Category: 23351-09-9

Ai, Han-Jun published the artcileRhodium-Catalyzed Carbonylative Coupling of Alkyl Halides with Phenols under Low CO Pressure, Related Products of alcohols-buliding-blocks, the publication is ACS Catalysis (2020), 10(9), 5147-5152, database is CAplus.

A rhodium-catalyzed carbonylative transformation of alkyl halides under low pressure of CO has been developed. This robust catalyst system allows using phenols as the carbonylative coupling partner and, meanwhile, exhibits high functional group tolerance and good chemoselectivity. Substrates even with a large steric hindrance group or multiple reaction sites can be selectively converted into the desired products in good to excellent yields. A gram-scale experiment was performed and delivered an almost quant. amount of the product. Control experiments were performed as well, and a possible reaction mechanism is proposed.

ACS Catalysis published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Taeufer, Tobias published the artcilePalladium-Catalyzed Synthesis of N,N-Dimethylanilines via Buchwald-Hartwig Amination of (Hetero)aryl Triflates, Product Details of C10H9NO, the publication is Journal of Organic Chemistry (2020), 85(11), 7097-7111, database is CAplus and MEDLINE.

This work delineates the synthesis of N,N-dimethylaniline derivatives from dimethylamines and aryl triflates. The palladium-catalyzed C-N bond formation proceeds in excellent yields, using an unsophisticated catalytic system, a mild base, and triflates as electrophiles, which are readily available from inexpensive phenols. N,N-Dimethylanilines are multifunctional reaction partners and represent useful but underutilized building blocks in organic synthesis.

Journal of Organic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C14H17BF2O2, Product Details of C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chatzopoulou, Maria published the artcileDecreasing acidity in a series of aldose reductase inhibitors: 2-Fluoro-4-(1H-pyrrol-1-yl)phenol as a scaffold for improved membrane permeation, COA of Formula: C10H9NO, the publication is Bioorganic & Medicinal Chemistry (2014), 22(7), 2194-2207, database is CAplus and MEDLINE.

Targeting long-term diabetic complications, as well as inflammatory pathologies, aldose reductase inhibitors (ARIs) have been gaining attention over the years. In the present work, in order to address the poor membrane permeation of previously reported ARIs, derivatives of N-phenylpyrrole, bearing groups with putative pK_a ≥ 7.4, were synthesized and evaluated for aldose reductase inhibitory activity. The 2-fluorophenol group proved the most promising moiety, and further modifications were explored. The most active compound was identified as a submicromolar inhibitor (IC₅₀ = 0.443 μM), was also selective against the homologous enzyme aldehyde reductase. Cross-docking revealed that the above mentioned compound displays a peculiar interaction network that may be responsible for high affinity. Physicochem. profiling of it showed a pK_a of 7.64, rendering it less than 50% ionized in the physiol. pH range, with potentially favorable membrane permeation. The latter was supported from the successful inhibition of sorbitol formation in rat lenses and the ability to permeate rat jejunum.

Bioorganic & Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, COA of Formula: C10H9NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Agarwal, Sameer published the artcileDiscovery of a Potent and Orally Efficacious TGR5 Receptor Agonist, SDS of cas: 23351-09-9, the publication is ACS Medicinal Chemistry Letters (2016), 7(1), 51-55, database is CAplus and MEDLINE.

TGR5 is a G protein-coupled receptor (GPCR), activation of which promotes secretion of glucagon-like peptide-1 (GLP-1) and modulates insulin secretion. The 2-thio-imidazole derivative 6g was identified as a novel, potent, and selective TGR5 agonist (hTGR5 EC₅₀ = 57 pM, mTGR5 = 62 pM) with a favorable pharmacokinetic profile. The compound 6g was found to have potent glucose lowering effects in vivo during an oral glucose tolerance test in DIO C57 mice with ED₅₀ of 7.9 mg/kg and ED₉₀ of 29.2 mg/kg.

ACS Medicinal Chemistry Letters published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cherkasov, Rafael A. published the artcileThiophosphorylation of Pharmacophoric Phenols, Diols, and Triols, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2013), 188(1-3), 24-26, database is CAplus.

Novel organyldithiophosphonic and bis(aryldithiophosphonic) acids were obtained by the reaction of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with paracetamol, 4-(1H-pyrrol-1-yl)phenol, ethambutol dihydrochloride, vitamin B₆, and its acetonide derivatives

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Jae Won published the artcileA Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry & Biology (Cambridge, MA, United States) (2011), 18(4), 476-484, database is CAplus and MEDLINE.

Summary: Cancer cells show alterations in metabolism that support malignancy and disease progression. Prominent among these metabolic changes is elevations in neutral ether lipids (NELs). We have previously shown that the hydrolytic enzyme KIAA1363 (or AADACL1) is highly elevated in aggressive cancer cells, where it plays a key role in generating the monoalkylglycerol ether (MAGE) class of NELs. Here, we use activity-based protein profiling-guided medicinal chem. to discover a highly potent and selective inhibitor of KIAA1363, the carbamate JW480. We show that JW480, and an shRNA probe that targets KIAA1363, reduce MAGEs and impair the migration, invasion, survival, and in vivo tumor growth of human prostate cancer cell lines. These findings indicate that the KIAA1363-MAGE pathway is important for prostate cancer pathogenesis and designate JW480 as a versatile pharmacol. probe for disrupting this pro-tumorigenic metabolic pathway.

Chemistry & Biology (Cambridge, MA, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nizamov, I. S. published the artcileDithiophosphonation of 4-(1H-pyrrol-1-yl)phenol and 4-(1H-imidazol-1-yl)phenol, HPLC of Formula: 23351-09-9, the publication is Russian Journal of Organic Chemistry (2015), 51(9), 1272-1276, database is CAplus.

Reactions of 4-(1H-pyrrol-1-yl)phenol and 4-(1H-imidazol-1-yl)phenol with 2,4-diaryl-1,3,2λ⁵,4λ⁵– dithiadiphosphetane 2,4-disulfides gave the corresponding O-4-hetarylphenyl hydrogen arylphosphonodithioates which were converted into ammonium salts. The latter showed antimicrobial activity against Gram pos. bacteria and antifungal activity against fungi of the genus Candida.

Russian Journal of Organic Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, HPLC of Formula: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Guo-Ying published the artcileApplication of Fragment-Based Drug Discovery against DNA Gyrase B, SDS of cas: 23351-09-9, the publication is ChemPlusChem (2015), 80(8), 1250-1254, database is CAplus and MEDLINE.

Bacterial resistance to antibiotics remains a serious threat to global health. The gyrase B enzyme is a well-validated target for developing antibacterial drugs. Despite being an attractive target for antibiotic development, there are currently no gyrase B inhibitory drugs on the market. A fragment screen using 1,800 compounds identified 14 fragments that bind to Escherichia coli (E. coli) gyrase B. The detailed characterization of binding is described for all 14 fragments. With the aid of X-ray crystallog., modifications on a low-affinity fragment (K_D=253 μΜ, IC₅₀=634 μΜ) has led to the development of a new class of potent Ph aminopyrazole inhibitors against E. coli gyrase B (IC₅₀=160 nΜ). The study presented here combines the use of a set of biophys. techniques including differential scanning fluorimetry, NMR, isothermal titration calorimetry, and X-ray crystallog. to methodically identify, quantify, and optimize fragments into new chem. leads.

ChemPlusChem published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, SDS of cas: 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xiao-Feng published the artcileA General and Efficient Palladium-Catalyzed Alkoxycarbonylation of Phenols To Form Esters through In Situ Formed Aryl Nonaflates, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry – A European Journal (2012), 18(13), 3831-3834, S3831/1-S3831/27, database is CAplus and MEDLINE.

A novel process for the palladium catalyzed alkoxycarbonylation of phenols is presented. Activation of the phenols occurs via convenient in situ generation of aryl nonaflates. Electron-withdrawing or electron-donating substituents on the aryl or ester moiety are tolerated amongst the varied functional groups. Notably, not only homoesterification, but also cross-coupling of two different phenols (alcs.) are possible under these conditions.

Chemistry – A European Journal published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C22H18O2, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hosseini-Sarvari, M. published the artcileNano-sulfated titania as a heterogeneous solid acid catalyst for the synthesis of pyrroles by Clauson-Kaas condensation under solvent-free conditions, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Chemistry of Heterocyclic Compounds (New York, NY, United States) (2014), 49(12), 1732-1739, database is CAplus.

A new and environmentally benign method for the preparation of N-substituted pyrroles from one-pot condensation reaction of 2,5-dimethoxytetrahydrofuran with amines and diamines in the presence of nano sulfated titania under solvent-free conditions was presented. This new protocol features simple operation, easy availability, stability, and eco-friendliness of catalyst, as well as high to excellent yields of products. In addition, we report for the first time an alternative method for the synthesis of pyrroles from aromatic amines containing the β-lactam fragment using nano sulfated titania as catalyst.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts