Category: 2595-07-5

Xia, Chengfeng published the artcileThio-isoglobotrihexosylceramide, an Agonist for Activating Invariant Natural Killer T Cells, Formula: C9H16O6, the main research area is thioisoglobotrihexosylceramide natural killer T cell activation.

Thio-isoglobotrihexosylceramide (S-iGb3) might be resistant to α-galactosidases in antigen-presenting cells and have a longer retaining time in the lysosome before being loaded to CD1d. The biol. assay showed that S-iGb3 demonstrates a much higher increase as a stimulatory ligand toward invariant natural killer T (iNKT) cells as compared to iGb3.

Organic Letters published new progress about CD1d antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Formula: C9H16O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rich, Jamie R. published the artcileChemical and chemoenzymatic synthesis of S-linked ganglioside analogs and their protein conjugates for use as immunogens, Category: alcohols-buliding-blocks, the main research area is Tetanus toxoid bovine serum albumin protein antigen vaccine immunogen; glycoprotein ganglioside synthesis coupling glycosyltransferase catalyzed immunogen glycosylation vaccine; hydrolase resistance glycoside antigen thioglycosidic linkage immunogenic antibody oligosaccharide; neuraminic acid ganglioside coupling disaccharide sphingosine glycosyltransferase catalyzed trisaccharide; sialic acid chemoenzymic synthesis ganglioside protein conjugate immunogen disaccharide.

Analogs of the tumor-associated gangliosides GM3 and GM2 containing terminal S-linked neuraminic acid residues and an amino terminated, truncated ceramide homolog have been synthesized and conjugated to a protein. The synthesis involved coupling of a S-linked sialyl α(2→3) galactose disaccharide with a glucosyl sphingosine analog, followed by elaboration and deprotection to give amino-terminated glycosyl ceramide. Glycosyltransferase-catalyzed extension of the trisaccharide provided access to the modified GM2 tetrasaccharide or sulfur-containing GD3 analog. Owing to their potentially enhanced resistance to endogenous exo-glycoside hydrolases and their inherent non-self character, carbohydrate antigens containing non-reducing terminal thioglycosidic linkages may be more immunogenic than O-linked antigens and may stimulate the production of antibodies capable of recognizing naturally occurring oligosaccharides. Our initial results suggest that in fact these antigens are viable immunogens and furthermore, that immune sera cross reacts with O-gangliosides in the context of a heterologous glycoprotein conjugate.

Chemistry – A European Journal published new progress about Antibodies and Immunoglobulins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiffoleauu-Giraud, V. published the artcileβ-Galactosidase transferase activity in ice and use of vinyl-β-D-galactoside as donor, HPLC of Formula: 2595-07-5, the main research area is oligosaccharide disaccharide preparation enzymic; vinylgalactoside transglycosidation glycoside galactosidase catalyst.

The ability of vinyl-β-D-galactoside as a donor in transglycosylation reactions catalyzed by the β-glycosidase from Aspergillus oryzae using allylic alc. and methyl-α-galactoside as acceptors is tested. A kinetic study made in comparison with another donor, the 2-nitrophenyl-β-D-galactoside, shows that the use of the latter leads at room temperature to better yields than those obtained form the former. A reverse situation is observed in ice at -7°C, conditions in which the yield for transglycosylation can be enhanced from 59% to 82% with methyl-α-galactoside as an acceptor.

Tetrahedron: Asymmetry published new progress about Enzymic transglycosylation. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, HPLC of Formula: 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nilsson, Kurt G. I. published the artcileInfluence of various parameters on the yield and regioselectivity of glycosidase-catalyzed formation of oligosaccharide glycosides, COA of Formula: C9H16O6, the main research area is disaccharide formation galactosidase mannosidase.

The effects of the nature of the donor and acceptor aglycons and the temperature of the yields and regioselectivity of glycosidase-catalyzed disaccharide formation were studied. α-Galactosidase catalyzed the preponderant formation of either α(1→2)-, 2(1→3)-, or α(1→6)-linked digalactosides by using different α-galactosyl derivatives as acceptor. α-Mannosidase mainly formed α(1→6)-linked or α(1→2)-linked dimannose or dimannosyl derivatives, depending on the donor and acceptors. The yields and regioselectivity of p-nitrophenyl and Me digalactosides formed by α-galactosidase decreased with increasing temperature

Annals of the New York Academy of Sciences published new progress about. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, COA of Formula: C9H16O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Krylov, Vadim B. published the artcilePyranoside-into-Furanoside Rearrangement: New Reaction in Carbohydrate Chemistry and Its Application in Oligosaccharide Synthesis, Safety of (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, the main research area is disaccharide enzymic UDP galactopyranose mutase rearrangement uronate; pyranoside furanoside rearrangement oligosaccharide synthesis sulfation acid catalyst; carbohydrates; furanoside; glycosylation; rearrangement; sulfation.

Great interest in natural furanoside-containing compounds has challenged the development of preparative methods for their synthesis. Herein a novel reaction in carbohydrate chem., namely a pyranoside-into-furanoside (PIF) rearrangement permitting the transformation of selectively O-substituted pyranosides into the corresponding furanosides is reported. The discovered process includes acid-promoted sulfation accompanied by rearrangement of the pyranoside ring into a furanoside ring followed by solvolytic O-desulfation. This process, which has no analogy in organic chem., was shown to be a very useful tool for the synthesis of furanoside-containing complex oligosaccharides, which was demonstrated by synthesizing disaccharide derivatives α-D-Galp-(1→3)-β-D-Galf-OPr, 3-O-s-lactyl-β-D-Galf-(1→3)-β-D-Glcp-OPr, and α-L-Fucf-(1→4)-β-D-GlcpA-OPr related to polysaccharides from the bacteria Klebsiella pneumoniae and Enterococcus faecalis and the brown seaweed Chordaria flagelliformis.

Chemistry – A European Journal published new progress about Oligosaccharides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Safety of (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Haimei published the artcileAn array consisting of glycosylated quantum dots conjugated to MoS2 nanosheets for fluorometric identification and quantitation of lectins and bacteria, Safety of (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, the main research area is lectin glycosylated quantum dot molybdenum disulfide nanosheet fluorometry; Fluorescence; Linear discriminant analysis; Milk sample; Multiple analysis; Saccharide binding.

A fluorescent array based on the use of saccharide-functionalized multicolored quantum dots (s-QDs) and of 4-mercaptophenylboronic acid-functionalized MoS2 nanosheets (PBA-MoS2) was constructed for multiple identification and quantitation of lectins and bacteria. In this array, the fluorescence of the s-QDs is quenched by the PBA-MoS2 nanosheets. In the presence of multiple lectins, s-QDs differentially detach from the surface of PBA-MoS2 nanosheets, producing distinct fluorescence response patterns due to both quenching and enhancement of fluorescence. By analyzing the fluorescence responses with linear discriminant anal., multiple lectins and bacteria were accurately identified with 100% accuracy. The limits of detection of Con A, Pisum sativum agglutinin, Peanut agglutinin, and Ricius communis I agglutinin are as low as 3.7, 8.3, 4.2 and 3.9 nM, resp. The array has further been evidenced to be potent for distinguishing and quantifying different bacterial species by recognizing their surface lectins. The detection limits of Escherichia coli and Enterococcus faecium are 87 and 66 cfu mL-1, resp.

Microchimica Acta published new progress about Arachis hypogaea (agglutinin). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Safety of (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Di Brisco, Riccardo published the artcileDevelopment of a fluorescent probe for the study of the sponge-derived simplexide immunological properties, Application In Synthesis of 2595-07-5, the main research area is simplexide immunol fluorescent probe disaccharide glycoside preparation glycosylation pentatriacontanol.

Simplexide is a glycolipid of marine origin, endowed with immunol. properties, composed of a long chain secondary alc. glycosylated by an α-D-glucosyl-(1→4)-β-D-galactosyl disaccharide residue. Herein we describe the preparation of a fluorescent derivative of simplexide, labeled at position 6 of the distal glucose with a dansyl group, as a probe for future studies on the mechanism by which simplexide affects the immune system. Fluorescent simplexide was prepared from a 6”-amino functionalized compound, which in turn was obtained through a highly efficient glycosylation between the preformed activated disaccharide and the long chain secondary alc. 18-pentatriacontanol.

Carbohydrate Research published new progress about Fluorescent indicators. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Application In Synthesis of 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Perez, Maria published the artcileSynthesis of novel glycoconjugates and evaluation as inhibitors against β-glucosidase from almond, SDS of cas: 2595-07-5, the main research area is hydrolase glucosidase inhibition glycoside glycoconjugate preparation disaccharide structure activity; amino glycoside disaccharide preparation glucosidase inhibitor glycoconjugate glucosaminide lactose.

Hydrolytic activity of glycosidases can be influenced by inhibitors of glycosidic nature. We have synthesized glycoconjugates consisting of galactose, glucosaminide or lactose 1-O-linked with allyl alc., pentenol or tetra-ethylene-glycol moieties. These compounds were found to be inhibitors of the hydrolase activity of the β-glucosidase from almond, with Ki in the range of 7.7-107 mM and presenting different types of inhibition. Based on the structure of the functionalized glycosides and the inhibition studies performed, we suggest that the nature of the carbohydrate is determinant in the inhibitory strength of these glycoconjugates.

Journal of Molecular Catalysis B: Enzymatic published new progress about Disaccharides Role: BSU (Biological Study, Unclassified), RCT (Reactant), SPN (Synthetic Preparation), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation). 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, SDS of cas: 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Yu-Ya A. published the artcileOlefin Cross-Metathesis on Proteins: Investigation of Allylic Chalcogen Effects and Guiding Principles in Metathesis Partner Selection, Synthetic Route of 2595-07-5, the main research area is olefin cross metathesis protein allylic chalcogen.

Olefin metathesis has recently emerged as a viable reaction for chem. protein modification. The scope and limitations of olefin metathesis in bioconjugation, however, remain unclear. Herein the authors report an assessment of various factors that contribute to productive cross-metathesis on protein substrates. Sterics, substrate scope, and linker selection are all considered. It was discovered during this investigation that allyl chalcogenides generally enhance the rate of alkene metathesis reactions. Allyl selenides were exceptionally reactive olefin metathesis substrates, enabling a broad range of protein modifications not previously possible. The principles considered in this report are important not only for expanding the repertoire of bioconjugation but also for the application of olefin metathesis in general synthetic endeavors.

Journal of the American Chemical Society published new progress about Bacillus lentus. 2595-07-5 belongs to class alcohols-buliding-blocks, name is (2R,3R,4S,5R,6R)-2-(Allyloxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C9H16O6, Synthetic Route of 2595-07-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts