Category: 2240-88-2

Jimenez, Elena published the artcileAtmospheric lifetimes and global warming potentials of CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH, HPLC of Formula: 2240-88-2, the publication is ChemPhysChem (2010), 11(18), 4079-4087, database is CAplus and MEDLINE.

A comprehensive study of several atm. degradation routes for two hydrofluoroalcs., CF₃(CH₂)_x=1,2CH₂OH, is presented. The gas-phase kinetics of their reactions with hydroxyl radicals (OH) and chlorine (Cl) atoms are investigated by absolute and relative techniques, resp. The room-temperature rate coefficients (±σ, in cm³ mol.^-1 s^-1) k_OH and k_Cl, are resp. (9.7 ± 1.1) × 10^-13 and (1.60 ± 0.45) × 10^-11 for CF₃CH₂CH₂OH, and (2.62 ± 0.32) × 10^-12 and (8.71 ± 0.24) × 10^-11 for CF₃(CH₂)₂CH₂OH. Average lifetimes of CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH due to the OH and Cl reactions are estimated to be 12 and 4 days, and greater than 20 and 4 years, resp. Also, the IR and UV absorption cross sections of CF₃(CH₂)_x=1,2CH₂OH are determined in the spectral ranges of 500-4000 cm^-1 and 200-310 nm. Photolysis of CF₃(CH₂)_x=1,2CH₂OH in the actinic region (λ ≥ 290 nm) is negligible compared to their homogeneous removal. Addnl., computational IR spectra are consistent with the exptl. ones, thus giving high confidence in the obtained results. The lifetimes of CF₃(CH₂)_x=1,2CH₂OH and IR spectra reported herein allow the calculation of the direct global warming potential of these hydrofluoroalcs. The contribution of CF₃(CH₂)_xCH₂OH to radiative forcing of climate change will be negligible.

ChemPhysChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, HPLC of Formula: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Avery, Mitchell A. published the artcileStructure-Activity Relationships of the Antimalarial Agent Artemisinin. 7. Direct Modification of (+)-Artemisinin and In Vivo Antimalarial Screening of New, Potential Preclinical Antimalarial Candidates, Formula: C3H5F3O, the publication is Journal of Medicinal Chemistry (2002), 45(19), 4321-4335, database is CAplus and MEDLINE.

On the basis of earlier reported quant. structure-activity relationship studies, a series of 9β-16-(arylalkyl)-10-deoxoartemisinins, e.g. I, were proposed for synthesis. Several of the new compounds were synthesized employing the key synthetic intermediate II. In a second approach, the natural product (+)-artemisinic acid (III) was utilized as an acceptor for conjugate addition, and the resultant homologated acids were subjected to singlet oxygenation and acid treatment to provide artemisinin analogs. Under a new approach, we developed a one step reaction for the interconversion of artemisinin into artemisitene (IV) that did not employ selenium-based reagents and found that 2-arylethyliodides would undergo facile radical-induced conjugate addition to the exomethylene lactone of IV in good yield. The lactone carbonyls were removed sequentially by diisobutylaluminum hydride reduction followed directly by a second reduction (BF₃-etherate/Et₃SiH) to afford the desired corresponding pyrans. Six addnl. halogen-substituted aromatic side chains were installed via IV furnishing the bioassay candidates. The analogs were examined for in vitro antimalarial activity in the W-2 and D-6 clones of Plasmodium falciparum and were addnl. tested in vivo in Plasmodium berghei- and/or Plasmodium yoelii-infected mice. Several of the compounds emerged as highly potent orally active candidates without obvious toxicity. Of these, two were chosen for pharmacokinetic evaluation, V and VI.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Takechi, Naoto published the artcileNovel Nucleophilic Trifluoromethylation of Vicinal Diol Cyclic Sulfates, Formula: C3H5F3O, the publication is Organic Letters (2002), 4(26), 4671-4672, database is CAplus and MEDLINE.

A novel method for highly regioselective and stereospecific nucleophilic trifluoromethylation of vicinal diol cyclic sulfates, using the reagent derived from reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE), is presented.

Organic Letters published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C10H15ClO3S, Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abraham, Michael H. published the artcileDescriptors for fluorotelomere alcohols. Calculation of physicochemical properties, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Physics and Chemistry of Liquids (2021), 59(6), 932-937, database is CAplus.

Abraham model solute descriptors are calculated for several environmentally important fluorotelomer alcs. from published partition coefficient and solubility data. The various descriptors all show a gradual trend from 1:2FTOH to 8:2FTOH. The maximum deviation from self-consistent values is 0.19 log units in the calculations on vapor pressure (concentration in air) and solubility in water (concentration in water).

Physics and Chemistry of Liquids published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Simoes, Ana V. C. published the artcileAmphiphilic meso(sulfonate ester fluoroaryl)porphyrins: refining the substituents of porphyrin derivatives for phototherapy and diagnostics, Quality Control of 2240-88-2, the publication is Tetrahedron (2012), 68(42), 8767-8772, database is CAplus.

A set of amphiphilic fluorinated porphyrins appended with sulfonate ester groups were synthesized and fully characterized. The reaction proceeds efficiently, with high yields, with an improved methodol. Their potential use as imaging and phototherapeutic agents was assessed measuring relevant photophys. properties. It is shown that these porphyrins have good photostability, long triplet lifetimes (between 47 μs and 102 μs), high singlet oxygen quantum yields (0.74≤FD≤1.00), low fluorescence quantum yields (<0.04) and sharp ¹⁹F NMR peaks. The data on the new meso(sulfonate ester fluoroaryl)porphyrins illustrate the potential of perfluorinated sulfonate esters to improve phys. properties relevant for cancer imaging and photodynamic therapy.

Tetrahedron published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C10H16Br3N, Quality Control of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pawle, Robert H. published the artcileBandgap Engineering of Conjugated Materials with Nonconjugated Side Chains, Related Products of alcohols-buliding-blocks, the publication is Macromolecules (Washington, DC, United States) (2014), 47(7), 2250-2256, database is CAplus.

Controlling the optical properties of conjugated materials, especially their bandgaps, is critical to nearly all of applications of these materials. The most prevalent strategy involves changes to the structures of conjugated backbones, while side chains are generally reserved for imparting solubility This paper, using a series of donor-acceptor conjugated oligo- and poly(arylene-ethynylene)s that have terephthalate units as the electron-deficient unit, demonstrates examples of how the structures of side chains that are not formally part of the conjugated backbone can have significant effects on bandgaps of these materials. In organic solution, changing alkoxy substituents on the terephthalate unit yields changes in absorbance onsets of, in some cases, greater than 20 nm; the position of absorbance spectra of these materials correlates with the Taft σ* values of the ester alkoxy groups, consistent with the side chains inductively altering the electron-accepting nature of the terephthalate ring. This structure-property relationship persists in the solid state. These results indicate that synthetically simple side-chain substitutions of formally nonconjugated groups may be useful in rational design of the optoelectronic properties of conjugated materials in both solution and the solid state.

Macromolecules (Washington, DC, United States) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts