Category: 22483-09-6

Wang, Yuanze published the artcileDiverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Mueller Reactions, Quality Control of 22483-09-6, the main research area is isoquinoline scaffold preparation Ugi Pomeranz Fritsch Schlittler Mueller.

The Pomeranz-Fritsch reaction and its Schlittler-Mueller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde di-Et acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds, and benzo[d]azepinone scaffolds, were synthesized in generally moderate to good yield. All the authors’ syntheses provide a short MCR-based sequence to novel or otherwise difficult to access scaffolds. Hence, the authors foresee multiple applications of these synthesis technologies.

Organic Letters published new progress about Carbolines Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hang, Zhaojun published the artcileA practical method for N-cyanation of secondary amines and sulfonamides, HPLC of Formula: 22483-09-6, the main research area is cyanamide preparation; secondary amine sulfonamide CBX cyanation alk condition.

Cyanamides are an important class of mols. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1,2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.

Tetrahedron Letters published new progress about Cyanamides Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fillery, Shaun M. published the artcileExpeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations, Computed Properties of 22483-09-6, the main research area is tricyclic pyrrolopyridone preparation; bromopyridone bromoaniline cyclic ketone Buchwald Hartwig Heck Fischer indole.

The facile synthesis of both saturated and unsaturated tricyclic pyrrolo-pyridones starting from a single readily available, common monocyclic reagent has been developed. An intermol. annulation via a tandem Buchwald-Hartwig/Heck reaction led to the synthesis of β-carbolinones. The analogous semisatd. tricyclic pyrrolo-pyridones were prepared in good to excellent yields by sequential Buchwald-Hartwig and Fischer indole reactions. The methods feature mild reaction conditions and good functional group tolerance.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (bromo). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Braun, Carolin published the artcilePlanar-chiral [2.2]Paracyclophane-based Pyridonates as Ligands for Tantalum-catalyzed Hydroaminoalkylation, HPLC of Formula: 22483-09-6, the main research area is planar chiral paracyclophane pyridonate ligand tantalum catalyzed hydroaminoalkylation.

By using planar chiral [2.2]paracyclophane-containing N,O-chelating ligands for tantalum-catalyzed hydroaminoalkylation, one of the most versatile catalytic systems for this reaction to date was obtained [e.g., 4-methoxy-N-methylaniline + 1-octene I (90%)]. Convenient Csp3-Csp3 bond formation of amines with terminal and internal alkenes was enabled by the same in situ synthesized catalytic system of [2.2]paracyclophane-based pyridonates and Ta(CH2TMS)3Cl2 that shows also very promising results for N-containing heterocycles.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (internal). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileSynthesis of Alkylphosphoryl-Containing 4(5)-Arylimidazolin-2-ones, Synthetic Route of 22483-09-6, the main research area is phosphoryl aryl imidazolinone preparation.

The acid-catalyzed reaction of {2-[1-(2,2-dimethoxyethyl)-3-(phenylcarboxamido)]ethyl}phosphonate or di-Et [2-(2-oxo-3-phenyl-2,3-dihydro-1H-imidazol-1-yl)ethyl]phosphonate with resorcinol and its derivatives afforded new 4(5)-arylimidazolin-2-ones. The ratio of the resulting regioisomers is significantly affected by the structure of the starting compounds, which allows one to obtain products with a predominance of one regioisomer.

Russian Journal of General Chemistry published new progress about Imidazolinones Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Synthetic Route of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zhengnian published the artcileDiscovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing, Name: 2,2-Dimethoxyethanamine, the main research area is benzopyrimidodiazepinone TNK2 inhibitor; Benzopyrimidodiazepinone; Kinase inhibitor; Scaffold morphing; TNK2.

The protein kinase TNK2 (ACK1) is an emerging drug target for a variety of indications, in particular for cancer where it plays a key role transmitting cell survival, growth and proliferative signals via modification of multiple downstream effectors by unique tyrosine phosphorylation events. Scaffold morphing based on our previous TNK2 inhibitor XMD8-87 identified urea 17 (I) from which we developed the potent and selective compound 32 (II). A co-crystal structure was obtained showing 32 interacting primarily with the main chain atoms of an alanine residue of the hinge region. Addnl. H-bonds exist between the urea NHs and the Thr205 and Asp270 residues.

Bioorganic & Medicinal Chemistry Letters published new progress about Crystal structure (co-crystal structure of enzyme-inhibitor complex). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Name: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reynard, Guillaume published the artcileEtherification of phenols by amines via transient diazonium intermediates, Related Products of alcohols-buliding-blocks, the main research area is phenol alkyl amine propanedinitrite etherification; alkyl phenyl ether preparation.

The synthesis of alkyl aryl ethers from electron poor phenols and amines using 1,3-propanedinitrite was described. Due to the mild conditions, functionalized primary, secondary and tertiary alkyl groups were successfully introduced, denoting a highly tolerant process that allowed for unprotected alcs. and acetals. The reaction was thought to proceeded through the formation of a diazonium intermediate that undergoes subsequent SN2> or SN1 reactions.

Canadian Journal of Chemistry published new progress about Alkyl aryl ethers Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Wei-Jin published the artcileElectrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction, Quality Control of 22483-09-6, the main research area is pyrrole preparation electrochem; dicarbonyl compound aldehyde amine three component radical addition reaction.

An efficient electrochem. synthesis of 1,2,3-trisubstituted pyrroles I (R1 = n-Pr, Bn, cyclohexyl, etc.; R2 = H, Ph, Bn, i-Pr, etc.; R3 = Me, OMe, OEt, OPr, Ph) was developed by one-pot three-component reaction of β-dicarbonyl compounds, R3C(O)CH2C(O)CH3 aldehydes R2CH2CHO with amines R1NH2. The target products could be obtained in good to excellent yields. The investigations indicate that β-enamino ketone is a key intermediate in this transformation and the reaction mechanism may involve a radical addition reaction pathway.

Tetrahedron Letters published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Krieg, Sara-Cathrin published the artcileStereoselective Synthesis of 2-Oxyenamides, Computed Properties of 22483-09-6, the main research area is acylated oxyenamide diastereoselective preparation DFT; acyl chloride aminoacetaldehyde dimethyl acetal acylation; sulfonylated oxyenamide diastereoselective preparation DFT; sulfonyl chloride aminoacetaldehyde dimethyl acetal sulfonylation.

An improved route for highly stereoselective synthesis of (Z)-2-oxyenamides I [R = cyclohexyl, 2-furyl, 4-BrC6H4, etc.; R1 = Me, 2-thienyl, 4-MeOC6H4, etc.] was reported. The desired products could be accessed in only three steps from aminoacetaldehyde di-Me acetal as common, readily available building block in a highly modular fashion. The improved procedure had been applied to synthesis of various acylated and sufonylated oxyenamides. Mechanistic and theor. studies provided a conclusive rationale for observed stereoselectivities.

European Journal of Organic Chemistry published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent) (aminoacetaldehyde). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hadian, Mojgan published the artcileSustainability by design: automated nanoscale 2,3,4-trisubstituted quinazoline diversity, Safety of 2,2-Dimethoxyethanamine, the main research area is formyl acid preparation amine isocyanide Ugi reaction; amido carboxyquinazoline preparation.

The synthetic execution of a newly designed quinazoline reaction towards a transformative sustainability in chem. was exemplified. This included nanoscale synthesis, deep chem. space exploration, scalability over 6 orders of magnitude from milligram up to 10-g resynthesis of quinazolines enabled by the simultaneous variation of four classes of building blocks. Benefits of our approach include a simple to perform, one-step procedure, mild reaction conditions and access to a very large chem. space through accessing many available building blocks. More than thousand derivatives were produced in an automated fashion on a nanoscale using pos. pressure facilitated dispensing. Along with these advantages, there is a considerable reduction in synthetic effort, reagents, solvent, glass and plastic consumables and power consumption to decrease the footprint of synthetic chem.

Green Chemistry published new progress about Amides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts