Synthetic Route of 246232-73-5 ,Some common heterocyclic compound, 246232-73-5, molecular formula is C17H21NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Part II – Synthesis of 3-(tei”i-butyl-dimethyl-silanyloxy)-2-dibenzylamino-propan-l-ol [0317] 2-Dibenzylamino-propane-l ,3-diol (4.0 g, 15 mmol) and imidazole (1.8 g, 27 mmol) were combined in DMF (2.5 mL) and dichloromethane (100 mL). tert-Butyldimethylsilyl chloride (3.34 g, 22.1 mmol) was added and the reaction was stirred for one hour at room temperature. The reaction mixture was diluted with ethyl acetate and washed three times with water and brine, dried (Na2S04), concentrated, and purified by column chromatography (EtOAc/hexanes) to give 3-(tert-butyl-dimethyl-silanyloxy)-2-dibenzylamino-propan-l-ol. LCMS (ESI): calc. C23H35N02Si = 385; obs. M+H = 386.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 246232-73-5, 2-(Dibenzylamino)propane-1,3-diol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine; WO2013/169704; (2013); A2;,
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