Category: 25574-11-2

Synthetic Route of 25574-11-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3-(4-bromophenyl)propanol (8.15 g, 37.9 mmol), potassium acetate (11.2 g, 113.7 mmol), bis(pinacolato)diboron (10.6 g, 41.7 mmol), dimethyl sulfoxide (150 mL) and 1, l ‘-bis(diphenyl-phosphino) ferroncene-palladium dichloride dichloromethane complex (1:1) (1.55 g, 1.89 mmol) was heated at 800C under nitrogen overnight. Upon cooling, the reaction mixture was poured into water (-300 mL), and the product was extracted with Et2O-hexanes (1:1) (3x300mL). The combined organic extracts were washed with water (~300 mL), brine, dried (Na2SO4) and concentrated to afford 3-[4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl]propanol, which was used without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 25574-11-2, 3-(4-Bromophenyl)propan-1-ol.

Reference:
Patent; MERCK & CO., INC.; WO2008/51405; (2008); A1;,
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Reference of 25574-11-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol, molecular formula is C9H11BrO, molecular weight is 215.087, as common compound, the synthetic route is as follows.

Under a nitrogen atmosphere, DPPA (diphenylphosphoryl azide) (2 eq) and l,8-Diazabicycloundec-7-ene (DBU) (2 eq) were subsequently added to a cooled (0 C) solution of the corresponding alcohol (4) (1 eq) in dry Nu,Nu’- dimethylformamide (0.4 M). After 0.5 h. NaN3 (2 eq) was added and the reaction mixture was heated for 3 h. at 100 C. After cooling to room temperature, the reaction was worked up by dilution with water and extraction with diethyl ether (x5). The combined organic layers were washed with water (x2), brine (xl), dried over sodium sulfate and concentrated in vacuo. Finally the crude material was purified by column chromatography to give the desired azide 3-(l-(8-azidooctyl)-lH-l,2,3-triazol-4-yl)pyridine ; The title compound was prepared from (54) according to the general procedure of example 5, but the reaction mixture was heated to 50 C for 24 h. The crude material was purified by column chromatography using PE/EtOAc 98:2 as eluant, to give a colorless oil; yield 79%; IR (KBr) 2941, 2097, 1488, 1254, 1072, 1011, 831, 795 cm”1; 1H- MR (300 MHz, CDC13) delta 7.41 (dd, J = 6.4/1.8 Hz, 2-H), 7.06 (dd, J = 6.4/1.8 Hz, 2-H), 3.28 (t, J= 6.7 Hz, 2-H), 2.66 (t, J = 7.3 Hz, 2-H), 1.88(quint, J = 6.7 Hz, 2-H) ppm; 1 C-NMR (75 MHz, CDC13) delta 139.9, 131.7, 130.3, 120.0, 50.6, 32.2, 30.4 ppm.

The chemical industry reduces the impact on the environment during synthesis 25574-11-2, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE “AMEDEO AVOGADRO”; GENAZZANI, Armando A.; TRON, Gian Cesare; GALLI, Ubaldina; TRAVELLI, Cristina; CUZZOCREA, Salvatore; GROSA, Giorgio; SORBA, Giovanni; CANONICO, Pier Luigi; WO2014/178001; (2014); A1;,
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Adding a certain compound to certain chemical reactions, such as: 25574-11-2, 3-(4-Bromophenyl)propan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C9H11BrO, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C9H11BrO

Reference Example 1 4-(3-Benzyloxypropyl)bromobenzene A suspension of sodium hydride (60%, 0.97 g), 3-(4-bromophenyl)-1-propanol (1.0 g) and benzyl bromide (0.69 ML) in benzene (24 ML) was stirred under reflux for 7 hours.. After cooling to room temperature, a saturated aqueous ammonium chloride solution (50ML) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (100 ML).. The organic layer was washed with water (40 ML) and brine (40 ML) and dried over anhydrous sodium sulfate.. The solvent was removed under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 20/1) to give 4-(3-benzyloxypropyl)bromobenzene (1.4 g).1H-NMR (CDCl3) delta ppm: 1.85-2.00 (2H, m), 2.60-2.75 (2H, m), 3.47 (2H, t, J=6.2Hz), 4.50 (2H, s), 7.00-7.10 (2H, m), 7.20-7.45 (7H, m)

The synthetic route of 25574-11-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kissei Pharmaceutical Co., Ltd.; EP1367060; (2003); A1;,
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