Category: 22436-06-2

Synthetic Route of 22436-06-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 22436-06-2 as follows.

Under a nitrogen atmosphere, a 1 L three-necked glass vial was charged with 54 g of (±)-2-methyl-3-phenyl-1-propanol, 64 g of phthalic anhydride, 1.38 g of pyridine, and 540 g of tetrahydrofuran.The reaction was stirred at 0 C – 20 C for 30 hours, and concentrated to give a crude product (122 g).After crystallization with ethyl acetate as a solvent,103 g of (±)-2-methyl-3-phenyl-1-propanol-phthalic acid monoester were obtained, and the purity of the liquid chromatography was ?98%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22436-06-2, its application will become more common.

Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Diao Bozhen; Zhang Limeng; Kang Jie; (12 pag.)CN109503319; (2019); A;,
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Electric Literature of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Methanesulfonyl chloride (6.29 mmol) was added dropwise to asolution of the alcohol (5.72 mmol) and diisopropylethylamine (8.58 mmol) in DCM (20.5 mL) at 0 C and warmed to room temperature. After 90 min, the mixture was partitioned with distilled water (2*20 mL), 1M HCl (2*10 mL), and brine (20 mL). The organic layer was dried (MgSO4), filtered, and concentrated under vacuum to give the desired compound, which was taken forward without purification

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shouksmith, Andrew E.; Evans, Laura E.; Tweddle, Deborah A.; Miller, Duncan C.; Willmore, Elaine; Newell, David R.; Golding, Bernard T.; Griffin, Roger J.; Australian Journal of Chemistry; vol. 68; 4; (2015); p. 660 – 679;,
Alcohol – Wikipedia,
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Electric Literature of 22436-06-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Under nitrogen protection,Add to a 1L three-neck glass bottle54g of (±)-2-methyl-3-phenyl-1-propanol,64g of phthalic anhydride,1.38 g of pyridine,540 g of tetrahydrofuran.The reaction was stirred at 0 C – 20 C for 30 hours.Concentrated to give 122 g of crude material.After crystallization with ethyl acetate as a solvent,Obtained 103g of (±)-2-methyl-3-phenyl-1-propanol- phthalic acid monoester,The purity of the liquid chromatography is ?98%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22436-06-2, (S)-2-Methyl-3-phenylpropan-1-ol.

Reference:
Patent; Jiangsu Guangyu Chemical Co., Ltd.; Diao Bozhen; Zhang Limeng; Kang Jie; (13 pag.)CN109534957; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, the common compound, a new synthetic route is introduced below. Formula: C10H14O

General procedure: To a CH2Cl2 solution (2 mL) of the (Sax)-chloride 1a (429 mg,1.0 mmol) was added a solution of 2-methyl-1-hexanol (2a)(119 mg, 1.0 mmol) in CH2Cl2 (1 mL) and Et3N (0.14 mL,1.0 mmol) at room temperature under an Ar atmosphere. Theresulting solution was stirred at reflux in CH2Cl2 for 6.5 h.The reaction mixture was poured into water and extracted withCH2Cl2. The organic layer was dried over MgSO4, filtered, concentrated,and purified by column chromatography on silicagel (CH2Cl2:hexane = 1:5) to give the corresponding ester 3a(429 mg, 84%, 54 : 46) as a white solid.

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Murai, Toshiaki; Itoh, Hikaru; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 2; (2016); p. 163 – 173;,
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Related Products of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetyl chloride (1.816 g, 23.14 mmol) was added slowly to a solution of (±)-4a (1.728 g, 11.50 mmol) and dry pyridine (2.757 g,34.85 mmol) in dry CH2Cl2 (30 mL) at 0 C. The reaction mixture was stirred overnight at room temperature. The reaction was quenched with water (30 mL) at 0 C. The mixture was extracted with Et2O (50 mL). The organic layer was washed with brine (30 mL), dried over anhydrous Na2SO4 and filtered. After removal ofthe solvent, the residue was purified by column chromatography on silica gel (hexane/EtOAc 5/1) to afford (±)-5a (2.079 g, 94%) as a colorless oil. 1H NMR data were identical to those reported in the literature [40].

The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kato, Daiki; Kawasaki, Masashi; Morita, Yuko; Okada, Takuya; Tanaka, Yasuo; Toyooka, Naoki; Tetrahedron; (2020);,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 22436-06-2, (S)-2-Methyl-3-phenylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 22436-06-2, blongs to alcohols-buliding-blocks compound. Quality Control of (S)-2-Methyl-3-phenylpropan-1-ol

General procedure: To a CH2Cl2 solution (0.8mL) of the (Sax)-chloride 1b (118mg,0.2 mmol) was added a solution of 2-methyl-1-hexanol (1a)(71.7 mg, 0.6 mmol) in CH2Cl2 (0.8 mL) and Et3N (0.03 mL,0.2 mmol) at room temperature under an Ar atmosphere. Theresulting solution was stirred at reflux in CH2Cl2 for 7 hr. Thereaction mixture was poured into water and extracted withCH2Cl2. The organic layer was dried over MgSO4, filtered, concentrated,and purified by column chromatography on silicagel (CH2Cl2:hexane = 1:5) to give the corresponding ester 5a(71.3 mg, 53%, 50:50) as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22436-06-2, its application will become more common.

Reference:
Article; Murai, Toshiaki; Itoh, Hikaru; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 191; 2; (2016); p. 163 – 173;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 22436-06-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol. A new synthetic method of this compound is introduced below.

Example 115.1 g (100 mmol) of 2-methyl-3-phenylpropanol were introduced as initial charge in 87 g of dichloromethane. Over the course of 4 hours, 13.4 g (100 mmol) of AlCl3 and 9.3 g (100 mmol) of tert-butyl chloride were added at a temperature of 1-10 C. The mixture was heated to room temperature and worked-up with water and sodium hydroxide solution and the solvent was removed. This gave a mixture with the following composition: 2-methyl-3-(3-tert-butylphenyl)propanol (41%); 2-methyl-3-(4-tert-butylphenyl)propanol (24%); 3-(3,5-di-tert-butylphenyl)-2-methylpropanol (19%); 2-methyl-3-phenylpropanol (15%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22436-06-2, (S)-2-Methyl-3-phenylpropan-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; BASF SE; US2012/209030; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts