Category: 25240-59-9

Anaby, Aviel published the artcileB-H Bond Cleavage via Metal-Ligand Cooperation by Dearomatized Ruthenium Pincer Complexes, COA of Formula: C6H13BO3, the publication is Organometallics (2014), 33(14), 3716-3726, database is CAplus.

Organic derivatives of boronic acid are widely used reagents useful in various synthetic applications. A fundamental understanding and the exploration of new reaction pathways of boronic reagents with organometallic systems hold promise for useful advancement in chem. catalysis. Herein the authors present the reactions of simple boranes with dearomatized Ru pincer complexes based on PNP (2,6-bis(di-tert-butylphosphinomethyl)pyridine) or PNN (2-(di-tert-butylphosphinomethyl)-6-(diethylaminomethyl)pyridine) ligands. NMR studies revealed dehydrogenative addition of the borane B-H bond across the metal center and the ligand. Remarkably, new complexes were observed, which contain the boryl moiety at the benzylic C of the pincer ligand arm. X-ray crystal structures of new dearomatized boryl pincer complexes were obtained, and DFT calculations revealed mechanistic details of the adduct formation process through a dehydrogenative pathway. Catalytic aryl-boron coupling reactions were explored. The new boryl pincer systems may possibly be useful in future post-modification techniques for Ru pincer complexes, as well as in catalytic B-B and B-C coupling reactions.

Organometallics published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, COA of Formula: C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salomon, Marcel Ahijado published the artcileStepwise oxygenation of pinacolborane by a rhodiumperoxo complex: detection of an intermediate metal borate and perborate, Quality Control of 25240-59-9, the publication is Angewandte Chemie, International Edition (2008), 47(46), 8867-8871, database is CAplus and MEDLINE.

Acting as go-between: A Rh borate and perborate were identified as intermediates in the Rh-mediated oxygenation of pinacolborane (HBpin). The Rh(III)-peroxo complex reacts with the Lewis acidic B compound HBpin by O transfer from the Rh center to HBpin to give a Rh(I) species. The reaction sequence might play a crucial role in the homocoupling of boronic acid.

Angewandte Chemie, International Edition published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Quality Control of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuang, Yunyan published the artcileHydrogen Peroxide Inducible DNA Cross-Linking Agents: Targeted Anticancer Prodrugs, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2011), 133(48), 19278-19281, database is CAplus and MEDLINE.

The major concern for anticancer chemotherapeutic agents is the host toxicity. The development of anticancer prodrugs targeting the unique biochem. alterations in cancer cells is an attractive approach to achieve therapeutic activity and selectivity. We designed and synthesized a new type of nitrogen mustard prodrug that can be activated by high level of reactive oxygen species (ROS) found in cancer cells to release the active chemotherapy agent. The activation mechanism was determined by NMR anal. The activity and selectivity of these prodrugs toward ROS was determined by measuring DNA interstrand cross-links and/or DNA alkylations. These compounds showed 60-90% inhibition toward various cancer cells, while normal lymphocytes were not affected. To the best of our knowledge, this is the first example of H₂O₂-activated anticancer prodrugs.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Wenbing published the artcileReactive Oxygen Species (ROS) Inducible DNA Cross-Linking Agents and Their Effect on Cancer Cells and Normal Lymphocytes, Formula: C6H13BO3, the publication is Journal of Medicinal Chemistry (2014), 57(11), 4498-4510, database is CAplus and MEDLINE.

Reducing host toxicity is one of the main challenges of cancer chemotherapy. Many tumor cells contain high levels of ROS that make them distinctively different from normal cells. The authors report a series of ROS-activated aromatic nitrogen mustards that selectively kill chronic lymphocytic leukemia (CLL) over normal lymphocytes. These agents showed powerful DNA crosslinking abilities when coupled with H₂O₂, one of the most common ROS in cancer cells, whereas little DNA crosslinking was detected without H₂O₂. Consistent with chem. observation, in vitro cytotoxicity assay demonstrated that these agents induced 40-80% apoptosis in primary leukemic lymphocytes isolated from CLL patients but less than 25% cell death to normal lymphocytes from healthy donors. The IC₅₀ for the most potent compound (2) was âˆ? μM in CLL cells, while the IC₅₀ was not achieved in normal lymphocytes. Collectively, these data provide utility and selectivity of these agents that will inspire further and effective applications.

Journal of Medicinal Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Formula: C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

O’Brien, Luke published the artcileGold(I)-Catalyzed Nucleophilic Allylation of Azinium Ions with Allylboronates, Computed Properties of 25240-59-9, the publication is Angewandte Chemie, International Edition (2022), 61(22), e202202305, database is CAplus and MEDLINE.

Gold(I)-catalyzed nucleophilic allylations of pyridinium and quinolinium ions with various allyl pinacolboronates was reported. The reactions was completely selective with respect to the site of the azinium ion that was attacked, to give various functionalized 1,4-dihydropyridines and 1,4-dihydroquinolines. Evidence suggested that the reactions proceed through nucleophilic allylgold(I) intermediates formed by transmetalation from allylboronates. D. functional theory (DFT) calculations provided mechanistic insight.

Angewandte Chemie, International Edition published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Computed Properties of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Gracia Lux, Caroline published the artcileControlled degradation and release of polymer based nanoparticles, Quality Control of 25240-59-9, the publication is PMSE Preprints (2012), No pp. given, database is CAplus.

Polymer based nano and microparticles have recently received much interest for their ability both to encapsulate a therapeutic and release a payload on demand, in response to stimuli such as removal of a protecting group, pH, light and oxidative conditions. Upon exposure to specific conditions, these materials undergo reactions which degrade them in a very controlled manner. This paper presents controlled degradation and release studies from two new polymeric nanoparticles. First we use oxidative conditions to trigger the degradation of H₂O₂ bioresponsive polymeric nanoparticles. Then, using another approach, we exploit light sensitive end-cap groups to trigger the disassembly of a linear self-immolative material. Encapsulation of drugs could provide improved pharmacokinetics as they would be protected from the physiol. environment. Selected release could also allow lower drug loading through effective site delivery.

PMSE Preprints published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Quality Control of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts