Category: 2525-05-5

In 1966,Polimery (Warsaw, Poland) included an article by Mleziva, Josef. Formula: C10H14O2. The article was titled 《Inhibitors of the copolymerization of unsaturated polyester resins》. The information in the text is summarized as follows:

The effect of 32 inhibitors (p-quinones, hydroquinones, pyrocatechols, pyrogallols, and naphthols) was studied in 3 polymerization mixture (fumaric acid in %, maleic acid in %, modifying acid, glycol and telomerization agent given): (mixture A) 29.1, 1.7, phthalic acid (I), ethylene glycol (II), methylcyclohexanol (III); (mixture B) 21.1, 1.3, I, II, III; (mixture C) 24.3, 2.1, adipic acid, diethylene glycol, -. The polyesters had 51, 49.4, and 30.8 acid number, resp. The polymerization was performed at 20° in the dark, in sunlight, in regular lamp light, or at 110° and then the polyesters were cured at 20° in presence of 3% methylcyclohexanol peroxide and 1% Co naphthenate. Best results were obtained with 2,5-dichloro-p-benzoquinone.4-Butylbenzene-1,2-diol(cas: 2525-05-5Formula: C10H14O2) was used in this study.

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Formula: C10H14O2 Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Inhibition of the autoxidation of fats and oils. IX. Antioxidant activity of some 4-alkylcatechols》 was published in Nippon Nogei Kagaku Kaishi in 1954. These research results belong to Tamura, Saburo; Okubo, Hide; Kaneta, Hiroshi. Computed Properties of C10H14O2 The article mentions the following:

cf. C.A. 50, 6403b. 4-Alkylcatechols, 1,2,4-(HO)2C6H3R (I), were synthesized and studied for the relationship between the antioxidant property and chem. structure. Veratrole (20 g.) and 13 g. Ac2O in PhNO2 with 26 g. AlCl3 below 0° gave 19 g. 4-acetylveratrole, b15 170-5°, 13 g. of which was hydrogenated with 40 g. Zn amalgam to 6 g. 4-ethylveratrole, b55 150°, which was demethylated with HI to 60% I (R = Et) (II), b9 130-2°. Similar processes gave: I (R = Bu) (III), b5 143-8°, m. 42-3°, from 4-butylveratrole, b8 128-35° (prepared from 4-butyroylveratrole, b9 175°, m. 52-3°); I (R = hexyl) (IV), b5 164-70°, from 4-hexylveratrole, b11 155-60° (prepared from 4-hexanoylveratrole, b17 176-8°); I (R = decyl) (V), m. 73-4°, from 4-decylveratrole, m. 25-6° (prepared from 4-decanoylveratrole, m. 60-1°); and I (R = dodecyl) (VI), m. 75-6°, from 4-dodecylveratrole, m. 39-40° (prepared from 4-dodecanoylveratrole, m. 57°). Guaiacol propionate, b8 115-18°, prepared from guaiacol and propionic acid in the presence of SOCl2, was treated with AlCl3 and CS2 to obtain 4-propionylguaiacol, b15 182-7°, which was converted to 4-propylguaiacol, b15 130-6°, and then to I (R = Pr) (VII), b12 155-7°. Other I were prepared from catechol esters: 4-valeroylcatechol, b10 245-55°, gave I (R = pentyl) (VIII), b7 155-60°; and 4-octanoylcatechol, b4 210-20°, gave I (R = octyl) (IX), b5 175-80°. The relative antioxidant activity was expressed as in Part V (C.A. 50, 6402b). At 0.01% on a molar basis, the results by the active O method (hrs.) and the inhibitor ratio, resp., were: lard (no antioxidant), 4.5, -; dihydronorguaiaretic acid (IXa), 28.0, 0.53; catechol, 26.0, 0.48; II, 61.0, 1.25 (the most active); VII, 52.0, 1.07; III, 51.0, 1.05; VIII, 48.0, 0.98; IV, 47.0, 0.96; IX, 40.5, 0.81; V, 50.0, 1.00; VI, 42.0, 0.84; propionylcatechol, 8.0, 0.05; and dodecanoylcatechol, 8.0, 0.08. However, most of these alkylcatechols were apt to produce eczema on human skin and discolored the product. In the experiment, the researchers used many compounds, for example, 4-Butylbenzene-1,2-diol(cas: 2525-05-5Computed Properties of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Computed Properties of C10H14O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Inhibition of the autoxidation of fats and oils. X. Antioxidant activity of some catechol derivatives for vitamin A in fish-liver oil》 were Tamura, Saburo; Okuma, Kazuhiko; Okubo, Hide. And the article was published in Nippon Nogei Kagaku Kaishi in 1954. Reference of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:

A com. product consisting of liver oils from cods and sharks containing about 36,000 international units of vitamin A/g. oil served as the substrate. The antioxidant activity was expressed by the stability (number of days required for 50% loss of vitamin A in the liver oil) and the inhibitor ratio defined as (Lx-Lc)/(Ls-Lc), where Lc is the stability of liver oil in the absence of antioxidant, Ls the stability of the oil treated with the standard antioxidant, IXa, Lx the stability of the oil treated with the test antioxidant. The inhibitor ratio for 0.05 and 0.10%, resp., was as follows: Et gallate, 0.70, 0.98; Et 4-(3,4-dihydroxyphenyl)butyrate, 0.63, 0.77; Me 6-(3,4-dihydroxyphenyl)hexanoate, 0.67, 0.77; [3,4-(HO)2C6H3]2(CH2)n (A) (n = 3), 0.83, 1.00; A (n = 4), 1.42, 1.40; A (n = 5), 1.17, 1.21; A (n = 6), 1.17, 1.21; A (n = 9), 0.88, 0.91; A (n = 10), 0.88, 1.00; II, 1.08, 1.12; VII, 1.08, 0.98; and III, 0.75, 0.81.4-Butylbenzene-1,2-diol(cas: 2525-05-5Reference of 4-Butylbenzene-1,2-diol) was used in this study.

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Reference of 4-Butylbenzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application In Synthesis of 4-Butylbenzene-1,2-diolOn November 15, 1990 ,《Stimulatory effect of 4-alkylcatechols and their diacetylated derivatives on the synthesis of nerve growth factor》 appeared in Biochemical Pharmacology. The author of the article were Furukawa, Yoshiko; Fukazawa, Nobuyuki; Miyama, Yukio; Hayashi, Kyozo; Furukawa, Shoei. The article conveys some information:

A series of 4-alkylcatechols and 1,2-diacetoxy-4-alkylbenzenes (Me to Bu) were synthesized for in vitro evaluation as stimulators of nerve growth factor (NGF) synthesis. All compounds were potent in stimulating NGF synthesis in L-M cells (a mouse fibroblast cell line) and mouse astroglial cells. In a series of 4-alkylcatechols, 4-methylcatechol and 4-ethylcatechol severely affected viability and cell adhesive properties. In a series of 1,2-diacetoxy-4-alkylbenzenes, the concentrations required for the maximal effect and the effective ranges of concentrations were higher than those in the 4-alkylcatechol series, and the cell adhesive properties or viabilities were not affected. Evidence is also presented to indicate that the elevation of NGF synthesis by these compounds was not associated with the cell growth. In addition to this study using 4-Butylbenzene-1,2-diol, there are many other studies that have used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Application In Synthesis of 4-Butylbenzene-1,2-diol) was used in this study.

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Application In Synthesis of 4-Butylbenzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 1954,Nippon Nogei Kagaku Kaishi included an article by Okuma, Kazuhiko; Tamura, Saburo. COA of Formula: C10H14O2. The article was titled 《Inhibition of the autoxidation of fats and oils. XI. Syntheses of some ω-(2,5-dihydroxyphenyl)alkanoic esters and ω,ω’-bis(2,5-dihydroxyphenyl)alkanes》. The information in the text is summarized as follows:

Since hydroquinone derivatives seemed to have generally higher antioxidant activity than catechol derivatives, the 2,5-dihydroxyphenyl derivatives rather than 3,4-dihydroxyphenyl derivatives were synthesized as possible antioxidants. Me-γ-(2,5-dihydroxyphenyl)butyrate (X) was obtained by esterifying the corresponding free acid (XI). Fieser, et al. (C.A. 35, 889), could not prepare XI by demethylation of γ-(2,5-dimethoxyphenyl)butyric acid. This was presumed to be due to cyclization. β-(2,5-Dimethoxybenzoyl)propionic acid (XII), m. 101-2°, prepared according to F., et al. (loc. cit.), was demethylated with HI to β-(2,5-dihydroxybenzoyl)propionic acid (XIII), m. 180-2°, yellow columns in 81% yield. XIII was hydrogenated with Zn-Hg to XI, m. 131-2°, in low yield (1 g. from 20 g. XIII). XI (0.3 g.) refluxed with MeOH and H2SO4 gave 71.8% X, m. 66-7°, tabular crystals. XII (10 g.) demethylated with 13 g. AlCl3 and 100 cc. PhCl did not give XIII, but β-(2-hydroxy-5-methoxybenzoyl)propionic acid, m. 140° [the positions of OH and OMe in the benzene nucleus were not determined, but were assumed by analogy to the formation of 2-hydroxy-5-methoxy-β-chlorochalcone (Simonis and Danishevski, C.A. 21, 1255]). Hydroquinone di-Me ether (69 g.) with polymeric adipic anhydride, m. 75° (prepared from 73 g. adipic acid and 300 cc. Ac2O), in the presence of 140 g. AlCl3 gave 55 g. δ-(2,5-dimethoxybenzoyl)valeric acid, m. 78-80°, needles, 30 g. of which hydrogenated with 72 g. Zn amalgam gave 14.7 g. ε-(2,5-dimethoxyphenyl)hexanoic acid, b5 200-2°, m. 64-7°. This was demethylated with HI to give ε-(2,5-dihydroxyphenyl)hexanoic acid, m. 112-13° [m. 96.8-97.6°, by Fieser, et al. (loc. cit.), but the analysis conformed with the theoretical]. This was methylated to give Me ester, which could not be crystallized (analysis differed somewhat from the theoretical). Hydroquinone di-Me ether (30 g.) with 14.6 g. adipic acid and 25 cc. SOCl2 gave 12 g. 1,4-bis(2,5-dimethoxybenzoyl)butane, m. 105-6°, needles, 5 g. of which with 2.5 cc. 80% hydrazine hydrate gave 3.7 g. yellow 1,6-bis(2,5-dimethoxyphenyl)hexane. This was not purified, but was demethylated with HI to give 1,6-bis(2,5-dihydroxyphenyl)hexane, m. 159-60°, scales. Similarly, 1,10-bis(2,5-dihydroxyphenyl)decane, m. 148-50°, scales, was obtained in 46.3% yield by demethylation with HI of 1,10-bis(2,5-dimethoxyphenyl)decane, m. 76-8°, needles, in 56.2% yield from 1,8-bis(2,5-dimethoxybenzoyl)octane, m. 99-100°, needles, prepared from hydroquinone di-Me ether and sebacoyl chloride. The experimental process involved the reaction of 4-Butylbenzene-1,2-diol(cas: 2525-05-5COA of Formula: C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.COA of Formula: C10H14O2 Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Quantitative structure activity relationships of catechol derivatives on nerve growth factor secretion in L-M cells》 was written by Kourounakis, Angeliki; Bodor, Nicholas. Electric Literature of C10H14O2 And the article was included in Pharmaceutical Research on August 31 ,1995. The article conveys some information:

Although many catechol derivatives are potent stimulators of Nerve Growth Factor synthesis in L-M cells, not much is known about their mechanism of action. In order to obtain a Quant. Structure Activity Relationship (QSAR), AM1 quantum mech. calculations were performed on a group of 23 catechol derivatives with different levels of activity. A set of 18 parameters/descriptors were obtained by AM1 quantum mech. calculations for each catechol derivative Linear combinations of the calculated descriptors were fitted to the activity (as extracted from literature data) of the compounds by using simple or multiple regression anal. The results show that activity is associated with parameters related to the oxidation of the catechol derivatives, strongly supporting recent literature suggesting that an oxidative process is involved in their action. After reading the article, we found that the author used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Electric Literature of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Electric Literature of C10H14O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Some derivatives of catechol and pyrogallol. I》 were Haworth, Robert D.; Woodcock, David. And the article was published in Journal of the Chemical Society in 1946. Category: alcohols-buliding-blocks The author mentioned the following in the article:

In view of the vesicancy attributed to pyrocatechol (I) derivatives occurring in natural lacquers, a number of 3- and 4-acyl- and -alkyl-pyrocatechols and -pyrogallols containing C4 to C18 side chains have been synthesized and tested. 1,2,3-C6H3(OH)3 (1 mol.), 2.1 mols. aliphatic acid, and 1 mol. anhydrous ZnCl2 are heated 2 h. at 135-40°, the cooled mixture treated with dilute HCl, the product taken up in ether and, after washing with H2O, distilled at 0.5 mm.; the following 4-acylpyrogallols were thus prepared: butyryl, m. 90-1°, 60% (Hart and Woodruff, C.A. 30, 8186.8, give 101°); hexanoyl, m. 72-4°, 50% (H. and W., loc. cit., give 86°); octanoyl, m. 73-4°, 40%; hendecanoyl, m. 76-7°, 35%; dodecanoyl, m. 76-7°, 30%; tetradecanoyl, m. 82-4°, 25%; hexadecanoyl, m. 89-90°, 30%; octadecanoyl, m. 91-3°, 25%. Clemmensen reduction (1 part phenol, 5 parts amalgamated Zn, and 5 parts concentrated HCl refluxed 24 h.) gives 50-65% 4-alkylpyrogallols: octyl, m. 106-7°; nonyl, m. 109-10°; hendecyl, m. 110-11°; dodecyl, m. 109-10°; tetradecyl, m. 112-13°; hexadecyl, m. 116°; octadecyl, m. 114-15°. 4-Acylcatechols were prepared by heating equal weights of I, the acid, and anhydrous ZnCl2 at 135-40° for 2 h.: hendecanoyl, m. 105°, 15%; dodecanoyl, m. 97-8°, 20%; tetradecanoyl, m. 98-9°, 20%; hexadecanoyl, m. 99-100°, 10%; octadecanoyl, m. 100-1°, 10% (Rosenmund and Lohfert, C.A. 23, 2161, give 70°). In the preparation of 4-nonanoylcatechol (m. 92-3°, 40%), 1 mol. I diester, 1 mol. I, and 2 mols. AlCl3 in 20 mols. PhNO2 were heated 2 h. at 80-100°; for the preparation of 4-heptanoylcatechol (m. 93-4°, 50%; Miller, et al., C.A. 32, 1669.2, give 79°), 1 mol. I and 1.5 mols. AlCl3 in 20 parts CS2 were gradually treated with 1 mol. acid chloride, heated to 40-50°, the solvent removed, and the residue heated at 150° for 4 h. Because of the inaccessibility of the higher aliphatic acids with an odd number of C atoms, (MeO)2C6H3CHO was reacted with RMgX and the product dehydrated with KHSO4 at 180°; the following were obtained crystalline: 17-(3,4-dimethoxyphenyl)-1-heptadecene, m. 40-1°, 60%; 15-(2,3-dimethoxyphenyl)-1-pentadecene, b0.5 190°, m. 52°, 35%. Catalytic reduction (10% Pd-C in EtOH for 4-12 h.) yields 100% of 1-(3,4-dimethoxyphenyl)heptadecane, m. 53-4°, and 1-(2,3-dimethoxyphenyl)pentadecane, m. 34-6°. These compounds were demethylated with HI or HBr (3 conditions given). The following 4-alkylpyrocatechols were prepared by Clemmensen reduction: Bu, m. 39-41°; Am, m. 57-9°; heptyl, m. 65-7° (M., loc. cit., gives 40°); octyl, m. 57-8° (M. gives 40°); nonyl, m. 68°; hendecyl, m. 81-2°; dodecyl; m. 75-6°; tetradecyl, m. 65-7°; hexadecyl, m. 75-6°; octadecyl, m. 78-9°. The 3-alkylpyrocatechols were prepared by demethylation: Bu, m. 33-6°; Am, m. 34-5°; hexyl, m. 30-1°, heptyl, solid at 5°; octyl, b0.4 135-40°. None of the compounds produced vesication but several caused erythema. Pyrocatechols are more irritant than the corresponding pyrogallol derivatives In the 4-alkylpyrocatechol series, the members from Bu to octyl have approx. the same activity, which decreases with increasing length of side chain; in the 3-alkyl series, the optimum activity is found in the 3-heptyl derivative, but there is no pronounced difference in the activity of the 3- and 4-alkyl series. Acylpyrocatechols and -pyrogallols are completely inactive. The slight activity of 4-amylresorcinol suggests that the irritant properties are not limited to the I series. In the experiment, the researchers used 4-Butylbenzene-1,2-diol(cas: 2525-05-5Category: alcohols-buliding-blocks)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Category: alcohols-buliding-blocks Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Naito, Youichiro; Sugiura, Masanori; Yamaura, Yasunari; Fukaya, Chikara; Yokoyama, Kazumasa; Nakagawa, Yoshiaki; Ikeda, Tokuji; Senda, Mitsugi; Fujita, Toshio published an article in Chemical & Pharmaceutical Bulletin. The title of the article was 《Quantitative structure-activity relationship of catechol derivatives inhibiting 5-lipoxygenase》.Safety of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:

Various catechol derivatives (β-substituted 3,4-dihydroxystyrenes, 1-substituted 3,4-dihydroxybenzenes, and 6-substituted 2,3-dihydroxynaphthalenes) were synthesized and their inhibition of 5-lipoxygenase was assayed. Their structure-activity relationships were examined quant. with substituent and structural parameters and regression anal. The variations of the inhibitory activity were explained in bilinear hydrophobic parameter (log P) terms, and steric (mol. thickness) and electronic (1H-NMR chem. shift of the proton adjacent to the catechol group) parameter terms. The hydrophobicity of the inhibitor mol. was important, and the optimum value of log P was ∼4.3-4.6, beyond which inhibition did not increase further. A lower electron d. of the aromatic ring containing the catechol group and the greater thickness of the lipophilic side chains were unfavorable to the activity. The results added a physicochem. basis for the selection of candidate compounds for developmental studies. In the experimental materials used by the author, we found 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.Safety of 4-Butylbenzene-1,2-diol Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Antiseptics. IV. Alkylcatechols》 was published in Journal of the American Chemical Society in 1938. These research results belong to Miller, Ellis; Hartung, Walter H.; Rock, Henry J.; Crossley, Frank S.. Electric Literature of C10H14O2 The article mentions the following:

cf. C. A. 27, 1873. Catechol alkyl ketones were prepared by the Fries rearrangement of the appropriate ester of either catechol (method I) or of guaiacol (method II); in the latter case the reaction is accompanied by simultaneous demethylation. Full details are given of the technic for each method. Pr, m. 139° (II, 23-62% yield); Bu, m. 93-4° (I, 50%); iso-Bu, b4 200-10°, m. 106.5-7.5° (I, 69%); Am, m. 93.8° (I, 72%; II, 30-47%); iso-Am, m. 73-3.5° (I, 60%); hexyl, m. 78-9° (II, 8-17%); heptyl, b5 225°, m. 95.5-6° (I, 50%). In a few cases the 3-isomer, 1,2,3-(HO)2C6H3COR, was isolated in small quantity by fractional crystallization from C6H6, the 4-isomer being less soluble: Et, b5 182-7°, m. 102.5-3.5°; iso-Bu, m. 93-5°; iso-Am, b. 195-205°; heptyl, b4 210-20°, m. 87-8°. Catalytic reduction gives 4-alkylcatechols; Clemmensen reduction gives less satisfactory results. Bu, b5 143-7°, 75% yield, PhOH coefficient 29; Am, b7 158-9°, 86%; iso-Am, b6 155-60°, m. 55.5-8.5°, 70.5%; hexyl, b5 164-9°, PhOH coefficient 129; isohexyl, b5 161-4°; heptyl, b12 195-200°, m. 40°, PhOH coefficient 177; octyl, b5 178°, m. 40°. The experimental part of the paper was very detailed, including the reaction process of 4-Butylbenzene-1,2-diol(cas: 2525-05-5Electric Literature of C10H14O2)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Electric Literature of C10H14O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

SDS of cas: 2525-05-5On November 30, 2010 ,《The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors》 appeared in European Journal of Medicinal Chemistry. The author of the article were Xiao, Zhu-Ping; Ma, Tao-Wu; Fu, Wei-Chang; Peng, Xiao-Chun; Zhang, Ai-Hua; Zhu, Hai-Liang. The article conveys some information:

Some pyrogallol and catechol derivatives were synthesized, and their urease inhibitory activity was evaluated by using acetohydroxamic acid (AHA), a well known Helicobacter pylori urease inhibitor, as pos. control. The assay results indicate that many compounds showed potential inhibitory activity against H. pylori urease. 4-(4-Hydroxyphenethyl)phen-1,2-diol (I) was found to be the most potent urease inhibitor with IC50s of 1.5 ± 0.2 μM for extracted fraction and 4.2 ± 0.3 μM for intact cell, at least 10 times and 20 times lower than those of AHA (IC50 of 17.2 ± 0.9 μM, 100.6 ± 13 μM), resp. This finding indicates that I would be a potential urease inhibitor and deserves further research. Mol. dockings of I into H. pylori urease active site were performed to understand the observed activity. In the experiment, the researchers used many compounds, for example, 4-Butylbenzene-1,2-diol(cas: 2525-05-5SDS of cas: 2525-05-5)

4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry.SDS of cas: 2525-05-5 Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts