Category: 2425-41-4

Electric Literature of 2425-41-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, molecular formula is C12H16O4, molecular weight is 224.25, as common compound, the synthetic route is as follows.

Example 1Compound 204, of which structure was shown above, was synthesized from monobenzalpentaerythritol (Compound A) known from literature [described in Org. Syntheses Coll., Vol. 4, 679 (1963)] as a starting material according to the following scheme. Two hydroxy groups of Compound A were condensed with phytanic acid by using a condensing agent, EDC (l-ethyl-3-(3-dimethylamino)propylcarbodiimide hydrochloride), to obtain a diester compound, Compound B [Jikken Kagaku Koza (Lecture of Experimental Chemistry), 4th edition, edited by the Chemical Society of Japan, Maruzen, Vol. 22, p.258]. The benzylidene group of Compound B was successively removed by catalytic reduction [Hanessian et al, Synthesis, 396 (1981)], and then one of the hydroxy groups was made into an oleic acid ester (Compound C). The other hydroxy group and 8-hydroxyoctanoic acid were condensed to convert the compound into an omega -hydroxy ester compound, Compound D204.

Statistics shows that 2425-41-4 is playing an increasingly important role. we look forward to future research findings about (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol.

Reference:
Patent; FUJIFILM CORPORATION; WO2007/72983; (2007); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

(8) A mixture of 2-phenyl-5,5-dihydroxymethyl-1,3-dioxane (2.2 g, 0.01 mol)4-nitrophthalonitrile (1.73 g, O. Olmol),Potassium carbonate (6.9 g, 0.05 mol)Add N, N-dimethylformamide, 50 mL; (9) The reaction was heated at 80 C for 12 hours;(10) After the reaction was stopped, the potassium carbonate was filtered off, the solvent was removed,Column chromatography using methanol / dichloromethane = 1/200 phase gave a white solid which was recrystallized from n-hexane / methylene chloride in a yield of 42%

With the rapid development of chemical substances, we look forward to future research findings about 2425-41-4.

Reference:
Patent; Shandong University , Weihai; BAI, MING; LU, RAN; WAN, PEIHONG; (8 pag.)CN104557949; (2016); B;,
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Adding a certain compound to certain chemical reactions, such as: 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2425-41-4, blongs to alcohols-buliding-blocks compound. Safety of (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

To a solution of (5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)methanol (0.66 g) in DMF (10 mL) was added NaH (0.12 g). The mixture was stirred at RT for 1 hr. To the mixture was added 2-{3-[4-(4-cyclopropylbenzyloxy)-3-methoxyphenyl]azetidine-1-carbonyl}pyridin-4-ylmethyl methanesulfonate (0.7 g) prepared in Example 1 (7). The reaction mixture was stirred at RT for 1 hr. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with water, and then dried over MgSO4. The solvent was removed under reduced pressure to give the crude title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2425-41-4, its application will become more common.

Reference:
Patent; JAPAN TOBACCO INC.; US2010/331301; (2010); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, the common compound, a new synthetic route is introduced below. Application In Synthesis of (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

Example 1A; 5,5′-Bis(octyloxymethyl)-2-phenyl-1 ,3-dioxane (1 a); 1a[00105] Sodium hydride (60% oil dispersion, washed with hexanes, 8.6 g, 0.22 mol, 2.0 5 eq) is added in portions slowly to a stirred solution of mono-O-benzylidenepentaerythritol (II, Scheme 1 , prepared by the method of Issidorides, C. H.; Gulen, R. C. Organic Syntheses Collected Volume IV, Rabjohn, N., Ed.; John Wiley and Sons: New York, 1963; pp 679-681) (24.11 g, 0.1076 mol) in dry DMF (600 ml_) under a nitrogen atmosphere. The stirred reaction mixture is cooled with an ice water bath for one hour,10 then 1-bromooctane (46.76 ml_, 51.90 g, 0.268 mol, 2.5 eq) is added dropwise over 2 h. After the reaction mixture has been stirred 12 h, another addition of sodium hydride (4.5 g, 0.11 mol, 1.0 eq) and 1-bromooctane (20 ml_, 0.11 mol, 1.0 eq) is made. If after the reaction mixture has been stirred a further 12 h, TLC shows that some mono-O-octyl product is present, another identical addition is made. When all of the mono-O-octyl15 derivative has been consumed, the reaction mixture is quenched by the addition of methanol dropwise until foaming ceases. The reaction mixture is filtered under vacuum and the reaction flask and filter are washed with dichloromethane (~150 ml_). The combined filtrate and washings are concentrated and the residue is extracted with hexanes (300 mL, then 200 ml_). The combined extracts are washed with water (10020 mL), dried (MgSO4) and concentrated under reduced pressure to an oily residue that is passed through a short silica gel column using hexanes, then 5% ethyl acetate/95% hexanes as eluents. The title compound (1a) is a colourless oil (44.71 g, 93 %): RF 0.46 (94 : 6, hexanes : ethyl acetate); 1H NMR (500.13 MHz) delta 0.88, 0.89 (2 t, 6H, J = 6.5 Hz, 2 x Me), 1.20-1.35 (br m, 2OH, 10 x CH2), 1.54, 1.57 (2 pentet, 4H, J = 6.8 Hz, 225 OCH2CH2), 3.22 (s, 2H, eq CCH2O), 3.35 (t, 2H, J = 6.5 Hz, eq octyl OCH2), 3.45 (t, 2H, J = 6.6 Hz, ax octyl OCH2), 3.71 (s, 2H, ax OCH2C), 3.88, 4.09 (2d, 4H, J = 11.5 Hz, H- 4,H-4′, H-6.H-6′), 5.42 (s, 1 H, acetal H), 7.31-7.49 (m, 5H, Ph); 13C NMR delta 138.5 (q Ph) , 128.8 (para Ph), 128.3 (2C, mPh), 126.1 (2C, oPh), 101.7 (acetal C), 71.8 (eq OCH2CH2), 71.7 (ax OCH2CH2), 70.8 (eq OCH2C), 70.2 (C-4 and C-6), 69.4 (ax OCH2C),30 38.9 (q C), 2 x 31.89 (CH2CH2CH3), 29.68, 29.54, 29.51 , 29.45, 2 x 29.34 (6 octyl CH2), 26.22, 26.19 (CH2CH2CH2O), 2 x 22.70 (CH2CH3), 14.3 (Me); MS ESI: CaIc for C28H49O4 449.3631 , found 449.2; calc for C28H48O4Na+ 471.35, found 471.3; calc for (C28H68O4)2Ca2+ 468.34, found 468.5; calc for C28H48O4K+ 487.32, found 487.3.

The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ST. FRANCIS XAVIER UNIVERSITY; MARANGONI, D. Gerrard; GRINDLEY, T. Bruce; JAHAN, Nusrat; PETROPOLIS, Christian; TRAN, Thomas; PAUL, Nawal; WO2010/48715; (2010); A1;,
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Reference of 2425-41-4 , The common heterocyclic compound, 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, molecular formula is C12H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

20 g of 60 wt% NaH (Mw = 24 ? 0, 0.5 mol) were dispersed in 200 mL of dry tetrahydrofuran. 44.8 g of 2- ((2-phenyl) -1,3-dioxocyclohexyl) -1,3-propanediol (Mw = 224.25, 0.2 mol) were dissolved in 400 mL of dry tetrahydrofuran and suspended in NaH at room temperature Liquid, 25-30 C after the addition was continued for 2 hours. Cooled to 10 C, 42.6mol dimethyl sulfate (0.45mol) was added dropwise, after completion of the reaction was continued at room temperature for 4 hours, the reaction was refluxed for 4 hours. The reaction was stopped and 100 mL of water was added dropwise. The organic phase is washed twice with water, dried and filtered. The solvent was distilled off and the residue was distilled under reduced pressure to obtain about 46.3 g of product, yield 92%.

The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sinopec Corporation; Sinopec Corporation Beijing Chemical Institute; Zhou Qilong; Zhang Rui; Song Weiwei; Tan Zhong; Xu Xiudong; Yan Lian; Li Fengkui; Yu Jinhua; Yin Shanshan; (14 pag.)CN104591979; (2016); B;,
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Adding a certain compound to certain chemical reactions, such as: 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, blongs to alcohols-buliding-blocks compound. name: (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol

The monobenzalpentaerythritol (5.00 g, 22.3 mmol), (3.5) 12G1-C02H (4b) (24.07 g, 49.05 mmol), and DPTS (5.90 g, 22.3 mmol) were dissolved in anhydrous CH2C12 (120 mL). DCC (1 1.96 g, 57.97 mmol) dissolved in anhydrous CH2C12 (20 mL) was added and the reaction was stirred for 12 h. at room temperature under nitrogen atmosphere. After the reaction was complete, the mixture was diluted, filtered, and rinsed with Et20. The solvent was removed and the crude product was purified by column chromatography (Si02, 5% Et20:hexane) and followed by precipitation in MeOH to give a white solid as a product: 25.29 g (97%). XH NMR (500 MHz, CDC13) delta 7.55 – 7.46 (m, 2H, PhH-3, 5), 7.41 – 7.34 (m, 3Eta, PhH-2, 4, 6), 7.12 (d, J= 2.3 Hz, 2H, ArH-2, 6), 7.1 1 (d, J= 2.2 Hz, 2H, ArH-2′, 6′), 6.64 (t, J= 2.2 Hz, 1H, ArH-4), 6.62 (t, J= 2.2 Hz, 1H, ArH-4′), 5.52 (s, 1Eta, CH-acetal), 4.82 (s, 2Eta, ArC02CH2), 4.33 (d, J= 11.8 Hz, 2H, 20CHaHb-ring), 4.26 (s, 2H, ArC02CH2), 4.03 (d, J= 11.8 Hz, 2H, 20CHaHb-ring), 3.98 – 3.90 (m, 8Eta, 4ArOCH2), 1.81 – 1.73 (m, 8Eta, 4ArOCH2CH2), 1.48 – 1.40 (m, 8Eta, 4ArOCH2CH2CH2), 1.26 (m, 64Eta, 4(CH2)8CH3), 0.88 (t, J= 6.9 Hz, 12H, 4CH3). 13C NMR (126 MHz, CDC13) delta 166.3 (C=0), 166.2 (C=0′), 160.4 (ArC-3, 5), 160.3 (ArC-3 ‘, 5’), 137.8 (PhC-1), 131.7 (PhC-3, 5), 131.2 (PhC-4), 129.4 (PhC-2, 6), 128.5 (ArC-1), 126.3 (ArC-1 ‘), 107.89 (ArC-2, 6), 107.85 (ArC-2′, 6′), 106.81 (ArC-4), 106.5 (ArC- 4′), 102.4 (CH-acetal), 69.9 (OC-ring), 68.52 (ArOCH2), 68.49 (ArOCH2′), 64.2 (ArC02CH2), 63.5 (ArC02CH2’), 38.0 (C(CH20)4), 32.1 (CH2CH2CH3), 29.82, 29.79, 29.76, 29.73, 29.6, 29.5, 29.3, 26.2 (ArOCH2CH2CH2), 22.8 (CH2CH3), 14.3 (CH3). The spectroscopic data of 16b are in agreement with those previously reported.

The synthetic route of 2425-41-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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Related Products of 2425-41-4 ,Some common heterocyclic compound, 2425-41-4, molecular formula is C12H16O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The monobenzalpentaerythritol, 12 (4.16 g, 18.5 mmol), (3.4) 12G1-C02H (4a) (20.00 g, 40.75 mmol), and DPTS (5.45 g, 18.5 mmol) were dissolved in anhydrous CH2C12 (100 mL). DCC (9.94 g, 48.2 mmol) dissolved in anhydrous CH2C12 (10 mL) was added and the reaction was stirred for 12 h at room temperature under nitrogen atmosphere. After the reaction was complete, the mixture was diluted, filtered, and rinsed with Et20. The solvent was removed and the crude product was purified by column chromatography (Si02, 10% Et20:hexane) and followed by precipitation in MeOH to give a white solid as a product: 21.18 g (98%). NMR (500 MHz, CDC13) delta 7.60 (m, 2H, 2ArH-6), 7.54 – 7.48 (m, 4Eta, 2ArH-2, PhH- 3, 5), 7.38 (m, 3Eta, 3PhH-2, 4, 6), 6.83 (overlapped d, 2Eta, 2ArH-5), 5.51 (s, 1Eta, CH-acetal), 4.81 (s, 2Eta, ArC02CH2), 4.32 (d, J= 1 1.7 Hz, 2H, 20CHaHb-ring), 4.25 (s, 2H, ArC02CH2), 4.07 – 3.98 (m, 10Eta, 4ArOCH2, 20CHaHb-ring), 1.87 – 1.78 (m, 8Eta, 4ArOCH2CH2), 1.51 – 1.43 (m, 8Eta, 4ArOCH2CH2CH2), 1.26 (m, 64Eta, 4(CH2)8CH3), 0.88 (t, J= 6.8 Hz, 12H, 4G). 13C NMR (126 MHz, CDC13) delta 166.0 (C=0), 165.9 (C=0′), 153.5 (ArC-4), 153.3 (ArC-4′), 148.6 (ArC-3), 148.51 (ArC-3′), 137.6 (PhC-1), 129.1 (PhC-3, 5), 128.3 (PhC-4), 126.1 (PhC-2, 6), 123.5 (ArC- 1), 123.4 (ArC-1 ‘), 122.0 (ArC-6), 121.5 (ArC-6′), H4.3 (ArC-2), 1 14.2 (ArC-2′), 11 1.84 (ArC- 5), 1 11.80 (ArC-5′), 102.2 (CH-acetal), 69.7 (OC-ring), 69.2 (ArOCH2), 69.0 (ArOCH2), 68.9 (ArOCH2′), 63.7 (ArC02CH2), 62.9 (ArC02CH2’), 37.73 (C(CH20)4), 31.8 (CH2CH2CH3), 29.62, 29.60, 29.57, 29.55, 29.52, 29.35, 29.30, 29.28, 29.1, 28.98, 28.96, 25.94 (ArOCH2CH2CH2), 25.88 (ArOCH2CH2CH2), 22.6 (CH2CH3), 14.0 (CH3). The spectroscopic data of 16a are in agreement with those previously reported.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PERCEC, Virgil; WO2014/190024; (2014); A1;,
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Electric Literature of 2425-41-4, Adding some certain compound to certain chemical reactions, such as: 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol,molecular formula is C12H16O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2425-41-4.

General procedure: Toa solution of (5-hydroxymethyl-2-phenyl-[1,3]dioxan-5-yl)methanol (0.66 g) inDMF (10 mL) was added NaH (0.12 g). The mixture was stirred at RT for 1 hr. Tothe mixture was added 2-{3-[4-(4-Cyclopropylbenzyloxy)-3-methoxyphenyl]-azetidine-1-carbonyl}pyridin-4-ylmethylmethanesulfonate (0.7 g). The reaction mixture was stirred at RT for 1 hr.Water was added to the reaction mixture and the mixture was extracted withethyl acetate. The organic layer was washed with water, and then dried overMgSO4. The solvent wasremoved under reduced pressure to give the crude title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ikegashira, Kazutaka; Ikenogami, Taku; Yamasaki, Takayuki; Oka, Takahiro; Hase, Yasunori; Miyagawa, Naoki; Inagaki, Koji; Kawahara, Iichiro; Koga, Yoshihisa; Hashimoto, Hiromasa; Bioorganic and Medicinal Chemistry Letters; vol. 29; 7; (2019); p. 873 – 877;,
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Reference of 2425-41-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, molecular formula is C12H16O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5109 (1 0.0 g, 44.6 mmol) in dichloromethane (180 ml) under argon were addedbromoacetonitrile (13.0 g, 108.4 mmol), Silver( I) oxide (20.7 g, 89.2 mmol), and tetrabutylammonium iodide (3.3 g, 8.92 mmol), and the resulting mixture was stirred overnight. The mixture was filtered overCelite, and the filtrate was evaporated to give a black residue, which was subjected to flash silica gelcolumn purification on ISCO companion (hexane/ethyl acetate, 15 – 90%) to give 5.55 g (41 %) of thedesired compound S127 as a viscous oil. ESI MS for C15H1sN204 calculated 302.3, observed [M+H]+ 303.3.

According to the analysis of related databases, 2425-41-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SOLSTICE BIOLOGICS, LTD.; SAKAMURI, Sukumar; BRADSHAW, Curt, W.; ELTEPU, Laxman; MEADE, Bryan, R.; LAM, Son; (237 pag.)WO2018/35380; (2018); A1;,
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Synthetic Route of 2425-41-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2425-41-4, name is (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol. A new synthetic method of this compound is introduced below.

under argon at 0 oC was added a solution of diol (S109, 4.92 g, 22.0 mmol) in THF (20 mL) dropwise; the resulting mixture was warmed to room temperature and stirred for 1h. The reaction mixture was cooled to 0 oC, a solution of propargyl bromide (18.6 g, 158.4 mmol) in THF (25 mL) was added slowly, and the resulting mixture was warmed to room temperature and stirred overnight at 40 oC. After the product was consumed, as observed by TLC, the reaction was quenched by dropwise addition of water at 0 oC, and the resulting mixture was extracted with dichloromethane (50 mL x 2). The combined organic layers were washed with brine and dried over anhydrous Na2SO4, filtered, and evaporated to give a residue, which was purified by flash silica gel column using ISCO companion (hexane/ethyl acetate, 0 – 30%) to give 5.92 g (89.5%) of compound S110 as an oil.1H NMR (500 MHz, CDCl3; ppm): d7.49-7.47 (dd, J 8.0, 1.5 Hz, 2H), 7.38-7.34 (m, 3H), 5.43 (s, 1H), 4.21 (d, J 2.5 Hz, 2H), 4.12 (t, J 2.5 Hz, 4H), 4.10 (s, 1H), 3.91 (s, 1H), 3.89 (s, 1H), 3.37 (s, 2H); ESI MS for C18H20O4 calculated 300.34, observed [M+H]+ 301.3.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2425-41-4, (2-Phenyl-1,3-dioxane-5,5-diyl)dimethanol, and friends who are interested can also refer to it.

Reference:
Patent; TOLLNINE, INC.; PONS, Jaume; WAN, Hong I.; BRADSHAW, Curt W.; SIM, Bang Janet; KUO, Tracy Chia-Chien; (239 pag.)WO2020/81744; (2020); A1;,
Alcohol – Wikipedia,
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