Category: 23351-09-9

Joshi, Shrinivas D. published the artcileChemical synthesis and in silico molecular modeling of novel pyrrolyl benzohydrazide derivatives: Their biological evaluation against enoyl ACP reductase (InhA) and Mycobacterium tuberculosis, Application In Synthesis of 23351-09-9, the publication is Bioorganic Chemistry (2017), 181-200, database is CAplus and MEDLINE.

In efforts to develop new antitubercular agents, we report here the synthesis of a series of novel pyrrole hydrazine derivatives The mols. were evaluated against inhibitors of InhA, which is one of the key enzymes involved in type II fatty acid biosynthetic pathway of the mycobacterial cell wall as well as inhibitors of Mycobacterium tuberculosis H37Rv. The binding mode of compounds at the active site of enoyl-ACP reductase was explored using the surflex-docking method. The model suggests one or two H-bonding interactions between the compounds and the InhA enzyme. Some compounds exhibited good activities against InhA in addition to promising activities against M. tuberculosis.

Bioorganic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Varma, Anil Kumar published the artcilePyrolysis of pine needles: effects of process parameters on products yield and analysis of products, Quality Control of 23351-09-9, the publication is Journal of Thermal Analysis and Calorimetry (2018), 131(3), 2057-2072, database is CAplus.

Pyrolysis of pine needles was carried out in a semi-batch reactor. The effects of pyrolysis parameters such as temperature (350-650°C), heating rate (10 and 50°C min^-1), nitrogen flow rate (50-200 cm³ min^-1) and biomass particle size (0.25-1.7 mm) were examined on products yield. Maximum bio-oil yield of 43.76% was obtained at pyrolysis temperature of 550°C with a heating rate of 50°C min^-1, nitrogen flow rate of 100 cm³ min^-1 for biomass particle size of 0.6 < d_p < 1 mm. The characterization of pyrolysis products (bio-oil, bio-char) has been made through different instrumental methods like Fourier transform IR spectroscopy, gas chromatog.-mass spectrometry, NMR spectroscopy (¹H NMR), X-ray powder diffraction, field emission scanning electron microscope and Brunauer-Emmett-Teller surface area anal. The empirical formula of the bio-oil and bio-char was found as CH_1.47O_0.36N_0.005 and CH_0.56O_0.28N_0.013 with heating value of 26.25 and 25.50 MJ kg^-1, resp. Results show that bio-oil can be potentially valuable as a renewable fuel after upgrading and can be used as a feedstock for valuable chems. production The properties of bio-char reveal that it can be used as solid fuels, as a cheap adsorbent and as a feedstock for activated carbon production

Journal of Thermal Analysis and Calorimetry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C13H10O2, Quality Control of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rohit, Kizhakkekuttu Radhakrishnan published the artcileA solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation, Name: 4-(1H-Pyrrol-1-yl)phenol, the publication is Journal of Heterocyclic Chemistry (2022), 59(1), 194-200, database is CAplus.

The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrroles I (R = Ph, 2-bromo-4-methylphenyl, 1,3-benzothiazol-2-yl, etc.) synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines RNH₂ has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO₃)₂.4H₂O is employed as the catalyst under microwave conditions with a very short reaction time (20 min). The above qualities attest to the green nature of this reaction.

Journal of Heterocyclic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Name: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ouyang, Mi published the artcileStudy on electrochromic performance of the copolymer based on 4-(1H-pyrrol-1-yl) phenyl 4-(1H-pyrrol-1-yl) butanoate with 3,4-ethylenedioxythiophene, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2011), 335-336(Pt. 2), 929-933, database is CAplus.

A new polypyrrole derivative 4-(1H-pyrrol-1-yl) Ph 4-(1H-pyrrol-1-yl) butanoate (NPB) was synthesized by chem. method and characterized by ¹H and ¹³C NMR spectroscopy. A new copolymer based on NPB and 3,4-ethylenedioxythiophene(EDOT) was electrochem. synthesized. Cyclic voltammogram and spectroelectrochem. characterization showed that the copolymer film had a well-defined reversible redox process as well as electrochromic behavior. Moreover, the copolymer film exhibited a multicolor electrochromism at different potentials, fast switching time of 0.8 s at 365 nm and an optical contrast of 17% at 1100nm.

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Caliskan, Burcu published the artcilePyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is European Journal of Medicinal Chemistry (2011), 46(10), 5021-5033, database is CAplus and MEDLINE.

Thirty-six title compounds were synthesized and led to potent inhibition of leukotriene (LT) biosynthesis in activated human neutrophils. Some examples showed IC₅₀ values in the range of 1.6-3.5 μM. Moreover, several compounds showed a substantial inhibition of platelet COX-1 activity with IC₅₀ of 2.5, 0.041, 0.3, 0.9 and 0.014 μM, resp., leading up to dual acting inhibitors. On the basis of their high potency in cellular environment, these straightforward pyrazole-3-propanoic acid derivatives may possess potential in the design of more potent compounds for intervention with inflammatory and allergic diseases.

European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kritikos, Nikolaos published the artcileQuantitative structure-chemiluminescence intensity relationships of 4-substituted phenols acting as luminol signal enhancers, Computed Properties of 23351-09-9, the publication is Chemometrics and Intelligent Laboratory Systems (2015), 478-484, database is CAplus.

The addition of a forth compound into this system has been thoroughly explored over the years, namely an enhancer promoting potency in the signal attained. Improvements in this regard serve to increase sensitivity and applicability of various biochem. methods. Studies exploring the ability of compounds to act as enhancers have proposed several chem. groups as possible candidates, amongst which 4-substituted phenols have been widely employed. Although some studies have explored the effect of the substituent on enhancer potency, no quant. structure – property relationships employing mol. descriptors for this group of compounds have been presented. Current study provides two such cross- and externally validated models, constructed by the projection to latent structures by means of partial least squares (PLS) multivariate linear regression method: i) a PLS-DA model contributing to the classification of such compounds into classes (relative to the signal), and ii) a PLS model for predicting the signal acquired. Validation was based on statistical metrics Q²ext(F3) for the test set and Roy’s metrics r²m(Av) & r²m(δ), assessing both predictive stability and internal validity. Applied in tandem, those models can assist in the recognition of available compounds as potential enhancers or inspire the synthesis of novel analogs. The significance of some characteristics governing the compounds’ behavior are also discussed based on the mol. descriptors chosen.

Chemometrics and Intelligent Laboratory Systems published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Computed Properties of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dotsikas, Yannis published the artcileEffect of the luminol signal enhancer selection on the curve parameters of an immunoassay and the chemiluminescence intensity and kinetics, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Talanta (2007), 71(2), 906-910, database is CAplus and MEDLINE.

In the present study, three luminol signal enhancers {4-methoxyphenol, 4-hydroxybiphenyl and 4-(1H-pyrrol-1-yl)phenol} were utilized in the chemiluminescence (CL) substrate solution of horseradish peroxidase (HRP). The latter was applied in a heterogeneous enzyme immunoassay that has been previously described. The employment of these mols. greatly affected important assay parameters, such as detection limit and the range of the calibration curve and the results were compared with those obtained from other two similar enhancers that have been described from the authors’ group. Practically, the use of a novel enhancer, even if this is a slightly changed 4-substituted phenol derivative, can affect assay properties so dramatically, one can assume that another substrate/enzyme system was applied. Furthermore, the use of different luminol signal enhancers in the luminol/HRP/H₂O₂ system affected not only the intensity of the obtained signal, which is well known, but also its kinetics. It was monitored that the stronger intensity was combined with a more rapid decrease of the CL signal.

Talanta published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Duraiswamy, Athisayamani Jeyaraj published the artcileDiscovery and Optimization of a Porcupine Inhibitor, Application In Synthesis of 23351-09-9, the publication is Journal of Medicinal Chemistry (2015), 58(15), 5889-5899, database is CAplus and MEDLINE.

Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleates the Wnts and hence is essential for their secretion and function. The inhibition of PORCN could serve as a therapeutic approach for the treatment of a number of Wnt-dependent cancers. Herein, the authors describe the identification of a Wnt secretion inhibitor from cellular high throughput screening. Classical SAR based cellular optimization provided us with a PORCN inhibitor I with nanomolar activity and excellent bioavailability that demonstrated efficacy in a Wnt-driven murine tumor model. Finally, the authors also discovered that enantiomeric PORCN inhibitors show very different activity in the reporter assay, suggesting that such compounds may be useful for mode of action studies on the PORCN O-acyltransferase.

Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Duraiswamy, Athisayamani Jeyaraj published the artcileDiscovery and Optimization of a Porcupine Inhibitor, Application In Synthesis of 23351-09-9, the publication is Journal of Medicinal Chemistry (2015), 58(15), 5889-5899, database is CAplus and MEDLINE.

Wnt proteins regulate various cellular functions and serve distinct roles in normal development throughout life. Wnt signaling is dysregulated in various diseases including cancers. Porcupine (PORCN) is a membrane-bound O-acyltransferase that palmitoleates the Wnts and hence is essential for their secretion and function. The inhibition of PORCN could serve as a therapeutic approach for the treatment of a number of Wnt-dependent cancers. Herein, the authors describe the identification of a Wnt secretion inhibitor from cellular high throughput screening. Classical SAR based cellular optimization provided us with a PORCN inhibitor I with nanomolar activity and excellent bioavailability that demonstrated efficacy in a Wnt-driven murine tumor model. Finally, the authors also discovered that enantiomeric PORCN inhibitors show very different activity in the reporter assay, suggesting that such compounds may be useful for mode of action studies on the PORCN O-acyltransferase.

Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application In Synthesis of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatzopoulou, Maria published the artcileClauson-Kaas-type synthesis of pyrrolyl-phenols, from the hydrochlorides of aminophenols, in the presence of nicotinamide, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Synthetic Communications (2013), 43(21), 2949-2954, database is CAplus.

A facile Clauson-Kaas-type pyrrolyl-phenol synthesis was achieved in the presence of nicotinamide, which is inexpensive and nontoxic. The starting material is aminophenol hydrochloride. This is advantageous in certain cases because it is the only isolable form of the corresponding aminophenol.

Synthetic Communications published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts