Category: 23147-58-2

Application of 23147-58-2 ,Some common heterocyclic compound, 23147-58-2, molecular formula is C4H8O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 68 (S)-N-((S)-5-((l-(2-Cyanophenyl)-lH-indazol-3-yl)methyl)-4-oxo-2,3,4,5- tetrahydrobenzo [b] [ 1 ,4]oxazepin-3 -yl)-2-(2 -hydroxyethylamino)propan amide Na(OAc)3BH (14.2 mg, 67.0 muetaiotaomicron, Eq: 1.4) was added to a solution of (S)-2-amino-N- ((S)-5-((l-(2-cyanophenyl)-lH-indazol-3-yl)methyl)-4-oxo-2,3,4,5- tetrahydrobenzo[b][l ,4]oxazepin-3-yl)propanamide (23 mg, 47.9 muetaiotaomicron, Eq: 1.00) and glycolaldehyde dimer (3.16 mg, 26.3 muetaiotaomicron, Eq: 0.55) in DCM (1.5 mL). After 72 h. at RT, the mixture was diluted with NaHC03 and extracted with DCMThecombined extracts were concentrated. The residue was purified by preparative TLC to give the title compound (16 mg, 95 %) as a solid. MS m/z 525 (MH+)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23147-58-2, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DONNELL, Andrew F.; HAN, Xiaochun; KESTER, Robert Francis; KONG, Norman; LE, Kang; LOU, Yan; MICHOUD, Christophe; MOLITERNI, John Anthony; REMISZEWSKI, Stacy; RUPERT, Kenneth Carey; YUN, Weiya; WO2014/23708; (2014); A1;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 23147-58-2, Glycerol aldehyde dimer, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 23147-58-2, blongs to alcohols-buliding-blocks compound. 23147-58-2

A mixture of final compound 2 (prepared according to Bl. b) (0.001 mol, 0.5 g), 1,4- dioxane-2,5-diol (0. 001 mol, 0.113 g) and 3-thiophene boronic acid (0. 001 mol, 0.106 g) in ethanol (5 ml) was stirred at room temperature for 18 hours. This was followed by addition of solution OF KC03 (10 %) and extracted with ethyl acetate. The combined organic layers were dried (MgSO4), filtered and concentrated under vacuum. The residue (0.6 g) was purified by column chromatography over silica gel (eluent: CH2Cl2/MeOH/NH40H 93/07/0.5) and the product fractions were concentrated. Yield: 0.075 g (12 %) of final compound 349.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,23147-58-2, its application will become more common.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2004/56799; (2004); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts