Category: 23351-09-9

Kiraz, Asli Ozturk published the artcileTheoretical investigation of triazine based a star shape pyrrole monomer, Quality Control of 23351-09-9, the publication is Journal of Macromolecular Science, Part A: Pure and Applied Chemistry (2017), 54(1), 16-23, database is CAplus.

In this work, we report a comprehensive theor. investigation of electroactive star shaped pyrrole functionalized triazine monomer with two main goals. First goal of this work is to explore the phys. and chem. properties of the monomer, then to investigate correlation between the exptl. and the theor. properties of monomer. The scale factor which is calculated from B3LYP/cc-pVDZ was determined as 0.985 for FT-IR and it is an important and reliable contribution to the literature. It is determined that the most appropriate basis set for this mol. The other novel objective of this research is to investigate temperature effect on displacement of chlorine atoms in 2,4,6-trichloro-1,3,5-triazine. This method applied for the first time in the literature for triazines is especially crucial to the synthesis of unsym. triazines.

Journal of Macromolecular Science, Part A: Pure and Applied Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

More, Uttam A. published the artcileDiscovery of target based novel pyrrolyl phenoxy derivatives as antimycobacterial agents: An in silico approach, Category: alcohols-buliding-blocks, the publication is European Journal of Medicinal Chemistry (2015), 317-339, database is CAplus and MEDLINE.

A new series of pyrrolyl phenoxy derivatives bearing alkoxy linker were synthesized and evaluated for anti-tubercular activity (anti-TB) against Mycobacterium tuberculosis. Mol. modeling, pharmacophore constructed using GALAHAD to produce an effective alignment of data set and evaluated by Pareto ranking. The pharmacophore features were filtered by Surflex-dock study using enoyl ACP reductase from M. tuberculosis, which is one of the key enzymes involved in type II fatty acid biosynthesis pathway of M. tuberculosis. Compound I showed the H-bond with NAD⁺, whereas compound II showed H-bonds with Tyr158, Thr196, Met199 and NAD⁺ that fitted well into the binding pocket of target InhA. The alkoxy linker bridge and acceptor groups with benzene ring were advantageous for anti-TB activity, which merit further investigation.

European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bachovchin, Daniel A. published the artcileSuperfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening, Quality Control of 23351-09-9, the publication is Proceedings of the National Academy of Sciences of the United States of America (2010), 107(49), 20941-20946, S20941/1-S20941/172, database is CAplus and MEDLINE.

Serine hydrolases (SHs) are-one of the largest and most diverse enzyme classes in mammals. They play fundamental roles in virtually all physiol. processes and are targeted by drugs to treat diseases such as diabetes, obesity, and neurodegenerative disorders. Despite this, we lack biol. understanding for most of the 110+ predicted mammalian metabolic SHs, in large part because of a dearth of assays to assess their biochem. activities and a lack of selective inhibitors to probe their function in living systems. We show here that the vast majority (>80%) of mammalian metabolic SHs can be labeled in proteomes by a single, active site-directed fluorophosphonate probe. We exploit this universal activity-based assay in a library-vs.-library format to screen 70+ SHs against 140+ structurally diverse carbamates. Lead inhibitors were discovered for ∼40% of the screened enzymes, including many poorly characterized SHs: Global profiles identified carbamate inhibitors that discriminate among highly sequence-related SHs and, conversely, enzymes that share inhibitor sensitivity profiles despite lacking sequence homol. These findings indicate that sequence relatedness is not a strong predictor of shared pharmaol. within the SH superfamily. Finally, we show that lead carbamate inhibitors can be optimized into pharmacol. probes that inactivate individual SHs with high specificity in vivo.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Westphal, Matthias V. published the artcileWater-compatible cycloadditions of oligonucleotide-conjugated strained allenes for DNA-encoded library synthesis, COA of Formula: C10H9NO, the publication is Journal of the American Chemical Society (2020), 142(17), 7776-7782, database is CAplus and MEDLINE.

DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles, and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features, related to elements found to be powerful in phenotypic screening. DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features-related to elements found to be powerful in phenotypic screening.

Journal of the American Chemical Society published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C15H21BO2, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cirpan, A. published the artcileConducting polymers of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester, Quality Control of 23351-09-9, the publication is Materials Chemistry and Physics (2004), 85(1), 222-226, database is CAplus.

A dipyrrolyl monomer was synthesized via the reaction between 4-pyrrol-1-yl phenol and decanedioyl dichloride. The electrochem. behavior of this monomer was studied. Polymerization of decanedioic acid bis-(4-pyrrol-1-yl-phenyl) ester (DAPE) was achieved by chem. and constant current electrolyzes methods. Copolymerization of DAPE with thiophene was performed by constant potential electrolysis in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB), dichloromethane-TBAFB, solvent-electrolyte couples. The chem. structures and properties were investigated by Fourier transform IR spectroscopy, NMR spectroscopy, differential scanning calorimetry and thermal gravimetry anal. The conductivities of the samples were measured by a four-probe technique.

Materials Chemistry and Physics published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bingoel, Bahar published the artcileSynthesis and Characterization of Thiophen-3-yl Acetic Acid 4-Pyrrol-1-yl Phenyl Ester and its Conducting Polymers, Quality Control of 23351-09-9, the publication is International Journal of Polymeric Materials (2005), 54(8), 713-730, database is CAplus.

Thiophen-3-yl acetic acid 4-pyrrol-1-yl Ph ester (TAPE) monomer was synthesized via reaction of thiophen-3-yl acetyl chloride with 4-pyrrol-1-yl phenol. Homopolymers were achieved by using electrochem. and chem. polymerization techniques. Copolymers of TAPE with bithiophene or pyrrole were synthesized by potentiostatic electrochem. polymerization in acetonitrile-tetrabutylammonium tetrafluoroborate (TBAFB) solvent-electrolyte couple. The chem. structures were confirmed by both NMR and FTIR. DSC and TGA were used to examine the thermal behavior of the polymers. The morphologies of the films were investigated by SEM. Two-probe technique was used to measure the conductivities of the samples. Moreover, investigations of electrochromic and spectroelectrochem. properties of poly(TAPE-co-BiTh) carried out and the characteristics of dual type electrochromic device based on poly(TAPE-co-BiTh) and poly(3,4-ethylenedioxythiophene) (PEDOT) were reported.

International Journal of Polymeric Materials published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Andorfer, Mary C. published the artcileUnderstanding Flavin-Dependent Halogenase Reactivity via Substrate Activity Profiling, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is ACS Catalysis (2017), 7(3), 1897-1904, database is CAplus and MEDLINE.

The activity of four native FDHs and four engineered FDH variants on 93 low mol. weight arenes was used to generate FDH substrate activity profiles. These profiles provided insights into how substrate class, functional group substitution, electronic activation, and binding impact FDH activity and selectivity. The enzymes studied could halogenate a far greater range of substrates than previously recognized, but significant differences in their substrate specificity and selectivity were observed Trends between the electronic activation of each site on a substrate and halogenation conversion at that site were established, and these data, combined with docking simulations, suggest that substrate binding can override electronic activation even on compounds differing appreciably from native substrates. These findings provide a useful framework for understanding and exploiting FDH reactivity for organic synthesis.

ACS Catalysis published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileNew poly(p-substituted-N-phenylpyrrole)s. Electrosynthesis, electrochemical properties and characterization, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Synthetic Metals (2013), 74-85, database is CAplus.

Poly(N-p-hydroxyphenylpyrrole) [poly(HOPhPy)], poly(N-p-methoxyphenylpyrrole) [poly(MeOPhPy)], poly(N-p-thiophene-phenylpyrrole) [poly(ThPhPy)], poly(1,1′-phenylene dipyrridyl) [poly(PhDPy)] and poly(1,1′-diphenylene dipyrridyl) [poly(DPhDPy)] were electrosynthesized from the corresponding monomers on Pt electrode in 0.1 M tetrabutylammonium hexafluorophosphate (TBAPF₆) acetonitrile solutions, using cyclic voltammetry (CV), galvanostatic and potentiostatic modes. The electrodeposited films were characterized by CV, FT-IR spectrometry, X-ray photoelectron spectra (XPS), and SEM. Electron-donating substituent effects on the polymer electrochem. properties were investigated by CV. The CV of the films indicated a good redox behavior and a peak position depending on the nature of substituent. FT-IR spectral studies allowed one to predict a linear and regular structure of the polymer chains, the coupling taking place in the 2 and 5 positions of the pyrrole rings. XPS anal. showed a variation of the film doping levels (26-42% for oxidized films and 6-12% for reduced films) with the electron-donor character of the Ph p-substituents. The conjugated π-electronic system was extended by strong electron-donating substituents which led to a higher doping level of the polypyrrolic chains and a polymer structure with high-energy and polar bonds like CN⁺ and CN⁺. SEM anal. revealed changes in the polymer film morphol. and thickness with the nature of substituents.

Synthetic Metals published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diaw, A. K. D. published the artcileAn experimental study of the electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles and their electrosynthesized polymers, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy (2015), 1107-1114, database is CAplus and MEDLINE.

Electronic absorption and fluorescence spectral properties of new p-substituted-N-phenylpyrroles (N-PhPys), including HOPhPy, MeOPhPy, ThPhPy, PhDPy, DPhDPy, PyPhThThPhPy, and their available, electrosynthesized polymers were investigated. Electronic absorption spectra, fluorescence excitation and emission spectra, fluorescence quantum yields (Φ_F) and lifetimes (τ_F), and other photophys. parameters of these N-PhPy derivatives and their polymers were measured in DMF, DMSO diluted solutions and/or solid state at room temperature The electronic absorption spectra of N-PhPy derivatives and their polymers included one to several bands, located in the 270-395 nm region, according to the p-Ph substituent electron-donating effect and conjugated heteroaromatic system length. The fluorescence excitation spectra were characterized by one broad main peak, with, in most cases, one (or more) poorly resolved shoulder (s), appearing in the 270-405 nm region, and their emission spectra were generally constituted of several bands located in the 330-480 nm region. No significant shift of the absorption, fluorescence excitation and emission spectra wavelengths was found upon going from the monomers to the corresponding polymers. Φ_F Values were high, varying between 0.11 and 0.63, according to the nature of substituents(s) and to the conjugated system extension. Fluorescence decays were mono-exponential for the monomers and poly-exponential for PyPhThThPhPy and for polymers. τ_F Values were relatively short (0.35-5.17 ns), and markedly decreased with the electron-donor character of the Ph group p-substituent and the conjugated system extension.

Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Sai published the artcileInterfacial Effects of the CuO/GO Composite to Mediate the Side Reactions of N,N-Dimethylformamide Fragments, HPLC of Formula: 23351-09-9, the publication is ACS Applied Materials & Interfaces (2014), 6(24), 22174-22182, database is CAplus and MEDLINE.

The interface between nanocatalysts and graphene oxide (GO) has been found to play a crucial role in enhancing the catalytic activity and improving the selectivity of amination reactions in N,N-dimethylformamide (DMF). The composite catalysts of CuO/GO used for the catalytic coupling of aryl halides with amines in DMF can completely inhibit the side reaction between the aryl halides and fragments of DMF. With identical amounts of Cu-catalysts, the conversion of iodobenzene and the selectivity for the target product reached 100% when CuO/GO composite catalysts were employed, while these results were 70.3 and 42.8%, resp., when CuO catalysts were used alone. Exptl. evidence confirms that the interfacial effect of CuO/GO is the origination of the improved performance of composite catalysts, which has been found to efficiently transfer fragments of DMF to GO and avoid unexpected side reactions during the catalytic process.

ACS Applied Materials & Interfaces published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C7H16Cl2Si, HPLC of Formula: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts