Category: 23828-92-4

Sharma, Kamna published the artcileDevelopment and Validation of UV-Spectrophotometric and RP-HPLC Methods for Simultaneous Estimation of Fexofenadine Hydrochloride, Montelukast Sodium and Ambroxol Hydrochloride in Tablet Dosage Form, Related Products of alcohols-buliding-blocks, the publication is Analytical Chemistry Letters (2018), 8(6), 829-843, database is CAplus.

A UV-spectrophotometric and RP-HPLC method was developed and validated for concurrent estimation of fexofenadine hydrochloride (FEX), montelukast sodium (MLK) and ambroxol hydrochloride (AMB). In RP-HPLC chromatog., the retention time for FEX, MLK and AMB was 2.775 min, 9.529 min and 5.261 min, resp. and detection at _max 210 nm for all three of drugs (overlain spectra). Linear regression anal. shows a good linear relationship; in the concentration range of 10-30, 10-50 and 5-25μg/mL; for FEX, MLK and AMB with r² > 0.999. The UV-spectrophotometric estimation was done by two methods; zero order and first derivative method. These methods were based on the measurement of absorbance at 220.20, 283.42 and 245.84 nm in zero order; 221, 287.52 and 262.25 nm in first order derivative method. In both UV methods, the drugs follow the Beer-Lambert’s law in the concentration range of 6-26, 4-24 and 8-28μg/mL, resp. showing correlation coefficient r² > 0.999. The RP-HPLC and UV methods showed good reproducibility and recovery with the percent relative standard deviation (RSD) less than 5%. These methods were successfully applied for reliable quantification of FEX, MLK and AMB in a com. and routine anal. in combined dosage form.

Analytical Chemistry Letters published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C4H6O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gomes, Raimundo Nonato S. published the artcileAdverse effects of respiratory disease medicaments and tooth brushing on teeth: A scanning electron microscopy, X-ray fluorescence and infrared spectroscopy study, Synthetic Route of 23828-92-4, the publication is Microscopy Research and Technique (2019), 82(9), 1489-1499, database is CAplus and MEDLINE.

The present study aims to evaluate the effect of brushing with fluoride dentifrice on teeth severely affected by erosion due to respiratory medicaments. Enamel (n = 50) and dentin (n = 50) bovine specimens were prepared and treated with artificial saliva (S-control), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS) and subjected to cycles of demineralization (immersing in 3 mL, 1 min, three times a day at intervals of 1 h, for 5 days) followed by remineralization (saliva, 37°C, 1 h). Simulated brushing with fluoridated toothpaste was performed using 810 strokes in a reciprocal-action brushing simulator. SEM, micro energy dispersive X-ray fluorescence (μ-EDXRF) spectroscopy and attenuated total reflection Fourier transform IR (ATR FTIR) spectroscopy were then performed. μ-EDXRF images showed extensive erosion after treatment with all medicaments. SEM images showed enamel erosion in order SS > BR > AC = AM > S after brushing and fluoridation. FTIR results were in agreement. In case of dentin, μ-EDXRF measurements showed significant difference in mineral content (percent weight of calcium and phosphate) in SS + brushing + fluoridation treated enamel compared to control, while μ-EDXRF images showed erosive effects in the order SS > AM>BR > AC = S post brushing + fluoridation. SEM images showed erosion in the order SS > AM = BR > AC > S post brushing + fluoridation. Again, FTIR multivariate results were in agreement. Overall, our study shows that proper oral care is critical when taking certain medication. The study also demonstrates the possible use of FTIR for rapid clin. monitoring of tooth erosion in clinics.

Microscopy Research and Technique published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Synthetic Route of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gomes, Raimundo Nonato Silva published the artcileATR-FTIR spectroscopy and μ-EDXRF spectrometry monitoring of enamel erosion caused by medicaments used in the treatment of respiratory diseases, Quality Control of 23828-92-4, the publication is Microscopy Research and Technique (2018), 81(2), 220-227, database is CAplus and MEDLINE.

Medicaments essential for alleviation of diseases may sometime adversely affect dental health by eroding the enamel, owing to their acidic nature. It is therefore highly desirable to be able to detect these effects quickly and reliably. In this study, we evaluated the erosive capacity of four most commonly prescribed respiratory disease syrup medicaments on enamel using micro-energy-dispersive X-ray fluorescence spectrometry (μ-EDXRF) and attenuated total reflection Fourier transform IR spectroscopy (ATR-FTIR). Fifty-five enamel fragments obtained from 30 bovine teeth were treated with artificial saliva (S), acebrofilin hydrochloride (AC), ambroxol hydrochloride (AM), bromhexine hydrochloride (BR), and salbutamol sulfate (SS); by immersing in 3 mL of resp. solutions for 1 min, three times a day at intervals of 1 h, for 5 days. μ-EDXRF anal. of enamel surface did not reveal significant erosion caused by the medications. However, ATR-FTIR showed a detectable shift in the phosphate (PO4) antisym. stretching mode (ν3) at ~985 cm^-1 for AM, BR, and SS, indicating erosion. Multivariate statistical anal. showed that AC, AM, SS, and BR could be classified with 70%, 80%, 100%, and 100% efficiency from S (control), further highlighting the ability of ATR-FTIR to identify degree of erosion. This suggests ATR-FTIR may be used to rapidly and nondestructively investigate erosive effects of medicaments.

Microscopy Research and Technique published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Li published the artcileTopical administration of ambroxol eye drops augments tear secretion in rabbits, Computed Properties of 23828-92-4, the publication is Graefe’s Archive for Clinical and Experimental Ophthalmology (2021), 259(6), 1529-1538, database is CAplus and MEDLINE.

To investigate if topical administration of ambroxol promotes tear secretion and to compare with Diquas ophthalmic eye drop. Two consecutive studies were conducted using sixteen (32 eyes) New Zealand White rabbits. The first study compared the efficacy of ambroxol hydrochloride (0.05%, 0.2%, and 1.0%) on tear and mucin secretion when administered twice daily. Tear secretion was assessed by Schirmer test I and mucin production by conjunctival impression cytol. and PAS stain. The second study compared 0.2% ambroxol hydrochloride with Diquas. A human goblet cell line and human conjunctival tissue were used to test the effect of ambroxol hydrochloride on the expression of aquaporin 5 (AQP5) and MUC5AC, using reverse transcriptase-quant. polymerase chain reaction and immunoblotting. All three concentrations of ambroxol hydrochloride demonstrated significant efficacy on tear stimulation within 2 wk of treatment and total mucin component appeared increased. When administered topically twice daily, 0.2% ambroxol hydrochloride was more effective in augmenting tear secretion than Diquas. With 24 h of treatment, 5μM of ambroxol hydrochloride upregulated AQP5 and MU5AC mRNA and MUC5AC protein in a goblet cell line. When tested on preserved human conjunctiva tissue, a trend of increased production of MUC5AC protein was seen (P = 0.26). Ambroxol is effective in augmenting tear secretion at the ocular surface in rabbits. With actions desirable of a candidate dry eye drug, further investigation of ambroxol and related compounds is warranted to explore their value toward clin. application.

Graefe’s Archive for Clinical and Experimental Ophthalmology published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C20H28B2O4S2, Computed Properties of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Debbarma, Bimal published the artcileFormulation and in-vitro evaluation of taste masked fast dissolving tablets of Ambroxol hydrochloride, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is World Journal of Pharmacy and Pharmaceutical Sciences (2021), 10(2), 1528-1550, database is CAplus.

The purpose of the present work was to mask the taste of Ambroxol hydrochloride and to formulate its patient-friendly dosage form. Complexation technique using KYRON -T-114 an ion-exchange resin was used to mask the bitter taste and the drug loading onto the ion-exchange resin was optimized for ratio of drug to resin, effect of pH and effect on soaking time. The resinate was evaluated for taste masking and characterized by FT-IR and DSC. Then the taste-masked drug was formulated into a fast dissolving tablet (FDT). The developed tablets were evaluated for hardness, friability, drug content, weight variation, content uniformity, friability, water absorption ratio, in-vitro disintegration time and in-vitro drug release studies. IR and DSC spectra revealed that there were no possible interactions between the drug and polymer. Maximum loading was obtained at drug- resin ratio 1:2, pH 7, and soaking time 30 min. A successful taste masking of resinate was confirmed by time intensity method. The values of pre-compression parameters evaluated and were within prescribed limits and indicated good free flowing properties. The data obtained of post-compression parameters found superior over conventional formulation. The F3 batch with disintegration time 30.4±0.64 s and dissolution 98.4±2.69 was selected as optimized formulation, This was compared with conventional marketed formulation and was found superior. The obtained results revealed that Ambroxol hydrochloride has been successfully taste masked and formulated into an FDT as a suitable alternative to the conventional tablets.

World Journal of Pharmacy and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kiran Kumar, A. published the artcileReverse phase-UPLC method of analysis for simultaneous estimation of Levosalbutamol sulphate, Guaiphenesin and Ambroxol hydrochloride in pharmaceutical cough, cold liquid dosage forms, Application In Synthesis of 23828-92-4, the publication is International Journal of Research in Pharmaceutical Sciences (Madurai, India) (2019), 10(2), 927-934, database is CAplus.

The three most drug combinations for cough, cold are widely used worldwide now a day. The purpose of the study was to build up an innovative RP-UPLC technique for simultaneous estimation of Levosalbutamol Sulfate (LEV), Guaiphenesin (GUA) and Ambroxol Hydrochloride (AMB) in liquid dosage forms. Chromatog. was carried out on UHPLC (WATERS)⊕MMETRY C18 4.6mm × 1000mm, 3.5μm, (Agilent – Zorbax Eclipse Plus C18 – Rapid Resolution) with an isocratic mobile phase with pH 3.0 composed of buffer, methanol and Acetonitrile (60:20:20) with a flow rate of 0.8mL/min. The detection was carried out with column temperature at 25°C using a UV detector at 276nm. Validation parameters like linearity, specificity, precision, accuracy, limit of detection (LOD), limit of quantification (LOQ), system suitability, Solutions stability and robustness were considered as affirmed in the ICH guidelines. Retention times for LEV, GUA & AMB were 1.07 min, 1.99 min & 3.55 min resp. The assay of syrups with the relative standard deviation found to be less than 2%. The parameters values were found, and the method was found to be satisfactory. This validated UHPLC method is cost-effective, receptive and precise than other chromatog. methods.

International Journal of Research in Pharmaceutical Sciences (Madurai, India) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dey, Piyali published the artcileDesign and evaluation of anti-fibrosis drug engineered resealed erythrocytes for targeted delivery, Formula: C13H19Br2ClN2O, the publication is Drug Delivery and Translational Research (2019), 9(5), 997-1007, database is CAplus and MEDLINE.

Resealed erythrocytes (RSE) are potential, site-specific carrier system for drug delivery with prolonged drug release activity. In this study, erythrocytes obtained from Wistar albino rats were loaded with ambroxol hydrochloride (AH) with the focus to convenience the lung targeting possibility of the carrier erythrocytes. AH loading in erythrocytes using preswell dilution technique with glutaraldehyde (GA) as a crosslinking agent was evaluated and validated. Drug-loaded erythrocyte was characterized in terms of in vitro drug release followed by osmotic fragility study which showed amplified drug entrapment efficiency (DEE) and Hb content values as well. In vivo lung fibrosis study, rats were sensitized to egg albumin by i.p. (i.p.) injection and then inhalation in a whole body inhalation chamber. A sign of inflammation, airway sub-mucosal fibrosis, hypertrophy, and hyperplasia was observed A series of in vivo studies were carried out to describe the effect of AH-loaded RSE including measurement of cytokines in Bronchoalveolar Lavage (BAL) fluid and histopathol. study. AH showed a stepwise reduced level of cytokines in BAL at a different time interval after being injected of AH-loaded RSE. Furthermore, in vivo lung distribution experiments were performed for optimized formulation, and degree of distribution of the drugs inside the targeted organ was found to be satisfactory.

Drug Delivery and Translational Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kumar, Rakesh published the artcileDevelopment and validation of RP-HPLC method for the simultaneous estimation of salbutamol sulphate and ambroxol hydrochloride in oral liquid dosage form, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Asian Journal of Pharmaceutical Research and Development (2021), 9(1), 84-94, database is CAplus.

Pharmaceutical anal. is imported branch of science deals with to check the identity, strength, quality and purity of chem. and herbal compounds Qual. anal. of drugs and pharmaceutical compounds Quant. anal. is of much importance and done by various methods. One of the most accurate and precise methods is spectrophotometry which comprises the measurement of intensity of electromagnetic radiation emitted or absorbed by the compound Another most popular method of for quant. anal. is high performance liquid chromatog. (HPLC). In the present article a RP-HPLC method was developed for the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride in oral liquid doses form and validation of the developed method. Developed methods include selection of mobile phase, chromatog. method, and wavelength whereas validation involves the system suitability, accuracy, precision, linearity, reproducibility, robustness, specificity and solution stability of the developed method. The result showed that the developed method is the best suited to the simultaneous determination of salbutamol sulfate and ambroxol hydrochloride and validated as per the standards

Asian Journal of Pharmaceutical Research and Development published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Panchale, Wrushali A. published the artcileConcurrent analysis of ambroxol HCl and salbutamol sulphate from tablet formulation by RP-HPLC, HPLC of Formula: 23828-92-4, the publication is GSC Biological and Pharmaceutical Sciences (2020), 13(3), 197-202, database is CAplus.

RP-HPLC method was developed for concurrent anal. of ambroxol HCl and salbutamol sulfate from tablet formulation. Analytes were separated with mobile phase consisting of mixture of methanol and water (0.1% triethylamine) in the ratio 50: 50 at a flow rate of 0.7 mL/min with Nucleosil (4.6 mm I.D x 250 mm) C18 column. The retention time of ambroxol HCl and salbutamol sulfate was found to be 3.61 and 6.20 min, resp. The detection was carried out at 224 nm. The dynamic range for ambroxol HCl and salbutamol sulfate observed was 15-75μg/mL and 1-5μg/mL, resp. The percent recovery obtained for ambroxol HCl and salbutamol sulfate were close to 100%. Obtained statistical data of results was found to satisfactorily.

GSC Biological and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Panchale, Wrushali A. published the artcileFirst-order derivative spectrophotometric estimation of gemifloxacin mesylate and ambroxol HCl in tablet dosage form, Category: alcohols-buliding-blocks, the publication is GSC Biological and Pharmaceutical Sciences (2021), 14(2), 29-36, database is CAplus.

Aim of present work was to develop and validate a simple, precise and accurate uv-vis spectrophotometric method for the simultaneous estimation of gemifloxacin mesylate (GEMI) and ambroxol HCl (AMB) in their combined tablet dosage form. The method is based on first-order derivative spectroscopy. For determination of sampling wavelengths, each of GEMI and AMB were scanned in the wavelength range of 200-400 nm in the spectrum mode and sampling wavelengths were selected at 360 nm (zero crossing of GEMI) where AMB showed considerable absorbance and at 221.6 nm (zero crossing of AMB) where GEMI showed considerable absorbance. The linearity was obtained in the concentration range of 32-192μg/mL for GEMI and 7.5-45μg/mL for AMB. The correlation coefficients were found to be 0.9987 and 0.9992 for GEMI and AMB, resp. The method was validated as per ICH guidelines. Mean recoveries were found satisfactory. All the data of validation study was found to be satisfactorily. The proposed method can be applied for simultaneous estimation of both the drugs.

GSC Biological and Pharmaceutical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts