hyo, Jung; PARK, Kyung, Eun; KIM, Hyoungrae; KIM, Jinyeong; MIN, Ji, Young; KIM, Sung, Min; LEE, Byung, Soo; WOO, Dong, Hyun; JUN, Ji, Eun; LEE, Su, In; (272 pag.)WO2017/89890; (2017); A1;,
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Electric Literature of 2615-15-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 2615-15-8 as follows.

1005671 A solution of hexaethylene glycol (10 g, 35.46 mmol) in DCM (100 mL) was charged with Ag20 (12.34 g, 53.19 mmol), KI (1.17 g, 7.04 mmol) and stirred at room temperature for 15 mm. This solution was charged with tosyl chloride (7.35 g, 38.68 mmol)and stirred at room temperature for 6 h. The reaction mixture was filtered through a pad of celite and the filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 2% methanol in DCM to give 8.80 g, 57% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.9 Hz, 2H), 7.48 (d, J= 7.7 Hz, 2H), 4.56 (t, J= 5.4 Hz, 1H), 4.11 (t, J= 4.3 Hz, 2H), 3.563.32 (m, 22H), 2.42 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2615-15-8, its application will become more common.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Electric Literature of 2615-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, molecular weight is 282.33, as common compound, the synthetic route is as follows.

j00346j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (5 g, 1.70 mmol) in THF (100 mL) was charged with tosyl chloride (10.1 g, 5.30 mmol) and solution of potassium hydroxide (5.9 g, 5.30 mmol) in H20 (100 mL) at room temperature. The resulting solution was heated to 60 C for 5 h then cooled to room temperature and evaporated in vacuo. Theresidue obtained was diluted with DCM (100 mL) and filtered. The filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCM to obtain 8 g, 76% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.94 Hz, 4H), 7.48 (d, J= 8.38 Hz, 4H), 4.08-4.13 (m, 4H), 3.54-3.59 (m, 4H), 3.43 -3.50 (m, 16H), 2.42 (s, 6H).

Statistics shows that 2615-15-8 is playing an increasingly important role. we look forward to future research findings about 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Electric Literature of 2615-15-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, molecular weight is 282.33, as common compound, the synthetic route is as follows.

j00346j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (5 g, 1.70 mmol) in THF (100 mL) was charged with tosyl chloride (10.1 g, 5.30 mmol) and solution of potassium hydroxide (5.9 g, 5.30 mmol) in H20 (100 mL) at room temperature. The resulting solution was heated to 60 C for 5 h then cooled to room temperature and evaporated in vacuo. Theresidue obtained was diluted with DCM (100 mL) and filtered. The filtrate was concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCM to obtain 8 g, 76% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.78 (d, J= 7.94 Hz, 4H), 7.48 (d, J= 8.38 Hz, 4H), 4.08-4.13 (m, 4H), 3.54-3.59 (m, 4H), 3.43 -3.50 (m, 16H), 2.42 (s, 6H).

Statistics shows that 2615-15-8 is playing an increasingly important role. we look forward to future research findings about 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
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Application of 2615-15-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: Preparation of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol ditosylate A solution of 73.91 g of p-toluenesulfonyl chloride (0.389 mol) in 400 mL of methylene chloride is added dropwise with stirring over a 2.5 hrs period to 400 mL of methylene chloride containing 50 g of hexaethylene glycol (0.177 mol) and 64 mL of triethylamine (39.36 g, 0.389 mol) at 0 C. The mixture is stirred for one hr at 0 C. and heated to ambient temperature for 44 hrs. The mixture is filtered and the filtrate concentrated in vacuo. The resulting residue is suspended in 500 mL of ethyl acetate and filtered. The filtrate is concentrated in vacuo to a yellow oil which was triturated eight times with 250 mL portions of warm hexane to remove unreacted p-toluenesulfonyl chloride. The resulting oil is then concentrated under high vacuum to yield 108.12 g of a yellow oil (quantitative yield). Analysis: Calculated for C26 H38 O11 S2: Calc.=C, 52.87; H, 6.48. found: C, 52.56; H, 6.39. PMR (“proton magnetic resonance”): (60 MHz, CDCl3) delta: 2.45 (s, 6H); 3.43.-3.8 (m, 20H); 4.2 (m, 4H); 7.8 (AB quartet, J=8 Hz, 8H). IR (“infrared”): (neat) cm-1: 2870, 1610, 1360, 1185, 1105, 1020 930, 830, 785, 670.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; Applied Gene Technologies, Inc.; US6379930; (2002); B1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

(a) 1,17-Diazido-3,6,9,12,15-pentaoxaheptadecane A solution of dry hexaethylene glycol (25 g, 88 mmol) and methanesulfonyl chloride (22.3 g, 195 mmol) in dry THF (125 mL) was kept under argon and cooled to 0 C. in an ice/water bath. A solution of triethylamine (19.7 g, 195 mmol) in dry THF (25 mL) was added dropwise over 45 min. After 1 hr the cooling bath was removed and the reaction was stirred for another for 4 hrs. Water (55 mL) was then added to the mixture, followed by sodium hydrogencarbonate (5.3 g, to pH 8) and sodium azide (12.7 g, 195 mmol). THF was removed by distillation and the aqueous solution was refluxed for 24 h (two layers were formed). The mixture was cooled, ether (100 mL) was added and the aqueous phase was saturated with sodium chloride. The phases were separated and the aqueous phase was extracted with ether (4*50 mL). The combined organic phases were washed with brine (2*50 mL) and dried (MgSO4). Filtration and evaporation of the solvent gave a yellow oil 26 g (89%). The product was used in the next step without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol.

Reference:
Patent; GE HEALTHCARE LIMITED; Engell, Torgrim; Grigg, Julian; Mantzilas, Dimitrios; (18 pag.)US2016/22847; (2016); A1;,
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Related Products of 2615-15-8 ,Some common heterocyclic compound, 2615-15-8, molecular formula is C12H26O7, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of hexaethylene glycol (2.99 g, 10.6 mmol) in CH2CI2 (1 0 mL) were successively added tosyl chloride (2.22 g, 1 1.6 mmol 1.1 equiv), silver (I) oxide (3.68 g5 15,9 mmol, 1.5 equiv) and potassium iodide (0.352 g, 0.212 mmol, 0.2 equiv) at 0C. The mixture (0297) FontWeight=”Bold” FontSize=”10″ Besenius, P.; Cormaek, PAS,,: Ludlow, S.F.; Otto, 5,; Sherrington, D.C Chem. Cam rt. 2:008, 24, 2809-2811. ;’ Svedhem, S.; Hollander, C.A.; Shi, Kortradsson, P.; Uedherg, 8.; Svensson, S.CT. J. Org, Chem. 2001, 68, 4494-4503. was stirred for 25 mia at this temperature, then filtered through a pad of Ceiite (m. I cm), which was then rinsed with methanol. Upon removing ail vol aides in vacuo, the residue was purified by flash chromatography (CH2Cl2/MeOH 1 : 0 to 9 : 1 ) to afford S4 (3.70 g, 8.48 mmol, 80%) as a colorless oil. The spectroscopic data of S4 matched well those reported in literature.4 *H NMR (CD?, 500 MHz): 7.79 (d, J ::: 7.9 Hz, 2H), 7.34 id, /-=== 7. Hz, 2H), 4.16 (t, J 4.7 Hz, 2H), 3.76-3.52 ( , 22H), 2.44 (s, 3H). MS (ESI) [M+Naf: m z 459.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; YALE UNIVERSITY; MERCK SHARP & DOHME CORP.; SPIEGEL, David, A.; CHIRKIN, Egor; ROEMER, Terry; NANTERMET, Philippe; (89 pag.)WO2018/35424; (2018); A1;,
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2615-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A solution of sodium hydroxide (5.48 g, 137 mmol) in water (30 mL) was added to a solution of PEG compound (904 mmol) in THF (30 mL). The resulting mixture was cooled to 0 C and a solution of p-toluenesulfonyl chloride (16.6 g, 87.4 mmol) in THF (100 mL) was slowly added under stirring for 2 hours. After stirring at 0 C for 3 hours, the reaction mixture was poured onto an ice/water mixture (500 mL). The organic layer was separated, and the aqueous layer was extracted with dichloromethane (3 ¡Á 200 mL). The combined organic layers were washed twice with water (100 mL), dried with MgSO4 and concentrated in vacuo.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Kachbi-Khelfallah, Souad; Monteil, Maelle; Cortes-Clerget, Margery; Migianu-Griffoni, Evelyne; Pirat, Jean-Luc; Gager, Olivier; Deschamp, Julia; Lecouvey, Marc; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1366 – 1370;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol. This compound has unique chemical properties. The synthetic route is as follows. 2615-15-8

j00479j A solution of 3,6,9,12,15-pentaoxaheptadecane-1,17-diol (7 g, 24.8 mmol) in DCM (50 mL) was cooled to 0 C and charged with silver oxide (8.60 g, 37.2 mmol), potassium iodide (822 mg, 4.95 mmol) and tosyl chloride (5.10 g, 27.17 mmol) and stirred at0C for 4 h. The reaction mixture was diluted with iN HC1 solution (15 mL), the organic layers was separated and dried over anhydrous Na2SO4, filtered and concentrated in vacuo resulting in a crude compound which was purified by chromatography on silica gel, eluting with 1-3% methanol in DCMto give 7.30 g, 67% yield of the title compound as colorless oil. ?H NMR (400 MHz, DMSO-d6): oe = 7.79 (d, J= 8.43 Hz, 2H), 7.48 (d, J= 7.98 Hz, 2H), 4.56 (t, J= 5.54 Hz, 1H), 4.08 -4.14 (m, 1H), 3.43 -3.59 (m, 20H), 3.41 (d, J= 5.32 Hz, 2H), 3.39 (s, 1H), 2.42 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2615-15-8, 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, and friends who are interested can also refer to it.

Reference:
Patent; COFERON, INC.; FOREMAN, Kenneth, W.; JIN, Meizhong; WANNER, Jutta; WERNER, Douglas, S.; WO2015/106292; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The common heterocyclic compound, 2615-15-8, name is 3,6,9,12,15-Pentaoxaheptadecane-1,17-diol, molecular formula is C12H26O7, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 2615-15-8

17-Hydroxy-3,6,9,12,15-pentaoxaheptadecyl 4-methylbenzenesulfonate (33) To a chilled (0 C.) solution of hexaethylene glycol (5.41 g, 19.2 mmol) in DCM (191 mL) were added TsCl (4.02 g, 21.1 mmol), Ag2O (6.67 g, 28.8 mmol), and KI (0.64 g, 3.84 mmol). After stirring for 20 min the reaction mixture was filtered through a 4 cm pad of celite and flushed with EtOAc. The resulted filtrate was concentrated under reduced pressure to give a yellow oil. The crude product was purified via silica flash chromatography using 3:2 DCM/Acetone as an eluent, providing 33 (6.24 g, 75%): 1H NMR (300 MHz, CDCl3) delta 7.79 (d, J=8.2 Hz, 2H), 7.33 (d, J=8.2 Hz, 2H), 4.23-4.07 (m, 2H), 3.82-3.51 (m, 22H), 2.55 (d, J=6.0 Hz, 1H), 2.44 (s, 3H).

The synthetic route of 2615-15-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; State of Oregon, acting by and through the State Board of Higher Education on Behalf of University; Johnson, Darren W.; Carroll, Calden; Haley, Michael M.; Engle, Jeff; US2014/31559; (2014); A1;,
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