Category: 2566-44-1

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2566-44-1, name is 2-Cyclopropylethanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H10O

To a solution of triphosgene (68 mg, 0.23 mmol) in dichloromethane (0.5 mL) was added 2-cyclopropylethanol (69 mg, 0.80 mmol). After the solution was stirred for 45 min at ambient temperature N,N-diisopropyl ethyl amine (156 mul, 0.912 mmol) and rac-{4-[(3S,4R)-3-(3,4-dichloro-phenyl)-4-methylamino-pyrrolidine-1-carbonyl]-piperidin-1-yl}-(1-methyl-cyclopropyl)-methanone (50 mg, 0.11 mmol) were added and the solution was stirred for 3 d at ambient temperature. It was diluted with ethyl acetate (15 mL) and washed with aqueous sodium carbonate (1 M, 15 mL) and brine (15 mL). The aqueous layers were extracted with ethyl acetate, dried over sodium sulfate and concentrated. Purification by chromatography (SiO2, ethyl acetate_methanol=100:0 to 80:20) afforded the title compound (59 mg, 94%) as an off-white foam. MS m/e: 550.3 [M]+.

With the rapid development of chemical substances, we look forward to future research findings about 2566-44-1.

Reference:
Patent; Knust, Henner; Koblet, Andreas; Nettekoven, Matthias; Ratni, Hasane; Riemer, Claus; Vifian, Walter; US2011/144081; (2011); A1;,
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Related Products of 2566-44-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.

a) 500 mg (2.01 mmol) 6-Hydroxy-3,4-dihydro-1 H-isoquinoline-2-carboxylicacid tertbutyl ester, 173 mg (2.01 mmol) 2-cyclopropylethanol and 526 mg (2.01 mmol) triphenylphosphine in 5 mL THF are stirred at 000 under inert gas atmosphere. Then420 iL (2.01 mmol) diisopropylazodicarboxylate are added slowly and the reaction mixture is stirred at r.t. over night. After that time, the reaction mixture is filtered, concentrated and the residue purified by H PLC. 019 H27 N 03ES I-MSR (H PLC):(M = 317.4g/mol) 318 [M+H]1.12 mm (method A)

Statistics shows that 2566-44-1 is playing an increasingly important role. we look forward to future research findings about 2-Cyclopropylethanol.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ROTH, Gerald Juergen; FLECK, Martin; HAEBEL, Peter Wilhelm; HEIMANN, Annekatrin; HEINE, Niklas; (172 pag.)WO2016/41845; (2016); A1;,
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Adding a certain compound to certain chemical reactions, such as: 2566-44-1, 2-Cyclopropylethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C5H10O, blongs to alcohols-buliding-blocks compound. Formula: C5H10O

A mixture of 2-cyclopropyl-ethanol (4.1 g) and DME (15 mL) under argon was treated with NaH (60% in mineral oil, 0.45 g). After 4 hours 5-bromo-2-fluoro-pyridine (3.0 g) was added at 000. After 4 hours at room temperature, the mixture was distributed between water and EA. The organic phase was washed twice (water), dried (Na2SO4) and concentrated. The residue was purified by chromatography (Si02 EA/heptane 1:4) to provide the subtitle compound. MS ESI: mlz = 242 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2566-44-1, 2-Cyclopropylethanol, and friends who are interested can also refer to it.

Reference:
Patent; SANOFI; SCHWINK, Lothar; BUNING, Christian; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; HALLAND, Nis; LOHMANN, Matthias; POeVERLEIN, Christoph; RITTER, Kurt; WO2015/150565; (2015); A1;,
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2566-44-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2566-44-1, name is 2-Cyclopropylethanol. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of 3-((1R,5S,9r)-3-(2-cyclopropylethyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride To a solution of 2-cyclopropylethanol (0.21 g, 2.41 mmol) in dichloromethane (40 mL) was added silica (3 g), followed by pyridinium chlorochromate (0.52 g, 2.41 mmol). After 2 h of stirring the reaction mixture was filtered through a plug of silica and the desired aldehyde eluted with dichloromethane. The collected dichloromethane solution was concentrated to 30 mL and 3-((1R,5S,9r)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride (0.25 g, 0.80 mmol) added. To the resulting suspension was then added triethylamine (0.33 mL, 2.41 mmol) and sodium triacetoxyborohydride (0.51 g, 2.41 mmol) and the reaction mixture stirred for 3 hours. Concentrated aqueous ammonia was added and the mixture was extracted with dichloromethane (*3). The combined organic phases were concentrated and purified by reverse phase chromatography (C18) to give 3-((1R,5S,9r)-3-(2-cyclopropylethyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide (0.17 g, 62% yield). 2.0 M HCl in diethyl ether (0.25 mL, 0.50 mmol) was added to a solution of 3-((1R,5S,9r)-3-(2-cyclopropylethyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide (0.17 g, 0.50 mmol) in dichloromethane (5 mL) and then the volatiles removed. The residue was freeze-dried from water to give 3-((1R,5S,9r)-3-(2-cyclopropylethyl)-9-methoxy-3-azabicyclo[3.3.1]nonan-9-yl)benzamide hydrochloride (0.10 g, 55%)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 2566-44-1, 2-Cyclopropylethanol.

Reference:
Patent; Alkermes, Inc.; Wynn, Thomas Andrew; Alvarez, Juan C.; Moustakas, Demetri Theodore; Haeberlein, Markus; Pennington, Lewis D.; US2019/241524; (2019); A1;,
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