Category: 22620-34-4

Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. II. Preparation of 5-halo-3-pyridylmethanols>, HPLC of Formula: 22620-34-4, the main research area is fluoronicotinate; nicotinate halo reduction; halopyridinemathanol; pyridine methanol halo.

The 3-pyridinemethanols (I, R = Br, Cl, F) were prepared in 40, 52, and 73% yields resp. by NaBH4 or KBH4 reduction of the corresponding Et halonicotinates. 5-Fluoronicotinic acid was prepared in 48% yield by diazotizing 5-aminonicotinic acid in HBF4-THF-H2O and decomposing the resulting salt in refluxing ligroine.

Acta Pharmaceutica Suecica published new progress about 22620-34-4. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, HPLC of Formula: 22620-34-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. II. Preparation of 5-halo-3-pyridylmethanols>, HPLC of Formula: 22620-34-4, the main research area is fluoronicotinate; nicotinate halo reduction; halopyridinemathanol; pyridine methanol halo.

The 3-pyridinemethanols (I, R = Br, Cl, F) were prepared in 40, 52, and 73% yields resp. by NaBH4 or KBH4 reduction of the corresponding Et halonicotinates. 5-Fluoronicotinic acid was prepared in 48% yield by diazotizing 5-aminonicotinic acid in HBF4-THF-H2O and decomposing the resulting salt in refluxing ligroine.

Acta Pharmaceutica Suecica published new progress about 22620-34-4. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, HPLC of Formula: 22620-34-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Henke, Bettina; Westerlund, Douglas published the artcile< Hydrophobic chromatography and bioanalysis of some polar pyridine derivatives used as antilipolytic agents>, Category: alcohols-buliding-blocks, the main research area is pyridine derivative determination plasma chromatog; hypolipidemic determination plasma chromatog.

The antilipolytic compounds 5-fluoro-3-pyridinecarboxylic acid [402-66-4] and 5-fluoro-3-hydroxymethylpyridine [22620-32-2] were determined quant. in plasma (precisions = 5-7% in the concentration range 1-20 μg/mL) by liquid chromatog. on LiChrosorb RP-8 (5 μm) with phosphate buffer pH 3-4 as mobile phase, after precipitation of proteins and direct injection of the supernatant. Detection limits were 0.1-0.2 μg/mL plasma. The chromatog. retention was explained by adsorption of the uncharged compounds on to the support complemented by ion-pair adsorption with buffer components at extreme pH values.

Journal of Chromatography published new progress about Blood analysis. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Henke, Bettina; Westerlund, Douglas published the artcile< Hydrophobic chromatography and bioanalysis of some polar pyridine derivatives used as antilipolytic agents>, Category: alcohols-buliding-blocks, the main research area is pyridine derivative determination plasma chromatog; hypolipidemic determination plasma chromatog.

The antilipolytic compounds 5-fluoro-3-pyridinecarboxylic acid [402-66-4] and 5-fluoro-3-hydroxymethylpyridine [22620-32-2] were determined quant. in plasma (precisions = 5-7% in the concentration range 1-20 μg/mL) by liquid chromatog. on LiChrosorb RP-8 (5 μm) with phosphate buffer pH 3-4 as mobile phase, after precipitation of proteins and direct injection of the supernatant. Detection limits were 0.1-0.2 μg/mL plasma. The chromatog. retention was explained by adsorption of the uncharged compounds on to the support complemented by ion-pair adsorption with buffer components at extreme pH values.

Journal of Chromatography published new progress about Blood analysis. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. VI. Syntheses of some new halo-substituted pyridine compounds. Effects on noradrenaline-stimulated free fatty acid mobilization>, Formula: C6H6ClNO, the main research area is pyridine halo hydroxy hypolipidemic; hypolipidemic halopyridine.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

Acta Pharmaceutica Suecica published new progress about Lipids Role: RCT (Reactant), RACT (Reactant or Reagent). 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Formula: C6H6ClNO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jianmin; Huitema, Carly; Niu, Chunying; Yin, Jiang; James, Michael N. G.; Eltis, Lindsay D.; Vederas, John C. published the artcile< Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase>, Related Products of 22620-34-4, the main research area is aryl methylene ketone derivative preparation SARS 3C proteinase inhibitor; fluorinated methylene ketone derivative preparation SARS 3C proteinase inhibitor; structure activity SARS 3C like proteinase inhibiting ketone derivative.

The severe acute respiratory syndrome (SARS) virus depends on a chymotrypsin-like cysteine proteinase (3CLpro) to process the translated polyproteins to functional viral proteins. This enzyme is a target for the design of potential anti-SARS drugs. A series of ketones and corresponding mono- and di-fluoro ketones having two or three aromatic rings were synthesized as possible reversible inhibitors of SARS 3CLpro. The design was based on previously established potent inhibition of the enzyme by oxa analogs (esters), which also act as substrates. Structure-activity relationships and modeling studies indicate that three aromatic rings, including a 5-bromopyridin-3-yl moiety, are key features for good inhibition of SARS 3CLpro. 2-(5-Bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone and its α-monofluorinated analog, gave the best reversible inhibition with IC50 values of 13 μM and 28 μM, resp. In contrast to inhibitors having two aromatic rings, α-fluorination of compounds with three rings unexpectedly decreased the inhibitory activity.

Bioorganic Chemistry published new progress about Antiviral agents. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Related Products of 22620-34-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Misiorny, Alfons; Sjoberg, Berndt; Stjernstrom, Nils E.; Westin, Gertrud published the artcile< Potential hypolipidemic agents. VI. Syntheses of some new halo-substituted pyridine compounds. Effects on noradrenaline-stimulated free fatty acid mobilization>, Formula: C6H6ClNO, the main research area is pyridine halo hydroxy hypolipidemic; hypolipidemic halopyridine.

The pyridines I (R = CHO, CH2OH, CH2CN, CH2CO2H, CH2OCH2Ph, CH2O2CNHPh CH2O2CCMe2OC6H4Cl-p, etc.; R1 = 5-F, 6-F, 5-Cl, 6-Cl, 5-Br) were prepared Thus I (R = CH2OH, R1 = 5-F) was treated with SOCl2 and the product treated with KCN to give I (R = CH2CN, R1 = 5-F), which was hydrolyzed to give I (R = CH2CO2H, R1 = 5-F). 5-Fluoronicotinic acid and 5-fluoro-3-pyridylmethanol were oxidized with H2O2 to give the pyridine oxides (II, R = CO2H, R = CH2OH, resp.). The N-methylnicotinic acid (III) was also prepared The pharmacol. effects of the compounds on noradrenaline-induced free fatty acid mobilization in dogs was determined and related to nicotinic acid.

Acta Pharmaceutica Suecica published new progress about Lipids Role: RCT (Reactant), RACT (Reactant or Reagent). 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Formula: C6H6ClNO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Jianmin; Huitema, Carly; Niu, Chunying; Yin, Jiang; James, Michael N. G.; Eltis, Lindsay D.; Vederas, John C. published the artcile< Aryl methylene ketones and fluorinated methylene ketones as reversible inhibitors for severe acute respiratory syndrome (SARS) 3C-like proteinase>, Related Products of 22620-34-4, the main research area is aryl methylene ketone derivative preparation SARS 3C proteinase inhibitor; fluorinated methylene ketone derivative preparation SARS 3C proteinase inhibitor; structure activity SARS 3C like proteinase inhibiting ketone derivative.

The severe acute respiratory syndrome (SARS) virus depends on a chymotrypsin-like cysteine proteinase (3CLpro) to process the translated polyproteins to functional viral proteins. This enzyme is a target for the design of potential anti-SARS drugs. A series of ketones and corresponding mono- and di-fluoro ketones having two or three aromatic rings were synthesized as possible reversible inhibitors of SARS 3CLpro. The design was based on previously established potent inhibition of the enzyme by oxa analogs (esters), which also act as substrates. Structure-activity relationships and modeling studies indicate that three aromatic rings, including a 5-bromopyridin-3-yl moiety, are key features for good inhibition of SARS 3CLpro. 2-(5-Bromopyridin-3-yl)-1-(5-(4-chlorophenyl)furan-2-yl)ethanone and its α-monofluorinated analog, gave the best reversible inhibition with IC50 values of 13 μM and 28 μM, resp. In contrast to inhibitors having two aromatic rings, α-fluorination of compounds with three rings unexpectedly decreased the inhibitory activity.

Bioorganic Chemistry published new progress about Antiviral agents. 22620-34-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H6ClNO, Related Products of 22620-34-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts