Category: 23828-92-4

Zhou, Jing published the artcileClinical comparative study between Xiao′er feike granules and ambroxol hydrochloride syrup for chronic cough in children, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Xin Zhongyi (2021), 53(5), 120-123, database is CAplus.

Objective: To compare and analyze the clin. application value of Xiao′er Feike granules and ambroxol hydrochloride syrup in the treatment of chronic cough in children. Methods: A total of 200 children with chronic cough were divided into the study group and the control group, 100 cases each, by digital parity. Based on the routine treatment, the control group was addnl. treated with ambroxol hydrochloride syrup, and the study group was addnl. treated with Xiao′er Feike granules. After two weeks of treatment, the clin. symptoms and signs in the two groups and the clin. effect were evaluated, and the immune function. Results: The total effective rate in the study group of 93.00% was higher than what was 67.00% in the control group, which was statistically significant (P<0.05). Before treatment, the difference in the comparison of Chinese medicine syndrome scores between the two groups was no significant (P>0.05). After treatment, the Chinese medicine syndrome scores in the two groups were decreased and the scores was statistically significant between the study group and the control group (P<0.05). The cough relief time and cough disappearance time in the study group were earlier, what were statistically significant, than those in the control group (P<0.05). There was no significant difference before treatment in the comparison of the levels of CD4⁺, CD8⁺, CD4⁺/CD8⁺ between all groups (P>0.05). After treatment, the levels of CD8⁺ in the two groups were increased and the level of the study group was greater than that of the control group;the levels of CD4⁺ and CD4⁺/CD8⁺ were decreased and the level of the study group were greater, which was statistically significant, than those in the control group (P<0.05). Conclusion: Compared with ambroxol hydrochloride syrup, Xiao′er Feike granules is more beneficial to improving the clin. effect, relieving the clin. symptoms and improving the immune resistance of children.

Xin Zhongyi published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C11H10ClNO, Safety of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xing, Yan published the artcileClinical features and treatment of pediatric patients with drug-induced anaphylaxis: a study based on pharmacovigilance data, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is European Journal of Pediatrics (2018), 177(1), 145-154, database is CAplus and MEDLINE.

Pediatric drug-induced anaphylaxis cases collected by the Beijing Pharmacovigilance Database from 2004 to 2014 were analyzed. A total of 91 cases were identified. Drug-induced anaphylaxis was primarily caused by antibiotics (53%). Children of 0-5 years were more likely to develop cyanosis symptoms than children of 13-17 years (OR = 5.14, 95%CI [1.74, 15.20], P = 0.002). Children of 13-17 years were more likely to develop hypotension than children of 6-12 years (OR = 11.79, 95%CI [2.28, 60.87], P = 0.002), and to manifest both neurol. symptoms (OR = 3.56, 95%CI [1.26, 10.08], P = 0.015) and severe anaphylaxis than children of 0-5 years (OR = 15.46, 95%CI [1.85, 129.33], P = 0.002). Supratherapeutic doses of epinephrine were more likely with i.v. (IV) bolus (92%) in contrast to either i.m. (IM) (36%, OR = 19.25, 95% CI [1.77, 209.55], P = 0.009) or s.c. (SC) injections (36%, OR = 19.80, 95% CI [1.94, 201.63], P = 0.005). Only 62 (68%) patients received epinephrine treatment as the first-line therapy. This study demonstrates that antibiotics were the most common cause of pediatric drug-induced anaphylaxis. Children may present with different anaphylactic signs/symptoms based on age groups. Epinephrine is under-utilized and provider education on the proper management of drug-induced anaphylaxis is warranted. The most common cause of anaphylaxis in children is allergies to foods, while the second most common cause of pediatric anaphylaxis is drugs. IM epinephrine is the recommended initial treatment of anaphylaxis. Drug-induced anaphylaxis in pediatric patients has age-related clin. features. IV bolus epinephrine was overused and associated with supratherapeutic dosing.

European Journal of Pediatrics published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C7H7IN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tang, Haowei published the artcileThe application of ambroxol hydrochloride combined with fiberoptic bronchoscopy in elderly patients with severe pneumonia: A meta-analysis and systematic review, Related Products of alcohols-buliding-blocks, the publication is Medicine (Philadelphia, PA, United States) (2022), 101(4), e28535, database is CAplus and MEDLINE.

The role of ambroxol hydrochloride combined with fiberoptic bronchoscopy in elderly patients with severe pneumonia remains unclear, we aimed to analyze this issue to provide evidences into the management of clin. pneumonia. We searched PubMed et al databases up to Oct. 20, 2021 for the randomized controlled trials on the application of ambroxol hydrochloride combined with fiberoptic bronchoscopy in elderly patients with severe pneumonia. Related outcomes were extracted and analyzed. Review Manager 5.3 software was used for data anal. A total of 13 randomized controlled trials involving 1317 elderly patients (559 cases in the ambroxol hydrochloride+fiberoptic bronchoscopy group and 658 cases in the fiberoptic bronchoscopy group) with pneumonia were included. Meta-analyses indicated that the blood oxygen partial pressure [mean difference (MD)=5.75, 95% confidence interval (CI) (3.80, 7.70)], blood oxygen saturation [MD=6.43, 95% CI (4.39, 8.48)], oxygenation index [MD=26.75, 95% CI (14.61, 38.89)] of exptl. group was significantly higher than that of control group (all P001), the incidence of multiple organ failure [odds ratio=0.42, 95% CI (0.31, 0.56), P001], mortality on day 28 [odds ratio=0.44, 95% CI (0.33, 0.59)] of exptl. group was significantly less than that of control group (all P001). The high-dose ambroxol hydrochloride combined with fiberoptic bronchoscopy is beneficial to improve the patients blood gas indicators, and reduce mortality in elderly patients with severe pneumonia.

Medicine (Philadelphia, PA, United States) published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C8H7ClO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Junwu published the artcileEfficacy of high-dose ambroxol for paraquat poisoning: a meta-analysis of randomized controlled trials, Category: alcohols-buliding-blocks, the publication is Journal of Research in Medical Sciences (2020), 25(7), 67, database is CAplus and MEDLINE.

Background: Paraquat (PQ) poisoning is characterized by rapidly progressive acute poisoning with high mortality and no specific antidote. Although some clin. studies have been conducted to investigate the benefits of high-dose ambroxol as an adjuvant treatment for PQ poisoning, the efficacy is controversial. Materials and Methods: After searching for relevant articles in English and Chinese databases from 1978 to 2019 according to the keywords (paraquat poisoning/methy viologen/gramoxone, and ambroxol/mucosolvan/Bromhexine), we found seven articles that met our inclusion and exclusion criteria. A meta-anal. was performed using fixed-effects model and random-effects model according to the I2 value in Stata software (version 15.0). Four outcome indicators (hospital mortality, partial pressure of oxygen (PaO2), oxygenation index (PaO2/FiO2), and survival time of the deceased patients) were of interest to us. Results: The meta-anal. showed that adjuvant treatment with high doses of ambroxol increased PaO 2 (weighted mean difference [WMD] = 13.73 [mmHg], 95% confidence interval [CI]: 8.68-18.79, Z = 11.80, P < 0.001), PaO 2/FiO2 (WMD = 38.81 [mmHg], 95% CI: 29.85-47.76, Z = 8.49, P = 0.000), and survival time of the deceased patients (WMD = 2.58 [d], 95% CI: 0.97-4.18, Z = 3.15, P = 0.002) compared with usual treatment. Treatment with high doses of ambroxol also appeared to reduce the hospital mortality (relative risk = 0.69, 95% CI: 0.55-0.86, Z = 3.25, P = 0.001). Conclusion: This study found that high-dose ambroxol is an effective therapy for PQ poisoning and may reduce the in-hospital mortality.

Journal of Research in Medical Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C8H6ClN, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tantawy, Mahmoud A. published the artcileSimultaneous determination of guaifenesin enantiomers and ambroxol HCl using 50-mm chiral column for a negligible environmental impact, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Chirality (2019), 31(10), 835-844, database is CAplus and MEDLINE.

Chiral stationary phases are conveniently used for enantiomeric separation of drugs by liquid chromatog. Consumption of large volumes of hazardous solvents is considered as a common challenge for the sustainability of this technique. To this end, a columnar chromatog. has been adopted using 50-mm-length stationary phases. The study comprised five Phenomenex Lux cellulose- and amylose-based columns for the separation of guaifenesin (GUA) enantiomers. In addition, an exptl. design was used to optimize the gradient profile for the separation of racemic GUA and ambroxol HCl (AMB) binary mixture The chromatog. method was achieved using Lux Cellulose-1 (50 × 4.6 mm) as a chiral stationary phase and ethanol/water as a mobile phase with linear gradient elution of 20% to 70% ethanol in 6 min at a flow rate of 1.0 mL min^-1 and UV detection at 270 nm. Linearity ranges were found to be 50 to 1000 μg mL^-1 and 15 to 450 μg mL^-1 for each GUA enantiomer and AMB, resp. Environmental, health and safety tool was used to assess and compare greenness of the proposed and reported methods. Short column indeed reduces the environmental impact by decreasing waste by about 60% and utilizing only 1-mL ethanol in the mobile phase. The proposed method is a safer alternative for the simultaneous determination of drugs in their combined pharmaceutical formulation. The method has been validated and compared favorably with a reported one.

Chirality published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C9H9ClN2, Application of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yoshida, Shota published the artcileEffects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents, Product Details of C13H19Br2ClN2O, the publication is Journal of Toxicologic Pathology (2018), 31(4), 255-265, database is CAplus and MEDLINE.

Ambroxol hydrochloride (AH) is an expectorant drug used to stimulate pulmonary surfactant and serous airway secretion. Surfactant proteins (SPs) are essential for maintaining respiratory structure and function, although SP expression has also been reported in lung inflammatory and proliferative lesions. To determine whether AH exerts modulatory effects on these lung lesions, we examined its effects on pleural thickening induced by intrathoracic administration of dipotassium titanate (TISMO) in A/JJmsSlc (A/J) mice. We also analyzed the modulatory effects of AH on neoplastic lung lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice and by N-nitrosobis (2-hydroxypropyl) amine (DHPN) in F344/DuCrlCrj (F344) rats. A/J mice treated with TISMO showed decreased body weight, increased white blood cell (WBC) counts, and pleural thickening caused by pleuritis and poor general condition. However, A/J mice treated with TISMO + 120 ppm showed significant recovery of body weight and WBC counts to the same levels as those of A/J mice not treated with TISMO, although no significant differences were observed in histopathol. changes including the immunohistopathol. expression of IL-1β in the lung and maximum pleural thickness regardless of AH treatment. In the NNK and DHPN experiments, no significant differences in body weight, hematol., plasma biochem., and histopathol. changes were associated with AH concentration These results suggest that AH potentially exerts anti-inflammatory effects but does not have a direct suppressive effect on lung tumorigenesis in rodents.

Journal of Toxicologic Pathology published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C14H28O5S, Product Details of C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

He, Jing published the artcileEffect of ambroxol hydrochloride lavage with electronic bronchoscope on PCT and CRP levels in elderly patients with pneumonia and respiratory failure, Formula: C13H19Br2ClN2O, the publication is Guizhou Yiyao (2021), 45(3), 380-381, database is CAplus.

The effects of ambroxol hydrochloride lavage with electronic bronchoscope on inflammatory factors procalcitonin (PCT) and C-reactive protein (CRP) in elderly patients with pneumonia complicated with respiratory failure were analyzed. There was no significant difference in the levels of PCT and CRP between the observation group and the control group before treatment. One week after treatment, PCT and CRP in the two groups decreased, and the observer was lower than that in the control group. Studies have shown that ambroxol hydrochloride lavage through electronic bronchoscope can effectively reduce the level of inflammatory factors in elderly patients with pneumonia complicated with respiratory failure, improve pulmonary function and blood gas indexes, and does not increase the rate of adverse reactions or complications. It is a treatment scheme suitable for elderly patients with pneumonia complicated with respiratory failure.

Guizhou Yiyao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cai, Hongfeng published the artcileEffects of dexamethasone combined with ambroxol hydrochloride therapy on myocardial enzymes, leukocytes and platelet levels in patients with severe pneumonia, Application In Synthesis of 23828-92-4, the publication is Jianyan Yixue Yu Linchuang (2021), 18(8), 1149-1151, database is CAplus.

Objective: To investigate the effect of dexamethasone combined with ambroxol hydrochloride on myocardial enzymes, leukocytes and platelet levels in patients with severe pneumonia. Methods: A total of 78 patients with severe pneumonia admitted to our hospital from Jan. 2018 to Jan. 2020 were selected and divided into a control group and a research group according to the method of drawing lots, with 39 cases in each group. The control group was treated with a single ambroxol hydrochloride , the study group was treated with dexamethasone on the basis of the control group. The myocardial enzymes [lactate dehydrogenase (LDH), aspartate aminotransferase (AST), creatine kinase (CK) before and after treatment ) and its isoenzyme (CK-MB)], leukocytes, platelets, inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α)] levels The clin. efficacy and lung function were compared. Results: Before treatment, there was no significant difference in the levels of myocardial enzymes, leukocytes and platelets between the two groups (P>0.05). After treatment, the levels of myocardial enzymes, leukocytes and platelets in the study group were lower than those in the control group (P<0.05). The clin. treatment effect of the patients in the study group was significantly better than that in the control group (P<0.05); there was no significant difference in the pulmonary function between the two groups before treatment (P>0.05), and the pulmonary function of the patients in the study group was better than that in the control group after the treatment (P>0.05). There was no significant difference in the levels of inflammatory factors between the two groups before treatment (P>0.05), and the levels of serum inflammatory factors in the study group were lower than those in the control group after treatment (P<0.05). Conclusion: Dexamethasone combined with ambroxol hydrochloride has a significant effect in the treatment of severe pneumonia, can effectively control the levels of myocardial enzymes, leukocytes and platelets, improve the lung function of patients, and reduce the level of inflammatory factors, which is worthy of clin. application.

Jianyan Yixue Yu Linchuang published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xiaoliang published the artcileDetermination of sucrose and sorbitol in ambroxol hydrochloride oral solution by HPLC-RID, Category: alcohols-buliding-blocks, the publication is Jinri Yaoxue (2021), 31(10), 756-760, database is CAplus.

OBJECTIVE To establish a method for determination of sucrose and sorbitol in ambroxol hydrochloride oral solution and investigated the addition among samples from 21 manufacturers all over the whole country. METHODS The HPLC determination was performed on a HYPERSIL amino column (250 mm×4.6 mm, 5 μm). The mobile phase was consisted of acetonitrile and water (80:20, V/V) at the flow rate of 1.0 mL·min^-1. The column temperature was 35°C and the refractive index detector was used. RESULTS Sucrose and sorbitol could be well separated from ambroxol hydrochloride, and they had good linear relationship (n=6) at the range of 1-10 mg·mL^-1 with sucrose (r=0.9996) and sorbitol (r=0.9999), resp. The limits of quantitation of sucrose and sorbitol were 8.03 and 8.04 μg resp. and the average recoveries (n=9) were 101.0% and 100.9% with the RSD 1.03% and 0.97% resp. The samples from 22 enterprises in the whole country were determined and the determinated results for few individual manufacturers were inconsistent with the production prescription. CONCLUSION The established method is simple, accurate and good repeatability which can lay the foundation for the determination of the addition and quality evaluation of flavor agents in oral solution

Jinri Yaoxue published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C6H10O7, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Ya-rui published the artcileEffects of ambroxol hydrochloride combined with pulmicorin on changes of airway inflammation and allergic reaction EOS, ECP and IL-4 indexes in patients with bronchial asthma, Formula: C13H19Br2ClN2O, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(5), 707-708, database is CAplus.

Objective: To investigate the effect of ambroxol hydrochloride combined with pulmicorin on airway inflammation and the changes of EOS, ECP and IL-4 indexes in patients with bronchial asthma. Methods: A total of 60 patients with bronchial asthma who were admitted to our hospital from Feb. 2019 to Dec. 2019 were selected and divided into a control group and an exptl. group with 30 cases in each group according to the method of tossing a coin. The control group was given routine treatment, and the exptl. group was given ambroxol hydrochloride combined with pulmicoride on this basis. The levels of eosinophils (EOS), eosinophil cationic protein (ECP), interleukin-4 (IL-4) and adverse reactions were observed in the two groups. Results: Before treatment, there was no significant difference in the levels of IL-4, ECP and EOS between the two groups (P>0.05). After treatment, the levels of IL-4, ECP and EOS in the two groups were lower than those before treatment, and the exptl. group was significantly lower than the control group (P<0.05). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). Conclusion: Ambroxol hydrochloride combined with pulmicoride has pos. effect on airway inflammation and allergic reaction EOS, ECP and IL-4 levels in patients with bronchial asthma, with high safety, which is worthy of clin. application.

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C38H74Cl2N2O4, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts