Category: 25392-41-0

Adding a certain compound to certain chemical reactions, such as: 25392-41-0, 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

Reference Example 2Synthesis of ( 6-hydroxy-l-benzofuran-3-yl) acetic acid (lR)-l- phenylethylamine salt; 0381][0382]Sodium hydroxide (135 g) was dissolved in water (830 mL) to prepare a 14% aqueous sodium hydroxide solution. To a solution (623 mL) of 4- (chloromethyl ) -7-hydroxy-2H-chromen-2- one (254 g) in water was added the above-mentioned 14% aqueous sodium hydroxide solution at 5C, and the mixture was stirred at 25C for 1 hr and at 60C for 4 hr. The concentratedhydrochloric acid (270 mL) was added at 35C, a seed crystal was added, and the reaction mixture was stirred at 35C for 1 hr and at 5C for 1 hr. The precipitated crystals werecollected by filtration, washed with water (123 mL) , and dried at 60C under reduced pressure. To the crystals was added ethyl acetate (1.9 L) , and the mixture was stirred at room temperature for 1 hr. After filtration, the insoluble material was washed with ethyl acetate (144 mL) . To the filtrate was added activated carbon (16.5 g) , and the mixture was stirred at 25C for 1 hr and filtered again. The filtrate wasconcentrated and dried under reduced pressure to give (6- hydroxy-l-benzofuran-3-yl) acetic acid (146 g) . (6-Hydroxy-l- benzofuran-3-yl) acetic acid (130 g) was dissolved in methanol (270 mL) , a solution of (1R) -1-phenylethylamine (82 g) in methanol (90 mL) was added at 60C, and diisopropyl ether (3.6 L) was added at 55C. After stirring at 25C for 2 hr, the precipitated solid was collected by filtration. The obtained solid was washed with a mixed solvent (445 mL) of methanol- diisopropyl ether (1:9), and dried at 50C under reducedpressure to give the title compound (198 g) as white crystals. *H NMR (500 MHz, DMSO-d6) : delta 1.28-1.38 (m, 3H) , 3.38-3.50 (m, 2H) , 4.06-4.17 (m, 1H) , 6.72 (dd, 1H, J = 8.5, 2.2 Hz), 6.86 (d, 1H, J = 1.9 Hz), 7.21-7.29 (m, 1H) , 7.29-7.38 (m, 3H) , 7.38-7.44 (m, 2H) , 7.56-7.63 (m, 1H) . (protons derived from NH, OH and COOH were not detected)

The synthetic route of 25392-41-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YAMANO, Mitsuhisa; GOTO, Mitsutaka; KAJIWARA, Takeshi; MAEDA, Hiroyuki; KONISHI, Takahiro; SERA, Misayo; KONDO, Yuichiro; YAMASAKI, Seiji; WO2012/111849; (2012); A1;,
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Synthetic Route of 25392-41-0, Adding some certain compound to certain chemical reactions, such as: 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one,molecular formula is C10H7ClO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25392-41-0.

Take the above crude product (2g, 9.50mmol) in a 200ml single-necked flask.Add 1N NaOH solution (100ml),The solution immediately turns thick yellow,The above solution was placed in an oil bath and heated at reflux for 2 h.After the reaction,Cool to room temperatureThe pH was adjusted to 2-3 with concentrated sulfuric acid, and the resulting solution was extracted with ethyl acetate (30 ml x 4).Combine the organic phase,Wash with saturated brine (20ml x 2)Drying with anhydrous sodium sulfate,filter,The filtrate was evaporated under reduced pressure to give a tan brown columnar crystal of 1.3 g, and the crude yield was 71.2%.The above crude product (1 g, 5.20 mmol) was suspended in 10 ml of methanol.0.5ml concentrated sulfuric acid was added dropwiseAfter dripping, the temperature is increased to reflux for about 4 hours.After the reaction,Remove methanol under reduced pressureThe residual liquid is poured into 30 ml of water,Extract with ethyl acetate (20ml×3)Combine the organic phase,Wash with saturated sodium bicarbonate solution (15ml×2)Saturated brine (15ml x 2) washes,Drying with anhydrous sodium sulfate,filter,The filtrate was evaporated under reduced pressure to give a tan oil.Column chromatography (petroleum ether/ethyl acetate, 80:20, v/v) gave 0.75 g of a pale yellow solid in 70% yield.

According to the analysis of related databases, 25392-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Pharmaceutical University; Huang Wenlong; Qian Hai; Li Zheng; Wang Xuekun; Jiao Lei; Qiu Qianqian; (29 pag.)CN105017242; (2018); B;,
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Adding a certain compound to certain chemical reactions, such as: 25392-41-0, 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

The crude product (2 g, 9.50 mmol) in 200 mL single neck flask, adding 1 n naoh (100ml) the concentrated solution immediately turned yellow, and the solution was placed in an oil bath and heated to reflux for 2 h, and after the reaction, cooling to room temperature, with concentrated sulfuric acid to adjust the pH to 2 -3, and the resulting solution with ethyl acetate (30 ml × 4) the extraction, combining the organic phase with saturated saline (20 ml × 2, washed, dried over anhydrous sodium sulfate, filtered Solvent, the filtrate is evaporated under reduced pressure to obtain gray-brown columnar crystalline 1.3 g, the crude yield 71.2% of the crude product (1 g, 5.20 mmol) suspended in 10 mL of methanol and added dropwise 0 5 Ml of concentrated sulfuric acid, after dropping, heating under reflux to react for about 4 h, after the reaction, the methanol was removed under reduced pressure, the residual liquid is poured into 30 ml of water, in ethyl acetate (20 ml × 3) extraction, combining the organic phase with saturated sodium bicarbonate solution (15 mL × 2) washing, saturated brine (15 mL × 2, washed, dried over anhydrous sodium sulfate, filtered, the filtrate is decompressed and evaporated to obtain an yellow-brown oil, column chromatography (petroleum ether/ethyl acetate, 80: 20 Purification, v/v) to obtain light yellow solid 0.75 g, 70% yield

At the same time, in my other blogs, there are other synthetic methods of this type of compound,25392-41-0, 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one, and friends who are interested can also refer to it.

Reference:
Patent; ChinaPharmaceutical University; Huang, Wenlong; QIAN, Hai; Li, Zheng; YANG, Jianyong; Su, Xin; Pan, MiaoBo; (22 pag.)CN105566267; (2016); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 25392-41-0

Sodium hydroxide (1.35 g, 34 mmol) was dissolved in water (8 mL), under ice bath was slowly added 4-(chloromethyl) -7-hydroxy-2H-benzopyran-2-one (2.5 g, 12 mmol) in water (6 mL). The mixture was stirred at room temperature for 1 hour and then reacted at 60 C for 4 hours. Concentrated hydrochloric acid (2.8 mL, 34 mmol) was added at 35 C, maintained at the temperature for 1 hour, then stirred at room temperature for 1 hour. The resulting solid was suction filtered and washed three times with water. The solid was dried to give the product as a white solid (1.2 g, 52% yield).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 25392-41-0, 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one.

Reference:
Patent; Shandong Xuanzhu Pharma Co., Ltd.; Wu, Yongqian; (37 pag.)CN104250239; (2016); B;,
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Synthetic Route of 25392-41-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. This compound has unique chemical properties. The synthetic route is as follows.

4-Chloromethylcoumarin 12c (2.1g, 10mmol) was dissolved in dry DMF (35mL) and then Cs2CO3 (3.9g, 12mmol) was added followed by 3-chlorobenzyl bromide (1.3mL, 10mmol) after 15min of stirring. The mixture was stirred at room temperature for 24h and then poured onto crushed ice. The resulting solid was filtered, washed several times with hot water and crystallized from CHCl3/n-hexane yielding the desired product. Yield: 87%. Spectroscopic and analytical data are in full agreement with those reported in the literature [39].

According to the analysis of related databases, 25392-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Pisani, Leonardo; Catto, Marco; Nicolotti, Orazio; Grossi, Giancarlo; Di Braccio, Mario; Soto-Otero, Ramon; Mendez-Alvarez, Estefania; Stefanachi, Angela; Gadaleta, Domenico; Carotti, Angelo; European Journal of Medicinal Chemistry; vol. 70; (2013); p. 723 – 739;,
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Electric Literature of 25392-41-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. A new synthetic method of this compound is introduced below.

Reference Example 29; (6-hydroxy-l-benzofuran-3-yl) acetic acid; 4- (Chloromethyl)-7-hydroxy-2H-chromen-2-one (10.9 g, 51.8 mmol) was dissolved in 1 M aqueous sodium hydroxide solution (500 mL) , and the mixture was heated under reflux for 2 hr.The reaction mixture was allowed to cool, acidified with concentrated sulfuric acid, and extracted with ethyl acetate.The extract was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (8.27 g, yield 83%) as brown crystals .MS m/z 193 (M + H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/1931; (2008); A2;,
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Reference of 25392-41-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one. A new synthetic method of this compound is introduced below.

Coumarin 1 (1.77 g, 6.48 mmol) was suspended in 2 M NaOH(37 mL) and stirred at 80 C for 18 h. The resulting suspension was cooled to room temperature andacidified with concentrated hydrochloric acid to pH 1. The white precipitate was collected by vacuumfiltration and dried under reduced pressure (1.63 g, 99%); mp 154-156 C (lit. 156-157 C) [28]. H(500 MHz, DMSO-d6) 7.90 (1H, s, ArH), 7.86 (1H, s, ArH), 7.56 (1H, d, J = 8.0 Hz, ArH), 7.42 (1H, d,J = 8.25 Hz, ArH), 3.68 (2H, s, CH2). C (100 MHz, DMSO-d6) 172.2 (Cq), 155.4 (Cq), 144.8, 127.7 (Cq),126.2, 122.3, 117.3 (Cq), 114.9, 114.7 (Cq), 29.3 (CH2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25392-41-0, its application will become more common.

Reference:
Article; Duncan, Luke F.; Wang, Geqing; Ilyichova, Olga V.; Scanlon, Martin J.; Heras, Begona; Abbott, Belinda M.; Molecules; vol. 24; 20; (2019);,
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