Category: 224434-01-9

Related Products of 224434-01-9《Enantioselective Cu(I)-Catalyzed Cycloaddition of Prochiral Diazides with Terminal or 1-Iodoalkynes》 was published in 2020. The authors were Wang, Cai;Zhu, Ren-Yi;Liao, Kui;Zhou, Feng;Zhou, Jian, and the article was included in《Organic Letters》. The author mentioned the following in the article:

We report an unprecedented highly enantioselective desym. Cu(I)-catalyzed 1,3-dipolar cycloaddition of diazides with terminal alkynes and 1-iodoalkynes, affording tertiary alcs. bearing a 1,2,3-triazole moiety in high yield and excellent ee value. PYBOX ligands with a C4 shielding group once again show the promising ability to achieve higher enantioselectivity.(S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) were involved in the experimental procedure.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Related Products of 224434-01-9

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Product Details of 224434-01-9In 2020, Shao, Wen;Besnard, Celine;Guenee, Laure;Mazet, Clement published 《Ni-Catalyzed Regiodivergent and Stereoselective Hydroalkylation of Acyclic Branched Dienes with Unstabilized C(sp³) Nucleophiles》. 《Journal of the American Chemical Society》published the findings. The article contains the following contents:

Two complementary regiodivergent [(P,N)Ni]-catalyzed hydroalkylations of branched dienes are reported. When amides are employed as unstabilized C(sp³) nucleophiles, a highly regioselective 1,4-addition process is favored. The addition products are obtained in high yield and with excellent stereocontrol of the internal olefin. With use of a chiral ligand and imides as carbon nucleophiles, a 3,4-addition protocol was developed, enabling construction of two contiguous tertiary stereocenters in a single step with moderate to high levels of diastereocontrol and excellent enantiocontrol. Both methods operate under mild reaction conditions, display a broad scope, and show excellent functional group tolerance. The synthetic potential of the 3,4-hydroalkylation reaction was established via a series of postcatalytic modifications. To complete the study, the researchers used (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Product Details of 224434-01-9

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Computed Properties of C8H10FNOIn 2017, Guo, Jing;Zhu, Mingyue;Wu, Tianxiao;Hao, Chenzhou;Wang, Kai;Yan, Zizheng;Huang, Wanxu;Wang, Jian;Zhao, Dongmei;Cheng, Maosheng published 《Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study》. 《Bioorganic & Medicinal Chemistry》published the findings. The article contains the following contents:

Utilizing a pharmacophore hybridization approach, a novel series of substituted indolin-2-one derivatives were designed, synthesized and evaluated for their in vitro biol. activities against p21-activated kinase 4. Three compounds including I exhibited the most potent inhibitory activity against PAK4 (IC₅₀ = 22 nM, 16 nM and 27 nM, resp.). Among them, compound I showed the highest antiproliferative activity against A549 cells (IC₅₀ = 0.83 μM). Apoptosis anal. in A549 cells suggested that compound I delayed cell cycle progression by arresting cells in the G2/M phase of the cell cycle, retarding cell growth. Further investigation demonstrated that compound I strongly inhibited migration and invasion of A549 cells. Western blot anal. indicated that compound I potently inhibited the PAK4/LIMK1/cofilin signaling pathways. Finally, the binding mode between compound I with PAK4 was proposed by mol. docking. A preliminary ADME profile of the compound I was also drawn on the basis of QikProp predictions.(S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) were involved in the experimental procedure.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Computed Properties of C8H10FNO

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Reference of (S)-2-Amino-2-(4-fluorophenyl)ethanol《Cascade biocatalysis for regio- and stereoselective aminohydroxylation of styrenyl olefins to enantiopure arylglycinols》 was published in 2020. The authors were Zhang, Jiandong;Yang, Xiaoxiao;Dong, Rui;Gao, Lili;Li, Jing;Li, Xing;Huang, Shuangping;Zhang, Chaofeng;Chang, Honghong, and the article was included in《ACS Sustainable Chemistry & Engineering》. The author mentioned the following in the article:

Chiral β-amino alcs. are privileged scaffolds frequently found in pharmaceutically active mols. and natural products. Aminohydroxylation of olefins is one of the most powerful strategies to access chiral vicinal amino alcs. However, the direct regio- and stereoselective aminohydroxylation of olefins to unprotected enantioenriched β-amino alcs. remains a long-standing challenge. Herein, we report that a novel one-pot four-enzyme [styrene monooxygenase (SMO)/epoxide hydrolase (EH)/alc. dehydrogenase (ADH)/ω-transaminase (TA)] biocatalytic cascade efficiently catalyzes the direct transformation of readily available styrenyl olefins into unprotected 2-amino-2-Ph ethanols in good yields and excellent enantioselectivity. In vitro cascade biocatalysis aminohydroxylation of styrenyl olefins was first investigated by the combined four enzymes (SMO/EH/ADH/TA) with a trace amount of NADH (0.02 mM) and pyridoxal-5′-phosphate (0.1 mM), affording both enantiomers of β-amino alcs. 5a-j in 13.9-98.7% conversions and 86-99% ee. Whole-cell-based cascade biocatalysis was achieved by using the constructed recombinant Escherichia coli pairwise combinations and single tailor-made whole-cell biocatalyst without an addnl. NADH cofactor; (R)- and (S)-β-amino alcs. 5a-j could be obtained in 14.6-99.7% conversions and 86-99% ee. Moreover, the preparative experiments of this new cascade biocatalysis were demonstrated by the single tailor-made whole-cell biocatalyst [E. coli (CGS-DEM) and E. coli (CGS-DEB)] with the substrates 1a-b and 1h in an aqueous-organic two-phase system, affording chiral β-amino alcs. [(R)- or (S)-5a-b, h] in good yields (50.9-64.3%) and excellent ee (>99%). A new type of cascade biocatalysis was developed for regio- and enantioselective aminohydroxylation of styrenyl olefins to useful and valuable chiral arylglycinols in good yields and excellent ee. To complete the study, the researchers used (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Reference of (S)-2-Amino-2-(4-fluorophenyl)ethanol

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Name: (S)-2-Amino-2-(4-fluorophenyl)ethanol《Discovery and Optimization of Phosphopantetheine Adenylyltransferase Inhibitors with Gram-Negative Antibacterial Activity》 was published in 2018. The authors were Skepper, Colin K.;Moreau, Robert J.;Appleton, Brent A.;Benton, Bret M.;Drumm, Joseph E.;Feng, Brian Y.;Geng, Mei;Hu, Cheng;Li, Cindy;Lingel, Andreas;Lu, Yipin;Mamo, Mulugeta;Mergo, Wosenu;Mostafavi, Mina;Rath, Christopher M.;Steffek, Micah;Takeoka, Kenneth T.;Uehara, Kyoko;Wang, Lisha;Wei, Jun-Rong;Xie, Lili;Xu, Wenjian;Zhang, Qiong;de Vicente, Javier, and the article was included in《Journal of Medicinal Chemistry》. The author mentioned the following in the article:

In the preceding manuscript the authors described a successful fragment-based lead discovery (FBLD) strategy for discovery of bacterial phosphopantetheine adenylyltransferase inhibitors (PPAT, CoaD). Following several rounds of optimization two promising lead compounds were identified: triazolopyrimidinone (I) and 4-azabenzimidazole (II). Here the authors disclose the efforts to further optimize these two leads for on-target potency and Gram-neg. cellular activity. Enabled by a robust x-ray crystallog. system, the authors’ structure-based inhibitor design approach delivered compounds with biochem. potencies 4-5 orders of magnitude greater than their resp. fragment starting points. Addnl. optimization was guided by observations on bacterial permeability and physicochem. properties, which ultimately led to the identification of PPAT inhibitors with cellular activity against wild-type E. coli. The experimental procedure involved many compounds, such as (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Name: (S)-2-Amino-2-(4-fluorophenyl)ethanol

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Hamada, Yoshio;Ohta, Hiroko;Miyamoto, Naoko;Sarma, Diganta;Hamada, Takashi;Nakanishi, Tomoya;Yamasaki, Moe;Yamani, Abdellah;Ishiura, Shoichi;Kiso, Yoshiaki published 《Significance of interactions of BACE1-Arg235 with its ligands and design of BACE1 inhibitors with P₂ pyridine scaffold. [Erratum to document cited in CA151:049158]》 in 2009. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Category: alcohols-buliding-blocks The article mentions the following:

On page 2438, Table 2 is incorrect; the correct version of the table is given. And (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) was used in the research process.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Category: alcohols-buliding-blocks

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Category: alcohols-buliding-blocksIn 2011, Pan, Xingang;Jia, Liangbin;Liu, Xuejian;Ma, Haikuo;Yang, Wenqian;Schwarz, Jacob B. published 《A general asymmetric synthesis of phenylglycinols》. 《Tetrahedron: Asymmetry》published the findings. The article contains the following contents:

Hydride reduction and deprotection of siloxymethyl sulfinimines, e.g., I, reliably furnished chiral phenylglycinols, e.g., II or III, in high overall yield and enantiomeric purity. The experimental procedure involved many compounds, such as (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Category: alcohols-buliding-blocks

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Related Products of 224434-01-9《Chiral Alkyl Amine Synthesis via Catalytic Enantioselective Hydroalkylation of Enecarbamates》 was published in 2021. The authors were Qian, Deyun;Bera, Srikrishna;Hu, Xile, and the article was included in《Journal of the American Chemical Society》. The author mentioned the following in the article:

A nickel-catalyzed hydroalkylation method to assemble a wide range of chiral alkyl amines from enecarbamates (N-Cbz-protected enamines) and alkyl halides with high regio- and enantioselectivity was reported. The method works for both nonactivated and activated alkyl halides and was able to produce enantiomerically enriched amines with two minimally differentiated α-alkyl substituents. The mild conditions led to high functional group tolerance, which is demonstrated in the postproduct functionalization of many natural products and drug mols., as well as the synthesis of chiral building blocks and key intermediates to bioactive compounds And (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) was used in the research process.

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Related Products of 224434-01-9

Reference:
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Liu, En-Chih;Topczewski, Joseph J. published 《Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution》. The research results were published in《Journal of the American Chemical Society》 in 2019.Safety of (S)-2-Amino-2-(4-fluorophenyl)ethanol The article conveys some information:

In the presence of [Cu(OTf)]₂·PhMe and a nonracemic bis(chlorophenyl)pyridinebis(oxazoline), allylic azides such as I underwent enantioselective azide-alkyne cycloaddition reactions via dynamic kinetic resolution to yield nonracemic allylic triazoles such as II. A nonracemic propargyl alc. and propargyl-substituted natural products underwent enantioselective azide-alkyne cycloaddition reactions in high diastereoselectivities. The azide reactants are potentially explosive and should be handled with care; reaction mixtures should not be worked up with acid to avoid the formation of hydrazoic acid and their wastes should be kept sep. from other organic wastes. The experimental procedure involved many compounds, such as (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Safety of (S)-2-Amino-2-(4-fluorophenyl)ethanol

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts