Category: 23002-78-0

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ghosh, Arun K.; Pandey, Satyendra; Gangarajula, Sudhakar; Kulkarni, Sarang; Xu, Xiaoming; Rao, Kalapala Venkateswara; Huang, Xiangping; Tang, Jordan researched the compound: 1-(2-Methylthiazol-4-yl)ethanone( cas:23002-78-0 ).Application of 23002-78-0.They published the article 《Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors》 about this compound( cas:23002-78-0 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: aminodihydroquinazoline preparation secretase inhibitor; quinazoline aminodihydro preparation secretase inhibitor. We’ll tell you more about this compound (cas:23002-78-0).

Structure-based design, synthesis, and biol. evaluation of a series of 2-amino-3,4-dihydroquinazoline-derived β-secretase inhibitors incorporating thiazole and pyrazole-derived P2-ligands are described. One inhibitor showed potent enzyme inhibitory (Ki = 13 nM) and cellular (IC50 = 21 nM in neuroblastoma cells) assays. The model of this compound suggested possible interactions in the active site.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 1-(2-Methylthiazol-4-yl)ethanone, is researched, Molecular C6H7NOS, CAS is 23002-78-0, about Synthesis of 4-acetylthiazole and its 2-carboxylic acid ethyl ester, the main research direction is acetylthiazole oxime cleavage formaldehyde; thiazole acetyl; thiazole carboxylate acetyl.Related Products of 23002-78-0.

4-Acetylthiazole (I, R = H) was prepared by treating BrCH2COCMe:NOH with P2S5 and HCONH2 to give 30% 4-acetylthiazole oxime which was treated with aqueous CH2O to give 65% I (R = H). I (R = Me, Ph) were also obtained by cleaving their oximes with CH2O. I (R = CO2Et) was prepared by thiolating Et oxamate, treating Et thiooxamate with BrCH2COCMe:NOH and cleaving the oxime with CH2O.

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Product Details of 23002-78-0. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-(2-Methylthiazol-4-yl)ethanone, is researched, Molecular C6H7NOS, CAS is 23002-78-0, about Lipase kinetic enantiomeric resolution of 1-heteroarylethanols. Author is Kucher, Olexandr V.; Kolodyazhnaya, Anastasiya O.; Smolii, Oleg B.; Nazarenko, Nadiya K.; Kubyshkin, Vladimir; Mykhailiuk, Pavel K.; Tolmachev, Andrey A..

The use of lipases offers a simple and straightforward method toward various chiral secondary alcs. Here we examined the lipase resolution of 1-heteroarylethanols. Racemic substrates were subjected to a two step resolution strategy. The difference between the substituent sizes around the chiral fragment allowed the successful isolation of the (S)-alcs. with assistance of the Burkholderia cepacia lipase (ee ≥ 96%). The (R)-isomers were obtained after hydrolysis of the enantioenriched O-acetylated alcs. either with Candida antarctica lipase B or with potassium carbonate. The performance of the latter step was found to be substrate dependent.

Here is a brief introduction to this compound(23002-78-0)Product Details of 23002-78-0, if you want to know about other compounds related to this compound(23002-78-0), you can read my other articles.

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